Key Dates

Related Announcements

• June 22, 2023 - Notice of Early Expiration of NOT-AG-23-015, "Notice of Special Interest (NOSI): Alzheimer s-Focused Administrative Supplements for NIH Grants that are Not Focused on Alzheimer’s Disease". See Notice NOT-AG-23-031.
• October 9, 2020 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional). See NOFO PA-20-272.

Issued by

National Institute on Aging (NIA)

National Eye Institute (NEI)

National Heart, Lung, and Blood Institute (NHLBI)

National Human Genome Research Institute (NHGRI)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

National Institute of Allergy and Infectious Diseases (NIAID)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute on Deafness and Other Communication Disorders (NIDCD)

National Institute of Dental and Craniofacial Research (NIDCR)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

National Institute on Drug Abuse (NIDA)

National Institute of Environmental Health Sciences (NIEHS)

National Institute of General Medical Sciences (NIGMS)

National Institute of Mental Health (NIMH)

National Institute of Neurological Disorders and Stroke (NINDS)

National Institute of Nursing Research (NINR)

National Institute on Minority Health and Health Disparities (NIMHD)

National Library of Medicine (NLM)

Fogarty International Center (FIC)

National Center for Complementary and Integrative Health (NCCIH)

National Cancer Institute (NCI)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

Purpose

Since 2017, the National Institute on Aging (NIA) has sponsored a successful Administrative Supplement program to stimulate the field of Alzheimer’s disease (AD) and its related dementias (ADRD) (e.g., frontotemporal dementia, Lewy body dementia, Vascular Contributions to Cognitive Impairment and Dementia (VCID), and multiple etiology dementias) (NOT-AG-22-025; NOT-AG-21-018; NOT-AG-20-034; NOT-AG-17-008). This program has especially been effective in bringing researchers into the AD/ADRD research realm. Once more, the participating Institutes and Centers (ICs) are inviting supplement applications to take advantage of this opportunity to support the value of their projects, consistent with the previously peer-reviewed objectives. Therefore, as administrative supplements, the work proposed must be within the scope of the research or training that is already supported in order to be considered for funding. Active awards with project end dates in fiscal year (FY) 2025 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2024. Please note that a few ICs limit no-cost extensions in the final non-competing year of an award. For that reason, it is important to contact staff at the IC supporting the award when planning the request.

As administrative supplements, the work proposed needs to be within the scope of the research or training that is already supported. Center awards and resource awards are most likely to be able to justify these supplements, as they tend to have a broad content scope. Some research grants will also qualify if the current research is on a related topic (e.g., cognitive decline in aging, caregiving, the biology of neurodegeneration, genetics, imaging, computational methods, pain perception, or biostatistical tools that have application to research on AD/ADRD). NIA hosts a website that provides details on how AD/ADRD is defined and some examples of currently supported research. Awardees are expected to seek competing support to continue promising leads from the research supported through the supplement. Additional information on areas of interest and Notices of Funding Opportunity Announcements can be found here: Funding Opportunities | National Institute on Aging.

Awards that currently focus on research on AD/ADRD are not eligible for this program. If an investigator is uncertain whether the project does carry an AD focus,as defined by NIH, then the investigator should contact the appropriate Program Officer who can check that status. (For example, the parent award may focus on cognitive change due to chemotherapy in cancer patients. Does that research have a current focus on AD/ADRD? Contact the program officer for the award to check its status.)

Institute-, Center-, and Office-Specific Information

National Eye Institute (NEI)

NEI supports basic and clinical research into diseases and disorders of the visual system and the special needs of people with impaired vision or who are blind. NEI supports research in many areas that pertain to AD/ADRD. These include, but are not limited to: molecular signaling in the cornea, lens, and retina, degeneration of the optic nerve and brain tissue, and the decline of visual cognition in cases of dementia. Particularly appropriate for this supplement are studies that compare visual system biology in normal animals to that observed in animal models of AD.

National Human Genome Research Institute (NHGRI)

NHGRI supports studies that provide generalizable methods and knowledge in all three scientific areas of genome sciences, genomic medicine and genomics and society. Work proposed in supplements must fall within the scope of the aims of the NHGRI grant to be supplemented.

Investigators are encouraged to contact their NHGRI Scientific Program Officer for the grant to be supplemented before preparing an application, to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities.

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIAAA is interested in understanding alcohol’s impacts on the onset and progression of AD/ADRD. The research areas include, but not limited to, the following:

• Determine the effects of alcohol on pathology and cognitive decline associated with onset and progression of dementias across a spectrum of alcohol drinking patterns.
• Examine the fundamental mechanism underlying alcohol effects on the vulnerability to the cognitive impairments associated with dementias.
• Determine how alcohol’s effects on the multi-organ systems contribute to the pathology and cognitive changes associated with dementias.
• Investigate how possible interactions of alcohol-related peripheral immune disruption may contribute to dementias.
• Investigate sex differences in alcohol’s impact on the vulnerability to develop dementias and the disease progression.
• Examine how alcohol’s effects on neuroinflammation, neuroimmune interactions, and the neurovascular system contribute to the pathology and cognitive impairments associated with dementias.
• Determine how alcohol exposure across the lifespan, including prenatal or adolescent alcohol exposure, impacts susceptibility to and development of dementias.

Investigators are encouraged to contact their NIAAA Scientific Program Officer for the grant to be supplemented before preparing an application to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities.

National Institute of Child Health and Human Development (NICHD)

NICHD is particularly interested in studies that explore the linkages between early life events and later development of AD/ADRD. Topics of interest include, but are not limited to, the following:

• The linkages between pregnancy complications such as hypertension and preeclampsia and later development of dementia.
• The connection between pediatric CNS infections and post-infectious complications and/or effects of in utero exposure to infection/inflammation and later development of dementia.
• The role of head trauma and brain injury in the later development of dementia and the possible benefit of rehabilitation interventions for cognition and gait/balance in AD/ADRD.
• The significantly increased risk of Alzheimer’s disease in adults with Down syndrome.
• Population-representative data that examines how cognitive changes in later life are affected by exposures and experiences during early life, and by social determinants directly and through interaction with biological variables.
• The use of statistical modeling to address issues related to the development and treatment of cognitive decline leading to AD/ADRD.

Investigators are encouraged to contact their NICHD Scientific Program Officer before preparing an application to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIDCD invites responsive applications that align with the Institute's scientific programs of: normal and disordered hearing and balance; normal and disordered taste and smell; communication disorders of voice, speech, and language. For more information, please see here.

National Institute of Environmental Health Sciences (NIEHS)

The mission of NIEHS is to discover how the environment affects people to promote healthier lives. NIEHS priority areas include supporting research projects that address or seek to understand how exposures to toxic environmental insults alter biologic processes and are linked to disease initiation, progression, or morbidity. In addition, NIEHS is interested in research that leads to the development of prevention and intervention strategies to reduce potential environmentally induced risk of AD/ADRD outcomes. Examples of environmental exposures relevant to the mission of the NIEHS include, but are not limited to, industrial chemicals or manufacturing byproducts, e-waste, metals, pesticides, herbicides, and inhaled toxicants including indoor air pollutants from cooking and other sources, climate variability and the environmental impacts of natural and man-made disasters.

Investigators are strongly encouraged to consult with their NIEHS Program Official for the grant to be supplemented when developing plans for an application. This early contact will provide an opportunity to discuss whether the proposed project is within scope of the parent grant and relevant to the Institute’s research priorities.

National Institute of Nursing Research (NINR)

NINR supports research to solve pressing health challenges and inform practice and policy optimizing health and advancing health equity into the future. NINR discovers solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care. Drawing on the strengths of nursing’s holistic, contextualized perspective, core values, and broad reach, NINR funds multilevel and cross-sectoral research that examines the factors that impact health across the many settings in which nurses work, including homes, schools, workplaces, clinics, justice settings, and the community. Observational, intervention, and implementation research are of interest.

National Institute on Minority Health and Health Disparities (NIMHD)

NIMHD is interested in supporting multi-level, multi-domain research (see the NIMHD Research Framework) that examines AD/ADRD risk, incidence, morbidity, and mortality in U.S. populations that experience health disparities. NIH-designated health disparity populations include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asians, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. Studies may include, but are not limited to, multidisciplinary translational, biobehavioral, epidemiological, or health services research projects. Additionally, projects can involve primary and/or secondary data collection and analyses.

Priority areas of interest include, but are not limited to, the following:

• How multiple health determinants (social, environmental, biological/genetic/epigenetic, psychosocial, economic, and health care) contribute to AD/ADRD risk, incidence, age of onset, morbidity and mortality in health disparity populations.
• How geographic and neighborhood-level factors contribute to AD/ADRD risk, resilience, and health outcomes in health disparity populations.
• The role of access to and quality of care related to AD/ADRD risk assessment, diagnosis, and treatment in AD/ADRD-related health disparities.
• Trajectories of AD/ADRD risk and resilience across the life course in the context of the NIMHD research framework.

National Cancer Institute (NCI)

Aging is a significant risk factor for most adult-onset cancers and AD/ADRD. Examples of research areas in NCI’s award portfolio that might qualify for this administrative supplement program include, but are not limited to, the following:

• Biologic and genetic mechanisms of cancer and aging;
• Preclinical drug/drug combination development in an aging context;
• Cancer- and cancer treatment-related neurocognitive function;
• Treatment tolerability, toxicity, and symptom management;
• Behavioral and social risk factors and outcomes;
• Attention, sensation, and perception;
• Geriatric assessment;
• Epidemiologic cohort studies of cancer risk or survivorship;
• Premature/accelerated/accentuated aging in those with a history of cancer;
• Financial toxicity;
• Cancer caregiving;
• Clinical trial development for, and accrual of, older adults;
• Transitions in care and models of health care delivery;
• Multimorbidity/multiple chronic conditions;
• Computational methods, biostatistical tools, and measurement development; and
• Imaging and image-guided cancer intervention.

While not a research area per se, the inclusion of underserved and understudied populations in research studies is encouraged.

Review Process

Each IC will conduct administrative reviews of applications from their IC separately. NIA will make funds available to each of the participating ICs, provided that sufficient funds are available.

Criteria:

1. Is the work proposed within the scope of the active award?
2. Is the work proposed focused on AD/ADRD?
3. Is the work likely to stimulate additional activity leading to progress on any, or all, of these dementias?

Description of circumstances for which administrative supplements are available.

Application and Submission Information

Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.

• PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:

• Application Due Date(s) October 2, 2023 by 5:00 PM local time of applicant organization.
• For funding consideration, applicants must include NOT-AG-23-032 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
• Only electronic submissions will be accepted for this funding opportunity. Use one of the methods described in PA-20-272. Paper submissions and applications submitted as attachments will be returned.
• Requests may be for one year of support only.
• Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts but cannot exceed the direct costs of the parent award and must reflect the actual needs of the proposed project.
• The proposed budget period must be within the project period of the parent award.
• Requests must also adhere to the funding caps associated with the respective parent Notice of Funding Opportunity (NOFO) (e.g., salary caps on K s, SBIR/STTR limits, etc.).
• The Research Strategy section of the application is limited to 6 pages.
• Applicants may apply for more than one supplement to a given parent grant/award, provided they are scientifically distinct.

Inquiries

Please direct all inquiries to:

Ren Etcheberrigaray
National Institute on Aging (NIA)
Telephone: 301-451-9798
Email: [email protected]

Hongman Song
National Eye Institute (NEI)
Phone: 301-451-9768
Email: [email protected]

Lijuan Liu
National Heart, Lung, and Blood Institute (NHLBI)
Phone: 301-435-0582
Email: [email protected]

Bettie Graham
National Human Genome Research Institute (NHGRI)
Phone: 301-496-7531
Email: [email protected]

Philippe Marmillot
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Phone: 301-443-9737
Email: [email protected]

Michael Minnicozzi
National Institute of Allergy and Infectious Diseases (NIAID)
Phone: 240-627-3532
Email: [email protected]

Jana S. Eisenstein
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Email: [email protected]

Randy Lee King
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Phone: 301-451-0707
Email: [email protected]

Melissa Parisi
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Phone: 301-435-6880
Email: [email protected]

Judith Cooper
National Institute on Deafness and Other Communication Disorders (NIDCD)
Phone: 301-496-5061
Email: [email protected]

Preethi Chander
National Institute of Dental and Craniofacial Research (NIDCR)
Phone: 301-827-4620
Email: [email protected]

Brad Cooke
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phone: 301-480-9896
Email: [email protected]

Roger Little
National Institute on Drug Abuse (NIDA)
Phone: 301-435-1316
Email: [email protected]

Jonathan Hollander
National Institute of Environmental Health Sciences (NIEHS)
Phone: 984-287-3269
Email: [email protected]

Chris Chao, Ph.D.
National Institute of General Medical Sciences (NIGMS)
Phone: 301-594-3474
Email: [email protected]

Laura M. Rowland, Ph.D.
National Institute of Mental Health (NIMH)
Phone: 301-480-8335
Email: [email protected]

Roderick Corriveau
National Institute of Neurological Disorders and Stroke (NINDS)
Phone: 301-496-5680
Email: [email protected]

Karen A. Kehl
National Institute of Nursing Research (NINR)
Phone: 301-594-8010
Email: [email protected]

Priscah Mujuru
National Institute on Minority Health and Health Disparities (NIMHD)
Phone: 301-594-9765
Email: [email protected]

Meryl Sufian
National Library of Medicine (NLM)
Phone: 301-761-6249
Email: [email protected]

Unja Hayes
Fogarty International Center (FIC)
Phone: 301-827-6830
Email: [email protected]

Emrin Horgusluoglu
National Center for Complementary & Integrative Health (NCCIH)
Phone: 240-383-5302
Email: [email protected]

Paige Green
National Cancer Institute (NCI)
Phone: 240-276-6899
Email: [email protected]

Oleg Mirochnitchenko
Office of Research Infrastructure Programs (ORIP)
Phone: 301-435-0748
Email: [email protected]