Release Date:  January 11, 2001

NOTICE:  NOT-AI-01-004

Response Date:  March 9, 2001

National Institute of Allergy and Infectious Diseases

The Division of Acquired Immunodeficiency Syndrome (DAIDS), National 
Institute of Allergy and Infectious Diseases (NIAID), National 
Institutes of Health is conducting a market survey to determine the 
availability and capability of Offerors able to advance promising 
microbicide concepts to the product stage via focused, development-
based approaches. 

With current global estimates exceeding 36.5 million people infected 
with HIV and the majority of these infections acquired through sexual 
intercourse, there is an intensified need for the development of safe, 
effective, topically applied chemical barriers to prevent sexually 
transmitted HIV infection.  The capacity to identify and develop new 
and improved microbicide products, that merit further evaluation in 
human clinical trials, in an efficient and expeditious manner is an 
essential element of the efforts of the DAIDS, NIAID.   

When the need arises, the Offeror would be expected to: 1) Identify a 
specific microbicide concept to be pursued; 2) Articulate and implement 
a strategic development plan that includes key development objectives 
with a detailed work plan including time schedules for achieving 
contract objectives/milestones and a management strategy for 
maintaining quality control of contract operation; and 3) Produce an 
HIV microbicide, based on the concept chosen by the Offeror, under GMP 
conditions with all necessary government and ethical approvals to 
proceed to clinical trial.  

This is not a Request for Proposal (RFP).  No RFP is available and 
DAIDS is not committed to make an award pursuant to this announcement.  
Interested Offerors should furnish two copies of their capability 
information addressing the three areas cited above to the attention of 
Jacqueline C. Holden at the address listed above.  The capability 
information should not exceed 3 pages.  In the event that this market 
survey develops into a RFP, Offerors who choose to submit a proposal 
will not be obligated to pursue the specific microbicide concept 
outlined in the response to this announcement.  No collect calls will 
be accepted. 

Point of Contact: 
Jacqueline C. Holden
Senior Contracting Officer
Contract Management Branch
National Institute of Allergy and Infectious Diseases
6700-B Rockledge Drive, Room 2230, MSC 7612
Bethesda, Maryland 20892-7612
(301) 496-7119

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