RFP ANNOUNCEMENT: PRIMATE CORE IMMUNOLOGY VIROLOGY LABORATORIES - NIH- NIAID-DAIDS-03-02 Release Date: July 22, 2002 NOTICE: NOT-AI-02-036 National Institute of Allergy and Infectious Diseases (NIAID) (http://www.niaid.nih.gov) Receipt Date: October 23, 2002 DESCRIPTION The Division of Acquired Immune Deficiency Syndrome (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is re-competing their current contract with Beth Israel Deaconess Medical Center, Contract Number N01-AI-85343. This solicitation will be a Full and Open Competition, NAICS Code 541710, 500 employees. This RFP solicits proposals for laboratories to support the vaccine and prevention research program of the Preclinical Research and Development Branch, DAIDS. The Government has a need to continue this effort and expand laboratory support as part of the AIDS vaccine research agenda. The Primate Core Immunology and Virology Laboratories will provide resources in support of AIDS vaccine studies in non-human primates by conducting standardized assays to assess cellular and humoral immune responses of nonhuman primates to HIV and SIV vaccines and will also measure viral replication levels in the animals after viral infection. The new Primate Core Immunology-Virology Laboratories also will serve as Reference Laboratories for Quality Assurance and Quality Control of immune and virology-based assays, to aid in the standardization of assays across the non-human primate AIDS research field. Separate proposals are solicited for separate parts of this solicitation: Part A - Cellular Immunology Laboratory, Part B - Humoral Immunology Laboratory, and Part C - Quantitative Viral Laboratory. An offeror may respond to either Part A, Part B, or Part C, or may submit proposals for any combination of two or three parts. It is anticipated that one (1) to four (4) cost-reimbursement, completion-type contracts will awarded for a period of seven (7) years. Part A will focus on the conduct of assays for viral (SIV, HIV, SHIV) antigen-specific cellular immune responses, such as ELISPOT, Intracellular Cytokine Staining, CTL, and T cell proliferation assays. Part B will focus on the conduct of viral (SIV, HIV, and SHIV) neutralization assays, with an increasing focus on assays able to assess the ability of sera to neutralize infection with primary isolates of HIV-1. Part C will focus on the conduct of assays to quantitatively measure, with a high degree of sensitivity and accuracy, the plasma levels of SIV, SHIV, or HIV viral RNA in infected non-human primates. Contractors for each Part A, B, and C will be expected to continue to develop and improve assays in order to maintain a state-of-the-art capability in each area. It is anticipated that the period of performance for this contract will be a total of seven years. RFP-NIH-NIAID-DAIDS-03-02 will be available electronically on or about July 25, 2002, may be accessed through the NIAID Contract Management Branch (CMB) Home Page at http://www.niaid.nih.gov/contract and will be posted on FedBizOpps: www.fedbizopps.gov. Any responsible Offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. Contracting Office Address: National Institutes of Health National Institutes of Allergy and Infectious Diseases Contract Management Branch 6700-B Rockledge Drive Room 2230, MSC 7612 Bethesda, MD, 20892-7612 Point of Contact: Lois Eaton Contract Specialist Phone 301-496-0611 Fax 301-480-5253 Email le52u@nih.gov Jacqueline Holden Senior Contracting Officer Phone 301-496-7119 Fax 301-402-0972 Email jh55b@nih.gov


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