NIH Guide to Grants and Contracts

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Results: 1 to 25 of 1209

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Immunity in the Elderly (R01) Clinical Trial Optional - RFA-AI-17-037

Organization: NIAID 

Posting Date: 10-25-2017 

Expiration Date: 02-23-2018 

Activity Code: R01 

Summary: The goal of this reissued Funding Opportunity Announcement (FOA) is to expand understanding of age-related changes that occur in immune function during the aging process that influence responses to pathogens and/or vaccines, as well as oral and craniofacial health. Human studies are required, and inclusion of relevant animal studies is permitted for mechanistic understanding. This FOA solicits applications that will determine the mechanisms required for induction and maintenance of protective immunity in the elderly in response to infections and/or vaccinations, including the effects of chronic inflammation on those responses, and applications that will assess changes in immune processes in dental, oral and craniofacial tissues in the elderly.  

Collaboratory on Research Definitions for Cognitive Reserve and Resilience to Alzheimer's Disease (R24 - Clinical Trial Not Allowed) - RFA-AG-18-024

Organization: NIA 

Posting Date: 11-28-2017 

Expiration Date: 02-23-2018 

Activity Code: R24 

Summary: The purpose of this funding opportunity announcement (FOA) is to provide infrastructure support to advance development of operational definitions and approaches for the study of the concepts of cognitive reserve and resilience to Alzheimers disease and related dementias (ADRD) and age-related cognitive decline. The infrastructure support will facilitate a collaborative research network through meetings, conferences, small-scale pilots, and dissemination activities to foster development and champion use of state-of-the-art definitions, uniform nomenclature, and validated approaches that will be key to the advancement of research on maintenance of brain and cognitive health and treatment and/or prevention of ADRD. 

Interaction of HIV Infection and Alcohol Abuse on Central Nervous System Morbidity Limited Competition (U01 Clinical Trial Not Allowed) - RFA-AA-18-008

Organization: NIAAA 

Posting Date: 12-13-2017 

Expiration Date: 02-23-2018 

Activity Code: U01 

Summary: The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites a limited competing renewal of a U01 project to evaluate the cumulative and progressive effects on brain structure and cognitive/behavioral function of combined HIV infection and alcohol abuse. This project has recruited and longitudinally tracked a large cohort of individuals with HIV infection, or alcohol abuse, or the comorbid condition. As members of this cohort are growing older and living well longer due to antiretroviral medications, this project is well suited to address several questions of current interest in the HIV-AIDS research community. These questions include the effects of coinfection with the Hepatitis C virus, the involvement of peripheral neuropathy as a factor in frailty, potential neurotoxic effects of antiretroviral medications, and interactive effects with advancing age on sensory and motor functioning. 

NLM Grants for Scholarly Works in Biomedicine and Health (G13) - PAR-16-417

Organization: NLM 

Posting Date: 08-26-2016 

Expiration Date: 02-24-2018 

Activity Code: G13 

Summary: NLM Grants for Scholarly Works in Biomedicine and Health are awarded for the preparation of book-length manuscripts and other works of academic and/or public health policy value to U.S. health professionals, public health officials, biomedical researchers and historians of the health sciences. 

Change of Grantee Organization (Type 7 Parent) - PA-16-285

Organization: NIH 

Posting Date: 05-24-2016 

Expiration Date: 02-25-2018 

Activity Code: (Type 7) 

Summary: The National Institutes of Health (NIH) hereby notify grantee organizations holding specific types of NIH grants, listed in the full Funding Opportunity Announcement (FOA), that applications for change of grantee organization may be submitted in response to this FOA. This assumes such a change is programmatically permitted for the particular grant. Applications for change of grantee organization are considered prior approval requests (as described in Section 8.1.2.7 of the NIH Grants Policy Statement) and will be routed for consideration directly to the Grants Management Specialist named in the current award. Although requests for change of grantee organization may be submitted through this FOA, there is no guarantee that an award will be transferred to the new organization. All applicants are encouraged to discuss potential requests with the awarding IC before submission. 

Successor-in-Interest (Type 6 Parent) - PA-16-286

Organization: NIH 

Posting Date: 05-24-2016 

Expiration Date: 02-25-2018 

Activity Code: (Type 6) 

Summary: The National Institutes of Health (NIH) hereby notify grantee organizations holding specific types of NIH research grants, listed in the full Funding Opportunity Announcement (FOA), that applications for change of grantee organization status, often referred to in this announcement as Successor-In-Interest, may be submitted in response to this FOA. Applications for change of grantee organization status are considered prior approval requests (as described in Section 8.1.2.8 of the NIH Grants Policy Statement) and will be routed for consideration directly to the Grants Management Specialist named in the current award. Although successor-in-interest requests may be submitted through this FOA, there is no guarantee that an award will be transferred to the new organization. All applicants are encouraged to discuss potential requests with the awarding IC before submission. 

Research Supplements to Promote Diversity in Health-Related Research (Admin Supp) - PA-16-288

Organization: NIH 

Posting Date: 05-25-2016 

Expiration Date: 02-25-2018 

Activity Code: (Admin Supp) 

Summary: The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) hereby notify Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) holding specific types of research grants (activity codes listed above) that funds are available for administrative supplements to improve the diversity of the research workforce by recruiting and supporting students, postdoctorates, and eligible investigators from groups that have been shown to be underrepresented in health-related research. This supplement opportunity is also available to PD(s)/PI(s) of research grants who are or become disabled and need additional support to accommodate their disability in order to continue to work on the research project. Administrative supplements must support work within the scope of the original project.  

Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) - PA-16-289

Organization: NIH 

Posting Date: 05-24-2016 

Expiration Date: 02-25-2018 

Activity Code: (Admin Supp) 

Summary: The Office of Research on Women's Health (ORWH) and participating Institutes and Centers (ICs) of the National Institutes of Health (NIH) announce the continuation of the program for administrative supplements to research grants to support individuals with high potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances. The purpose of these supplements is to encourage such individuals to re-enter research careers within the missions of all the program areas of NIH. This program will provide administrative supplements to existing NIH research grants for the purpose of supporting full-time or part-time research by these individuals to update their existing research skills and knowledge. 

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Admin Supp) - PA-16-287

Organization: NIH 

Posting Date: 05-24-2016 

Expiration Date: 02-25-2018 

Activity Code: (Admin Supp) 

Summary: The National Institutes of Health (NIH) hereby notify Program Directors/Principal Investigators (PD(s)/PI(s)) holding specific types of NIH research grants listed in the full Funding Opportunity Announcement (FOA) that funds may be available for administrative supplements to meet increased costs that are within the scope of the approved award, but were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted. Applications for administrative supplements are considered prior approval requests (as described in Section 8.1.2.11 of the NIH Grants Policy Statement) and will be routed directly to the Grants Management Officer of the parent award. 

Biology Of Aging Dental, Oral And Craniofacial Tissues (R21 - Clinical Trial Not Allowed) - RFA-DE-18-010

Organization: NIDCR 

Posting Date: 09-19-2017 

Expiration Date: 03-01-2018 

Activity Code: R21 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative research to understand the biological mechanisms of aging in dental, oral, and craniofacial (DOC) tissues, as they relate to parallel processes in other tissues and organs. The areas of emphasis under this FOA include inflammation, tissue healing and regeneration, and epigenetic regulation. The overarching long-term goal of this effort is to improve oral health in older adults by addressing knowledge gaps in our understanding of the basic biology of age-associated changes in health and disease states of DOC tissues.  

Biology Of Aging Dental, Oral And Craniofacial Tissues (R01 - Clinical Trial Not Allowed) - RFA-DE-18-009

Organization: NIDCR 

Posting Date: 09-19-2017 

Expiration Date: 03-01-2018 

Activity Code: R01 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative research to understand the biological mechanisms of aging in dental, oral, and craniofacial (DOC) tissues, as they relate to parallel processes in other tissues and organs. The areas of emphasis under this FOA include inflammation, tissue healing and regeneration, and epigenetic regulation. The overarching long-term goal of this effort is to improve oral health in older adults by addressing knowledge gaps in our understanding of the basic biology of age-associated changes in health and disease states of DOC tissues.  

Developmental Centers for Interdisciplinary Research in Benign Urology (P20 - Clinical Trials Not Allowed) - RFA-DK-17-033

Organization: NIDDK 

Posting Date: 10-06-2017 

Expiration Date: 03-01-2018 

Activity Code: P20 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to seek applications for the Developmental Centers for Interdisciplinary Research in Benign Urology Program (P20). Among the goals of this Program is to further advance research in benign urology by building research teams and facilitating resources generation and sharing. The research teams should be composed of individuals with complementary expertise who propose to either develop innovative resources (Resource Development Projects) or a new research project (Scientific Research Projects) that utilize integrative approaches to address questions relevant to benign urological diseases or disorders. Patient-centered research is encouraged. Resources developed by the Resource Development Projects will be shared upon validation while resources developed within the Scientific Research Projects will be shared at the end or termination of the award, as appropriate and consistent with the program goal of further advancing research. Each Developmental Center is centered on a single Project and must contain an Administrative Core and an Educational Enrichment Program. As part of the efforts of the Division of Kidney, Urologic and Hematologic Diseases (DKUH) to expand and enhance benign urology research, the Developmental Centers Program will work in partnership with the George M. O'Brien Urology Cooperative Research Centers Program (U54) and the Multidisciplinary K12 Urologic Research (KURe) Career Development Program.  

Research on Pre-Exposure Prophylaxis (PrEP) to Prevent HIV in Health Disparity Populations (R01-Clinical Trial Not Allowed) - RFA-MD-18-003

Organization: NIMHD 

Posting Date: 11-30-2017 

Expiration Date: 03-01-2018 

Activity Code: R01 

Summary: The purpose of this initiative is to support community-based and healthcare setting-based research to understand the individual, interpersonal, community and societal factors that influence patterns of PrEP attitudes, access, availability, and adherence among health disparity populations in the US. Projects may involve primary quantitative/qualitative data collection and/or secondary analysis of existing data. 

Identification of Genetic and Genomic Variants by Next-Gen in Sequencing Non-human Animal Models (U01) - PAR-15-120

Organization: NIDA 

Posting Date: 02-13-2015 

Expiration Date: 03-02-2018 

Activity Code: U01 

Summary: The goals of this initiative are to identify gene variants of traits associated with addiction and substance abuse in selectively bred, and outbred non-human animal models using methodologies of Next Gen-Sequencing, mapping, and genotyping. This FOA will replace PAR-14-010 "Identification of Gene Variants for Addiction Related Traits by Next-Gen Sequencing in Model Organisms Selectively Bred for Addiction Traits (UH2/UH3)" 

Administrative Supplements to NCI Grant and Cooperative Agreement Awards to Support Collaborations with the PDX Development and Trial Centers Research Network (PDXNet)(Admin Suppl - Clinical Trial Not Allowed) - PA-18-496

Organization: NCI 

Posting Date: 12-15-2017 

Expiration Date: 03-02-2018 

Activity Code: (Admin Supp) 

Summary: This administrative supplement funding opportunity announcement is part of the Cancer Moonshot initiative to accelerate cancer research, and was developed in response to a recommendation from the Blue Ribbon Panel of experts charged with advising the National Cancer Advisory Board on the exceptional scientific opportunities that could be accelerated through this initiative. As part of the Cancer Moonshot initiative, the National Cancer Institute (NCI) created the Patient-Derived Xenograft (PDX) Development and Trial Centers Research Network (PDXNet), a collaborative network of centers of excellence focused on using patient-derived xenografts and other patient-derived models to accelerate the development of NCI investigational new drug (IND) agents (i.e., those that the NCI is developing in collaboration with pharmaceutical partners) in NCI-sponsored early phase clinical trials. This FOA supports supplemental funds to current NCI-funded research projects for new interdisciplinary collaborations between non-PDXNet investigators and PDXNet investigators to perform research within the scientific scope(s) of the parent grant and/or cooperative agreement award(s) that will lead to improved pre-clinical evaluations of novel therapeutic concepts using the large-scale PDX model collections of PDXNet, and that could ultimately be tested in NCI-sponsored clinical trials. 

Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01) - (Clinical Trials Not Allowed) - RFA-HL-18-026

Organization: NHLBI 

Posting Date: 10-26-2017 

Expiration Date: 03-03-2018 

Activity Code: K01 

Summary: This Funding Opportunity Announcement (FOA) invites applications to enhance the pool of of highly trained investigators from diverse backgrounds underrepresented in research. It is targeted toward individuals whose basic, clinical, and translational research interests are grounded in the advanced methods and experimental approaches needed to solve problems related to cardiovascular, pulmonary, and hematologic diseases and sleep disorders in the general and health disparities populations. This FOA invites applications from Institutions with eligible faculty members to undertake special study and supervised research under a mentor who is an accomplished investigator in the research area proposed and has experience in developing independent investigators. 

Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01) (Clinical Trial Required) - RFA-HL-18-027

Organization: NHLBI 

Posting Date: 11-09-2017 

Expiration Date: 03-03-2018 

Activity Code: K01 

Summary: This Funding Opportunity Announcement (FOA) invites applications to enhance the pool of of highly trained investigators from diverse backgrounds underrepresented in research. It is targeted toward individuals whose basic, clinical, and translational research interests are grounded in the advanced methods and experimental approaches needed to solve problems related to cardiovascular, pulmonary, and hematologic diseases and sleep disorders in the general and health disparities populations. This FOA invites applications from Institutions with eligible faculty members to undertake special study and supervised research under a mentor who is an accomplished investigator in the research area proposed and has experience in developing independent investigators. 

Transformative Technology Development for the Human BioMolecular Atlas Program (UG3/UH3 Clinical Trials Not Allowed) - RFA-RM-17-025

Organization: OSC 

Posting Date: 12-18-2017 

Expiration Date: 03-03-2018 

Activity Code: UG3/UH3 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to solicit transformative technologies that will significantly expand throughput, multiplexing and discrimination of biomolecules in human tissues for comprehensive mapping of individual cells and their context in human tissues. This FOA supports the accelerated proof-of-principle demonstration and validation of promising tools, techniques and systems that can be integrated, scaled and applied to multiple human tissues. The initial two-year UH2 phase will support accelerated development and demonstration of feasibility of these emerging, high impact technologies. The subsequent two-year UH3 phase will support validation in human tissues, optimization, scale-up, and generation of initial production level data. Funded projects will be expected to work closely as part of the Human BioMolecular Atlas Program to catalyze development of a framework for mapping the human body with high resolution. 

Tissue Mapping Centers for the Human BioMolecular Atlas Program (U54 Clinical Trials Not Allowed) - RFA-RM-17-027

Organization: OSC 

Posting Date: 12-18-2017 

Expiration Date: 03-03-2018 

Activity Code: U54 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Tissue Mapping Centers (TMCs) that will generate high-resolution, multi-parameter maps of non-diseased human organs and systems. Centers will be expected to integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through to data integration, analysis and interpretation. Centers will also be expected to work closely with the other funded projects as part of the Human BioMolecular Atlas Program to catalyze development of a framework for mapping the human body with micron resolution. 

AHRQ Health Services Research Projects: Making Health Care Safer in Ambulatory Care Settings and Long Term Care Facilities (R01) - PA-15-339

Organization: AHRQ 

Posting Date: 08-28-2015 

Expiration Date: 03-06-2018 

Activity Code: R01 

Summary: The purpose of this Funding Opportunity Announcement (FOA) is to support investigative research projects that examine the epidemiology of patient safety in ambulatory care settings and long term care facilities, gather evidence about strategies that can improve safety in these settings, and develop evidence-based tools to facilitate implementation of these strategies. 

Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp - Clinical Trial Not Allowed) - PA-18-517

Organization: NCI 

Posting Date: 12-19-2017 

Expiration Date: 03-06-2018 

Activity Code: (Admin Supp) 

Summary: This funding opportunity announcement (FOA) seeks to develop and nurture a national innovation ecosystem that builds upon biomedical research to develop technologies, products and services that benefit society. Toward meeting this objective, the I-Corps program is being offered. The I-Corps at NIH program is focused on educating researchers and technologists on how to translate technologies from the lab into the marketplace. Under this FOA, participating NIH and CDC Institutes and Centers will continue providing administrative supplement awards to currently-funded SBIR and STTR Phase I grantees. The program is designed to provide three-member project teams with access to instruction and mentoring in order to accelerate the translation of technologies currently being developed with NIH and CDC SBIR and STTR funding. It is anticipated that outcomes for the I-Corps teams participating in this program will include significantly refined commercialization plans and well-informed pivots in their overall commercialization strategies. Prospective applicants are strongly encouraged to contact NIH or CDC Scientific/Research staff for more information about the program before applying. 

Bridges to the Baccalaureate (R25) - PAR-16-110

Organization: NIGMS 

Posting Date: 02-22-2016 

Expiration Date: 03-08-2018 

Activity Code: R25 

Summary: The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIGMS R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development, Research Experiences, and Curriculum or Methods Development. A proposed program must include each activity and describe how they will be integrated. 

Integrated Preclinical/Clinical AIDS Vaccine Development Program (IPCAVD) (U19) - PAR-15-330

Organization: NIAID 

Posting Date: 08-14-2015 

Expiration Date: 03-10-2018 

Activity Code: U19 

Summary: The goal of the Integrated Preclinical/Clinical AIDS Vaccine Development Program (IPCAVD) Funding Opportunity Announcement (FOA) is to facilitate the translation of sufficiently advanced, innovative and promising vaccine candidates into early clinical testing. The IPCAVD program is designed to enable a multi-disciplinary team of investigators to complete all steps necessary from down-selection of a vaccine candidate through CGMP manufacture/testing/product release and into clinical trials.A preclinical research application alone is not sufficient for this announcement.Awards will provide the critical resources to allow the advancement of vaccine concepts to clinical trials within the project period of the award.However, this funding opportunity will not provide funds for conducting the clinical studies; applicants are encouraged to collaborate with NIAID-supported clinical trial networks or to develop other relationships to support the clinical studies. Investigators are expected to begin clinical studies by the end of the award. 

Studies of HIV in Digestive Diseases Limited to Gastrointestinal Mucosal Immunology and Liver Diseases (R01- Clinical Trial Optional) - RFA-DK-17-038

Organization: NIDDK 

Posting Date: 11-09-2017 

Expiration Date: 03-14-2018 

Activity Code: R01 

Summary: The goal of this FOA is to support innovative, basic and translational research in two areas, gastrointestinal (GI) mucosal immunology and liver disease. The emphasis for GI mucosal immunology is on elucidation of mechanisms whereby innate and adaptive immunity in the GI tract interacts with HIV infection in the presence or absence of antiretroviral therapy (ART) and contributes to HIV infection, persistence, disruption of GI homeostasis, and pathogenesis. The emphasis for liver disease is on pathophysiologic mechanisms of injury to the liver and the biliary system during HIV infection and epidemiological studies of liver diseases and disorders in HIV patients. 

Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01 Clinical Trial Optional) - RFA-DK-17-036

Organization: NIDDK 

Posting Date: 11-21-2017 

Expiration Date: 03-14-2018 

Activity Code: R01 

Summary: The goal of this Funding Opportunity Announcement (FOA) is to support innovative research to elucidate the role of HIV infection, including relevant host conditions or antiretroviral therapy, on metabolic and endocrine dysfunction, as well as to support innovative research delineating the pathophysiology, etiology, risk or protective factors, and potential strategies to prevent, treat, or reverse endocrine and metabolic dysfunction in HIV-infected individuals. This FOA supports both mechanistic research and clinical trials. Proposed projects must be related to the mission of the Division of Diabetes, Endocrinology, and Metabolic Diseases within NIDDK (DEM/NIDDK). 

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