Request for Information (RFI): To Solicit Input and Ideas on Priorities in Basic Vaccine Discovery Research

Notice Number: NOT-AI-08-048

Key Dates
Release Date: April 18, 2008
Opening Date: April 20, 2008
Closing Date: May 20, 2008

The email address for this RFI will not be available after COB May 20, 2008.

Issued by
National Institute of Allergy and Infectious Diseases (NIAID) (


NIAID is seeking input from the scientific community, health professionals, patient advocates, and the general public about current and emerging priorities in basic vaccine discovery research that could provide clues about how to make an HIV vaccine that establishes and maintains a state of resistance to HIV infection and/or disease.  Opinions from junior investigators and new faculty are particularly encouraged.

Please be advised that NIAID has published an RFI concurrent to this one for input on novel approaches to interrupt HIV transmission.  [NOT-AI-08-049]  Interested individuals are invited to respond to both RFIs.


The mission of the Division of AIDS (DAIDS) at NIAID is to pursue an end to the HIV/AIDS epidemic by (1) increasing basic knowledge of the pathogenesis and transmission of the human immunodeficiency virus (HIV), (2) supporting the development of therapies for HIV infection and its complications and co-infections, and (3) facilitating the development of vaccines and safe, effective prevention strategies.  DAIDS accomplishes its mission through planning, implementing, managing, and evaluating research programs and portfolios that address these goals.

In an effort to stimulate scientific discussion and debate among HIV investigators participating in each of these research areas, and focusing on prevention efforts carried out through HIV vaccine trials, the National Institute of Allergy and Infectious Diseases held a summit on March 25, 2008.  The summit consisted of three interactive panel discussions focused on the following themes:

The webcast of the full summit is available at:

Information Requested

Through this RFI, NIAID is following up on the vaccine summit by inviting the scientific community, health professionals, patient advocates, and the general public to respond to the following questions. The overall goal is to define research that will address the major scientific obstacles to more complete knowledge of HIV and contribute to the design of a safe and effective preventive vaccine.

1. In which areas of basic vaccine discovery research should resources and emphasis be focused to solve the key scientific obstacles in HIV vaccine research?
2. Which of these areas are best addressed through individual research projects and which through multi-disciplinary research teams?
3. How can multidisciplinary research best be fostered to enhance the chance of successful outcomes?
4. How can new investigators and new ideas from within and outside the HIV vaccine field best be attracted into these areas of research? 


Responses will be accepted through May 20, 2008 and may be sent to the following email address: (

You are asked to limit your total response to a maximum of 5 pages.

The information obtained from responses to this RFI will aid DAIDS, NIAID, in developing one or more future Funding Opportunity Announcements (FOA) for appropriate types of applications that address research areas identified through this inquiry.

This RFI shall not be construed as a solicitation for applications or as an obligation on the part of the government.  The government will not pay for the preparation of any information submitted.  Responders should be aware that the information provided will be analyzed and may be used to develop future funding opportunity announcements and/or appear in various reports.  The government cannot guarantee the confidentiality of the information provided.


Questions about this request for information may be directed to:

Jorge Flores, MD
Division of AIDS, NIAID, NIH
Telephone: 301-435-3758
FAX: 301-402-3684

Janet Young, Ph.D.
Division of AIDS, NIAID, NIH
Telephone: 301-496-6714
FAX: 301-402-3211

Weekly TOC for this Announcement
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