EXPIRED
Notice Number: NOT-AR-20-016
Key Dates
Release Date: January 15, 2020
First Available Due Date: March 13, 2020
Expiration Date: March 14, 2020
Issued by
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Drug Abuse (NIDA)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Nursing Research (NINR)
National Institute on Minority Health and Health Disparities (NIMHD)
National Center for Complementary and Integrative Health (NCCIH)
National Center for Advancing Translational Sciences (NCATS)
All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.
Office of Behavioral and Social Sciences Research (OBSSR)
Office of Research on Women's Health (ORWH)
Purpose
This Notice of Special Interest (NOSI) calls for research on pain management in the context of opioid use or opioid use disorder (OUD). In particular, NIAMS is interested in providing data-driven evidence regarding effective mechanisms for reducing reliance on opioids while maintaining quality of life. Funds for Competitive Revisions to active grants are available as part of the NIH HEAL (Helping to End Addiction Long-termSM) Initiative and awardees will operate within the Back Pain Consortium (BACPAC) Research Program, a part of the NIH HEAL InitiativeSM. Investigators with active grants in the area of chronic pain and/or addiction are encouraged to apply. This award has two phases, a one-year Planning Phase and a two to three year Research Project Phase.
Background
Back Pain is the major form of chronic pain among adults worldwide and the most common, non-cancer reason for opioid prescription in the US. The NIH HEAL InitiativeSM is a trans-NIH initiative with the aims of improving treatments for opioid misuse and addiction; and enhancing pain management, by understanding the biological underpinnings of chronic pain and accelerating the discovery and development of non-addictive treatments for pain. The Back Pain Consortium (BACPAC) Research Program, part of the NIH HEAL InitiativeSM, provides a platform for research at the intersection of pain management and opioid use or opioid use disorder (OUD). BACPAC is a patient-centric translational research initiative, that is taking a biopsychosocial approach to the study of chronic low back pain (cLBP) and the need for more effective and personalized treatments.
Research Objectives
In order to effectively reduce reliance on opioids in the treatment of chronic low back pain while maintaining quality of life, NIAMS is encouraging the submission of applications for Competitive Revisions to active grants to provide evidence-based data to inform clinical practice guidelines.
Research areas of interest include:
Project Planning Phase - What are the key questions providers and patients have with respect to opioid use for managing chronic pain? Questions of interest might be patient-centric and/or provider-focused, e.g., When is it appropriate to prescribe opioids for chronic pain; if someone is already taking opioids for pain management what are the most effective means for reducing this dependence; what alternatives exist?
Research Project Phase - Investigators should propose strategies to test the most effective means of managing pain while reducing dependence on opioids with the intent of informing clinical practice.
Award Information
NIAMS intends to commit $320,000 in FY2020, the Planning Phase, and $800,000 each year of the Research Project Phase, FY2021 through FY2023, to fund up to two awards. Budget and research project length should reflect project needs, and the parent grant must be active throughout the duration of the Competitive Revision.
Awardees are expected to share data and resources consistent with the guidelines and policies of the NIH, the NIH HEAL InitiativeSM, and as developed by the Steering Committee of the BACPAC Research Program. Adherence to these guidelines and policies will be required in the terms and conditions of award.
Application and Submission Information
Applications in response to this NOSI must be submitted using the following target funding opportunity:
Table 1: Eligible Activity Codes by Participating ICO
Activity Code |
NIAMS |
NIBIB |
NINR |
NIMHD |
NICHD |
NIAAA |
NCATS |
NCCIH |
NIDA |
NINDS |
Yes |
Yes |
No |
No |
No |
No |
No |
Yes |
Yes |
Yes |
|
No |
No |
No |
No |
No |
No |
No |
Yes |
Yes |
No |
|
No |
Yes |
No |
No |
No |
No |
No |
No |
No |
No |
|
Yes |
No |
No |
No |
No |
Yes |
No |
Yes |
Yes |
No |
|
Yes |
Yes |
Yes |
Yes |
No |
Yes |
Yes |
Yes |
Yes |
Yes |
|
No |
No |
No |
No |
No |
No |
No |
No |
Yes |
No |
|
Yes |
No |
No |
No |
No |
No |
No |
Yes |
Yes |
Yes |
|
Yes |
Yes |
Yes |
No |
No |
Yes |
Yes |
Yes |
Yes |
Yes |
|
Yes |
Yes |
No |
No |
No |
No |
No |
No |
Yes |
Yes |
|
Yes |
No |
No |
No |
Yes |
No |
No |
No |
Yes |
Yes |
|
U24 Resource-Related Research Projects Cooperative Agreements |
Yes |
Yes |
No |
No |
Yes |
No |
Yes |
No |
Yes |
Yes |
Yes |
Yes |
No |
Yes |
No |
No |
Yes |
Yes |
Yes |
No |
|
U2C Resource-Related Research Multi-Component Projects and Centers Cooperative Agreements |
No |
No |
No |
No |
No |
No |
No |
No |
Yes |
No |
UF1 Multi-Year Funded Research Project Cooperative Agreement |
No |
No |
No |
No |
No |
No |
No |
No |
Yes |
No |
Yes |
No |
No |
No |
No |
No |
No |
No |
Yes |
Yes |
|
UH3 Exploratory/Developmental Phased Award Cooperative Agreement |
Yes |
Yes |
No |
No |
No |
No |
Yes |
Yes |
Yes |
Yes |
No |
No |
No |
No |
No |
No |
No |
No |
Yes |
No |
All instructions in the SF424 (R&R) Application Guide and PA-18-935 must be followed, with the following additions:
Applications should must be submitted to PA-18-935, “Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)" using the application forms package with the Competition ID “NOT-AR-20-016-FORMS-E”
Inquiries
Please direct all inquiries to:
Scientific/Research Contact(s)
Leslie K. Derr, Ph.D
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Telephone: 301-402-4735
Email: derrl@mail.nih.gov
Laura Kwako, PhD
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-451-8507
Email: laura.kwako@nih.gov
Michael B. Wolfson, PhD
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Telephone: 301-451-4778
Email: Michael.Wolfson@nih.gov
Susan Marden PhD RN
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-435-6838
Email: mardens@mail.nih.gov
Shelley Su, PhD
National Institute on Drug Abuse (NIDA)
Telephone: 301-402-3869
Email: shelley.su@nih.gov
Benyam Hailu, MD, MPH
National Institute on Minority Health and Health Disparities (NIMHD)
Telephone: 301-594-8696
Email: Benyam.Hailu@nih.gov
Michael L. Oshinsky, PhD
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9964
Email: michael.oshinsky@nih.gov
D.P. Mohapatra, PhD
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9964
Email: dp.mohapatra@nih.gov
Lois A. Tully, PhD
National Institute of Nursing Research (NINR)
Telephone: 301-594-5968
Email: tullyla@mail.nih.gov
Lanay M. Mudd, PhD
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-594-9346
Email: Lanay.mudd@nih.gov
Jane Atkinson, DDS
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-827-6031
Email: jatkinso@mail.nih.gov
Lisa Begg, Dr.P.H., R.N.
Office of Research on Women’s Health (ORWH)
Telephone: 301/496-3975
E-mail: beggl@od.nih.gov