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Staying Connected: Internet Resources for the

Institutional Animal Care & Use Committee

Presented by

Cindy Hoorn

IACUC Officer, Pharmacia

Michigan Society for Medical Research (MISMR)

Biomedical Research 2000 - May 18, 2000

Based on a document originally prepared by:

Julie Watson, Consulting Veterinarian & Carol Wigglesworth, Senior Policy Analyst, OLAW

Search Strategies-

There are a wide variety of search engines available for tracking down information on the world wide web (e.g., www.yahoo.com or www.altavista.com or www.infoseek.com ). Remember, though, that no search engine covers more than a third of the estimated total indexed pages, and the drawback to using search engines is that it takes technique and time to get relevant results.

Where to Begin-

The fastest method when you’re looking for information and don’t have a good address is often to start from a focused database such as NetVet, or from another highly relevant site. This also has the advantage of letting the site maintain the various critical links, so you don’t have to do it!

IACUC.ORG is an information resource for IACUC members and staff, developed with funding from AALAS. It was developed as an organizing tool to quickly point to a topic of interest, helping IACUC members manage the overwhelming amount of information available on the web.

www.iacuc.org

The Animal Welfare Information Center is another great starting point, linking you to everything an IACUC member could ever need or want.

www.nal.usda.gov/awic/

NetVet covers a huge array of topics and hot links and can get you to almost anything that is animal-related. However, the down side is that because there is so much information, it can still take a little while to track things down.

netvet.wustl.edu/vet.htm

The Canadian Council on Animal Care site contains a wealth of information on animal care and use. They have policies and guidelines on every aspect of animal welfare and much of this information is applicable in the US as well.

www.ccac.ca

 

Essential Online References-

This link from the AWIC site gives you full text versions of the complete Animal Welfare Act and Regulations.

www.nal.usda.gov/awic/legislat/usdaleg1.htm

Online APHIS Animal Care Policy Manual includes the 29 (and counting…) official policy documents that clarify the intent of the Animal Welfare Act.

http://www.aphis.usda.gov/ac/polmanpdf.html

The Health Research Extension Act of 1985, ‘Animals in Research’.

grants.nih.gov/grants/olaw/references/hrea1985.htm

The PHS Policy on Humane Care and Use of Laboratory Animals applies to all facilities that receive NIH grant support.

grants.nih.gov/grants/olaw/references/phspol.htm

The Guide for the Care and Use of Laboratory Animals is an IACUC must read! PHS Policy incorporates these guidelines by reference.

www.nap.edu/readingroom/books/labrats/

The 2000 version of the Report of the AVMA Panel on Euthanasia sets the standards for euthanasia practices. PHS Policy incorporates these guidelines by reference.

www.nal.usda.gov/awic/pubs/noawicpubs/avmaeuth.htm

This 1996 ACLAM Report on Adequate Veterinary Care clarifies the expectations and requirements for an institution’s veterinary care program.

www.aclam.org/pub_adquate_care.html

A listing of all of ILAR’s publications can be found at:

http://dels.nas.edu/ilar/recentpubs.asp?id=recentpubs

A quick guide to the ever-useful AWIC Bibliographies.

http://www.nal.usda.gov/awic/pubs/awicdocs.htm

 

USDA/APHIS Animal Care-

www.aphis.usda.gov/ac/

 

Public Health Service: Office of Laboratory Animal Welfare (OLAW)-

grants.nih.gov/grants/olaw/olaw.htm

Note particularly the useful sample documents & forms located at…

grants.nih.gov/grants/olaw/sampledoc/index.htm

 

Laws, Regulations and Government Resources-

NetVet Law and Government Resources is a very extensive list of hotlinks organized alphabetically according to which branch of the government you are dealing with. In fact, it is so extensive that it is almost ‘too much of a good thing’.

netvet.wustl.edu/law.htm

The "Thomas" site has everything you ever wanted to know about the legislative process and more.

thomas.loc.gov/

The National Archives and Records Administration - Government Printing Office (GPO access) site allows you quick access to the Federal Register.

http://www.gpoaccess.gov/fr/index.html

Food and Drug Administration site, with links to all Centers.

www.fda.gov

 

Species-Specific Resources-

The Whole Mouse Catalog is geared to researchers, but could be useful resource for IACUC members, for example for localizing a hybridoma bank as an alternative to ascites production, description and sources of inbred strains, background information on transgenes and transgenic research.

www.rodentia.com/wmc/

The University of Michigan’s Transgenic Animal Model Core web site which is a very valuable resource on all aspects of transgenic animal care and oversight.

www.med.umich.edu/tamc

Model Organisms for Biomedical Research is a site sponsored by NIH, providing information on the use of rats, mice and non-mammalian species in research.

www.nih.gov/science/models/

This link will connect you with the Laboratory Primate Newsletter, which serves as a central source of practical information about establishing and running a facility with caged nonhuman primates. The site contains lots of links to information on primate enrichment.

www.brown.edu/Research/Primate/

Primate fact sheets from the Primate Info Net at Wisconsin Regional Primate Research Center.

www.primate.wisc.edu/pin/factsheets/index.html

Training-

This IACUC tutorial is not flashy, but it is a good orientation to the Animal Welfare Regulations and PHS policy for new IACUC members.

grants.nih.gov/grants/olaw/tutorial/index.htm

The Laboratory Animal Welfare Training Exchange (LAWTE) aims to promote an information exchange among laboratory animal welfare trainers on training programs, systems, materials and services for the purpose of promoting the highest standards of laboratory animal care and use.

www.lawte.org

ILAR Principles for the Use of Animals in Precollege Education (1989). This three page document describes the 10 basic principles and can be found as link on the ILAR site.

http://dels.nas.edu/ilar/prin_guide.asp(must use IE)

The Laboratory Animal Training Association site provides a guide to training resources, as well as online training, which is available for a fee.

www.latanet.com/

The Tech Tips database is provided by the University of Texas at Austin Animal Resources Center for the use of the laboratory animal community. Users are invited to search the database for solutions provided by their colleagues, or to create a record of a tip or solution you have come up with in your lab or facility.

http://utarcdb.arc.utexas.edu/ttips1/

Occupational Health and Safety-

This 1997 ILAR publication, Occupational Health and Safety in the Care and Use of Research Animals, is posted in graphic format.

www.nap.edu/catalog/4988.html

Many of the listed sites on OSHWEB appear to be geared to the occupational health and safety professional rather than the IACUC member. However, this is a very comprehensive listing, including information on radiation safety, chemical safety, and occupational health.

oshweb.me.tut.fi/index.html

This OSHA site includes a fairly useful listing of occupational health and safety organizations, and a few institutional departments.

If you are consulting for a very small company that doesn’t have its own safety department, consider downloading this OSHA Handbook for Small Businesses. It is a comprehensive booklet which explains the steps to take in setting up a safety program, contains an extensive series of checklists, and lists the applicable regulations and local addresses for OSHA offices. Beware though, this is a large document that takes a very long time to download!

http://www.osha.gov/Publications/osha2209.pdf

Biosafety in Microbiological and Biomedical Laboratories is a CDC publication.

http://www.cdc.gov/od/ohs/biosfty/bmbl4/bmbl4toc.htm

This Centers for Disease Control page has lots of information on zoonotic diseases, emerging diseases, and surveillance.

www.cdc.gov/ncidod/diseases/index.htm

The NIOSH home page has a hotlink to a compete list of publications by NIOSH, e.g. on individual hazardous substances—some of which are available to download as PDF files.

www.cdc.gov/niosh/homepage.html

Examples of Occupational Health & Safety Programs and Policies:

UC Davis Occupational Health Program site. Extensive and nicely organized pages encompassing the UC Davis Occupational Health Program, an animal contact medical review form to download, notes about protective practices, and extensive information on zoonotic diseases.

http://ehs.ucdavis.edu/animal/health/

Environmental Health and Safety Office UC Santa Barbara site is visually appealing, with lots of useful information on laboratory safety and zoonoses.

ehs.ucsb.edu/

U of Florida risk-based occupational health program (called Animal Contact Medical Monitoring Program). Includes table of occupational health program components for different levels of risk, examples of the zoonotic risks posed by various animals, and different degrees of risk for personnel based on the species of animal and extent of contact.

www.ehs.ufl.edu/Bio/Animal/achand.htm

Occupational Health Program for Animal Handlers, U of Michigan. Text intensive, but with a table of risk categorization based on occupation, and a FAQ section.

http://www.ulam.umich.edu/UCUCA/OSEH_New.HTM

A number of useful documents related to Q-Fever policy from U of FL.

www.ehs.ufl.edu/Bio/qfever/qmain.htm

Working Safely with Animals provides a nice, text-based summary of hazards associated with working with lab animals, including a very readable "case history" section.

http://las.rutgers.edu

Compliance with the NIH Guidelines for Research Involving Recombinant DNA Molecules - NIH Guide Notice of May 28, 2002

http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-052.html

Search an extensive listing of MSDS from Cornell University.

http://msds.pdc.cornell.edu/msdssrch.asp

U of Minnesota policies and guidelines on various topics, including sharps disposal and urethane use.

http://www.ahc.umn.edu/rar/safety.html

 

Alternatives to Animal Use-

ALTWEB is a great site for news, information, discussion, and resources from the field of alternatives to animal testing. A joint effort of Johns Hopkins CAAT and a number of other public and private organizations, it is intended to foster the development of scientifically acceptable in vitro and other alternatives to animal testing.

altweb.jhsph.edu/

The NORINA database provides audiovisual alternatives to the use of laboratory animals in teaching, including books, audiotapes, videotapes, CD ROMs, films, computer programs etc. It has an efficient search engine and provides extensive information on resources, including a detailed description of the contents, source, price, audience suitability, etc.

oslovet.veths.no/NORINA/default.html

The Interagency Coordinating Committee on the Validation of Animal Models (ICCVAM) site provides information on models that have been validated, those under development, and how the process works.

iccvam.niehs.nih.gov/

 

Ethical Use of Animals in Research-

On being a scientist – responsible conduct of research. National Academy of Sciences 1985.

www.nap.edu/readingroom/books/obas/

Guidelines for Ethical Conduct in the Care and Use of Animals from the American Psychological Association. An extensive and fairly practical series of guidelines for humane use of animals in research, especially useful for giving IACUCs guidance on the acceptability of various commonly-used procedures in psychology experiments.

www.apa.org/science/anguide.html

NASA Principles for the Ethical Care and Use of Animals.

grants.nih.gov/grants/olaw/references/dc97-2.htm

Bioethics and Research Compliance Resources. American Physiological Society

www.faseb.org/aps/pubaff/pa_bioethics_res_web.htm

Comprehensive Institutional Sites-

Pennsylvania State University has a nicely organized site that is easy to navigate. All of their forms and policies are available in either html or pdf formats.

www.research.psu.edu/orp/ani/othr/contents.html

Rutgers’ Laboratory Animal Services ‘homecage’ links you to a variety of resources, including their Animal Care Manual and a semiannual program review checklist developed by Dr. Stephen Curtis.

http://las.rutgers.edu

University of Arizona’s University Animal Care page has links to their IACUC Handbook and to training modules.

www.ahsc.arizona.edu/uac/

University of California, Davis’s site includes policy statements, protocol templates, policy and procedure manual excerpts, page of reference documents with links, and 11 autotutorials.

http://ehs.ucdavis.edu/animal/health/

University of California, Santa Barbara’s Animal Care Committee page includes tips on searching for alternatives, information on zoonotic diseases, and training information on individual species.

http://research.ucsb.edu/iacuc/iacuc.shtml

University of Florida’s IACUC page includes IACUC guidelines, IACUC review process, animal use approval forms, graphs of USDA trends of animal use for last 3 and last 20 years, species-specific information, and guidance on assigning pain categories.

nersp.nerdc.ufl.edu/~iacuc/

University of Iowa’s site has information on alternatives searching, as well as guidelines on monoclonal antibody production and the ascites model.

http://research.uiowa.edu/animal/

The University of Michigan’s Committee on the Use & Care of Animals site has a link to a wide array of forms and documents relevant to IACUC function.

www.ulam.umich.edu/UCUCA_Doc.html

Wayne State University’s site information was provided after the MISMR meeting by Dr. Merlyn Ekstrom. Check it out… a very useful site! Includes a very comprehensive online resource manual.

sun2.science.wayne.edu/~dlar

North Dakota State U IACUC Newsletter table of contents. Various issues provide succinct overviews on such topics as: USDA policy on painful procedures; consideration of alternatives: documentation; IACUC review of field studies.

www.ndsu.nodak.edu/instruct/gerst/iacuc/nletidx.htm

Additional Useful and Relevant Examples-

Many of the more comprehensive institutional sites mentioned above have excellent examples of IACUC forms, policies and documents as well. These are just some additional pages of note that have come to our attention:

Use of Adjuvants, particularly Freund’s Complete Adjuvant:

U of Florida guidelines-

http://iacuc.ufl.edu/OLD%20Web%20Site/freunds.htm

U of Iowa alternatives to Freund’s Complete Adjuvant-

http://research.uiowa.edu/animal/

Anesthetics/Analgesics-

Dosage tables of anesthetics and analgesics by species, including amphibians and reptiles. Specific references for individual dosages not given, nor guidance of expected effects of anesthesia. General anesthetic reference sources used are listed at the bottom of the list.

www.ra.utk.edu/

Ascites/Monoclonal Antibody/Hybridoma Production:

November 1997 "Dear Colleague" letter from the Office for the Protection from Research Risks (now OLAW) on the production of monoclonal antibodies. Includes numerous links…

grants.nih.gov/grants/olaw/references/dc98-01.htm

U of Tennessee-Knoxville guidelines-

http://research.utk.edu/ora/

Blood Collection-

U of Tennessee-Knoxville guidelines (includes reptiles & fish)-

http://research.utk.edu/ora/

U of Florida guidelines for bleeding rabbits-

http://iacuc.ufl.edu/OLD%20Web%20Site/rabbitbl.htm

Environmental Enrichment-

U of Tennessee-Knoxville guidelines-

http://research.utk.edu/ora/

Environmental Enrichment for Caged Rhesus Macaques (Macaca mulatta): Photographic documentation and literature review-

www.animalwelfare.com/lab_animals/rhesus/Photo.htm

Guidelines for Euthanasia-

Univ. of Iowa animal care unit guidelines for euthanasia, including a table of methods for various species. Useful reference page for those developing their own resources.

http://research.uiowa.edu/animal/?get=euthanasia#Table of Euthanasia Methods

Pain & Distress (Assessment)-

www.vetinfo.demon.nl/aw/index.html

Shipping Guidelines (U of Florida)-

http://iacuc.ufl.edu/OLD%20Web%20Site/shipping.htm

Surgical Care (Pre & Post)-

U of Iowa guidelines-

www.research.uiowa.edu/animal/

Surgery Guidelines for Rodents-

OLAW on PHS Policy standards for rodent survival surgery-

grants.nih.gov/grants/olaw/references/ilar93.htm#1

Tail/Toe Clipping-

FDA amendment to the Good Laboratory Practice Regulations discouraging toe clipping.

133.1.71.100/index/guide/inform/regulation/usadocs/fdaclip.txt

U of Tennessee-Knoxville guidelines for tail clipping-

http://research.utk.edu/ora/

Transgenics/Recombinant DNA:

Compliance with the NIH Guidelines for Research Involving Recombinant DNA Molecules-

http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-052.html

Tumor Burden-

U of Tennessee-Knoxville guidelines-

http://research.utk.edu/ora/

 

Animal Welfare Organizations-

These organizations can be of great assistance to you in staying current on animal welfare-related issues, regulations, accreditation standards, and current practices.

American Association for Laboratory Animal Science – now includes a wonderful site for kids!

www.aalas.org

www.kids4research.org/

American College of Laboratory Animal Medicine (ACLAM)

www.aclam.org

American Committee on Laboratory Animal Diseases (ACLAD)

http://www.aclad.org/

Americans for Medical Progress (AMP)

www.ampef.org

Applied Research Ethics National Association (ARENA)

http://www.primr.org/arena.html

Association for the Assessment & Accreditation of Laboratory Animal Care (AAALAC) International

www.aaalac.org

Institute of Laboratory Animal Research (ILAR)

http://dels.nas.edu/ilar/

Michigan Society for Medical Research (MISMR)

www.mismr.org

National Association for Biomedical Research (NABR)

www.nabr.org

Public Responsibility in Medicine & Research (PRIM&R)

http://www.primr.org/

Scientists Center for Animal Welfare (SCAW), including IACUC TALK forum.

scaw.com [must use IE]

scaw.com/iacuctalk.html

 

Animal Welfare, Rights, Humane, and Rescue Organizations-

The following list maintained by NETVET is a comprehensive compilation of the full range of animal welfare, rights, humane, and rescue organizations.

http://netvet.wustl.edu/welfare.htm