NIH Guide to Grants and Contracts

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Results: 1 to 25 of 1244

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mHealth Tools for Individuals with Chronic Conditions to Promote Effective Patient-Provider Communication, Adherence to Treatment and Self-Management (R21 Clinical Trial Optional) - PA-18-389

Organization: NINR 

Posting Date: 11-21-2017 

Expiration Date: 01-08-2021 

Activity Code: R21 

Summary: The purpose of this initiative is to stimulate research utilizing Mobile Health (mHealth) tools aimed at the improvement of effective patientprovider communication, adherence to treatment and self-management of chronic diseases. With the rapid expansion of cellular networks and substantial advancements in Smartphone technologies, it is now possible - and affordable - to transmit patient data digitally from remote areas to specialists in urban areas, receive real-time feedback, and capture that consultation in a database. These mHealth tools, therefore, may facilitate more timely and effective patient-provider communication through education communication around goal setting, treatment reminders, feedback on patient progress, and may improve health outcomes. This announcement encourages the development and testing of interventions utilizing mHealth technologies. There is also an interest in studying mHealth technologies in underserved populations. 

mHealth Tools for Individuals with Chronic Conditions to Promote Effective Patient-Provider Communication, Adherence to Treatment and Self-Management (R01 Clinical Trial Optional) - PA-18-386

Organization: NINR 

Posting Date: 11-21-2017 

Expiration Date: 01-08-2021 

Activity Code: R01 

Summary: The purpose of this initiative is to stimulate research utilizing Mobile Health (mHealth) tools aimed at the improvement of effective patientprovider communication, adherence to treatment and self-management of chronic diseases. With the rapid expansion of cellular networks and substantial advancements in Smartphone technologies, it is now possible - and affordable - to transmit patient data digitally from remote areas to specialists in urban areas, receive real-time feedback, and capture that consultation in a database. These mHealth tools, therefore, may facilitate more timely and effective patient-provider communication through education communication around goal setting, treatment reminders, feedback on patient progress, and may improve health outcomes. This announcement encourages the development and testing of interventions utilizing mHealth technologies. There is also an interest in studying mHealth technologies in underserved populations. 

Zika Virus (ZIKV) Complications (R21 Clinical Trial Optional) - PA-18-048

Organization: NICHD 

Posting Date: 11-15-2017 

Expiration Date: 01-08-2020 

Activity Code: R21 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to provide support for research on Zika virus (ZIKV) and its complications. This FOA replaces PAR-16-106 which had used rolling application due dates to facilitate the rapid review and award of particularly urgent or time-sensitive projects. The last date for submitting an application to PAR-16-106 is January 13, 2017. 

Youth Violence Prevention Interventions that Incorporate Racism/Discrimination Prevention (R01-Clinical Trial Required) - RFA-MD-18-005

Organization: NIMHD 

Posting Date: 11-30-2017 

Expiration Date: 05-26-2018 

Activity Code: R01 

Summary: The purpose of this initiative is to support research to develop and test youth violence prevention interventions that incorporate racism/discrimination prevention strategies for one or more health disparity populations. The target age range includes middle school to high school-aged youth, corresponding to an approximate age range of 11 to 18. 

Workshop on the Use of Adolescent Brain Cognitive Development (ABCD) Data (R25 Clinical Trial Not Allowed) - RFA-DA-19-006

Organization: NIDA 

Posting Date: 03-28-2018 

Expiration Date: 07-26-2018 

Activity Code: R25 

Summary: The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIDA R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs in the use of ABCD data. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development and Research Experience involving cooperative and competitive use of ABCD datas 

Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R21 Clinical Trial Optional) - PA-18-602

Organization: NIDA 

Posting Date: 01-29-2018 

Expiration Date: 05-08-2021 

Activity Code: R21 

Summary: The purpose of this FOA is two-fold: (1) to advance identification of male-females differences in drug and alcohol research outcomes, to uncover the mechanisms of those differences, and to conduct translational research on those differences, and (2) to advance research specific to women or highly relevant to women. Both preclinical and clinical studies are sought across all areas of drug and alcohol research 

Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R03 Clinical Trial Optional) - PA-18-601

Organization: NIDA 

Posting Date: 01-29-2018 

Expiration Date: 05-08-2021 

Activity Code: R03 

Summary: The purpose of this FOA is two-fold: (1) to advance identification of male-females differences in drug and alcohol research outcomes, to uncover the mechanisms of those differences, and to conduct translational research on those differences, and (2) to advance research specific to women or highly relevant to women. Both preclinical and clinical studies are sought across all areas of drug and alcohol research 

Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R01 Clinical Trial Optional) - PA-18-603

Organization: NIDA 

Posting Date: 01-29-2018 

Expiration Date: 05-08-2021 

Activity Code: R01 

Summary: The purpose of this FOA is two-fold: (1) to advance identification of male-females differences in drug and alcohol research outcomes, to uncover the mechanisms of those differences, and to conduct translational research on those differences, and (2) to advance research specific to women or highly relevant to women. Both preclinical and clinical studies are sought across all areas of drug and alcohol research 

Wearable Alcohol Biosensors (R43/R44 Clinical Trial Optional) - PAR-18-204

Organization: NIAAA 

Posting Date: 11-28-2017 

Expiration Date: 04-06-2019 

Activity Code: R43/R44 

Summary: The purpose of this funding opportunity announcement is to encourage Small Business Innovation Research (SBIR) applications from eligible small business concerns proposing to design and produce a non-invasive, discreet, wearable device to monitor blood alcohol levels in real time. Methods that quantify alcohol in blood or interstitial fluid as opposed to detection of alcohol that has exuded through the skin are of particular interest. 

Vet-LIRN Network Capacity-Building Projects - PAR-18-604

Organization: FDA 

Posting Date: 01-29-2018 

Expiration Date: 09-02-2023 

Activity Code: U18 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to support enhanced human and animal food safety by strengthening the capacity, collaboration, and integration of food-safety laboratories and networks, thereby facilitating an effective and coordinated response to future human and animal food safety issues. The current FOA solicits applications from FDA's Veterinary Laboratory Investigation and Response Network laboratories for research related to emerging public food safety issues identified by the Vet-LIRN network office (VPO), for equipment and personnel necessary to expand laboratory capability and capacity, and for other related activities. This cooperative agreement program is intended to build domestic laboratory capacity as put forth in the Food Safety Modernization Act (FSMA), by developing the Vet-LIRN laboratory Network capabilities and capacity to investigate potential animal foodborne illness outbreaks. 

Vet-LIRN Cooperative Agreement Program to Develop and Validate Testing Methods for Food Irradiation Specific Markers in Animal Feeds and Treats (U18) - PAR-16-132

Organization: FDA 

Posting Date: 03-15-2016 

Expiration Date: 05-02-2018 

Activity Code: U18 

Summary: Food irradiation is a food preservation method which is used in many countries, both in human and animal food manufacturing. Treating food with irradiation results in large reduction in microbial contamination and insect pests. It is also useful in slowing ripening of fruit and for inhibiting sprouting of plant products.In USA, the FDA regulates all aspects of irradiation, such as irradiation dose, product type, and labeling requirements.The use of irradiation requires development of analytical methods capable to determine the irradiation status of wide variety of foods, in order to ensure that food is properly labeled, as well as to insure that products were properly handled during irradiation process.Current FDA regulations allow a maximum absorbed dose of 50 kGy in animal feed, pet food, and treats that are irradiated to reduce microbial and insect pest contamination.There are however, very few tests, with limited application, to quantify the actual dose used when irradiating animal food products. Depending on the type of food, various methods are available to detect food irradiation. For fatty foods, the major methods are based on chemical determination of compounds formed from the irradiation of lipids (hydrocarbons and 2-alkylcyclobutanones). It is believed that 2-alkylcyclobutanones (2-ACBs) are formed in food only by irradiation, and they are considered as markers for detecting the irradiation in food.Electron spin resonance (ESP) spectroscopy detects irradiation induced paramagnetic centers (e.g. radicals). This method is applicable for detection of irradiated foods containing bone, cellulose or crystalline sugar. Thermoluminescence is a method applicable to those foods from which a sufficient amount of silicate minerals can be isolated. Photostimulated luminescence is a different method, which can be applied to detect irradiation of any food which contains mineral debris. DNA comet assay can be used to detect irradiation of any food containing DNA, with several limitations. Different microbiological methods are also available, but can only be used as a screening tool. 

Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01) - PAR-15-297

Organization: NCI 

Posting Date: 07-14-2015 

Expiration Date: 08-16-2018 

Activity Code: U01 

Summary: This Funding Opportunity Announcement (FOA) encourages the submission of applications that propose to advance research in cancer etiology and early detection biomarkers, utilizing the advantages of the unique biorepository resources of the NCI-sponsored Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial. The PLCO Biorepository offers high-quality, prospectively collected, serial pre-diagnostic blood samples from the PLCO screened arm participants, and a onetime collection of buccal cells from the control arm participants. Available data associated with the biospecimens includes demographic, diet, lifestyle, smoking, screening results, and clinical data. This FOA supports a wide range of cancer research including, but not limited to, biochemical and genetic analyses of cancer risk, as well as discovery and validation of early detection biomarkers. The proposed research project must involve use of PLCO biospecimens; additionally, it should also take advantage of the unique characteristics of the PLCO biospecimens. Research projects that do not involve the use of PLCO biospecimens will not be supported under this FOA. 

Utilizing Health Information Technology to Scale and Spread Successful Practice Models Using Patient-reported Outcomes (R18) - PA-17-077

Organization: AHRQ 

Posting Date: 12-12-2016 

Expiration Date: 01-26-2020 

Activity Code: R18 

Summary: This Funding Opportunity Announcement (FOA) invites R18 grant applications for research that demonstrates how health information technology (IT) can improve patient-centered health outcomes and quality of care in primary care and other ambulatory settings through the scale and spread of successful, health IT-enabled practice models that use patient-reported outcome (PRO) measures to achieve these objectives. 

Using Small Molecules and Molecular Genetics to Identify Novel Targets and Mechanisms Contributing to Tumor Immune Evasion (R01) - PA-17-330

Organization: NCI 

Posting Date: 07-21-2017 

Expiration Date: 09-08-2020 

Activity Code: R01 

Summary: The purpose of this funding opportunity (FOA) is to stimulate research on the identification of new and novel targets and mechanisms involved in tumor immune evasion, which may be amenable to analysis by small molecules, pharmacological, or molecular genetics approaches. A specific focus of this FOA is to encourage cross disciplinary collaborations between immunologists, cell biologists, medicinal chemists, pharmacologists, and molecular biologists. 

Using Information Technology to Support Systematic Screening and Treatment of Depression in Cancer (R21 Clinical Trial Optional) - PA-18-492

Organization: NCI 

Posting Date: 12-11-2017 

Expiration Date: 05-08-2021 

Activity Code: R21 

Summary: This funding opportunity announcement (FOA) encourages research to understand how information technology (IT) can support systematic screening and treatment of depression in cancer patients in a variety of oncology practice settings. The goals of this FOA are to: identify new, IT-enabled delivery models that support systematic screening and treatment of depression in cancer patients; test the feasibility of implementing these new delivery models in a variety of oncology practice settings, especially those serving under-served populations; and test the effectiveness of these new delivery models, and their components, in a variety of oncology practice settings, especially those serving under-served populations. 

Using Information Technology to Support Systematic Screening and Treatment of Depression in Cancer (R01 Clinical Trial Optional) - PA-18-493

Organization: NCI 

Posting Date: 12-11-2017 

Expiration Date: 05-08-2021 

Activity Code: R01 

Summary: This funding opportunity announcement (FOA) encourages research to understand how information technology (IT) can support systematic screening and treatment of depression in cancer patients in a variety of oncology practice settings. The goals of this FOA are to: identify new, IT-enabled delivery models that support systematic screening and treatment of depression in cancer patients; test the feasibility of implementing these new delivery models in a variety of oncology practice settings, especially those serving under-served populations; and test the effectiveness of these new delivery models, and their components, in a variety of oncology practice settings, especially those serving under-served populations. 

Use of Technology to Enhance Patient Outcomes and Prevent Illness (R21 Clinical Trial Optional) - PA-18-163

Organization: NINR 

Posting Date: 11-07-2017 

Expiration Date: 01-08-2020 

Activity Code: R21 

Summary: This Funding Opportunity Announcement (FOA) seeks clinical research focused on the development and utilization of technologies that can help address patient outcomes. Relevant areas of technology include remote healthcare delivery to patients via telehealth, robotics to enhance medication adherence, on-site (e.g., clinical or home setting) care delivery, mobile heath to increase access and adherence, web-based decision support tools, and others. Research projects may focus on assessment, diagnosis, intervention development, or intervention implementation. Research projects that a) incorporate emerging and cutting edge technologies to explain and predict patient trajectories, b) inform interventions, c) support real-time clinical decision making, and d) facilitate effective long-term management of chronic illness are especially needed. Critical to this FOA, proposed research should identify specific patient outcomes expected to improve from technological approaches. The specific tools or interventions proposed should clearly indicate how they will enhance patient benefits in environments, such as clinical settings, and/or in the home and community. 

Use of Technology to Enhance Patient Outcomes and Prevent Illness (R01 Clinical Trial Optional) - PA-18-145

Organization: NINR 

Posting Date: 11-07-2017 

Expiration Date: 01-08-2020 

Activity Code: R01 

Summary: This Funding Opportunity Announcement (FOA) seeks clinical research focused on the development and utilization of technologies that can help address patient outcomes. Relevant areas of technology include remote healthcare delivery to patients via telehealth, robotics to enhance medication adherence, on-site (e.g., clinical or home setting) care delivery, mobile heath to increase access and adherence, web-based decision support tools, and others. Research projects may focus on assessment, diagnosis, intervention development, or intervention implementation. Research projects that a) incorporate emerging and cutting edge technologies to explain and predict patient trajectories, b) inform interventions, c) support real-time clinical decision making, and d) facilitate effective long-term management of chronic illness are especially needed. Critical to this FOA, proposed research should identify specific patient outcomes expected to improve from technological approaches. The specific tools or interventions proposed should clearly indicate how they will enhance patient benefits in environments, such as clinical settings, and/or in the home and community. 

Understanding the Early Development of the Immune System (R01 - Clinical Trial Not Allowed) - PAR-18-333

Organization: NICHD 

Posting Date: 10-25-2017 

Expiration Date: 12-06-2019 

Activity Code: R01 

Summary: The purpose of this funding opportunity announcement (FOA) is to support studies on the very early development of the immune system and the humoral and cellular communication that exists between the mother and fetus that may shape or impact immune system development and maturation.  

Understanding and Modifying Temporal Dynamics of Coordinated Neural Activity (R21 Clinical Trial Optional) - PAR-18-554

Organization: NIMH 

Posting Date: 01-02-2018 

Expiration Date: 01-08-2021 

Activity Code: R21 

Summary: A rich body of evidence suggests that optimal cognitive, affective, and social processes are associated with highly coordinated neural activity. These findings suggest that oscillatory rhythms, their co-modulation across frequency bands, spike-phase correlations, spike population dynamics, and other patterns might be useful drivers of therapeutic development for treatment of cognitive, social, or affective symptoms in neuropsychiatric disorders. This funding opportunity supports projects that test whether modifying electrophysiological patterns during behavior can improve cognitive, affective, or social processing. Applications must use experimental designs that incorporate active manipulations to address at least one, and ideally more, of the following topics: (1) in animals or humans, determine which parameters of neural coordination, when manipulated in isolation, improve particular aspects of cognitive, affective, or social processing; (2) in animals or humans, determine how particular abnormalities at the genomic, molecular, or cellular levels affect the systems-level coordination of electrophysiological patterns during behavior; (3) determine whether in vivo, systems-level electrophysiological changes in behaving animals predict analogous electrophysiological and cognitive improvements in healthy persons or clinical populations; and (4) use biologically-realistic computational models that include systems-level aspects to understand the function and mechanisms by which oscillatory and other electrophysiological patterns unfold across the brain to impact cognitive, affective, or social processing. This FOA uses the R21 grant mechanism, encouraging shorter, higher-risk applications, whereas its companion funding opportunity seeks R01 grant applications. 

Understanding and Modifying Temporal Dynamics of Coordinated Neural Activity (R01) and Clinical Trial Optional - PAR-18-555

Organization: NIMH 

Posting Date: 01-02-2018 

Expiration Date: 01-08-2021 

Activity Code: R01 

Summary: A rich body of evidence suggests that optimal cognitive, affective, and social processes are associated with highly coordinated neural activity. These findings suggest that oscillatory rhythms, their co-modulation across frequency bands, spike-phase correlations, spike population dynamics, and other patterns might be useful drivers of therapeutic development for treatment of cognitive, social, or affective symptoms in neuropsychiatric disorders. This funding opportunity supports projects that test whether modifying electrophysiological patterns during behavior can improve cognitive, affective, or social processing. Applications must use experimental designs that incorporate active manipulations to address at least one, and ideally more, of the following topics: (1) in animals or humans, determine which parameters of neural coordination, when manipulated in isolation, improve particular aspects of cognitive, affective, or social processing; (2) in animals or humans, determine how particular abnormalities at the genomic, molecular, or cellular levels affect the systems-level coordination of electrophysiological patterns during behavior; (3) determine whether in vivo, systems-level electrophysiological changes in behaving animals predict analogous electrophysiological and cognitive improvements in healthy persons or clinical populations; and (4) use biologically-realistic computational models that include systems-level aspects to understand the function and mechanisms by which oscillatory and other electrophysiological patterns unfold across the brain to impact cognitive, affective, or social processing. This FOA uses the R01 grant mechanism, whereas its companion funding opportunity seeks shorter, higher-risk R21 grant applications. 

Understanding and Improving Diagnostic Safety in Ambulatory Care: Strategies and Interventions (R18) - PA-15-179

Organization: AHRQ 

Posting Date: 04-08-2015 

Expiration Date: 09-27-2020 

Activity Code: R18 

Summary: Despite the growing interest and rapid pace of recent achievements, not much is known with a high degree of confidence about the strategies and interventions that might reduce diagnostic failures and patient harms or enhance the resilience and safety of diagnostic work. This Funding Opportunity Announcement (FOA) solicits applications from research institutions and their investigators to conduct Health Services Research Demonstration and Dissemination Projects (R18) to evaluate strategies and interventions for reducing diagnostic failures and patient harms, including approaches that enable organizations, providers and patients to better anticipate emerging diagnostic risk before failure and harm occurs.  

Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01) - PA-15-180

Organization: AHRQ 

Posting Date: 04-08-2015 

Expiration Date: 11-06-2020 

Activity Code: R01 

Summary: Despite the growing interest and rapid pace of recent achievements, not much is known with a high degree of confidence about the prevalence of diagnostic failure in its various manifestations. This Funding Opportunity Announcement (FOA) solicits applications from research institutions and their investigators to conduct Health Services Research Projects (R01) to gain a better understanding of the complexity and incidence of diagnostic failure and its associated costs and harms. 

Understanding Processes of Recovery in the Treatment of Alcohol Use Disorder (R21 - Clinical Trial Optional) - PA-18-620

Organization: NIAAA 

Posting Date: 02-02-2018 

Expiration Date: 05-08-2021 

Activity Code: R21 

Summary: The purpose of this FOA is encourage applications that seek to examine processes of recovery and relapse in the treatment of Alcohol Use Disorders. Applications high in innovation and significance are highly encouraged that address the following potential topics: 1) defining recovery; 2) Examining new and innovative methods to examine precipitants of relapse; 3) Understanding mechanisms of mutual help and recovery; 4) Evaluating recovery systems of care; and 5) Examining processes of extended treatment for AUD. 

Understanding Processes of Recovery in the Treatment of Alcohol Use Disorder (R01 - Clinical Trial Optional) - PA-18-619

Organization: NIAAA 

Posting Date: 02-02-2018 

Expiration Date: 05-08-2021 

Activity Code: R01 

Summary: The purpose of this FOA is encourage applications that seek to examine processes of recovery and relapse in the treatment of Alcohol Use Disorders. Applications high in innovation and significance are highly encouraged that address the following potential topics: 1) defining recovery; 2) Examining new and innovative methods to examine precipitants of relapse; 3) Understanding mechanisms of mutual help and recovery; 4) Evaluating recovery systems of care; and 5) Examining processes of extended treatment for AUD. 

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