Notice of Pre-Application Webinars for RFA-AG-24-040, Microphysiological Systems to Advance Precision Medicine for AD/ADRD Treatment and Prevention (U54 Clinical Trial Not Allowed)
Notice Number:

Key Dates

Release Date:

October 20, 2023

Related Announcements

  • October 19, 2023 - Microphysiological Systems to Advance Precision Medicine for AD/ADRD Treatment and Prevention (U54 Clinical Trial Not Allowed). See NOFO RFA-AG-24-040.

Issued by

National Institute on Aging (NIA)


The purpose of this Notice is to inform potential applicants that NIA will hold pre-application, technical assistance webinars regarding applications for RFA-AG-24-040 on Thursday, October 26, 2023 and Wednesday, November 1, 2023 from 3-4:30 PM EST.

RFA-AG-24-040 invites U54 Cooperative Agreement applications aiming to establish multi-component Alzheimer’s Disease and Related Dementias Translational Centers for Microphysiological Systems (AD/ADRD MPS Translational Centers). The overarching purpose of this Centers program is to develop 2D and 3D models of AD/ADRD as reproducible and scalable platforms that recapitulate key features of human AD/ADRD pathophysiology to be used as precision medicine research tools to investigate the complex biology of AD/ADRD and to accelerate multiple aspects of drug discovery and preclinical drug development.

To this end, the funded Centers will focus on the development and validation of 2D and 3D MPS models of AD/ADRD, conduct extensive characterization and deep phenotyping of these 2D and 3D MPS models, discover and characterize translatable biomarkers, and develop standardized methods to facilitate the assessment of bioavailability, efficacy, and toxicity of candidate therapeutic agents. Central to this initiative are the rapid dissemination of 2D and 3D MPS models and transparent reporting of research methodology and preclinical safety and efficacy testing findings to all qualified researchers for their use in basic research and preclinical therapy development. To achieve these goals, the Centers will need to bring together experts in AD/ADRD disease biology, bioengineering, microfluidics, material science, systems biology, computational biology, electrophysiology, pharmacology, biostatistics, and clinical science.

The purpose and objectives of the RFA will be reviewed during the webinars. Written questions submitted by participants either prior to or during the webinar will also be addressed. Potential applicants are strongly encouraged to submit questions prior to the webinars to Please indicate "U54 NIA MPS Translational Centers Webinar" in the subject line of the email.

Potential applicants interested in participating in the webinar should register by sending an email to at least three days prior to the event date. Please indicate "U54 NIA MPS Translational Centers Webinar Registration" in the subject line of the email. Call-in information will be provided once registration is received.

The webinar is optional and is not required for submission to the RFA.


Please direct all inquiries to:

Zane Martin, Ph.D.
National Institute on Aging (NIA)
Phone: 301-827-7130