Alzheimer's-focused administrative supplements for NIH grants that are not focused on Alzheimer's disease

Notice Number: NOT-AG-18-039

Key Dates
Release Date: November 26, 2018

Related Announcements
PA-18-591

Issued by
National Institute on Aging (NIA)
National Cancer Institute (NCI)
National Eye Institute (NEI)
National Heart, Lung, and Blood Institute (NHLBI)
National Human Genome Research Institute (NHGRI)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institute on Dental and Craniofacial Research (NIDCR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Nursing Research (NINR)
National Institute on Minority Health and Health Disparities (NIMHD)
National Library of Medicine (NLM)
Fogarty International Center (FIC)
National Center for Complementary and Integrative Health (NCCIH)
Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

Purpose

The participating Institutes and Centers (ICs) are inviting applications to expand existing awards in these ICs that are not currently focused on Alzheimer’s disease and its related dementias (ADRD) to allow them to develop a focus on ADRD. Active awards with project end dates in FY 2020 or later are eligible. The award may not be in terminal no cost extension or going into no cost extension in FY2019. Please note that a few ICs limit no cost extensions in a non-competing year of an award. For that reason, it is important to contact staff at the Institute supporting the award when planning the duration of the supplement request.

As administrative supplements the work proposed needs to be within the scope of the research or training that is already supported. Center awards and resource awards are most likely to be able to justify these supplements as they tend to have a broad content scope. Some research grants will also qualify if the current research is on a related topic (such as cognitive decline in aging; caregiving; the biology of neurodegeneration; genetics; imaging; computational methods; pain perception; or biostatistical tools that have application to research on Alzheimer’s and its related dementias).

As part of the application, investigators should submit an abstract of the proposed research that shows the relevance to ADRD. The work may include pilot projects or resource development.  In preparing the submission, indicate that it is a response to NOT-AG-18-039 in Field 4.b on the SF 424 form.

Investigators should submit applications as responses to the parent active administrative supplement PA: https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html.

Electronic submissions are strongly preferred for this funding opportunity. Use one of the methods described in PA-18-591Electronic submissions allow expedited administration and review of the applications. They allow tracking of applications received and simple movement of applications between Institutes - a requirement for this initiative. The ASSIST system allows most complex awards to submit supplement requests electronically.

Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts.  Though supplement requests are not limited to one per award, we will consider substantial additional funding to an award as beyond the scope of the funded award.

Requests must be received by February 26, 5:00 p.m. local time of the applicant organization for funding in FY 2019.

Institute-, Center-, and Office-specific Instructions

National Human Genome Research Institute: NHGRI in collaboration with NIA will support supplements to NHGRI grants up to $500,000 direct cost, to support research that accomplishes NIA’s research goals described in this notice. NHGRI will support studies that provide generalizable methods and knowledge in all three scientific areas of genome sciences, genomic medicine and genomics and society. Work proposed in supplements must fall within the scope of the aims of the NHGRI grant to be supplemented.

Investigators are encouraged to contact their NHGRI Scientific Program Officer for the grant to be supplemented before preparing an application, to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD is particularly interested in studies that explore the linkages between pregnancy complications such as hypertension and preeclampsia and later development of dementia; the role of head trauma and brain injury in the later development of dementia and the possible benefit of rehabilitation interventions for cognition and gait/balance in AD/ADRD; and in the significantly increased risk of Alzheimer’s disease in adults with Down syndrome.

Review Process

Each IC will conduct administrative reviews of applications from their IC separately. NIA will make funds available for at least ten awards from each of the participating ICs.

Criteria:

  1. Is the work proposed within the scope of the active award?
  2. Is the work proposed focused on Alzheimer’s disease or its related dementias?
  3. Is the work likely to stimulate additional activity leading to progress on ADRD?

Inquiries

Please direct all inquiries to:

Robin A. Barr
National Institute on Aging (NIA)
Telephone: 301-402-7715
Email: rb42h@nih.gov

Paige Green
National Cancer Institute (NCI)
Telephone: 240-276-6899
Email: paige.green@nih.gov

Martha Flanders
National Eye Institute (NEI)
Telephone: 301-451-2020
E-mail: Martha.flanders@nih.gov

Jue Chen
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0550
Email: jue.chen@nih.gov

Bettie Graham
National Human Genome Research Institute (NHGRI)
Telephone: 301-496-7531
E-mail: grahambj@exchange.nih.gov

Abraham Bautista
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-9737
E-mail: Bautista@mail.nih.gov

Michael Minnicozzi
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 240-627-3532
Email: minnicozzim@niaid.nih.gov

Robyn Bent
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Telephone: 301-827-2272
Email: robin.bent@nih.gov

Randy King
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Telephone:301-451-4780
E-mail: randy.king@nih.gov

Melissa Parisi
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-496-1383
Email: parisima@mail.nih.gov

Judith Cooper
National Institute on Deafness and Other Communication Disorders (NIDCD)
Telephone: 301-496-5061
E-mail: cooperj@nidcd.nih.gov

Preethi Chander
National Institute of Dental and Craniofacial Research (NIDCR)
Telephone: 301-827-4620
E-mail: Preethi.chander@nih.gov

Luke Stoekel
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-741-9223
E-mail: luke.stoeckel@nih.gov

Roger Little
National Institute on Drug Abuse (NIDA)
Telephone: 301-435-1315
Email: roger.little@nih.gov

Jonathan Hollander
National Institute of Environmental Health Sciences (NIEHS)
Telephone: 984-287-3269
E-mail: jonathan.hollander@nih.gov

Paula Flicker
National Institute of General Medical Sciences (NIGMS)
Telephone: 301-594-0943
Email: flickerp@nigms.nih.gov

Jovier Evans
National Institute of Mental Health (NIMH)
Telephone: 301-443-1369
E-mail: jevans1@mail.nih.gov

Roderick Corriveau
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-5680
E-mail: roderick.corriveau@nih.gov

Lois Tully
National Institute of Nursing Research (NINR)
Telephone: 301-594-5968
E-mail: lois.tully@nih.gov

Adelaida Rosario
National Institute on Minority Health and Health Disparities (NIMHD)
Telephone: 301-402-1366
E-mail: Adelaida.rosario@nih.gov

Hua-Chuan Sim
National Library of Medicine (NLM)
Telephone: 301-594-4882
E-mail: simh@mail.nlm.nih.gov

Marya Levintova
Fogarty International Center (FIC)
Telephone: 301-496-1653
E-mail: levintovam@mail.nih.gov

Dave Clark
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-827-1916
E-mail: dave.clark@nih.gov

Oleg Mirochnitchenko
Office of Research Infrastructure Programs (ORIP)
Telephone: 301-435-0748
Email: oleg.mirochnitchenko@nih.gov