Notice of Special Interest: Administrative Supplements for HIV/AIDS and Aging Research
Notice Number:

Key Dates

Release Date:

April 21, 2023

First Available Due Date:
May 22, 2023
Expiration Date:
May 23, 2023

Related Announcements

  • October 9, 2020 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional). See NOFO PA-20-272.

Issued by

National Institute on Aging (NIA)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

National Institute of Allergy and Infectious Diseases (NIAID)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

National Institute on Drug Abuse (NIDA)

National Institute of Mental Health (NIMH)

National Institute of Neurological Disorders and Stroke (NINDS)

National Institute on Minority Health and Health Disparities (NIMHD)

National Center for Complementary and Integrative Health (NCCIH)

National Cancer Institute (NCI)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Office of Research on Women's Health (ORWH)


The National Institute on Aging (NIA) and NIH Office of AIDS Research (OAR) with participating NIH Institutes and Centers announce the availability of administrative supplements to support research on HIV/AIDS and aging. Eligible parent awards include existing projects funded by the participating Institutes and Centers listed above with or without an existing focus on HIV/AIDS as long as other eligibility criteria are met and are within scope of the original project. Supplemental projects may involve a variety of scientific approaches and methods provided that they are focused on HIV/AIDS, can be conducted within one year of the supplement award, address previously unforeseen research opportunities, and fit within the scope of the parent grant. Within scope means that the proposed aims do not add to or expand the existing study in a manner that would be more appropriate for a competing peer-reviewed mechanism and/or revision application. Examples of potential supplemental studies could include:

  • Addition of participants with HIV to an ongoing study where such participants were either not included originally or not enrolled in sufficient numbers to make meaningful comparisons between groups
  • Addition of older adult participants to an ongoing study involving subjects with HIV where such participants were either not included originally or not enrolled in sufficient numbers to make meaningful comparisons between groups
  • Exploration of measures relevant to HIV and aging
  • Development of enhanced approaches to improve the recruitment and retention of aging individuals with HIV 

Depending on the parent project, not all of the above approaches would be considered within scope, and other approaches may also be possible. Prospective applicants are strongly encouraged to discuss their proposed aims with their program officer to verify eligibility criteria and fit within the scope of their existing award. 

Grantees whose awarding IC is not listed above are encouraged to reach out to their program officer.

Scientific topics of interest include, but are not limited to:

  • Understanding the impact of HIV infection and pathogenesis in the context of aging-related genetic, molecular, and cellular changes and physiological outcomes.
  • Understanding molecular mechanisms that may be common to multiple comorbid conditions related to aging with HIV.
  • Understanding the contributions of individual, interpersonal, social, structural, institutional, and healthcare system factors to the physical, psychological, and economic well-being of persons aging with HIV and to social inequalities and health disparities.
  • Understanding relationships between HIV infection and cognitive decline, especially in Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) and other neurological impairments in people with HIV and advancing age.
  • Enhancing assessment and treatment of older individuals with HIV and comorbidities, polypharmacy, frailty, disability, or disparities in health outcomes.

Research Objectives

The specific research objective of this Notice of Special Interest (NOSI) is to accelerate new knowledge related to the science of HIV and aging, and to expand the pool of researchers conducting studies at the intersection of HIV and aging. Applications should focus on one or more Key HIV Research Areas as outlined in the FY2021-2025 NIH Strategic Plan for HIV and HIV-Related Research. Applications must be focused on HIV-relevant research for consideration through this NOSI. Applicants may consider leveraging existing HIV cohorts and resources, such as NA-ACCORDMACS/WIHS Combined Cohort StudyVeteran Aging Cohort Study, and the National NeuroAIDS Tissue Consortium. Specific interests of participating ICs are described below:

National Institute on Aging (NIA)

NIA welcomes research supplements that fall within NIA’s mission to support genetic, biological, clinical, behavioral, social, and economic research on aging. NIA encourages applicants to address priorities outlined in the NIA Health Disparities Research Framework. Investigators interested in analyses of existing datasets may consider using NIA-supported observational and interventional studies such as those listed in the Aging Research Biobank, NIA’s Research Resources page, and those listed in NOT-AG-21-020. NIA-supported Research Centers may be particularly useful for accessing recruitment resources, analytic capabilities, specimens, specialized expertise, and other aging-related research resources. More information about each of these Centers programs can be found at their respective links: Alzheimer's Disease Research CentersArtificial Intelligence and Technology CollaboratoriesCenters on the Demography and Economics of AgingClaude D. Pepper Older Americans Independence CentersNathan Shock Centers of Excellence in the Basic Biology of AgingEdward R. Roybal Centers for Translation Research in the Behavioral and Social Sciences of Aging, and Resource Centers for Minority Aging Research. Coordination among all of NIA's Centers programs is facilitated through the NIA Research Centers Collaborative Network.

National Institute of Alcohol Abuse and Alcoholism (NIAAA)

NIAAA seeks supplements to address alcohol use among aging individuals with varying patterns of alcohol use. Levels of alcohol use that may be harmful could be substantially lower in people with HIV (PWH), and clinical studies focused on understanding how alcohol exacerbates geriatric syndromes like falls, delirium, frailty, and complications from polypharmacy are of particular interest.

While alcohol use contributes to overall frailty, it can also exacerbate HIV pathogenesis in multiple organ systems. Improvement in health outcomes of PWH who drink may be complicated by multiple comorbidities associated with continued heavy alcohol use and a range of alcohol use disorders (AUD). These comorbidities include diabetes, cardiovascular disease (CVD), cancers, and other skeletal and metabolic injury. Supplements to advance cross-cutting basic research on these complications are also of interest. 

National Institute of Allergy and Infectious Diseases (NIAID)

NIAID welcomes research topics aimed at elucidating the interactions of aging with HIV-related coinfections and the effects of aging on achieving durable viral suppression. Research may include such topics as viral hepatitis, tuberculosis, other coinfections with significant impact on the health of people living with HIV (PLWH), HIV reservoirs, and sustaining virologic response.  

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIAMS seeks research supplements focusing on aging and HIV-associated comorbidities within the mission areas of systemic rheumatic, musculoskeletal, and skin diseases. NIAMS supports studies on how HIV infection or HIV treatment impact the earlier onset or greater risk of diseases and conditions that are associated with aging and relevant to the NIAMS mission. These include, but are not limited to, osteoporosis, osteopenia, bone fracture, musculoskeletal frailty and pain, rheumatic and dermatological manifestations. We also support studies focused on the elucidation of pathophysiology and management strategies of these comorbidities among older people living with HIV/AIDS. NIAMS will not support clinical trial applications in response to this NOSI.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIDDK invites research topics aimed at elucidating effects of aging on HIV-related comorbidities and coinfections within its mission. These include loss of gastrointestinal immune and microbial homeostasis, enteropathy, noncommunicable liver and biliary diseases, viral hepatitis, nutritional inadequacies, obesity, metabolic/endocrine dysfunction and perturbations, kidney disease, benign genitourinary diseases and disorders, and hematologic sequelae. NIDDK also encourages studies that address how these comorbidities and coinfections in older people impact HIV reservoirs in anatomical sites relevant to its mission. These sites include the gastrointestinal mucosa, the liver, adipose tissue, the kidney, and the male genital tract.

National Institute on Drug Abuse (NIDA)

NIDA is interested in research to explore the impact of substance use and substance use disorders (SUD) in aging people with HIV. Addictive substances of interest include: cannabinoids, nicotine, cocaine, stimulants, opioids, prescription drugs, or combinations of these drugs.

The research areas of interest include but are not limited to:

  • Identifying mechanisms underlying vulnerability or resilience to HIV-related neuropathogenesis or neurocognitive impairment as a function of SUD history in aging people with HIV.
  • Leveraging existing epidemiological data (i.e., MWCCS: MACS/WIHS Combined Cohort Study) to elucidate effects of short- and long-term cannabis use in older adult populations with HIV.
  • Generating multi-omic (genomic, epigenomic, proteomic, metabolomic, microbiome) data as a resource for studying HIV and SUD in aging people living with HIV.
  • Examining long-term HIV infection and substance use outcomes, as well as medical consequences, among aging persons living with HIV in order to enhance healthcare access and utilization.
  • Research to identify biomarkers for and mechanisms that contribute to vulnerability to HIV exposure, aggravate HIV pathologies, regulate HIV persistence, or increase the risk for comorbidities including SUD and other poor health outcomes in aging people with HIV. 

National Institute of Mental Health (NIMH)

NIMH will support research supplements focused on the Division of AIDS Research’s priorities in people aging with HIV. NIMH will support studies that focus on HIV/AIDS-related differences in behavioral risk, cognitive and social functioning, or mental health issues in the context of aging populations with HIV. For instance, studies that examine how social and contextual characteristics guide the development of effective multi-level HIV/AIDS social and behavioral interventions in at-risk and infected populations of older adults throughout the lifespan are of interest to NIMH. NIMH is also interested in epidemiological, behavioral, biological, and treatment studies of age-associated central nervous system (CNS) complications in people with HIV. Further, NIMH is interested in basic and clinical studies in aging populations with HIV related to CNS viral dynamics (reservoir), immune dysfunction/inflammation, and alterations in neuronal circuitry. It is strongly recommended that applicants consult with the Program Officer listed on their grant before submitting the research supplement.

National Institute of Neurological Disorders and Stroke (NINDS) 

NINDS supports basic, translational, and clinical research on the brain and nervous system and uses that knowledge to reduce the burden of neurological disease. In the context of HIV disease, NINDS is particularly interested in the neurological complications of HIV infection that affect the brain, spinal cord, and peripheral nervous system. For the purposes of this notice, specific topics of interest might include (but would not be limited to): the long-term consequences of latent HIV in the CNS as it pertains to the modulation of chronic neuroinflammation and cognitive impairment in aging; the mechanisms by which chronic HIV exacerbates long-term blood-brain barrier damage and cerebrovascular dysfunction; studies of the mechanisms by which chronic HIV primes the CNS for neurodegeneration, including in the context of AD/ADRD; potential interactions between chronic HIV infection and other neurological disorders within the mission of NINDS; the long-term effect of chronic antiretroviral therapy (ART) exposure throughout the lifespan on the central and peripheral nervous systems; mechanisms of HIV-associated peripheral neuropathy and chronic pain; and studies that address the question of whether chronic HIV infection and exposure to ART cause accelerated aging of the CNS. It is strongly encouraged that potential NINDS applicants contact the program officer listed at the bottom of this Notice to discuss proposals prior to submission.

NINDS urges investigators to follow the NIH guidance for rigor and transparency in grant applications ( and additionally recommends the research practices described at to ensure that robust experiments are designed, potential experimenter biases are minimized, results and analyses are transparently reported, and results are interpreted carefully. These recommended research practices include, where applicable: rationale for the chosen model(s) and primary/secondary endpoints, clear descriptions of tools and parameters, blinding, randomization, ensuring adequate sample size, pre-specified inclusion/exclusion criteria, handling of missing data and outliers, appropriate controls, preplanned analyses, appropriate quantitative techniques, clear indication of exploratory vs. confirmatory components of the study, consideration of limitations, and plans for transparent reporting of all methods, analyses, and results so that other investigators can evaluate the quality of the work and potentially perform replications.

National Institute on Minority Health and Health Disparities (NIMHD)

The mission of the NIMHD is to lead scientific research to improve minority health and reduce health disparities. Studies must include a focus on one or more of the following NIH-designated populations that experience health disparities in the United States: African Americans, Latinos/Hispanics, American Indians and Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, less privileged socioeconomic groups, underserved rural populations, and sexual and gender minorities. Comparison groups/populations may also be included as appropriate for the research questions posed. Proposed studies should utilize multi-level approaches as identified in the NIMHD Research Framework and address the relevant social determinants of health using measures available in the PhenX Toolkit, as appropriate. In the context of this NOSI, interdisciplinary approaches are encouraged to elucidate the biological, behavioral, clinical, and social mechanisms of aging in populations that experience health disparities, and to address the growing health concerns and improve health outcomes in PWH. Studies that address care coordination challenges among PWH with multiple comorbidities to optimize care delivery in diverse care settings, especially rural settings, are also encouraged. Finally, studies that are focused on HIV and women from racial and ethnic minority populations, including but not limited to addressing access to care, stigma, discrimination, and intimate partner violence, especially in cis and transgender women, are encouraged. Please note that NIMHD will not support animal studies. 

National Center for Complementary and Integrative Health (NCCIH)

NCCIH is interested in supporting research on complementary and integrative approaches to improve resilience, restore health, manage HIV-related comorbidities, and reduce health disparities for PWH as they age. In the context of this NOSI, NCCIH is particularly interested in encouraging applications that propose expanding existing clinical trials to include greater numbers of older PWH, performing secondary analyses of datasets that include older PWH, and conducting basic and mechanistic studies to explain age-related health outcomes in PWH. Proposals should support a whole person health framework and address priorities outlined in the NCCIH Strategic Plan FY 2021–?2025.

National Cancer Institute (NCI) 

NCI welcomes research supplements that help to understand how aging in the presence of chronic HIV infection affects the risk, spectrum, and biology of cancer (AIDS-defining and non-AIDS-defining cancers). Supplements that are focused on the interplay between host factors and immune perturbations in older individuals living with HIV who develop cancer is also encouraged. 

The Office of Research on Women's Health (ORWH)

ORWH is part of the Office of the Director, NIH, and works with the 27 NIH Institutes and Centers to advance rigorous research of relevance to the health of women. ORWH does not award grants but co-funds women’s health-related applications and research projects that have received an award from one of the participating NIH Institutes and Centers listed in the announcement. Applications seeking ORWH co-funding, in response to this Notice, should ensure that the proposed work is aligned with at least one goal and objective outlined in the Trans-NIH Strategic Plan for Women’s Health Research.

ORWH supports research projects that address topics of relevance to aging, HIV, and women across the lifespan – including cisgender, transgender, and gender diverse women – and individuals assigned female at birth. Intersectional approaches to women, aging, and HIV are encouraged. Areas of interest include:

  • Understanding the influence of sex on HIV infection, pathogenesis and treatment
  • The influence of comorbidity among older populations of women with HIV
  • Impact of HIV on menopause
  • Understanding the role of HIV in violence, trauma, and mental health in aging women with HIV
  • Addition of participants to existing studies to enable meaningful sex and/or gender comparisons 


Applications will be evaluated according to the following criteria:

  • Does the administrative supplement fit within the aims of the parent grant?
  • Is the administrative supplement focused on Key NIH HIV Research Areas? Does it have an HIV/AIDS research component?
  • Will the administrative supplement result in advancing knowledge and/or collaborations leading to additional research activity at the intersection of HIV and aging?

Application and Submission Information

Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.

  • PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Administrative supplements may only be used to meet increased costs that are within the scope of the approved award, but were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted.

All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:

  • Application Due Date(s) – May 22, 2023, by 5:00 PM local time of applicant organization.
  • For funding consideration, applicants must include “NOT-AG-23-008” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
  • Administrative supplement requests may be for one year of support only.
  • The proposed budget period must be within the project period of the parent award. Active awards with project end dates in FY 2024 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2023. 
  • Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts, cannot exceed the direct costs of the parent award, and must reflect the actual needs of the proposed project.
  • Requests must also adhere to the funding caps associated with the respective parent NOFO (e.g., salary caps on K’s, SBIR/STTR limits, etc.).
  • Applicants may apply for more than one supplement to a given parent grant/award, provided they are scientifically distinct. However, though supplement requests are not limited to one per award, we will consider substantial additional funding to an award as beyond the scope of the funded award.
  • The Research Strategy section of the application is limited to 6 pages.

Funding decisions of applications submitted in response to this Notice are subject to program priorities and availability of funds.


Please direct all inquiries to the following Scientific/Research Contacts:

Stacy Carrington-Lawrence, Ph.D.
National Institute on Aging (NIA)
Division of Aging Biology (DAB)
Telephone: 301-496-6402

Melissa Gerald, Ph.D.
National Institute on Aging (NIA)
Division of Behavioral and Social Research (DBSR)
Telephone: 301-496-3136

Basil Eldadah, M.D., Ph.D.
National Institute on Aging (NIA)
Division of Geriatrics and Clinical Gerontology (DGCG)
Telephone: 301-496-6761

Maja Maric, Ph.D.
National Institute on Aging (NIA)
Division of Neuroscience (DN)
Telephone: 301-496-9350

Geetanjali Bansal, Ph.D.
Office of AIDS Research (OAR)
Telephone: 240-669-5073

Kendall J. Bryant, Ph.D.
Coordinator, HIV/AIDS and Alcohol Research
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Robert C. Palmer, MS, MSc
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 240-292-4842

Heiyoung Park, Ph.D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Telephone: 301-594-5032

Peter Perrin, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-451-3759

Vasundhara Varthakavi, DVM, Ph.D.
National Institute on Drug Abuse (NIDA)
Telephone: 240-669-5020

Vasudev R Rao, MBBS, MS
National Institute of Mental Health (NIMH)
Telephone: 301-825-3259

William P. Daley, Ph.D.
National Institutes of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-1431

Seema N. Desai, Ph.D.
National Institute on Minority Health and Health Disparities (NIMHD)
Telephone: 301-827-6698

Sekai Chideya-Chihota, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 240-552-2994

Geraldina Dominguez, Ph.D.
National Cancer Institute (NCI)
Telephone: 301-920-6044

Chyren Hunter, Ph.D.
Office of Research on Women's Health (ORWH)
Telephone: 301-402-4158