NIH Guide to Grants and Contracts

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Results: 1 to 25 of 11506

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BIOTECHNOLOGY TRANSFER TO EPIDEMIOLOGIC STUDIES IN CANCER - RFA-CA-92-023

Organization: NCI 

Posting Date: 07-31-1992 

Expiration Date: 11-20-1992 

Activity Code: R01 

Summary:  

VIRAL GENETICS IN HIV/CNS DISEASE: IMPLICATIONS FOR PATHOGENESIS - RFA-MH-02-012

Organization: NIMH 

Posting Date: 03-29-2002 

Expiration Date: 06-13-2002 

Activity Code: R01 

Summary: The National Institute of Mental Health (NIMH), the National Institute of Neurological Disorders and Stroke (NINDS), and the National Institute on Drug Abuse (NIDA) solicit applications for grants to support studies focused on understanding the molecular and viral genetic factors controlling HIV-1 neuropathogenesis in the setting of highly active anti-retroviral therapy (HAART). The objective of this cooperative effort is to foster investigations utilizing genetic approaches to study mechanisms of HIV-1 induced nervous system disease with emphasis on trafficking, cell type specific and regional compartmentalization, viral evolution, functional diversity, establishment of latent reservoirs and the emergence of drug resistance in the central nervous system (CNS) versus other body compartments.  

AGING WOMEN AND BREAST CANCER - PA-00-001

Organization: NIA 

Posting Date: 10-05-1999 

Expiration Date: 10-06-2002 

Activity Code: R01 R03 R21 

Summary: The National Institute on Aging (NIA), the National Cancer Institute (NCI), and the National Institute of Nursing Research (NINR) invite research applications to focus on the unique problems of older women with breast cancer. Breast cancer affecting elderly women is a major health problem. The purpose of this broad-based program announcement is to expand the knowledge base on breast cancer in older women through studies in the fields of biology, clinical medicine, epidemiology, and the behavioral and social sciences.  

DRUG ABUSE PREVENTION INTERVENTION RESEARCH - PA-00-002

Organization: NIDA 

Posting Date: 10-05-1999 

Expiration Date: 10-05-2002 

Activity Code: P01 P30 P50 P60 R01 R03 R21 

Summary: The purposes of the National Institute on Drug Abuse"s (NIDA) prevention research program are: to examine the efficacy and effectiveness of new and innovative theory-based prevention approaches, to determine the components of research-based intervention strategies and programs that account for effectiveness of approaches, to clarify factors related to the effective and efficient provision of prevention services, and to develop and test methodologies appropriate for studying these complex aspects of prevention science. Prevention science takes a multi-disciplinary systems perspective in examining interactions, transactions, and mechanisms within and across levels of the human environment that deter the development of substance abuse patterns and addiction. To accomplish this, NIDA funds investigator-initiated research focusing on developmentally appropriate universal, selective, and indicated drug abuse prevention strategies for individuals, groups, and specific populations. Contexts of interest include the family, peer-group and community (schools, workplace, neighborhood, media), and focus on these venues as arenas for prevention from the intra-individual level through to the policy level.  

MENTORED CLINICAL SCIENTIST DEVELOPMENT AWARD (K08) - PA-00-003

Organization: NIH 

Posting Date: 10-08-1999 

Expiration Date: 07-01-2006 

Activity Code: K08 

Summary: The purpose of the Mentored Clinical Scientist Development Award (K08) is to support the development of outstanding clinician research scientists. This mechanism provides specialized study for individuals with a health professional doctoral degree committed to a career in laboratory or field- based research. Candidates must have the potential to develop into independent investigators. The K08 supports a three, four, or five year period of supervised research experience that may integrate didactic studies with laboratory or clinically-based research. The proposed research must have intrinsic research importance as well as serving as a suitable vehicle for learning the methodology, theories, and conceptualizations necessary for a well trained independent researcher.  

COOPERATIVE PROGRAM ON RETINAL DEGENERATIVE DISEASE RESEARCH - PA-00-009

Organization: NEI 

Posting Date: 11-10-1999 

Expiration Date: 11-10-2002 

Activity Code: R41 R42 R43 R44 

Summary:  

MENTORED CLINICAL SCIENTIST DEVELOPMENT AWARD - PA-00-010

Organization: AHRQ 

Posting Date: 11-10-1999 

Expiration Date: 11-10-2002 

Activity Code: K08 

Summary: The Agency for Health Care Policy and Research (AHCPR) announces its interest in supporting the Mentored Clinical Scientist Development Award (K08) in health services research. The K08 provides support for the development of outstanding research scientists. It provides specialized study support for trained professionals who are committed to a career in research and have the potential to develop into independent investigators. Because of the focus on progression to independence, the prospective candidate should propose a period of study and development consistent with his/her needs, and previous research or clinical experience. The proposed length of the award must be well explained and justified. Support will only be provided for the period deemed necessary to achieve independence, as recommended by peer review and Agency decision making.  

DEEP INFECTIONS OF TOTAL JOINT REPLACEMENTS - PA-00-014

Organization: NIAMS 

Posting Date: 12-01-1999 

Expiration Date: 12-01-2002 

Activity Code: R01 

Summary: Total joint replacement has been shown to be a highly effective treatment for end-stage arthritis of the major weight-bearing joints. Despite this success, complications persist, including dislocation, deep infection, aseptic loosening and osteolysis. Although relatively uncommon, deep infections in a total joint replacement are potentially catastrophic events for patients and for society. Through this program announcement (PA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute of Child Health and Human Development (NICHD) seek to stimulate the receipt of a broad range of basic science and clinical studies to better understand the pathophysiology, diagnosis and treatment of deep infections around total joint replacement implants. The National Institute of Allergy and Infectious Diseases (NIAID) has interests in related areas, and applications responding to this PA may receive assignment to NIAID in accordance with assignment guidelines.  

RESEARCH ON ADHERENCE TO INTERVENTIONS FOR MENTAL DISORDERS - PA-00-016

Organization: NIMH 

Posting Date: 12-01-1999 

Expiration Date: 12-01-2002 

Activity Code: R01 R03 R21 

Summary: This program announcement is intended to expand research on adherence and behavior change that integrates findings from the basic behavioral sciences with interventions for mental disorders, symptoms, or related disability. Included are studies of mechanisms and processes that enhance or interfere with adherence to preventive, treatment, and rehabilitative interventions. The interventions may be pharmacological, behavioral, or psychosocial. Emphasis is on the development of innovative approaches to adherence and behavior change, especially models of interventions to improve adherence. A well-articulated, empirically-based conceptual framework is therefore essential in applications solicited under this announcement. Priority will be given to applications that also include a detailed plan for initial tests of that conceptual model.  

RECEPTORS AND SIGNALING IN BONE IN HEALTH AND DISEASE - PA-00-017

Organization: NIDDK 

Posting Date: 12-02-1999 

Expiration Date: 12-02-2002 

Activity Code: R01 

Summary: The objective of this initiative is to elicit grant submissions that focus on systemic hormones, local growth factors, and bone-active cytokines, their receptors and mechanisms of signaling in bone. While the primary focus is on basic research, the long-term emphasis is on identifying mechanisms or processes related to hormone action with potential applicability as targets for therapeutic agents that may have efficacy in the treatment of diseases that adversely affect bone, such as osteoporosis and primary hyperparathyroidism.  

MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD (K01) - PA-00-019

Organization: NIH 

Posting Date: 12-02-1999 

Expiration Date: 10-04-2005 

Activity Code: K01 

Summary: The Mentored Research Scientist Development Award (K01) provides support for an intensive, supervised career development experience in one of the biomedical, behavioral, or clinical sciences leading to research independence. Candidates for this award normally must have a research or health-professional doctorate and postdoctoral research experience at the time of application. In addition, the candidate must be able to demonstrate the need for a three, four, or five-year period of additional supervised research as well as the capacity and/or the potential for highly productive independent research. The proposed career development experience must be in a research area new to the applicant and/or one in which an additional supervised research experience will substantially add to the research capabilities of the applicant. The candidate must provide a plan for achieving independent research support by the end of the award period.  

INDEPENDENT SCIENTIST AWARD (K02) - PA-00-020

Organization: NIH 

Posting Date: 12-02-1999 

Expiration Date: 07-01-2006 

Activity Code: K02 

Summary: The Independent Scientist Award (K02) provides up to five years of salary support for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. This award is intended to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research.  

SENIOR SCIENTIST AWARD (K05) - PA-00-021

Organization: NIH 

Posting Date: 12-02-1999 

Expiration Date: 12-02-2005 

Activity Code: K05 

Summary: The Senior Scientist Award (K05) provides stability of support to outstanding scientists who have demonstrated a sustained, high level of productivity and whose expertise, research accomplishments, and contributions to the field have been and will continue to be critical to the mission of the particular NIH center or institute. The award provides salary support for award periods of up to five years as a means of enhancing the individual recipient"s skills and dedication to his/her area of research. The Senior Scientist Award (K05) permits NIH institutes and centers to identify and support exceptionally talented investigators who are well established in their field of research.  

THE ROLE OF ENDOTHELIAL DYSFUNCTION IN DIABETIC COMPLICATIONS - PA-00-026

Organization: NIDDK 

Posting Date: 12-13-1999 

Expiration Date: 12-13-2002 

Activity Code: R01 R21 

Summary: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites investigator-initiated research grant applications to study the role of endothelial alteration or dysfunction in the etiology and pathogenesis of the micro- and macrovascular complications of diabetes. Endothelial function is known to be abnormal in diabetes and may be an early step in the development of atherosclerotic lesions. Recent work has also focused attention on the role of endothelial function in the pathogenesis of microvascular complications. This PA, with a $1 million dollar annual set- aside, is intended to stimulate the application of new molecular technologies to this area. Understanding the pathogenesis of endothelial dysfunction in diabetes at the molecular and cellular level will provide new targets for pharmacologic or genetic manipulations to prevent complications of diabetes.  

THE ROLE OF MICROGLIA IN NORMAL AND ABNORMAL IMMUNE RESPONSES OF THE NERVOUS SYSTEM - PA-00-029

Organization: NINDS 

Posting Date: 12-15-1999 

Expiration Date: 12-16-2002 

Activity Code: R01 

Summary: The National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH), National Center for Research Resources (NCRR), National Institute on Deafness and other Communicative Disorders (NIDCD), and National Institute on Drug Abuse (NIDA), invite applications to promote research into the role of microglia in the initiation and expansion of autoimmune processes of the central nervous system (CNS) and the resulting injury to CNS components. Microglia become reservoirs of infectious agents including viruses, fungi, treponema and prions. Under certain conditions, they assume the phenotypes and functions of macrophages. They may become activated and then be able to serve in antigen presentation. The contributions of these cells not only to infections of the CNS, but also to autoimmunity, are beginning to be appreciated. The intent of this PA is to intensify interest and investigator-initiated research to attract new investigators to this field and to mobilize interdisciplinary approaches.  

POPULATION MOVEMENT: DETERMINANTS AND CONSEQUENCES - PA-00-032

Organization: NICHD 

Posting Date: 12-22-1999 

Expiration Date: 12-22-2002 

Activity Code: R01 

Summary: The Demographic and Behavioral Sciences Branch (DBSB), Center for Population Research, National Institute of Child Health and Human Development (NICHD), and the Demography and Population Epidemiology Branch, Behavioral and Social Research Program, National Institute on Aging (NIA), invite qualified researchers to submit applications for research on the determinants and consequences of population movement. The "determinants" of migration include characteristics of places and sociopolitical units, and of persons and their families. The "consequences" of migration refer to the relative performance of migrants in their new location, the effects of migration on origin and destination populations, and the impact of migrants on population structure, density, crowding, and environmental outcomes. The potential contribution of demographic research and methods to understanding individual and social outcomes extends broadly across the spheres of health, human development, aging, retirement, family, and material well-being. Research on population movement encompasses studies of migration within national boundaries (internal migration) as well as movement across borders (international migration). This announcement highlights topics especially salient to the former, but encompasses research on all forms of population movement. For a fuller treatment of issues related to international migration, potential applicants are encouraged to review an earlier announcement that gives fuller treatment to immigration (PA-95-035, Research on U.S. Immigration).  

EXPLORATORY GRANTS FOR GENOMIC IMPRINTING AND ENVIRONMENTAL DISEASE SUSCEPTIBILITY - PA-00-034

Organization: NIEHS 

Posting Date: 12-22-1999 

Expiration Date: 12-22-2002 

Activity Code: R21 

Summary: The exploratory/developmental (R21) grant mechanism is used for pilot projects or feasibility studies to support creative, novel, high risk/high payoff research that may produce innovative advances in science. This PA is to encourage applications from individuals who are interested in testing novel or conceptually creative ideas to understand the potential role environmental agents play in causing epigenetic changes in the DNA that can alter imprint gene expression, thereby resulting in a multitude of genetic diseases including cancer and neuro-behavioral disorders.  

TRADITIONAL, INDIGENOUS SYSTEMS OF MEDICINE - PA-00-041

Organization: NCCIH  (formerly NCCAM)

Posting Date: 01-10-2000 

Expiration Date: 01-10-2003 

Activity Code: R01 R21 

Summary: The National Center for Complementary and Alternative Medicine (NCCAM) is committed to investigating the efficacy and safety of traditional, indigenous systems of medicine, including the support of well-designed, well-executed, definitive randomized clinical trials (RCT). The main objective of a full- scale, definitive RCT (Phase III trial) is to determine whether the intervention is more effective than that used in a control (or comparison) group. Before proceeding to a large RCT (Phase III trial), developmental studies are often required.  

CELLULAR AND MOLECULAR MECHANISMS OF PRIMARY PULMONARY HYPERTENSION - PA-00-043

Organization: NHLBI 

Posting Date: 01-10-2000 

Expiration Date: 01-10-2003 

Activity Code: R01 

Summary: The goal of this Program Announcement is to promote research in primary pulmonary hypertension (PPH) with an emphasis on elucidating a mechanistic understanding of the disease. Studies are encouraged, at the cellular and molecular level, to address the basic mechanisms involved in the unique vascular remodeling that occurs in PPH, regulation of pulmonary vascular tone and the genetic basis of PPH. Investigators are encouraged to consider a scientific approach that integrates new data with existing data in the field to define and delineate mechanisms in PPH pathology. Research to identify novel genes or vasoactive mediators important in PPH pathology and determination of their functional effects on pulmonary vascular cells, on extracellular matrix and on pulmonary vascular tone is a high priority. Further, research integrating the relationship between mediators of vasoconstriction and pulmonary vascular remodeling is strongly encouraged. The ultimate goal is to develop new and effective therapies.  

INNOVATION GRANT PROGRAM FOR AIDS VACCINE RESEARCH - PA-00-044

Organization: NIAID 

Posting Date: 01-10-2000 

Expiration Date: 01-10-2003 

Activity Code: R21 

Summary: This program announcement (PA) is a continuation of the Innovation Grant Program for Approaches in HIV Vaccine Research, implemented by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), on the recommendation of the AIDS Vaccine Research Committee (AVRC). This program encourages the entrance of novel and innovative vaccine discovery and development concepts into the research pipeline. As such, the emphasis of this program is on supporting prophylactic vaccine research projects that are particularly innovative, novel, may be high risk/high impact, and that exhibit the potential to advance AIDS prophylactic vaccine design or evaluation. Applications are especially welcome from young investigators and those not currently active in the field of AIDS research. The Innovation Grant Program utilizes a grant mechanism that provides funding for projects of an exploratory nature to generate preliminary data for further studies.  

NEUROBIOLOGICAL AND BEHAVIORAL RESEARCH ON NICOTINE AND TOBACCO COMPONENTS - PA-00-045

Organization: NIDA 

Posting Date: 01-19-2000 

Expiration Date: 01-19-2003 

Activity Code: R01 R03 R21 

Summary: Nicotine is one of thousands of chemicals in tobacco products, but it is considered the primary compound that affects brain function. Reports from the U.S. Surgeon General, the American Psychiatric Association, and the World Health Organization, among others, have supported four major conclusions: (1) cigarettes and other forms of tobacco are addictive, (2) half of the people who continue to use cigarettes will die from diseases related to smoking, (3) nicotine is the drug in tobacco that causes addiction, and (4) physiological and behavioral processes that determine tobacco addiction are similar to those that determine addiction to heroin and cocaine.  

BIOBEHAVIORAL RESEARCH FOR EFFECTIVE SLEEP - PA-00-046

Organization: NINR 

Posting Date: 01-19-2000 

Expiration Date: 01-19-2003 

Activity Code: R01 

Summary: The National Institute of Nursing Research (NINR), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Child Health and Human Development (NICHD), National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH), and the National Cancer Institute (NCI) invite applications to investigate sleep deprivation in health and illness. The goal of this program announcement is to stimulate clinical and applied research on behavioral, psychosocial and physiological consequences of acute and chronic partial sleep deprivation in either chronically ill or healthy individuals and to develop environmental, clinical management, and other interventions with the potential to reduce sleep disturbances and significantly improve the health of large numbers of people. Although sleep disorders are a cause of sleep loss in affected individuals, the questions to be addressed under this solicitation should focus on causes and consequences of sleep deprivation, apart from any sleep pathology.  

COLLABORATIONS FOR ADVANCED STRATEGIES IN COMPLICATIONS OF HIV INFECTION - PA-00-048

Organization: NIAID 

Posting Date: 01-28-2000 

Expiration Date: 01-28-2003 

Activity Code: R01 

Summary: The National Institute of Allergy and Infectious Diseases (NIAID), the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and National Institute of Mental Health (NIMH) invite applicants to expand the clinical knowledge of the complications of HIV by expediting the translation of promising innovative preclinical findings into clinical research applications. NIAID, NIDA, NIAAA, NIDDK and NIMH are interested in supporting focused collaborative research between preclinical and clinical scientists to test, refine, and improve diagnostic, pathogenic, or therapeutic concepts. It anticipates such research will lead to innovative approaches for the prevention and management of complications causing significant morbidity or mortality in HIV infected persons, including the recently recognized metabolic complications, coincident pathogens such as hepatitis C virus, and the opportunistic pathogens. This type of collaborative research would be dedicated to the expedited development and use of advanced preclinical findings into clinical applications and would be designed to: elucidate pathogenic mechanisms involved in metabolic dysregulation or in the human host-pathogen relationship in HIV-associated complications, develop strategies to prevent or treat complications of HIV or HIV therapy, or develop approaches to measure treatment response. The NIDA will support research on metabolic disorders in drug users with HIV infection. The NIAAA is interested in supporting research as it relates to alcohol consumption as a cofactor in HIV infection. The NIMH will support research on the neurobiological/neuropsychiatric complications of HIV infection and associated therapies.  

ENHANCING ADHERENCE TO DIABETES SELF-MANAGEMENT BEHAVIORS - PA-00-049

Organization: NINR 

Posting Date: 01-27-2000 

Expiration Date: 01-27-2003 

Activity Code: R01 

Summary: This Program Announcement (PA) solicits applications for investigator- initiated research related to sociocultural, environmental, and behavioral mechanisms and biological/technological factors that contribute to successful and ongoing self-management in diabetes. Self-management is defined as client strategies and behaviors that contribute to blood glucose normalization, improved health, and prevention or reduction of complications. It is broader than adherence to specific regimen components and incorporates deliberate problem solving and decision making processes. Applications are encouraged for both type 1 and type 2 diabetes, representative and minority populations, and all age groups.  

HIGHER-ORDER COGNITIVE FUNCTIONING AND AGING - PA-00-052

Organization: NIA 

Posting Date: 02-02-2000 

Expiration Date: 02-02-2003 

Activity Code: P01 R01 

Summary: The National Institute on Aging (NIA) invites qualified researchers to submit new applications for research projects that focus on adulthood and aging- related changes in the higher-order processes and strategies required for judgment, decision-making, reasoning, problem-solving, and processing complex information. As in earlier periods of life older adults continue to make decisions related to everyday life, but with advanced age, new, and sometimes even more complex, decision-making is required of them. Recent research indicates that age-related limitations in cognitive processing resources (e.g., speed and working memory) may impact decision-making. Research also indicates that some older adults experience growth in specific areas of cognitive functioning (e.g., expertise, semantic knowledge, emotional regulation) and continue to use adaptive intelligence, demonstrating multi- directionality in adult cognitive change. It is generally recognized that research on higher-order processing is underdeveloped in the field of aging. Research proposals are needed that examine the actual processes that are engaged when older adults make important decisions, how these processes change with age and context, and what environmental supports, interventions, and training may be necessary for optimal functioning. Research may investigate either individual or collaborative, or social processes.  

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