Notice Number: NOT-AA-20-005
Release Date: April 08, 2020
Estimated Publication Date of Funding Opportunity Announcement: May 01, 2020
First Estimated Application Due Date: November 17, 2020
Earliest Estimated Award Date: May 15, 2021
Earliest Estimated Start Date: June 01, 2021
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on human studies that will advance operations or implementation research in the context of alcohol and HIV/AIDS by facilitating the development of: (1) broader systems approaches for monitoring complex HIV and alcohol-related morbidity and mortality, and (2) interventions to reduce the impact of alcohol on HIV disease progression and transmission. Research funded under the FOA should serve as the foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol-related interventions and treatments for people living with HIV (PLWH) in healthcare and community settings. This proposed research initiative is aligned with the research priorities set forth in the NIH Strategic Plan for HIV and HIV-Related Research FY2021-2025 (Comorbidities, Coinfections, and Complications). Research funded by this FOA can, but does not have to, facilitate progress toward National HIV/AIDS Strategy for Ending the HIV Epidemic (EHE) initiative launched by the U.S. Department of Health and Human Services. In addition,, a recent workshop more fully discusses the Office of AIDS Research priority for HIV-Associated Comorbidities, Coinfections, and Coinfections (NIH Workshop on HIV-Associated ComorbidiTies, co-Infections and cOmplicatioNs - HIV ACTION Workshop, September 19-20, 2019, Bethesda, MD)
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The FOA is expected to be published in Spring 2020 with an expected application due date in Fall 2020.
This FOA will utilize the P01 activity code. Details of the planned FOA are provided below.
Ressearch Initiative Details
Harmful alcohol use is common among people living with HIV (PLWH). Patterns of alcohol use impact transmission of HIV, engagement and retention in care, and susceptibility to coinfections (e.g., COVID-19, hepatitis C and tuberculosis). HIV can now be treated effectively with multiple antiretroviral medications, which suppress viral replication and result in a longer life. Even after establishing viral control, alcohol use remains a complicating factor with clinical manifestations such as continuing systemic inflammation. Research on patterns of alcohol use is needed to understand how and at what levels alcohol consumption complicates HIV treatment. In addition, more studies are necessary to: (1) elucidate the mechanisms by which alcohol use impacts comorbidities, (2) determine whether decreasing alcohol use improves HIV-relevant outcomes, (3) examine whether state-of-the-art medications used to treat Alcohol Use Disorders and common comorbidities or coinfections are safe for PLWH who drink alcohol, and 4) implement interventions in diverse geographically distributed vulnerable populations. Support for studies using both validated biological measurements and self-reports of alcohol use would promote the identification of subgroup variation and ensure better understanding of the risks to particularly vulnerable populations.
Anticipated Eligible Organizations
Please direct all inquiries to: