Notice of Special Interest: Administrative Supplements for HIV/AIDS and Aging Research
Notice Number:

Key Dates

Release Date:

February 22, 2022

First Available Due Date:
April 25, 2022
Expiration Date:
April 26, 2022

Related Announcements

PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Issued by

National Institute on Aging (NIA)


The National Institute on Aging (NIA) and the NIH Office of AIDS Research (OAR) announce the availability of administrative supplements to support research on HIV/AIDS and aging. Eligible parent awards include NIA-funded projects with or without an existing focus on HIV/AIDS as long as other eligibility criteria are met. Supplemental projects may involve a variety of scientific approaches and methods provided that they are focused on HIV/AIDS, fit within the scope of the parent grant, and can be conducted within one year of the supplement award.

Research Objectives

The specific research objective of this Notice of Special Interest (NOSI) is to accelerate new knowledge related to the science of HIV and aging, and to expand the pool of researchers conducting studies at the intersection of HIV and aging. NIA welcomes research supplements that fall within NIA’s mission to support genetic, biological, clinical, behavioral, social, and economic research on aging. Applications should focus on one or more Key HIV Research Areas as outlined in the FY2021-2025 NIH Strategic Plan for HIV and HIV-Related Research. Topics of interest include, but are not limited to:

  • Understanding the impact of HIV infection and pathogenesis in the context of aging-related genetic, molecular, and cellular changes and physiological outcomes.
  • Understanding molecular mechanisms that may be common to multiple comorbid states with HIV.
  • Understanding the contributions of individual, interpersonal, social, structural, and institutional factors to the physical, psychological, and economic well-being of persons aging with HIV and to social inequalities and health disparities.
  • Understanding relationships between HIV infection and cognitive decline, especially in Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD) and other neurological impairments in people with HIV and advancing age.
  • Enhancing assessment and treatment of older individuals with HIV and comorbidities, polypharmacy, disability, or disparities in health outcomes.

NIA encourages applicants to address priorities outlined in the NIA Health Disparities Research Framework.

Investigators interested in analyses of existing datasets may consider using NIA-supported observational and interventional studies such as those listed in the Aging Research Biobank and NIA’s Research Resources page or existing HIV aging cohorts and resources such as NA-ACCORD, MACS/WIHS Combined Cohort Study, Veteran Aging Cohort Study, and the National NeuroAIDS Tissue Consortium. See also NOT-AG-21-020.

NIA-supported Research Centers may be particularly useful for accessing recruitment resources, analytic capabilities, specimens, specialized expertise, and other aging-related research resources. More information about each of these Centers programs can be found at their respective links: Alzheimer's Disease Research Centers, Centers on the Demography and Economics of Aging, Claude D. Pepper Older Americans Independence Centers, Nathan Shock Centers of Excellence in the Basic Biology of Aging, Edward R. Roybal Centers for Translation Research in the Behavioral and Social Sciences of Aging, and Resource Centers for Minority Aging Research. Coordination among all of NIA's Centers programs is facilitated through the NIA Research Centers Collaborative Network.

Applications must be focused on HIV-relevant research for consideration through this NOSI.


Applications will be evaluated according to the following criteria:

  • Does the administrative supplement fit within the aims of the parent grant?
  • Is the administrative supplement focused on Key NIH HIV Research Areas? Does it have an HIV/AIDS research component?
  • Will the administrative supplement result in new knowledge and/or collaborations leading to additional research activity at the intersection of HIV and aging?

Application and Submission Information

Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.

  • PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:

  • Application Due Date(s) – April 25, 2022, by 5:00 PM local time of applicant organization.
  • For funding consideration, applicants must include “NOT-AG-22-014” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
  • Administrative supplement requests may be for one year of support only.
  • Active awards with project end dates in FY 2023 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2022.
  • Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts. Though supplement requests are not limited to one per award, we will consider substantial additional funding to an award as beyond the scope of the funded award.
  • Applicants may apply for more than one supplement to a given parent grant/award, provided they are scientifically distinct.
  • For administrative supplement requests, the Research Strategy section of the application is limited to 6 pages.

Funding decisions of applications submitted in response to this Notice are subject to NIA budget appropriations and availability of funds.


Please direct all inquiries to the contacts in Section VII of the listed funding opportunity announcements with the following additions/substitutions:

Scientific/Research Contact(s) for NIA

Division of Aging Biology (DAB):
Stacy Carrington-Lawrence, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-6402

Division of Behavioral and Social Research (DBSR):
Melissa Gerald, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-3136

Division of Geriatrics and Clinical Gerontology (DGCG):
Basil Eldadah, M.D., Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-6761

Division of Neuroscience (DN):
Miroslaw Mackiewicz, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-9350

Scientific/Research Contact(s) for the Office of AIDS Research

Geetanjali Bansal, Ph.D.
Office of AIDS Research (OAR)
Telephone: 240-669-5073