EXPIRED
July 7, 2022
PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
National Institute on Aging (NIA)
National Eye Institute (NEI)
National Heart, Lung, and Blood Institute (NHLBI)
National Human Genome Research Institute (NHGRI)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Nursing Research (NINR)
National Institute on Minority Health and Health Disparities (NIMHD)
National Library of Medicine (NLM)
Fogarty International Center (FIC)
National Center for Complementary and Integrative Health (NCCIH)
National Cancer Institute (NCI)
All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.
Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
The participating Institutes and Centers (ICs) are inviting applications to expand existing awards that are not currently focused on Alzheimer’s disease and its related dementias (AD/ADRD)—frontotemporal dementia, Lewy body dementia, Vascular Contributions to Cognitive Impairment and Dementia (VCID), and multiple etiology dementias—to allow the research to develop such a focus. Active awards with project end dates in FY 2024 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2023. Please note that a few ICs limit no-cost extensions in the final non-competing year of an award. For that reason, it is important to contact staff at the IC supporting the award when planning the request.
As administrative supplements, the work proposed needs to be within the scope of the research or training that is already supported. Center awards and resource awards are most likely to be able to justify these supplements, as they tend to have a broad content scope. Some research grants will also qualify if the current research is on a related topic (such as cognitive decline in aging, caregiving, the biology of neurodegeneration, genetics, imaging, computational methods, pain perception, or biostatistical tools that have application to research on AD/ADRD). NIA hosts a website that provides details on how Alzheimer’s disease and its related dementias are defined and some examples of currently supported research. Awardees are expected to seek competing support to continue promising leads from the research supported through the supplement. Additional information on areas of interest and funding opportunity announcements can be found here: Funding Opportunities | National Institute on Aging (nih.gov).
Awards that currently focus on research on Alzheimer’s disease or its related dementias are not eligible for this program. If an investigator is uncertain whether the project does carry an Alzheimer’s focus as defined by NIH, then the investigator may contact the appropriate program officer who can check that status. (For example, the parent award may be focusing on cognitive change due to chemotherapy in cancer patients. Does that research have a current focus on Alzheimer’s or its related dementias? Contact the program officer for the award to check its status.)
Institute-, Center-, and Office-Specific Information
National Eye Institute
The National Eye Institute (www.nei.nih.gov) supports basic and clinical research into diseases and disorders of the visual system and the special needs of people with impaired vision or who are blind. NEI supports research in many areas that pertain to Alzheimer’s disease and its related dementias. These include but are not limited to: molecular signaling in the cornea, lens, and retina, degeneration of the optic nerve and brain tissue, and the decline of visual cognition in cases of dementia. Particularly appropriate for this supplement are studies that compare visual system biology in normal animals to that observed in animal models of Alzheimer’s disease.
National Human Genome Research Institute
NHGRI will support studies that provide generalizable methods and knowledge in all three scientific areas of genome sciences, genomic medicine and genomics and society. Work proposed in supplements must fall within the scope of the aims of the NHGRI grant to be supplemented.
Investigators are encouraged to contact their NHGRI Scientific Program Officer for the grant to be supplemented before preparing an application, to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities.
National Institute on Alcohol Abuse and Alcoholism
NIAAA is interested in understanding alcohol’s impacts on the onset and progression of Alzheimer’s disease (AD) and its related dementias (AD/ADRD). The research areas include, but not limited to:
Investigators are encouraged to contact their NIAAA Scientific Program Officer for the grant to be supplemented before preparing an application to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities.
National Institute of Child Health and Human Development
NICHD is particularly interested in studies that explore the linkages between early life events and later development of Alzheimer’s disease and its related dementias (AD/ADRD). Topics of interest include, but are not limited to, the following:
Investigators are encouraged to contact their NICHD Scientific Program Officer before preparing an application to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities
National Institute of Nursing Research
The National Institute of Nursing Research (NINR) supports research to solve pressing health challenges and inform practice and policy - optimizing health and advancing health equity into the future. NINR discovers solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care. Drawing on the strengths of nursing’s holistic, contextualized perspective, core values, and broad reach, NINR funds multilevel and cross-sectoral research that examines the factors that impact health across the many settings in which nurses work, including homes, schools, workplaces, clinics, justice settings, and the community. Observational, intervention, and implementation research are of interest.
National Institute on Minority Health and Health Disparities
NIMHD is interested in supporting multi-level, multi-domain research (see the NIMHD Research Framework, https://www.nimhd.nih.gov/about/overview/research-framework.html) that examines Alzheimer’s disease and its related dementias (AD/ADRD) risk, incidence, morbidity, and mortality in U.S. populations that experience health disparities. NIH-designated health disparity populations include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asians, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. Studies may include, but are not limited to, multidisciplinary translational, biobehavioral, epidemiological, or health services research projects. Additionally, projects can involve primary and/or secondary data collection and analyses.
Priority areas of interest include, but are not limited to:
National Cancer Institute
Aging is a significant risk factor for most adult-onset cancers and Alzheimer’s disease and its related dementias. Examples of research areas in NCI’s award portfolio that might qualify for this administrative supplement program include, but are not limited to, the following:
While not a research area per se, the inclusion of underserved and understudied populations in research studies is encouraged.
Review Process
Each IC will conduct administrative reviews of applications from their IC separately. NIA will make funds available to each of the participating ICs, provided that sufficient funds are available.
Criteria:
Application and Submission Information
Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.
All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:
Rene Etcheberrigaray, M.D.
National Institute on Aging (NIA)
Telephone: 301-451-9798
Email: rene.etcheberrigaray@nih.gov
Martha C. Flanders
National Eye Institute (NEI)
Phone: 301-827-5191
Email: martha.flanders@nih.gov
Jue Chen
National Heart, Lung, and Blood Institute (NHLBI)
Phone: 301-435-0532
Email: chenj19@nhlbi.nih.gov
Bettie Graham
National Human Genome Research Institute (NHGRI)
Phone: 301-496-7531
Email: grahamb@odder.nhgri.nih.gov
Abraham P. Bautista, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Phone: 301-443-9737
Email: bautista@mail.nih.gov
Michael Minnicozzi, Ph.D.
National Institute of Allergy and Infectious Diseases (NIAID)
Phone: 240-627-3532
Email: minnicozzim@niaid.nih.gov
Jana S. Eisenstein
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Email: jana.eisenstein@nih.gov
Randy Lee King
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Phone: 301-451-0707
Email: randy.king@nih.gov
Melissa Parisi, MD, PhD
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Phone: 301-435-6880
Email: parisima@mail.nih.gov
Judith Cooper, Ph.D.
National Institute on Deafness and Other Communication Disorders (NIDCD)
Phone: 301-496-5061
Email: cooperj@nidcd.nih.gov
Preethi Chander, PhD
National Institute of Dental and Craniofacial Research (NIDCR)
Phone: 301-827-4620
Email: preethi.chander@nih.gov
Brad Cooke, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phone: 301-480-9896
Email: brad.cooke@nih.gov
Roger Little, Ph.D.
National Institute on Drug Abuse (NIDA)
Phone: 301-435-1316
Email: Roger.Little@nih.gov
Jonathan Hollander, Ph.D.
National Institute of Environmental Health Sciences (NIEHS)
Phone: 984-287-3269
Email: jonathan.hollander@nih.gov
Paula F. Flicker
National Institute of General Medical Sciences (NIGMS)
Email: flickerp@nigms.nih.gov
Jovier Evans, Ph.D.
National Institute of Mental Health (NIMH)
Phone: 301-443-6328
Email: jevans1@mail.nih.gov
Keith William Whitaker, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
Phone: 301-496-5680
Email: keith.whitaker@nih.gov
Karen A. Kehl, Ph.D., RN
National Institute of Nursing Research (NINR)
Phone: 301-594-8010
Email: karen.kehl@nih.gov
Priscah Mujuru, DrPH, MPH, RN
National Institute on Minority Health and Health Disparities (NIMHD)
Phone: 301-594-9765
Email: mujurup@mail.nih.gov
Meryl Sufian
National Library of Medicine (NLM)
Phone: 301-761-6249
Email: sufianm@mail.nih.gov
Unja Hayes
Fogarty International Center (FIC)
Phone: 301-827-6830
Email: unja.hayes@nih.gov
E-mail: Emrin Horgusluoglu, Ph.D.
National Center for Complementary & Integrative Health (NCCIH)
Phone: 240-383-5302
Email: emrin.horgusluoglu-moloch@nih.gov
Paige Green, Ph.D., MPH
National Cancer Institute (NCI)
Phone: 240-276-6899
Email: paige.green@nih.gov
Oleg Mirochnitchenko
Office of Research Infrastructure Programs (ORIP)
Phone: 301-435-0748
Email: mirochnitcheno@mail.nih.gov