Notice Number: NOT-AR-19-022
Key DatesRelease Date: October 9, 2018
NOT-AR-19-023 Notice of Intent to Publish a Funding Opportunity Announcement for the Back Pain Consortium (BACPAC) Research Program: Data Integration, Algorithm Development and Operations Management Center (U24) (Clinical Trial Not Allowed)
NOT-AR-19-025 Notice of Intent to Publish a Funding Opportunity Announcement for the Back Pain Consortium (BACPAC) Phase 2 Clinical Trials (UG3/UH3) (Clinical Trial Required)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIAMS intends to publish a Funding Opportunity Announcement (FOA) focused on chronic low back pain research using novel, inter and multidisciplinary integrated approaches and novel analytics for discovery of disease mechanisms and features for deep patient phenotyping and identification of new targets for intervention.
This Notice is being provided to allow potential applicants enough time to develop meaningful collaborations and responsive projects.
This FOA is expected to be published in November 2018 with an expected application due date in March 2019.
This FOA will utilize the U19 activity code. Details of the planned FOA are provided below.
Public Law 115-141, the Consolidated Appropriations Act of 2018 (signed March 23, 2018) includes a requirement that grantees from for-profit applicant organizations must provide a 50% match and/or in-kind contribution of all federally awarded dollars under the grant award (direct costs, as well as facilities and administrative costs) for research related to opioid addiction, development of opioid alternatives, pain management and addiction treatment.
Matching Requirement: A grantee from a for-profit organization funded under this funding opportunity announcement must match funds or provide documented in-kind contributions at a rate of not less than 50% of the total-Federally awarded amount, as stipulated by Public Law 115-141, the Consolidated Appropriations Act of 2018.The applicant will be required to demonstrate that matching funds and/or in-kind contributions are committed or available at the time of, and for the duration of, the award. Applications must identify the source and amount of funds proposed to meet the matching requirement and how the value for in-kind contributions was determined. All matching funds and/or in-kind contributions must be used for the portion of allowable project costs not paid by Federal funds under the grant award. NIH will not be the recipient, nor serve as a pass-through entity, of any such matching funds and/or in-kind contributions required under this announcement. See 45 CFR 75.306 for additional details.
Research Initiative Details
NIH has identified a set of research priorities reflecting urgent unmet needs across the lifespan, areas of promising scientific opportunity, and concrete strategies capable of providing rapid and durable solutions to the opioid crisis including improved understanding of the biological underpinnings of chronic pain and discovery and testing of new non-addictive pain treatments.
The NIAMS intends to launch the Back-Pain Consortium (BACPAC) initiative, a patient-centric translational research program focused on chronic low back pain. Back pain is a major contributor to the use of opioids in the US. The mechanisms of low back pain are likely to be complex, with a variety of organs, tissues and cell types interacting in an environment heavily influenced by mechanical, physical, biological and biopsychosocial factors that result in the experience of pain, a decrease in physical function and in emotional and social distress. BACPAC will conduct studies that will dissect these components and mechanisms and integrate all new information to identify, prioritize and test new therapies targeted to specific mechanisms. The goal of this initiative is to probe the biomedical mechanisms of the disease in a biopsychosocial context using interdisciplinary methods and innovative technologies so that novel individualized targeted treatments can be developed, tested and combined for an integrated approach to eradicate chronic low back pain. This highly collaborative research program will conduct research to deliver an integrated model of low back pain and patient-based algorithms to facilitate the identification of treatments tailored to the individual patient.
The BACPAC Research Program consists of four primary components that will work collaboratively to achieve the goals:
This Notice encourages investigators with expertise and insights into translational and clinical back pain research to consider organizing collaborative groups to prepare applications for the Back Pain Consortium (BACPAC) Mechanistic Research Centers (U19) FOA. Successful applicants will foster the translation of new scientific findings and technological development into better approaches for improving the lives of patients with low back pain. Each Center should focus on clinical and interdisciplinary research to understand the mechanisms of disease and rapidly translate them to low back pain classification, diagnosis, patient phenotyping and sub phenotyping, and outcome assessments to inform clinical trials.
Overall, the BACPAC Mechanistic Center research should be carried out by a multi, inter or transdisciplinary team of scientists who will address a highly significant translational research theme or challenge in low back pain. Mechanistic Research Centers will be expected to work collaboratively across the BACPAC Research Program, with extensive sharing and integration of clinical and research data across all research centers and sites.
The lead investigators of the research components may be based in different departments, divisions and/or institutions.
Mechanistic Centers will NOT support:
Estimated Total Funding: NA
Expected Number of Awards: 4-6
Estimated Award Ceiling: NA
Primary CFDA Number: 93.846
Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education)
For-Profit Organization (Other than Small Business)
Indian/Native American Tribal Government (Federally Recognized)
City or township governments
Special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Applications are not being solicited at this time.
Please direct all inquiries to:
Back Pain Consortium (BACPAC) Research Program
National Institute of Arthritis and Musculoskeletal and Skin Diseases