NIA Intervention Testing Program (ITP) Announces Annual Call for Compounds to Test for Anti-Aging Activity in Mice
Notice Number:

Key Dates

Release Date:

November 3, 2021

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Issued by

National Institute on Aging (NIA)


The National Institute on Aging (NIA) Interventions Testing Program (ITP) was established to test compounds purported to extend lifespan and/or delay the onset of disease and disability. The NIA ITP tests such compounds in mice, using a variety of measured endpoints to assess the efficacy of interventions. There are three sites that perform the testing, one at the University of Michigan, one at the University of Texas Health Sciences Center-San Antonio, and one at The Jackson Laboratory. It is anticipated that approximately 5 compounds will be accepted for study in 2023.

The ITP is a collaborative effort between the study sites and the sponsors who recommend interventions for study. The sponsor’s role is to provide the rationale for investigating the intervention, make recommendations on the dose, route and timing for administration of the intervention, and propose assays and measurements to document the efficacy of the intervention. The sponsor will have access to all data developed from the treated mice, will assist in analysis of the data and will be a co-author on resulting publications. Sponsor's proposals for specific interventions are reviewed by an Access Panel and accepted protocols are prioritized by the ITP Steering Committee.

The NIA ITP is soliciting proposals for compounds to enter the study in 2023. This is not a funding opportunity announcement, but rather a solicitation of suggestions for compounds to be tested in the ITP. The deadline for receipt of proposals is February 28, 2022. Information on the NIA ITP and guidelines for proposal development are posted at: Proposals should be emailed to


Please direct all inquiries to:

Francesca Macchiarini, M.S., Ph.D.
National Institute on Aging
Telephone: 301-827-4013

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