Approval date

• NOT-OD-11-053. Guidance to Reduce Regulatory Burden for IACUC Administration Regarding Alternate Members and Approval Dates

Approval of extensions

• FAQ. May the IACUC administratively extend approval of a project that has expired?
• Lab Animal. 2012; 41(08). (PDF - 96 KB) Management of a holding protocol.
• Lab Animal. 2010; 39(11). (PDF - 178 KB) Refusal to renew an expiring protocol.
• Lab Animal. 2007; 36(7). (PDF - 60 KB) Getting around late protocol renewals.
• Lab Animal. 2003; 32(9):33-36, question #8.

Approval methods

• FAQ. What are the possible methods of IACUC approval?
• Lab Animal. 2011; 40(10). (PDF - 171 KB) Managing a pending IBC approval.
• Lab Animal. 2010; 39(6). (PDF - 180 KB) Revisiting approved protocols.
• Lab Animal. 2007; 36(9). (PDF - 77 KB) Of alternate and designated IACUC members.
• Lab Animal. 2003; 32(9):33-36, question #4.
• Lab Animal. 2002; 31(9). Correct Conduct of Full-Committee and Designated Member Protocol Reviews.
• Contemporary Topics. 2001; 40(6). Suggestions to Bring Electronic Protocol System into Compliance.
• Lab Animal. 2001; 30(6). Is Ad Hoc Approval Enough?
• Lab Animal. 2001; 30(3). Innovative, But Not Compliant.
• Lab Animal. 1998; 27(8). So Much Work, So Little Time.
• ILAR News. 1993; 35(3-4):47-49, question #3.

Collaborating institutions

• FAQ. When institutions collaborate or when the performance site is not the grantee institution, which IACUC is responsible for review of the research activity?
• Lab Animal. 2013; 42(04). (PDF - 159 KB) Communication between collaborating IACUCs.
• Lab Animal. 2009; 38(6). (PDF - 188 KB) Clinical study or research activity?

Conditional approvals

• FAQ. May the IACUC grant conditional or provisional approval?
• Lab Animal. 2011; 40(10). (PDF - 171 KB) Managing a pending IBC approval.
• Lab Animal. 2008; 37(2). (PDF - 95 KB) Collaborative studies and animal reuse.
• Lab Animal. 2003; 32(9):33-36, question #2.
• OPRR Reports. 90-01, 5/21/1990. Use of Expedited Protocol Review Procedures by IACUCs.

Conflict of interest

• Lab Animal. 2013; 42(03). (PDF - 246 KB) Should 'duplicative research' still be reviewed?
• Lab Animal. 2010; 39(6). (PDF - 180 KB) Revisiting approved protocols.

DMR & FCR

• FAQ. May an IACUC use designated member review (DMR) to review an animal study protocol subsequent to full committee review (FCR) when modifications are needed to secure approval?
• Lab Animal. 2012; 41(11). (PDF - 144 KB) Amendment submitted; protocol reviewed?
• Lab Animal. 2009; 38(7). (PDF - 182 KB) Required modifications and designated member reviews.
• NOT-OD-09-035. Guidance to IACUCs Regarding Use of Designated Member Review (DMR) for Animal Study Proposal Review Subsequent to Full Committee Review (FCR).
• Lab Animal. 2002; 31(9). Correct Conduct of Full-Committee and Designated Member Protocol Reviews.

Foreign-derived samples

• FAQ. Is IACUC approval required for the collection of samples in foreign countries from captive wild animals or research colonies?

Foreign institutions

• FAQ. If an animal activity will be performed outside of the US (either by a non-US grantee or by a foreign institution as a subproject for a domestic grantee), is the grantee's IACUC required to review and approve that activity?
• NOT-OD-12-081. Change in Criteria for Renewal of Animal Welfare Assurances for Foreign Institutions
• Contemporary Topics. 1997; 36(2):47-50, question #2.

Frequency of review

• FAQ. How frequently should the IACUC review research protocols?
• Lab Animal. 2012; 41(11). (PDF - 144 KB) Amendment submitted; protocol reviewed?
• Lab Animal. 2000; 29(3). Problem Children.
• ILAR News. 1993; 35(3-4):47-49, question #7.

Grant review

• FAQ. Is the IACUC required to review the grant application?
• Lab Animal. 2006; 35(2). Grants proposals and animal use protocols: Is the IACUC playing by the rules?
• Lab Animal. 2003; 32(9):33-36, question #1.
• Lab Animal. 1999; 28(7). Who's to Blame?
• View "Grants Policy and Congruence" (Windows Media Player - 1 Hour)

Nonresearch activities

• FAQ. Is IACUC approval required for the use of animals in breeding programs, as blood donors, as sentinels in disease surveillance programs, or for other non-research purposes?
• Lab Animal. 2003; 32(10). (PDF - 96 KB) Dog as Sculpture Models: Is IACUC Review Needed?

Nontraditional species

• FAQ. What guidelines should IACUCs follow for fishes, amphibians, reptiles, birds, and other nontraditional species used in research?
• Contemporary Topics. 1997; 36(2):47-50, question #6.

Pilot studies

• FAQ. May the IACUC approve pilot studies?
• Lab Animal. 2001; 30(3):21. A Pain in the Rat.

PIs

• FAQ. Is it acceptable to have different individuals named as PI on the grant application and the IACUC protocol?
• Lab Animal. 2007; 36(1). (PDF - 73 KB) The importance of being ‘in charge'.

3 R's

• FAQ. Should the IACUC consider the three “Rs” of alternatives when reviewing protocols?
• Lab Animal. 2010; 39(2). (PDF - 149 KB) Breeding without research.
• Lab Animal. 2009; 38(11). (PDF - 187 KB) Categorizing insufficient pain alleviation.
• Lab Animal. 2008; 37(7). (PDF - 95 KB) Deciding which animals to use.
• PI eAlert. 2010; Jul (PDF - 415 KB) Was McGill's “Mouse Pain” Study Compliant With Lab Animal Welfare?

Review criteria

• FAQ. What criteria should the IACUC consider when reviewing protocols?
• Lab Animal. 2009; 38(7). (PDF - 182 KB) Required modifications and designated member reviews.

Scientific merit

• FAQ. Is the IACUC responsible for judging the scientific merit of proposals?
• ILAR News. 1991; 33(4):68-70, question #7.

Significant changes

• FAQ. What is considered a significant change to a project that would require IACUC review?
• FAQ. Does OLAW expect the IACUC to notify NIH when there is a change in an animal activity supported by PHS funds?
• Lab Animal. 2012; 41(04). (PDF - 155 KB) Amending a protocol to import and breed knockout mice.
• Lab Animal. 2011; 40(10). (PDF - 171 KB) Managing a pending IBC approval.
• Lab Animal. 2007; 36(7). (PDF - 60 KB) Getting around late protocol renewals.
• NOT-OD-03-046. Office of Extramural Research Revised Guidance Regarding IACUC Approval of Changes in Personnel Involved in Animal Activities
• Lab Animal. 1995; 24(9):24-26, question #1.

SOPs

• FAQ. May standard operating procedures (SOPs) or blanket protocols that cover a number of procedures be utilized in lieu of repeating descriptions of identical procedures in multiple protocols?
• Lab Animal. 2012; 41(08). (PDF - 96 KB) Management of a holding protocol.

Time of grant award

• FAQ. Does the IACUC have to review proposed animal research activities at the time of grant award if the animal research activities will not be conducted until year 4 or 5 of a grant?
• “Just-In-Time”. Federal Register, 8/7/2002, 67 FR 51289 (PDF).

Unapproved work

• FAQ. May the investigator begin animal work before receiving IACUC approval?
• Lab Animal eAlert. 2010; No. 6 (PDF - 334 KB) What is Protocol for Reporting an Animal-Research Project Exceeding Its Expiration Date?

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