Notice of Special Interest (NOSI): Availability of Administrative Supplements for Research on Pain, Pain Management, and Opioids in Aging
Notice Number:

Key Dates

Release Date:

December 22, 2021

First Available Due Date:
April 28, 2022
Expiration Date:
April 29, 2022

Related Announcements

PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Issued by

National Institute on Aging (NIA)


The National Institute on Aging (NIA) is interested in receiving administrative supplement applications to parent awards that are already focused on pain, pain management, or opioids related to aging or older adults. This NOSI invites administrative supplements within the scope of the parent award that focus on improving the understanding of mechanisms underlying pain experience with aging; enhancing assessment, prevention, and management strategies for pain in older adults; and improving health equity of aging populations suffering with pain. For new applications, resubmissions, competing renewals, and competing revisions to existing awards focused on pain, pain management, and opioids related to aging or older adults and within NIA’s mission areas, please see NOT-AG-22-004.

Research Objectives

The specific research objective of this NOSI is to expand the scientific knowledge base of mechanisms, assessment, treatment, and outcomes of pain and pain-related conditions in aging humans and animal models. NIA welcomes basic and translational research supplements that fall within NIA’s mission to support genetic, biological, clinical, behavioral, social, and economic research on aging. Both new data collection and analyses of existing datasets are welcome. Leveraging of ongoing cohorts, intervention studies, networks, data and specimen repositories, model systems, and other existing research resources and infrastructure is encouraged. Study designs may include mechanistic studies, observational approaches, quasi-experimental designs, and interventional studies. NIA encourages applicants to address priorities outlined in the NIA Health Disparities Research Framework (

Administrative supplement applications should focus on aging-related studies of pain, pain management, or opioids. Topic areas of interest include, but are not limited to:

  • Elucidation of mechanisms underlying pain experience and its consequences in aging
  • Development and enhancement of strategies for collection of clinical pain data and for assessing, preventing, and managing pain in later life
  • Improving health equity of aging populations suffering from pain

Investigators interested in analyses of existing datasets may consider using NIA-supported observational and interventional studies such as those listed in the Aging Research Biobank and NIA’s Research Resources page. See also NOT-AG-21-020.

Investigators interested in studying pain in animal models may consider NIA’s Aging Rodent Colonies.

NIA-supported Research Centers may be particularly useful for accessing recruitment resources, analytic capabilities, specimens, specialized expertise, and other aging-related research resources. More information about each of these Centers programs can be found at their respective links: Alzheimer's Disease Research Centers, Centers on the Demography and Economics of Aging, Claude D. Pepper Older Americans Independence Centers, Edward R. Roybal Centers for Translation Research in the Behavioral and Social Sciences of Aging, Resource Centers for Minority Aging Research, NIA AD/ADRD Health Care Systems Research Collaboratory, and Artificial Intelligence and Technology Collaboratories for Aging. Coordination among all of NIA's Centers programs is facilitated through the NIA Research Centers Collaborative Network.

Application and Submission Information

Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.

  • PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:

  • Application Due Date(s) – April 28, 2022, by 5:00 PM local time of applicant organization.
  • For funding consideration, applicants must include “NOT-AG-22-005” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
  • Administrative supplement requests may be for one year of support only.
  • Active awards with project end dates in September 2023 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY2022.
  • Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts. Though supplement requests are not limited to one per award, we will consider substantial additional funding to an award as beyond the scope of the funded award.
  • Applicants may apply for more than one supplement to a given parent grant/award, provided they are scientifically distinct.
  • For administrative supplement requests, the Research Strategy section of the application is limited to 6 pages.

Funding decisions of applications submitted in response to this Notice are subject to NIA budget appropriations and availability of funds.


Please direct all inquiries to the contacts in Section VII of the listed funding opportunity announcements with the following additions/substitutions:

Scientific/Research Contact(s)

Division of Neuroscience (DN):
Devon Oskvig, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-827-5899

Division of Geriatrics and Clinical Gerontology (DGCG):
Basil Eldadah, M.D., Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-6761

Division of Behavioral and Social Research (DBSR):
Elizabeth Necka, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-3136

Division of Aging Biology (DAB):
John Williams, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-6402

Financial/Grants Management Contact(s)

E.C. Melvin
National Institute on Aging (NIA)
Telephone: 301-480-8991