Notice Number: NOT-AA-19-026
Key DatesRelease Date: October 01, 2019
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute on Aging (NIA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA) in partnership with the National Institute on Aging (NIA) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications to investigate mechanisms underlying the influence of alcohol on the onset and progression of Alzheimer’s disease and its related dementias.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and appropriate projects.
The FOA is expected to be published in Fall 2019 with an expected application due date in Spring 2020.
This FOA will utilize the R01 activity code. Details of the planned FOA are provided below.
Research Initiative Details
This Notice encourages investigators with expertise and insights into Impact of Alcohol on the Onset and Progression of Alzheimer’s Disease and Its Related Dementias to begin to consider applying for this new FOA.
The focus of the FOA is on understanding neurobiological mechanisms underlying the influence of alcohol on the onset and progression of Alzheimer's disease and related dementias. Recent longitudinal studies have provided strong evidence that alcohol use disorder is associated with the high risk of all types of dementia, and frequent heavy drinking increases risk of both Alzheimer’s disease and vascular dementia. Even moderate alcohol consumption may be a risk factor for adverse brain outcomes and cognitive decline. Although these studies link heavy and frequent alcohol drinking to dementia in aging populations, mechanisms contributing to this relationship are not well understood.
To achieve these goals, NIAAA and NIA will support, but not limited to, the following research:
research projects that combine diverse expertise and use innovative approaches to investigate mechanisms by which alcohol affects brain aging processes to produce dementia and influences development of Alzheimer’s disease
research studies employing novel techniques and research paradigms to generate mechanistic understanding of alcohol’s impact on the onset and progression of Alzheimer’s disease and its related dementias
collaborative research projects that combine expertise in alcohol research with Alzheimer's disease or related dementia
mechanistic studies using proper animal models and human subjects. For human subject research or innovative research paradigms, only those that focus on basic experimental studies are considered responsive to this RFA
Estimated Total Funding $3.0 M
Expected Number of Awards 6-8
Estimated Award Ceiling $250,000 direct cost per year
Primary CFDA Numbers 93.273; 93.866
Anticipated Eligible Organizations
Please direct all inquiries to:
Bradley C. Wise, Ph.D.
National Institute of Aging (NIA)