NIH Guide to Grants and Contracts

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Results: 1 to 25 of 1234

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Summer Research Education Experience Programs (R25) - PAR-15-184

Organization: NIAAA 

Posting Date: 04-16-2015 

Expiration Date: 05-24-2018 

Activity Code: R25 

Summary: The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this R25 program is to support educational activities that foster a better understanding of biomedical, behavioral and clinical research and its implications. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Research Experiences for high school, undergraduate and science teachers during the summer academic break.  

Maximizing Access to Research Careers Undergraduate - Student Training in Academic Research (MARC U-STAR) (T34) - PAR-17-068

Organization: NIGMS 

Posting Date: 12-06-2016 

Expiration Date: 05-25-2018 

Activity Code: T34 

Summary: The Maximizing Access to Research Careers (MARC) Undergraduate Student Training in Academic Research (U-STAR) program is designed to provide structured training programs to prepare high-achieving, underrepresented students for doctoral programs in biomedical research fields. Programmatic activities should include authentic research experiences, academic enhancements, skills development, and mentoring. The long-term goal of the program is to enhance the pool of underrepresented students earning baccalaureate and Ph.D. degrees in biomedical research fields and ultimately to contribute to the diversification of the nation's scientific workforce.  

AHRQ Health Services Research Demonstration and Dissemination Grants (R18) - PA-14-290

Organization: AHRQ 

Posting Date: 07-18-2014 

Expiration Date: 05-26-2018 

Activity Code: R18 

Summary: The Research Demonstration and Dissemination Grant (R18) is an award made by AHRQ to an institution/organization to support a discrete, specified health services research project. The project will be performed by the named investigator and study team. The R18 research plan proposed by the applicant institution/organization must be related to the mission and priority research interests of AHRQ. 

Research Initiative for Scientific Enhancement (RISE) (R25) - PAR-16-361

Organization: NIGMS 

Posting Date: 07-08-2016 

Expiration Date: 05-26-2018 

Activity Code: R25 

Summary: The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIGMS R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce. 

Youth Violence Prevention Interventions that Incorporate Racism/Discrimination Prevention (R01-Clinical Trial Required) - RFA-MD-18-005

Organization: NIMHD 

Posting Date: 11-30-2017 

Expiration Date: 05-26-2018 

Activity Code: R01 

Summary: The purpose of this initiative is to support research to develop and test youth violence prevention interventions that incorporate racism/discrimination prevention strategies for one or more health disparity populations. The target age range includes middle school to high school-aged youth, corresponding to an approximate age range of 11 to 18. 

Formulation drug product quality attributes in dermal physiologically-based pharmacokinetic models for topical dermatological drug products and transdermal delivery systems - RFA-FD-18-019

Organization: FDA 

Posting Date: 03-21-2018 

Expiration Date: 05-29-2018 

Activity Code: U01 

Summary: The purpose of this project is to incorporate drug product quality attributes into dermal physiologically-based pharmacokinetic models developed for dermatological topical dosage forms and transdermal delivery systems. The developed models will be utilized to identify drug-product specific critical quality attributes (model qualification) and perform virtual bioequivalence assessments between brand name and generic drug products to inform regulatory decisions relating to the development of dermatological drug products. 

Characterize skin physiology parameters utilized in dermal physiologically-based pharmacokinetic model development across different skin disease states - RFA-FD-18-017

Organization: FDA 

Posting Date: 03-20-2018 

Expiration Date: 05-30-2018 

Activity Code: U01 

Summary: The purpose of this project is to identify skin physiology characteristics that differ between healthy and skin disease population groups and incorporate them into dermal physiologically-based pharmacokinetic models to improve their predictability. The models developed will be utilized to perform virtual bioequivalence assessments between brand name and generic drug products to inform regulatory decisions relating to the development of generic topical dermatological drug products and transdermal delivery systems. 

Computational fluid dynamics (CFD) and discrete element modeling (DEM) approach for predictions of dry powder inhaler (DPI) drug delivery - RFA-FD-18-014

Organization: FDA 

Posting Date: 03-22-2018 

Expiration Date: 05-30-2018 

Activity Code: U01 

Summary: Current product-specific bioequivalence (BE) guidance published by the Office of Generic Drugs for dry powder inhalers (DPIs) include in vitro testing recommendations for single actuation content and aerodynamic particle size distribution, as well as recommendations for a pharmacokinetic study and a pharmacodynamic or clinical endpoint study. Given the extensive nature of current DPI BE guidance, it is desirable that current in vitro testing for DPIs be more reflective of in vivo performance. Computational fluid dynamics (CFD) and discrete element modeling (DEM) have been used to predict dry powder aerosol behavior, including the effects of agglomeration and deagglomeration. The purpose of the study will be to develop a CFD-DEM model which can be used to evaluate the impact of various physicochemical properties and device performance properties on regional deposition, to identify potentially biorelevant ranges for these properties that may be useful for future BE recommendations. 

Limited Competition: Revision Applications for International Centers of Excellence for Malaria Research (U19 Clinical Trial Optional) - RFA-AI-17-044

Organization: NIAID 

Posting Date: 12-22-2017 

Expiration Date: 05-31-2018 

Activity Code: U19 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to solicit revision applications from currently funded International Centers of Excellence for Malaria Research (ICEMR) investigators. These awards will support the conduct and oversight of observational studies or implementation studies to evaluate the impact of in-country, approved vector control and malaria prevention interventions on the incidence, prevalence, and transmission of malaria. This program will leverage the baseline data, infrastructure, and capacity established by the ICEMRs. The studies will augment or use the established malaria surveillance systems to study the impact of the vector control and malaria prevention interventions on human health outcomes. This FOA solicits three distinct types of studies: Study Type 1 is a Controlled study, Study Type 2 is an Observational study, and Study Type 3 is an Implementation study. Applications may propose projects for one of each Study Type. 

Team-Based Design in Biomedical Engineering Education (R25) - PAR-16-108

Organization: NIBIB 

Posting Date: 02-22-2016 

Expiration Date: 06-01-2018 

Activity Code: R25 

Summary: The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIBIB-NICHD R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. 

Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) - PAR-18-600

Organization: ORIP 

Posting Date: 01-29-2018 

Expiration Date: 06-01-2018 

Activity Code: S10 

Summary: The Shared Instrument Grant (SIG) Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems. The minimum award is $50,000. There is no maximum price requirement; however, the maximum award is $600,000. Types of instruments supported include, but are not limited to: X-ray diffractometers, mass and nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imagers. 

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) - PAR-18-598

Organization: ORIP 

Posting Date: 01-29-2018 

Expiration Date: 06-01-2018 

Activity Code: S10 

Summary: The High-End Instrumentation (HEI) Grant Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $600,001. The maximum award is $2,000,000. Types of instruments supported include, but are not limited to: X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers. 

Shared Instrumentation for Animal Research (SIFAR) Grant Program (S10 Clinical Trial Not Allowed) - PAR-18-599

Organization: ORIP 

Posting Date: 01-29-2018 

Expiration Date: 06-01-2018 

Activity Code: S10 

Summary: The Shared Instrumentation for Animal Research (SIFAR) Grant Program encourages applications from groups of NIH-funded investigators to purchase or upgrade scientific instruments necessary to carry out animal experiments in all areas of biomedical research supported by the NIH. Applicants may request clusters of commercially available instruments configured as specialized integrated systems or as series of instruments to support a thematic well-defined area of research using animals or related materials. Priority will be given to uniquely configured systems to support innovative and potentially transformative investigations. This FOA supports requests for state-of-the art commercially available technologies needed for NIH-funded research using any vertebrate and invertebrate animal species. This funding opportunity announcement (FOA) does not support requests for single instruments. At least one item of the requested instrumentation must cost at least $50,000, after all applicable discounts. No instrument in a cluster can cost less than $20,000, after all applicable discounts. There is no maximum price requirement; however, the maximum award is $750,000. 

Coordination Center for the Models of Infectious Disease Agent Study (MIDAS) Program (U24 Clinical Trial Not Allowed) - RFA-GM-18-003

Organization: NIGMS 

Posting Date: 03-28-2018 

Expiration Date: 06-01-2018 

Activity Code: U24 

Summary: The Coordination Center for the Models of Infectious Disease Agent Study (MIDAS) program will serve as a hub for collaboration, testing and dissemination of research products from the network of MIDAS investigators. The Coordination Center will also serve as the primary repository for MIDAS related datasets, models and software. The Coordination Center will maintain, promote and maximize utility and use of the shared MIDAS resources. In addition, the Program Director(s)/Principal Investigator(s) of the Coordination Center will proactively develop collaborative activities and training opportunities intended to enhance the utility of MIDAS resources and to improve the training experiences for members of the MIDAS network and their graduate students and postdoctoral researchers. Limited funding will also be provided to allow the Coordination Center to conduct impactful research on the evaluation and meta-analysis of existing modeling resources for the study of infectious disease spread and intervention. 

Alzheimer's Disease Research Centers (P30 - Clinical Trials Not Allowed) - RFA-AG-19-001

Organization: NIA 

Posting Date: 01-25-2018 

Expiration Date: 06-05-2018 

Activity Code: P30 

Summary: This Funding Opportunity Announcement (FOA) invites applications for P30 Alzheimer's Disease Research Centers. NIA-designated Alzheimer's Disease Research Centers (ADRCs) serve as major sources of discovery into the nature of Alzheimers disease (AD) and related dementias and into the development of more effective approaches to prevention, diagnosis, care, and therapy. They contribute significantly to the development of shared resources that support dementia-relevant research, and they collaborate and coordinate their research efforts with other NIH-funded programs and investigators. 

Three-Dimensional Approach for Modeling Nasal Mucociliary Clearance via Computational Fluid Dynamics (CFD) - RFA-FD-18-020

Organization: FDA 

Posting Date: 03-21-2018 

Expiration Date: 06-05-2018 

Activity Code: U01 

Summary: FDA's CDER is seeking a computational modeling approach to study the effects of mucociliary clearance on localized drug absorption in the nasal cavity. The modeling approach would utilize computational fluid dynamics (CFD) simulations of inhalation and droplet/particle transport to provide regional nasal spray deposition data, while the three-dimensional mucociliary clearance model would demonstrate localized drug absorption and indicate the efficacy of drug products that target specific nasal regions. The model should be adaptable to cases of interindividual variability, which may include variations in mucociliary clearance rates, changes in nasal geometry, and the presence of relevant disease states (e.g., nasal inflammation, changes in mucus properties, etc.). 

Bioequivalence of Topical Products: Evaluating the Cutaneous Pharmacokinetics of Topical Drug Products Using Non-Invasive Techniques - RFA-FD-18-012

Organization: FDA 

Posting Date: 03-22-2018 

Expiration Date: 06-05-2018 

Activity Code: U01 

Summary: The purpose of this funding opportunity is to support the research and development necessary to advance non-invasive (e.g., spectroscopic/ imaging tomography) technologies, methods, study designs, and methods of data analysis to characterize and compare the rate and extent to which a topically applied drug becomes available at or near a site of action within the skin. The expectation is that the funded work will produce an accurate, sensitive and reproducible approach that measures the amount of drug present in the skin at a series of depths below the skin surface, which can be utilized to monitor the cutaneous pharmacokinetics (PK) of the drug at selected depths (e.g., in the epidermis or dermis) by repeated measurements over time. The ultimate intent is to support the eventual development of an alternative, scientifically valid, cutaneous PK-based approach to efficiently evaluate the bioequivalence (BE) of topical products in vivo in human subjects. 

Renewal Applications: Centers of Excellence in Regulatory Science and Innovation - RFA-FD-18-011

Organization: FDA 

Posting Date: 03-23-2018 

Expiration Date: 06-05-2018 

Activity Code: U01 

Summary: As part of FDA's Advancing Regulatory Science Initiative, the Office of the Chief Scientist supports innovation aimed at development of new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products. This funding opportunity will provide support, depending on availability of FDA funding, for one or more of the following existing Centers of Excellence in Regulatory Science and Innovation (CERSIs): Yale University-Mayo Clinic, University of Maryland at College Park and Baltimore and Johns Hopkins University. The CERSI(s) will serve to advance the Agency's regulatory science goals predominantly through cutting-edge collaborative research with FDA; they may also provide training in regulatory science. 

Assuring Radiation Protection (U18) - RFA-FD-18-021

Organization: FDA 

Posting Date: 03-23-2018 

Expiration Date: 06-05-2018 

Activity Code: U18 

Summary: Food and Drug Administration/ Center for Devices and Radiological (CDRH) is announcing its intention to accept and consider a single source application for the award of a cooperative agreement in fiscal year 2018 to Conference of Radiation Control Program Directors, Inc. (CRCPD) in support of coordination of Federal and State actions to assure radiation protection of the American public. The primary purpose of this cooperative agreement is to assist CRCPD members (State radiation control programs) in their efforts to protect the public, radiation workers and patients from unnecessary radiation exposure. Its goals will include: 1.Producing radiation protection solutions that meet community needs. 2.Assisting States with improving tools for radiation control. 3.Coordinate Federal, State and Tribal activities to achieve effective solutions to present and future radiation control problems. 4.Be expected to obtain the States cooperation and participation on committees and working groups established to deal with individual problems. 5.Plan and facilitate an annual meeting, and develop and offer educational activities to demonstrate mutually beneficial techniques, procedures, and systems relevant to the mission of assuring radiation protection. 6.Establish committees to address, evaluate, and offer solutions for a wide range of radiation health and protection issues. 7. Providing training in radiation control for CRCPD members. 

Spermatogenic Stem Cell Culture Systems to Preserve and Restore Reproductive Capacity in Males (R01) - PAR-16-114

Organization: NICHD 

Posting Date: 02-25-2016 

Expiration Date: 06-06-2018 

Activity Code: R01 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of spermatogenic stem cell (SSC) biology.The overarching goal is to increase the chances that couples may have biological offspring without using conventional assisted reproductive modalities (i.e., IVF, ICSI).A focal point of the initiative is on the development of new techniques to culture and expand these cells over an extended period of time.Another area of study includes methods to eliminate malignant cells from SSC cultures following chemotherapy/radiation treatment. Also, spermatogenic stem cells from human adults could have a major impact on drug development and toxicity testing as animal-based systems do not sufficiently mirror the situation in humans. 

Methods for Prevention Packages Program IV (MP3 IV) (R01) - PAR-16-124

Organization: NIAID 

Posting Date: 03-09-2016 

Expiration Date: 06-08-2018 

Activity Code: R01 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to promote multidisciplinary research programs that (1) devise optimal HIV prevention packages (combination interventions) for specific populations and (2) perform feasibility and acceptability studies to demonstrate that the proposed prevention package is acceptable to the target population and the study design is appropriate and feasible. This FOA is intended to encourage collaborations between behavioral and biomedical clinical specialists, epidemiologists, mathematical modelers, and clinical research specialists.  

Collaborative Activities to Expedite Environmental Health Science Research, Translation, and Community Engagement Across EHS Core Centers (Admin Supp - Clinical Trial Not Allowed) - PA-18-770

Organization: NIEHS 

Posting Date: 05-08-2018 

Expiration Date: 06-08-2018 

Activity Code: (Admin Supp) 

Summary: These administrative supplements provide funds to awarded P30 Environmental Health Sciences Core Centers to enhance interactions across Centers to address emerging issues and to advance research, translational research, and community engagement. 

Partnership for Aging and Cancer Research (U01 - Clinical Trial Not Allowed) - PAR-18-552

Organization: NCI 

Posting Date: 12-22-2017 

Expiration Date: 06-09-2018 

Activity Code: U01 

Summary: The purpose of this funding opportunity announcement (FOA) is to invite U01 grant applications focused on advancing the understanding of mechanisms mediating aging in cancer. Qualifying applications must propose aging in cancer studies that are collaborations between non-NIH Principal Investigators (PIs) and intramural PIs from NCI and/or NIA as a co-investigator. 

NIAMS Skin Biology and Diseases Resource-based Centers (P30 Clinical Trial Not Allowed) - RFA-AR-19-001

Organization: NIAMS 

Posting Date: 02-08-2018 

Expiration Date: 06-12-2018 

Activity Code: P30 

Summary: The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS Resource-based Centers Program (P30) for skin biology and diseases research areas within its mission. The Resource-based Centers will provide critical research infrastructure, shared facilities, services, and/or resources to groups of investigators conducting research on skin biology and diseases, enabling them to conduct their independently-funded individual and/or collaborative research projects more efficiently and/or more effectively, with the broad overall goal of accelerating, enriching, and enhancing the effectiveness of ongoing basic, translational, and clinical research and promoting new research within the NIAMS mission. 

NIAMS Musculoskeletal Biology and Medicine Resource-based Centers (P30 Clinical Trial Not Allowed) - RFA-AR-19-002

Organization: NIAMS 

Posting Date: 02-08-2018 

Expiration Date: 06-12-2018 

Activity Code: P30 

Summary: The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS Resource-based Centers Program (P30) for research areas within its mission in musculoskeletal biology and medicine. The Resource-based Centers will provide critical research infrastructure, shared facilities, services, and/or resources to groups of investigators conducting research on musculoskeletal biology and medicine, enabling them to conduct their independently-funded individual and/or collaborative research projects more efficiently and/or more effectively, with the broad overall goal of accelerating, enriching, and enhancing the effectiveness of ongoing basic, translational, and clinical research and promoting new research within the NIAMS mission. 

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