September 23, 2020
PA-18-591 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
National Institute on Aging (NIA)
The purpose of this initiative is to increase the number of early stage physician-scientists in Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) research and improve patient care for veterans. To accomplish this goal, NIA and the U.S. Department of Veterans Affairs (VA) have created a two-part opportunity for early career VA physician-scientists to pair with both VA- and NIA-funded mentors in the AD/ADRD field. This will also facilitate the development of a sustainable process for collaboration and address key barriers or challenges that often hinder communication, sharing of resources, and increased coordination between the VA and NIA.
This opportunity is for VA-appointed physician-scientists who are early in their careers, defined as those who are no more than 5 years past their last clinical training (e.g., residency, internship, clinical fellowship) and no more than 10 years beyond receipt of their MD or DO.
NIA seeks to support research focused on one or more of the following areas:
Alzheimer's disease (AD): Includes AD diagnosis, treatment, etiology, and prevention. Mild cognitive impairment research is perceived by experts as AD prevention research and thus is included. Cognitive decline in aging is also relevant to this category.
Alzheimer's disease related dementias (ADRD): Includes frontotemporal dementia (FTD), Lewy body dementia (LBD), vascular cognitive impairment/dementia (VCID), and mixed etiology dementias (MEDs).
Related diseases: Studies that focus on traumatic brain injury (TBI) as a risk factor for AD/ADRD will be considered. Other neurodegenerative diseases, such as Parkinson's disease with dementia, are included when AD is also being studied and when common pathways are described. Other neurologic diseases, such as Huntington's disease, major depressive disorder, multiple sclerosis, Parkinson's disease, Batten disease, schizophrenia, and AIDS dementia are not included unless also researching AD/ADRD.
Caregiving: Studies on family caregivers of AD/ADRD patients, as well as Alzheimer's care in nursing homes, are included.
Basic research: Basic research on disease mechanisms, neuropathology, cognitive decline, memory loss, amyloid, tau, Lewy bodies, etc. is included when a relationship to AD/ADRD is stated.
Application and Submission Process
The IK2 award supported by the VA will provide up to $65,000 per year for clinician salary, travel expenses, and limited support for research supplies.
The NIA administrative supplement solicited by this Notice will support research expenses for conducting the study in the NIA mentor's laboratory (e.g. materials and supplies, support for a technician, post-doc, and/or consultant(s)). Funding can be requested for up to 5 years, with a maximum annual award of $185,000 in direct costs. It is anticipated that up to 10 awards will be funded. An annual progress report will be required.
Criteria and instructions for administrative supplements are outlined in PA-18-591.
Application and Submission Information
Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.
Lisa A. Opanashuk, Ph.D.
National Institute on Aging (NIA)