OPERATION OF A FACILITY FOR THE STUDY OF INFECTIOUS AGENTS, VACCINES AND 
ANTIMICROBIALS IN ADULT AND PEDIATRIC HUMAN SUBJECTS

Release Date:  August 3, 2000

NOTICE:  AI-00-008

REF Available:  NIH-NIAID-DIR-01-01

Response Date:  November 15, 2000

National Institute of Allergy and Infectious Diseases

The Laboratory of Infectious Diseases, Division of Intramural Research, 
National Institute of Allergy and Infectious Diseases (NIAID), National 
Institutes of Health (NIH) has a requirement to provide for the 
performance of clinical trials of vaccine candidates and their 
respective wild type viruses for a variety of viruses including 
respiratory viruses (e.g., respiratory syncytial and parainfluenza 
viruses), gastroenteritis viruses (e.g., rotaviruses), and other 
viruses (e.g., dengue viruses).  

These trials will be conducted in persons of all ages, such as 
pediatric populations (including one month old infants) for respiratory 
syncytial virus vaccines and adults over the age of 65 with influenza 
virus vaccines.  This will involve community education and publicity, 
participation in the development of protocols for the trials, 
recruitment and screening of volunteers, inoculation with candidate 
vaccines, recovery and characterization of vaccine viruses from 
infected vaccinees, assessment of humoral responses to the vaccines, 
medical evaluation of volunteers to assess potential toxic effects of 
the vaccines, challenge of adult volunteers with type virus, and 
reporting of the information at scientific meetings.  

The purpose of this contract is to support the NIAID in its mission to 
develop vaccines and to understand the immune factors responsible for 
resistance to viral disease.  It is anticipated that 1 contract will be 
awarded as for a period of seven years as a result of this 
solicitation. 

RFP NIH-NIAID-DIR-01-01 will be available electronically on or about 
August 16, 2000, and may be accessed through the NIAID Contract 
Management Branch (CMB) Home Page using the following address and 
instructions:
http://www.niaid.nih.gov/contract/default.htm

Once you are at the NIAID Contracts Page, select "RFPs" and then select 
"RFP-NIH-NIAID-DIR-01-01. 

Please note that the RFP for this acquisition has been revised to 
include only the Work Statement, deliverable and reporting 
requirements, special requirements and mandatory qualifications, the 
Technical Evaluation Criteria, and proposal preparation instructions.  
All information required for the submission of an offer will be 
contained in the electronic RFP package.  Following proposal submission 
and the initial review process, offerors comprising the competitive 
range will be requested to provide additional documentation to the 
Contracting Officer. 

Responses to this RFP will be due on 11/15/00.  Any responsible offeror 
may submit a proposal that will be considered by the Government.  This 
advertisement does not commit the Government to award a contract.

Offerors who are unable to access the Internet may request a copy by 
submitting a written request by mail, e-mail or by fax to:

Ms. Brenda Velez
Contracting Officer 
Contract Management Branch
National Institute of Allergy and Infectious Diseases
6700-B Rockledge Drive, Room 2230, MSC 7612
Bethesda, MD 20892-7612
301-496-7117 (direct)
301-496-0612 (main office)
Fax:  301-480-5253
E-mail:  [email protected]

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