Notice of Intent to Publish a Funding Opportunity Announcement for NIH Blueprint for Neuroscience Research: Dynamic Neuroimmune Interactions in the Transition from Brain Function to Dysfunction (R01)

Notice Number: NOT-AA-17-006

Key Dates
Release Date: June 14, 2017

Estimated Publication Date of Announcement: September 2017
First Estimated Application Due Date: December 2017
Earliest Estimated Award Date: September 2018
Earliest Estimated Start Date: September 2018

Related Announcements

Issued by
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH Blueprint for Neuroscience Research (
National Eye Institute (NEI)
National Institute on Aging (NIA)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Drug Abuse (NIDA)
National Institute on Dental and Craniofacial Research (NIDCR)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Center for Complementary and Integrative Health (NCCIH)


NIH Blueprint for Neuroscience Research intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research on Dynamic Neuroimmune Interactions in the Transition from Brain Function to Dysfunction.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The FOA is expected to be published in fall 2017 with an expected application due date in winter 2017. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into this area of neuroimmune interactions and neuroinflammation to begin to consider applying for this new FOA.

In addition, collaborative investigations combining expertise in diverse areas, such as neuroscience, neuroimmunology, or cutting-edge techniques and methods will be encouraged and these investigators should also begin considering applying for this application.

The goal of this FOA is to transform our understanding of how dynamic interactions among multiple cell types involved in neuroimmune inter actions (e.g., neurons, glia cells, neurovascular units) mediate the transition from normal brain function to disease conditions. Previous findings have markedly advanced our knowledge of neuroimmune interactions during normal brain function and in the context of established diseases. However, there is a lack of understanding of how multiple neuroimmune components mediate transitions from normal brain function to the early stages of central nervous system (CNS) disorders, how changes in immune signaling are integrated into neuronal networks, and how disease progression is orchestrated by multiple neuroimmune components. With this FOA, we encourage projects that combine diverse expertise and use innovative approaches to address these questions at the molecular, cellular, and circuitry levels. The outcomes of this research will provide an integrated view of the dynamic changes among multiple neuroimmune components and how they contribute to the onset and progression of CNS disorders.



Please direct all inquiries to:

Changhai Cui, PhD
National Institute on Alcohol Abuse and Alcoholism
Telephone: 301-443-1678