NIH Guide to Grants and Contracts

The NIH Guide for Grants and Contracts is our official publication for NIH grant policies, guidelines and funding opportunities. We publish daily, and issue a table of contents weekly. Learn more about the NIH Guide and subscribe today!

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Results: 1 to 25 of 1430

Display Results as:

Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC): Comprehensive Functional Mapping of Neuroanatomy and Neurobiology of Organs (OT2) - RFA-RM-15-018

Organization: Roadmap 

Posting Date: 11-16-2015 

Expiration Date: 06-15-2018 

Activity Code: OT2 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to invite applications (via limited competition) for SPARC Comprehensive Functional Mapping of Neuroanatomy and Neurobiology of Organs. These projects will comprehensively provide data for developing detailed, predictive functional and anatomical neural circuit maps for neural control of major functions of organs and their functionally-associated structures. Each project is to focus on a specific organ and the afferent and efferent innervation that controls function of the organ. Applications are only accepted after successful competition of the corresponding OT1 pre-application (See RFA-RM-15-003) and invitation to the applicant to submit the OT2 application. 

Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC): Technologies to Understand the Control of Organ Function by the Peripheral Nervous System (OT2) - RFA-RM-17-010

Organization: Roadmap 

Posting Date: 04-11-2017 

Expiration Date: 01-24-2018 

Activity Code: OT2 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to invite applications (via limited competition) for SPARC Technologies to Understand the Control of Organ Function by the Peripheral Nervous System. 

Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01, Clinical Trials Not Allowed) - PAR-18-583

Organization: Roadmap 

Posting Date: 01-16-2018 

Expiration Date: 03-23-2018 

Activity Code: X01 

Summary: As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First), the NIH invites applications to use submit samples from pediatric cohorts for whole genome sequencing at a Kids First-supported sequencing center. Applicants are encouraged to propose sequencing of existing pediatric cancer cohorts to elucidate the genetic contribution to childhood cancers, or to expand the range of disorders included within the Kids First Data Resource to investigate the genetic etiology of structural birth defects. Whole genome, exome, and transcriptome sequencing are available for tumor or affected tissue when justified. These data will become part of the Gabriella Miller Kids First Pediatric Data Resource (Kids First Data Resource) for the pediatric research community. 

Transformative Technology Development for the Human BioMolecular Atlas Program (UG3/UH3 Clinical Trials Not Allowed) - RFA-RM-17-025

Organization: OSC 

Posting Date: 12-18-2017 

Expiration Date: 03-03-2018 

Activity Code: UG3/UH3 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to solicit transformative technologies that will significantly expand throughput, multiplexing and discrimination of biomolecules in human tissues for comprehensive mapping of individual cells and their context in human tissues. This FOA supports the accelerated proof-of-principle demonstration and validation of promising tools, techniques and systems that can be integrated, scaled and applied to multiple human tissues. The initial two-year UH2 phase will support accelerated development and demonstration of feasibility of these emerging, high impact technologies. The subsequent two-year UH3 phase will support validation in human tissues, optimization, scale-up, and generation of initial production level data. Funded projects will be expected to work closely as part of the Human BioMolecular Atlas Program to catalyze development of a framework for mapping the human body with high resolution. 

Tissue Mapping Centers for the Human BioMolecular Atlas Program (U54 Clinical Trials Not Allowed) - RFA-RM-17-027

Organization: OSC 

Posting Date: 12-18-2017 

Expiration Date: 03-03-2018 

Activity Code: U54 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Tissue Mapping Centers (TMCs) that will generate high-resolution, multi-parameter maps of non-diseased human organs and systems. Centers will be expected to integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through to data integration, analysis and interpretation. Centers will also be expected to work closely with the other funded projects as part of the Human BioMolecular Atlas Program to catalyze development of a framework for mapping the human body with micron resolution. 

Development of Novel Tools and Devices to Support the Care of Animal Models and Animal Care Research Facilities (R41/R42) - PAR-15-185

Organization: ORIP 

Posting Date: 04-16-2015 

Expiration Date: 09-06-2018 

Activity Code: R41/R42 

Summary: This funding opportunity announcement (FOA) encourages applications from small business concerns (SBCs) for Small Business Technology Transfer (STTR) projects to develop novel tools and devices to improve handling of laboratory animals, to ease the management of animal facilities, and to enhance experiments which use animal models. The intent is to facilitate the development and implementation of tools and devices to directly benefit the welfare of research animals, and to advance equipment to improve infrastructure and environmental conditions of animal facilities that support biomedical and bio-behavioral research.  

Novel Tools and Devices for Animal Research Facilities and to Support the Care of Animal Models (R43/R44) - PAR-15-186

Organization: ORIP 

Posting Date: 04-16-2015 

Expiration Date: 09-06-2018 

Activity Code: R43/R44 

Summary: Research (SBIR) projects to develop novel tools and devices to improve handling of laboratory animals, to ease the management of animal facilities, and to enhance experiments which use animal models. The intent is to facilitate the development and implementation of tools and devices to directly benefit the welfare of research animals, and to advance equipment to improve infrastructure and environmental conditions of animal facilities that support biomedical and bio-behavioral research.  

Improvement of Animal Models for Stem Cell-Based Regenerative Medicine (R01) - PAR-16-093

Organization: ORIP 

Posting Date: 02-09-2016 

Expiration Date: 05-08-2019 

Activity Code: R01 

Summary: This FOA encourages Research Project Grant (R01) applications from institutions and organizations proposing research aimed at characterizing animal stem cells and improving existing, and creating new, animal models for human disease conditions.The intent of this initiative is to facilitate the use of stem cell-based therapies for regenerative medicine. The initiative focuses on the following areas: 1) comparative analysis of animal and human stem cells to provide information for selection of the most predictive and informative model systems; 2) development of new technologies for stem cell characterization and transplantation; and 3) improvement of animal disease models for stem cell-based therapeutic applications. 

Improvement of Animal Models for Stem Cell-Based Regenerative Medicine (R21) - PAR-16-094

Organization: ORIP 

Posting Date: 02-09-2016 

Expiration Date: 05-08-2019 

Activity Code: R21 

Summary: This FOA encourages Exploratory/Developmental Research grant (R21) applications from institutions and organizations proposing research aimed at characterizing animal stem cells and improving existing, and creating new, animal models for human disease conditions.The intent of this initiative is to facilitate the use of stem cell-based therapies for regenerative medicine. The initiative focuses on the following areas: 1) comparative analysis of animal and human stem cells to provide information for selection of the most predictive and informative model systems; 2) development of new technologies for stem cell characterization and transplantation; and 3) improvement of animal disease models for stem cell-based therapeutic applications. 

Development of Animal Models and Related Biological Materials for Research (R21) - PA-16-141

Organization: ORIP 

Posting Date: 03-18-2016 

Expiration Date: 05-08-2019 

Activity Code: R21 

Summary: This funding opportunity announcement (FOA) encourages highly innovative research to develop, characterize or improve animal models and related biological materials for human health and disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes. The proposed project must fall within the categorical interests of two or more NIH institutions/centers. Applications to develop models that relate strictly to a specific disease or category of research will not be accepted and should be proposed to the appropriate categorical Institute or Center of the NIH. 

Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R43/R44) - PA-16-180

Organization: ORIP 

Posting Date: 04-11-2016 

Expiration Date: 04-06-2019 

Activity Code: R43/R44 

Summary: The Office of Research Infrastructure Programs (ORIP) supports research-related resources that create, develop, preserve and supply a variety of high-quality animal models, and related biological materials. ORIP also supports the development and implementation of tools and devices that directly benefit the welfare of research animals, improve handling of laboratory animals, and ease the management of animal facilities. This Funding Opportunity Announcement (FOA) encourages small business concerns to submit Small Business Innovation Research (SBIR) grant applications that propose innovative approaches and technologies to further develop, improve and facilitate the use of animal models and related biological materials, to meet new biomedical challenges related to improvements in the health of humans and the welfare of animal models. 

Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R41/R42) - PA-16-181

Organization: ORIP 

Posting Date: 04-11-2016 

Expiration Date: 04-06-2019 

Activity Code: R41/R42 

Summary: The Office of Research Infrastructure Programs (ORIP) supports research-related resources that create, develop, preserve and supply a variety of high-quality animal models, and related biological materials. ORIP also supports the development and implementation of tools and devices that directly benefit the welfare of research animals, improve handling of laboratory animals, and ease the management of animal facilities. This Funding Opportunity Announcement (FOA) encourages small business concerns to submit Small Business Technology Transfer (STTR) grant applications that propose innovative approaches and technologies to further develop, improve and facilitate the use of animal models and related biological materials, to meet new biomedical challenges related to improvements in the health of humans and the welfare of animal models. 

Improvement of Animal Models for Stem Cell-Based Regenerative Medicine (R24) - PAR-16-322

Organization: ORIP 

Posting Date: 06-13-2016 

Expiration Date: 09-08-2019 

Activity Code: R24 

Summary: This FOA encourages applications from institutions and organizations proposing research aimed at characterizing animal stem cells and improving existing, and creating new, animal models for human disease conditions. The intent of this initiative is to facilitate the use of stem cell-based therapies for regenerative medicine. The initiative focuses on the following areas: 1) comparative analysis of animal and human stem cells to provide information for selection of the most predictive and informative model systems; 2) development of new technologies for stem cell characterization and transplantation; and 3) improvement of animal disease models for stem cell-based therapeutic applications.  

Resource-Related Research Projects for Development of Animal Models and Related Materials (R24) - PAR-16-369

Organization: ORIP 

Posting Date: 07-14-2016 

Expiration Date: 09-08-2019 

Activity Code: R24 

Summary: This FOA encourages grant applications aimed at developing, characterizing or improving animal models of human diseases; improving access to data and information about or generated from the use of animal models of human disease; or improving diagnosis and control of diseases of laboratory animals. The animal models and related materials to be developed must address the research interests of two or more of the categorical NIH Institutes and Centers (ICs). Applications to develop models that relate strictly to a specific disease or category of research will not be considered acceptable. Projects that predominantly address the research interests of one NIH Institute or Center but are peripherally related to the research interests of other Institutes and Centers will not be considered appropriate for this FOA.  

Animal and Biological Material Resource Centers (P40) - PAR-17-006

Organization: ORIP 

Posting Date: 10-07-2016 

Expiration Date: 01-08-2020 

Activity Code: P40 

Summary: This FOA encourages grant applications for national Animal Model, and Biological Material Resource Centers. These Centers provide support for special colonies of laboratory animals, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, national and international basis. Support for Animal and Biological Material Resource Centers is limited to those that span the interests of two or more categorical NIH Institutes/Centers/Offices (ICOs). This funding opportunity is designed to both support continuation of existing resources, and to develop new ones when appropriate. Prior to preparing an application, all applicants are strongly encouraged to consult with Scientific/Research staff to be advised on appropriateness of the intended resource plans for this program, competitiveness of a potential application and ORIP's program priorities.  

Limited Competition: Research Resource for Human Organs and Tissues (U42) - RFA-OD-17-001

Organization: ORIP 

Posting Date: 11-25-2016 

Expiration Date: 01-27-2018 

Activity Code: U42 

Summary: The purpose of this FOA is for the support of a Research Resource for Human Organs and Tissues for the continued availability of human tissues and organs to biomedical researchers in the United States. The research resource is expected to facilitate procurement, preservation, and distribution of human tissues and organs to qualified biomedical researchers. 

Limited Competition: National Primate Research Centers (P51) - PAR-17-144

Organization: ORIP 

Posting Date: 01-27-2017 

Expiration Date: 01-26-2020 

Activity Code: P51 

Summary: This FOA encourages grant applications that support the activities of the National Primate Research Centers (NPRCs). Nonhuman primates (NHPs) are most closely related to humans, both physiologically and genetically. Therefore, NHPs are critical animal models for translational research aimed at understanding human biology, both in normal and diseased states. Proper husbandry and management of NHPs require specialized physical and intellectual resources, which are most effectively and economically provided in centralized primate centers, the resources of which are made available to investigators on a national basis. The NPRCs provide these resources to investigators/grantees who utilize NHPs in biomedical research and thereby complement and help enable the missions of the NIH Institutes and Centers.  

Limited Competition: National Swine Resource and Research Center (U42) - PAR-17-255

Organization: ORIP 

Posting Date: 04-14-2017 

Expiration Date: 01-26-2018 

Activity Code: U42 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to provide continued support for the National Swine Resource and Research Center (NSRRC). The NSRRC serves as a central resource for reagents, the creation of genetically modified swine and the procurement, preservation, and distribution of those swine and their biological materials; and as a source of information and training related to the use of these animals in biomedical research as models of human health and disease. 

Limited Competition: Small Grant Program for ORIP Special Emphasis Research Career Award (SERCA) K01 Recipients (R03) - PAR-17-301

Organization: ORIP 

Posting Date: 06-05-2017 

Expiration Date: 05-08-2020 

Activity Code: R03 

Summary: The Office of Research Infrastructure Programs (ORIP) within the Division of Program Coordination, Planning, and Strategic Initiatives announces a program that provides ORIP-supported Special Emphasis Research Career Award (SERCA) K01 awardees who have completed the first two years (24 months) of their K01 award the opportunity to apply for Small Grant support. Through the use of this mechanism, ORIP is seeking to enhance the capability of ORIP SERCA K01 awardees to conduct research as they complete their transition to fully independent investigator status. The R03 mechanism supports different types of projects, including but not limited to pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology, and development of new research technology. The R03 is therefore intended to support research projects that can be achieved in a short period of time with limited resources and that provide preliminary data to support a subsequent R01 or equivalent application. 

Administrative Supplements for Research on Dietary Supplements (Admin Supp) - PA-17-307

Organization: ODS 

Posting Date: 06-07-2017 

Expiration Date: 04-16-2018 

Activity Code: (Admin Supp) 

Summary: This Funding Opportunity Announcement (FOA) announces the availability of administrative supplements to support research in which the supplemental funding would investigate the role of dietary supplements and/or their ingredients in health maintenance and disease prevention. Parent awards need not be focused on dietary supplements; this FOA may provide support to include dietary supplements within the scope of relevant research projects. Research interests of ODS are not limited to specific health conditions, organ systems or population groups. ODS supports all types of research, including pre-clinical, clinical, behavioral, and epidemiological. Additionally, ODS supports research and training programs that build future research capacity for studying the role of dietary supplements in health and disease prevention. Primary consideration for support will be given to applications that stimulate dietary supplement research where it is lacking or lagging, clarify gaps, opportunities and balance between benefits and risks where data are in conflict, target special population groups where additional science on dietary supplements is needed, and focus on the use of dietary supplements in improving or maintaining health and reducing the risk of chronic disease. This FOA will not support new clinical trials.  

Administrative supplements for validation studies of analytical methods for dietary supplements and natural products (Admin. Suppl.) - PA-17-447

Organization: ODS 

Posting Date: 08-01-2017 

Expiration Date: 04-16-2018 

Activity Code: (Admin Supp) 

Summary: The reproducibility and comparability of dietary supplement research is enhanced through rigorous analytical characterization of key experimental materials. The publication of analytical methods which have been thoroughly validated for specific, precise, accurate, and sensitive quantitative determination of chemical constituents of dietary supplements therefore makes critical contributions to the rigor and reproducibility of biomedical research. This FOA will build on existing NIH awards to support the performance and publication of formal single-laboratory validation studies of relevant quantitative analytical methods. The methods proposed for validation must be used to identify and quantify chemical constituents (active or marker chemical compounds, adulterants, contaminants) or metabolites thereof in experimental reagents, raw materials, and/or clinical specimens (for example urine or plasma samples). Methods must have been developed or utilized in fulfillment of the active parent grants specific aims. Candidate constituents for quantitative method validation studies may include (but are not limited to): phytochemicals, nutrients, and potentially deleterious substances such as pesticides and mycotoxins. Multi-laboratory validation studies will not be supported through this FOA.  

Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed) - PAR-17-476

Organization: ODP 

Posting Date: 09-07-2017 

Expiration Date: 06-28-2020 

Activity Code: R01 

Summary: The purpose of this funding opportunity announcement is to support basic research examining how Electronic Nicotine Delivery Systems (ENDS) aerosols affect normal and disease states relevant to human cells, tissues and organs. 

Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R21 - Clinical Trial Not Allowed) - PAR-17-475

Organization: ODP 

Posting Date: 09-07-2017 

Expiration Date: 06-28-2020 

Activity Code: R21 

Summary: The purpose of this funding opportunity announcement is to support basic research examining how Electronic Nicotine Delivery Systems (ENDS) aerosols affect normal and disease states relevant to human cells, tissues and organs. 

Developing Interventions for Health-Enhancing Physical Activity (R21/R33 - Clinical Trial Optional) - PAR-18-307

Organization: ODP 

Posting Date: 10-10-2017 

Expiration Date: 01-08-2021 

Activity Code: R21/R33 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to fund highly innovative and promising research aimed at developing multi-level physical activity intervention programs acting on at least two levels of the socioecological model and designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. This FOA provides support for up to two years (R21 phase) for research planning activities and feasibility studies, followed by a possible transition to expanded research support (R33 phase) for optimizing the intervention and conducting larger-scale feasibility studies. Transition to the R33 depends on the completion of applicant-defined milestones, as well as program priorities and the availability of funds. 

Testing Interventions for Health-Enhancing Physical Activity (R01 - Clinical Trial Optional) - PAR-18-324

Organization: ODP 

Posting Date: 10-17-2017 

Expiration Date: 01-08-2021 

Activity Code: R01 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to fund highly innovative and promising research that tests multi-level physical activity intervention programs acting on at least two levels of the socio-ecological model and designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. This FOA provides support for up to 5 years for research planning, intervention delivery, and follow-up activities. 

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