Notice Number: NOT-AA-19-006
Release Date:January 28, 2019
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
The primary goal of this notice is to more accurately assess, through improved measurement and analysis, the impact of HIV infection and alcohol use on health outcomes related to associated comorbidities, coinfections, and complications (CCC).
NIAAA seeks to implement novel analytic technologies for advancing high-priority HIV/AIDS research that is informed by patterns of both acute and chronic alcohol use. Advanced data-generating and data-analytic technologies should take advantage of existing datasets by either performing secondary analysis of existing data and biorepositories and/or augmenting these high-value datasets with informative measures that can be derived from multiple behavioral (e.g. ecological momentary assessment) and/or biological domains (biomarkers, biosensors, etc.) and /or informative combinations of multiple data sources. It is expected that this activity should significantly advance the use of “big data” and advanced analytic procedures that may in the future be able to address issues related to targeting interventions and expediting the use of individualized medicine. Proposals to support joint research projects between methodological experts and HIV care providers should lead to fundamental and multidisciplinary biomedical research, addressing prevention and treatment of HIV/AIDS and HIV-associated co-morbidities, coinfections, and complications.
Methodological advances include (but are not limited to) broadly improving measurement accuracy, reliability, and validity of alcohol exposure and its consequences in multiple cohorts of people living with HIV/AIDS supported by NIH through the Office of AIDS Research (OAR). In addition, this research may advance the use of predictive analytic techniques in both observational and intervention research for people living with HIV/AIDS who consume alcohol in collaboration with multiple institutes and utilization of novel technologies to improve self-report data, biomarkers, and biosensors. Advanced analytic techniques can be used to evaluate both direct and indirect effects of alcohol use and burden of disease on rates of new infections, diseases progression, and morbidity and mortality and to promote use of advanced decision-making tools/algorithms for implementation of preventive and treatment interventions.
NIAAA proposes to support evaluation for all HIV/AIDS applications with cohorts that utilize alcohol measures across institutes and identify where improvement in measurement and analytic approaches can be implemented within these cohorts. These models for attenuated effects of the accuracy for alcohol measurement can be extrapolated to treatment cascade and the effectiveness of development of interventions and combinations of interventions. Multiple levels of assessment can be tailored to these activities for (but are not limited to):
Prior to preparing an application, prospective applicants are encouraged to read the OAR and the NIAAA Strategic Plans, and to reach out to the scientific contact listed in this FOA..
Applications that include animal studies are not responsive.
Application and Submission Information:
Applications for this Notice must submit an application through NIH Parent Announcement PA-18-345: NIH Research Project Grant (Parent R01 Clinical Trial Required) or PA-18-484: NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed).
All instructions for the Parent Announcement must be followed.
Submissions should indicate that they are in response to NOT-AA-19-006 in Field 4.b on the SF 424 form.
Please direct all inquiries to: