Notice to Specify High-Priority Research Topic for PAR-19-070

Notice Number: NOT-AG-18-049

Key Dates
Release Date: November 29, 2018

Related Announcements

NOT-AG-22-006 - Notice to Expire NOSIs to PAR-19-070, "Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)"


Issued by
National Institute on Aging (NIA)


This Notice of Information specifies a high-priority topic of interest for PAR-19-070 "Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional).

Collaborative Studies on Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)

The National Institute on Aging engaged leading experts from academia, industry, and non-profit foundations, working in Alzheimer’s and other complex diseases, in a strategic planning process to help ensure that the next generation of Alzheimer's Disease Centers (ADCs) is poised to accomplish the goals of the National Alzheimer’s Plan. The resulting recommendations included several specific ideas centered around collaboration, including developing greater opportunities for collaborations across the ADCs, increasing interactions with other center programs, and making the resources at the ADCs available to outside investigators.

Building on this notion, this high-priority topic provides the opportunity to facilitate collaborative cross-disciplinary and multi-institutional approaches that will contribute new and vital information about the clinical and pathological course of both normal aging and AD/ADRD. Scientists within and outside the ADCs can gain access to unique resources (such as the availability of neuropathological data on thousands of participants) as well as support the collection and integration of new data and samples. This topic supports collaboration among investigators and a wider participation in the design, analysis and interpretation of studies utilizing these unique resources, further leveraging the existing investment. Applications may build on existing resources and data to answer a broad range of scientific questions. Project data may be used for new grants and/or provide standardization or methodologic development of value to AD and ADRD research goals.

This topic facilitates the wider sharing and leveraging of resources available through Alzheimer's Disease Centers, as well as of other existing resources, including, but not limited to: MODEL-AD, AMP-AD, M2OVE-AD, National Alzheimer's Coordinating Center (NACC), National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Alzheimer's Disease Genetics Consortium, NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS), the Alzheimer's Disease Sequencing Project, and those available at other NIH and NIA-funded centers, such as Pepper Centers, Roybal Centers, Shock Centers, and RCMARs. Applications considered high priorities for this topic may also leverage existing longitudinal cohort studies with data relevant to AD/ADRD (e.g., the Health and Retirement Study, the National Health and Aging Trends Study, Rochester Epidemiology Project, MIDUS, and studies participating in the Integrative Analysis of Longitudinal Studies of Aging and Dementia (IALSA).

Applications that either propose clinical trials or do not propose clinical trials may be considered a high priority.

Submissions should indicate that they are in response to NOT-AG-18-049 in Field 4.b on the SF 424 form.


Please direct all inquiries to:

Cerise L. Elliott, Ph.D

National Institute on Aging (NIA)

Telephone: 301-496-9350