Notice of Intent to Publish a Funding Opportunity Announcement (FOA) for Translational Research in Alcoholic Hepatitis (U01)

Notice Number: NOT-AA-11-009

Key Dates
Release Date: November 3, 2011

Issued by
National Institute on Alcohol Abuse and Alcoholism (NIAAA)


The National Institute on Alcohol Abuse and Alcoholism intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications that will form a consortium for research to expedite the translation of emerging findings that could advance the development of new or existing treatments for alcoholic hepatitis. A close collaboration between basic scientists and clinicians to further improve the understanding of the mechanisms underlying AH, and translate that knowledge into novel therapies is essential for this research activity. This initiative is specifically directed at alcoholic hepatitis and not at alcoholic fibrosis/cirrhosis and/or complications of portal hypertension.  

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in late fall 2011 with an expected receipt date in winter 2012.  

This FOA will utilize the U01 activity code. Details of the planned Funding Opportunity Announcement (FOA) are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into this area of biochemistry, immunology, pathology, hepatology, and nutrition, as well as clinicians to begin to consider applying for this new FOA.

In addition, collaborative investigations combining expertise in metabolism, proteomics, metagenomics, pharmacodynamics, medicinal chemistry, and computational biology will be encouraged and these investigators should also begin considering applying for this application.

Among the areas of research encouraged in this initiative, are to combine basic and clinical studies to fully understand the pathogenesis of alcoholic hepatitis, as well as research designed to improve the translation of existing knowledge of strategies for the treatment of alcoholic hepatitis.



Svetlana Radaeva, Ph.D.
Division of Metabolism and Health Effects
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-1189

Weekly TOC for this Announcement
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