Release Date:  April 24, 2001

NOTICE:  NOT-AI-01-021

National Institute of Allergy and Infectious Diseases
National Cancer Institute

Letter of Intent:          May 1, 2001
Application Receipt Date:  June 1, 2001

The National Institute of Allergy and Infectious Diseases (NIAID) 
and National Cancer Institute (NCI), National Institutes of Health 
(NIH), invite the submission of proposals to an ongoing drug 
development program initiative.  This program is designed to help 
AIDS research investigators facilitate the preclinical development 
of: 1) therapies for the treatment of HIV disease, AIDS-associated 
malignancies, opportunistic infections and tuberculosis associated 
with AIDS, and 2) microbicide-based prevention strategies for HIV.  
The program does NOT fund grants.  Instead, applications to the 
program are requests to NIAID and NCI to use their drug development 
resources to conduct specific tasks the applicants themselves are 
unable to carry out in their efforts to translate basic research 
findings to applied or clinical practice.  Examples of tasks that 
may be requested include High Throughput Screen (HTS) assay 
development, evaluation in animal efficacy models, Good 
Manufacturing Practice (GMP) scale-up synthesis of small molecules 
and biologics, clinical dosage formulation and manufacturing, and 
Good Laboratory Practice (GLP) toxicology.  Program proposals will 
be solicited twice a year and reviewed in a competitive manner.

The current deadline for receipt of applications is June 1, 2001; 
prior to that date (no later than May 1) a Letter of Intent must be 
submitted to the Inter-Institute Program Coordinator.  Further 
information about this program, including detailed instructions for 
preparing proposals and the Letter of Interest, can be found at the 
program web site at

Inter-Institute Program Coordinator
6130 Executive Boulevard, Suite 8000
Rockville, MD  20852
Telephone:  (301) 496-8720
Fax:  (301) 402-0831

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