Notice of Intent to Publish a Funding Opportunity Announcement for Alcohol Treatment and Recovery Research (R01 Clinical Trial Required)
Notice Number:

Key Dates

Release Date:
January 18, 2022
Estimated Publication Date of Funding Opportunity Announcement:
March 01, 2022
First Estimated Application Due Date:
June 01, 2022
Earliest Estimated Award Date:
March 01, 2023
Earliest Estimated Start Date:
May 01, 2023
Related Announcements


Issued by

National Institute on Alcohol Abuse and Alcoholism (NIAAA)


To solicit applications for collaborative research projects (U01) to investigate persistent changes in complex brain function-behavior relationships following adolescent alcohol exposure.

The National Institute on Alcohol Abuse and Alcoholism intends to publish a Funding Opportunity Announcement (FOA) to solicit applications for an R01 Clinical Trial Required mechanism focusing on alcohol treatment and recovery research. This FOA will focus broadly on topics relevant for treatment of and recovery from alcohol use disorder (AUD), including: medications development, precision medicine, behavioral therapies and mechanisms of behavioral change (MOBC), recovery, translational research, and innovative methods and technologies for AUD treatment and recovery.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The FOA is expected to be published in Spring 2022 with an expected application due date in Summer 2022.

This FOA will utilize the R01 Clinical Trial Required activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into the areas of treatment and recovery for Alcohol Use Disorder (AUD) to begin to consider applying for this new FOA.

This FOA will emphasize multiple topics related to the broad field of treatment of and recovery from AUD. Areas of interest include the following: medications development, precision medicine, behavioral health therapies and mechanisms of behavioral change (MOBC), recovery from AUD, and translational research. Medications development includes developing and evaluating new, more efficacious and safe medications for AUD and comorbid conditions. This topic includes developing new methods to discover druggable targets and predict their efficacy in clinical trials. Advancing precision medicine for AUD should informs diagnosis and treatment of AUD based on biomarkers and clinical and behavioral characteristics.

Other areas of interest include topics focusing on special-emphasis and underserved populations of individuals with AUD. Specific examples include research related to health disparities, age, gender, race and ethnicity, sexual and gender minorities, and co-occurring psychiatric and other substance use disorders.

Funding Information


Estimated Total Funding


Expected Number of Awards
Estimated Award Ceiling

$500,000 in direct costs per year

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Abraham P. Bautista, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-9737

Scientific/Research Contact:

Laura E. Kwako, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-451-8507