CHILD HEALTH RESEARCH CAREER DEVELOPMENT AWARDS Release Date: September 21, 2001 RFA: RFA-HD-01-019 (This RFA has been modified, see RFA-HD-05-027) National Institute of Child Health and Human Development (http://www.nichd.nih.gov/) Letter of Intent Receipt Date: January 25, 2002 Application Receipt Date: February 26, 2002 PURPOSE The National Institute of Child Health and Human Development (NICHD) supports a program of Child Health Research Career Development Awards (CHRCDA) intended to develop resources to speed the transfer of knowledge gained through studies in basic science to clinical applications that will benefit the health of children. The CHRCDA will support research career development of pediatricians who have recently completed subspecialty training, and who are commencing basic and/or clinical research relevant to child health. The goal of this initiative is to advance research in child health and to support educational institutions in their ability to stimulate novel research initiatives and career development experiences for junior investigators. This will be accomplished by increasing the number and effectiveness of established pediatric investigators who have a grounding in basic science and research skills that can be applied to the health problems of children, as well as by increasing the number of pediatric medical centers that can stimulate and facilitate the application of research findings to pressing pediatric problems. HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS- led national activity for setting priority areas. This Request for Applications (RFA) is related to several priority areas. Potential applicants may obtain "Healthy People 2010" at http://www.health.gov/healthypeople/. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, units of State and local governments, and eligible agencies of the Federal government. Foreign institutions are not eligible for this institutional career development award. Applications from institutions not previously funded for Child Health Research Career Development Awards are encouraged. Racial/ethnic minority individuals, persons with disabilities, and women are encouraged to apply as Principal Investigators. A CHRCDA may be awarded to a children’s hospital or to a department of pediatrics of an approved medical school in the U.S. that has as a primary teaching site either a general children’s hospital or a children’s program with an identifiable organizational structure that is part of a larger medical institution. Grantee institutions must have the clinical pediatric specialties and subspecialties, and the discrete clinical and research facilities sufficient to meet the purposes of the CHRCDA program, namely, to bridge clinical pediatric training with a career in basic and/or clinical research relevant to child health. CHRCDA Scholars must have an M.D. degree, or equivalent, must have completed a pediatric residency and subspecialty training, and must be within three years of completing their subspecialty training when starting the program. Scholars must be willing to spend 75 percent of full-time professional effort conducting research and research career development activities. Scholars must be U.S. citizens or noncitizen nationals, or must be able to provide legal proof of lawful admission for permanent residence. Individuals on temporary or student visas are not eligible. MECHANISM OF SUPPORT This RFA will use the National Institutes of Health (NIH) Mentored Clinical Scientist Development Program (K12) award mechanism. Responsibility for the planning, direction, and execution of the proposed program will be solely that of the applicant. The total project period for an application submitted in response to this RFA may not exceed five years. FUNDS AVAILABLE NICHD intends to commit approximately $3.2 million in total costs [Direct plus Facilities and Administrative (F & A) costs] in FY 2003 to fund up to eight new and/or competing continuation grants in response to this RFA. Applicants may request a project period of up to five years and a budget of up to $400,000 for direct costs per year. It is not required that applications request the allowable budgetary maximum. Small size is not a disadvantage for CHRCDA funding, if the support requested for core resources (administration, shared core laboratory) is in proportion to the activity in new project development which is the CHRCDA’s primary purpose. Facilities and administrative costs on K12 awards are limited to eight percent of modified total direct costs. Because the nature and scope of the new projects may vary, it is anticipated that the size of awards also will vary. Although the financial plans of NICHD provide support for this program, awards pursuant to this RFA are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications. RESEARCH OBJECTIVES A CHRCDA grant provides pediatric research institutions with an opportunity to build a greater capacity for nurturing junior investigators. Established investigators, with research funded by NIH or other sources through competitively awarded grants or contracts, combine to establish a center of research excellence in their institution. Individuals with a wide range of biomedical and biobehavioral backgrounds, especially those with a basic science orientation, are asked to mentor newly trained pediatricians just embarking on their research careers. The established investigators make available their expertise, guidance, and laboratory facilities to be utilized by junior investigators for research projects that will enhance their basic science knowledge and skills. Although mentors from collaborating departments may provide expertise and resources, the emphasis remains on research that is relevant to clinical pediatrics and its various subspecialty areas. Components of a CHRCDA (a) Principal Investigator The Principal Investigator of the CHRCDA must be the chairperson of the Department of Pediatrics or the chief of the pediatric service. He or she should possess the scientific expertise, leadership, and administrative capabilities required to coordinate and supervise a multidisciplinary research program of this scope. The Principal Investigator is responsible for appointing the Program Director and members of the Advisory Committee (see below). He or she makes the decisions regarding appropriate recipients of the program funds for research and career development, taking into consideration recommendations from the CHRCDA Advisory Committee. The Principal Investigator does not receive salary or fringe benefit support from the CHRCDA for this activity. The Principal Investigator is expected to attend the annual scientific meeting of the CHRCDA centers. (b) Administrative Staff The day-to-day administration of the CHRCDA may be made the responsibility of a senior faculty member, called the Program Director, supported for up to 10 percent time and effort for this activity. The Program Director must be knowledgeable about pediatric research, with a record of success in laboratory or clinical investigation and demonstrated skill in career development. The Principal Investigator may serve as Program Director, with appropriate support. The Program Director may be assisted by a part-time CHRCDA-supported secretary. Administrative staff funds also may be used for a well-qualified recruitment officer, supported up to 20 percent time and effort, to enhance participation in the program by women and members of minority groups that are underrepresented in pediatric research (see below). (c) Advisory Committee The Advisory Committee is a group of scientists, selected from the Pediatrics Department and other departments or institutions, as appropriate, who have interests and expertise relevant to pediatric research. The Advisory Committee is chaired by the Principal Investigator and must include the Program Director, the Core Laboratory Director, and some or all of the participating established investigators. It also may include the recruitment officer and any other persons considered essential by the Principal Investigator. It is the function of the Advisory Committee to evaluate applications for the use of the new project development funds and make recommendations to the Principal Investigator about appropriate awardees. It evaluates ongoing activities annually, makes recommendations about their continuation, and advises the Principal Investigator on setting priorities for use of the core laboratory resources. The committee may utilize institutional or outside consultants for these functions. The Advisory Committee provides expert counsel essential to the Principal Investigator for his or her administration of the program. It should meet regularly and its evaluation activities should be formalized. (d) Mentors At least six established investigators, supported by NIH or other competitively awarded grants, are required as mentors for a CHRCDA. They should be expert in the application of new advances in basic science methodology to problems of human development and pediatric disease that are relevant to the mission of the NICHD. Their research interests must contribute to areas that justify their collective designation as a Child Health Research Career Development Award center, making the CHRCDA attractive to recently trained pediatricians as a place to develop their investigative careers. The mentors need not be pediatric department members. Linkage to other departments can enhance the effectiveness of the CHRCDA and is expected to be a key feature of each center. When a junior investigator is to be supported by the CHRCDA through new project development funds, at least one of the established investigators must agree to provide his or her expertise as a mentor and collaborator, and allow the junior investigator access to his or her laboratories. Annual progress reports for a CHRCDA grant must describe ongoing research projects, current publications, and outside funding. These reports will be reviewed by NICHD staff and outside consultants to confirm that the institution is continuing to meet its goal of recruiting promising new pediatric investigators and facilitating their career development. The mentors do not receive support for their salaries or fringe benefits from the career development awards. Mentors may be added as appropriate to the roster of an ongoing funded CHRCDA center without prior NICHD approval. (e) Laboratory Resources The laboratory resources of the CHRCDA comprise the research laboratories of the established investigators, as well as a shared core laboratory to be utilized by the established investigators and the junior investigators whose activities they will supervise. Requests for funding to set up a new core must have strong justification of a cost-effective expansion or centralization of the research resources. The core, if any, must serve at least three CHRCDA Scholars. The CHRCDA grant may support professional supervision of the shared core laboratory (Core Laboratory Director, maximum 50 percent time and effort), as well as technical assistance, supplies, and equipment purchase and maintenance. The Principal Investigator, Program Director, and Core Laboratory Director are responsible for efficient and equitable utilization of the core laboratory on the basis of recommendations from the Advisory Committee. Core laboratory log books are subject to review by NICHD staff and outside consultants upon request of the former. There must be an institutional commitment to this shared core laboratory, which may take the form of alterations and renovations to establish it, the purchase of research equipment, the assignment of research space, and/or the support of personnel. The laboratories of the established investigators are not supported directly by the K12 grant. Funds for supplies, small equipment, and technical assistance needed for the conduct of center-supported research projects in these laboratories are provided through new project development funds. Support for projects conducted in the core laboratory by recipients of new project development funds may come either from those funds, the core laboratory budget, or both. (f) Career Development Program Support for new projects, conducted by junior investigators, is designed to enhance their research skills thereby providing a bridge between formal research training and the receipt of independent research grants. The novel feature of these grants is the flexibility in the use of the funds awarded for research support, decisions about which new projects and which junior investigators are to be supported are made by the grantee institution. Both competing and non-competing continuations of a CHRCDA grant are contingent on demonstration of good judgment in these decisions, as indicated by scientific progress, success of the junior investigators in competing for new research grants and contracts, and the development of new pediatric investigators. The Principal Investigator, after considering recommendations from the Advisory Committee, will make CHRCDA Scholar appointments to junior investigators for the pursuit of research projects under the guidance and supervision of an established investigator. The institution will support CHRCDA Scholars for periods of two to five years consisting of consecutive 12-month appointments. In addition to research activity, the program should include an initial didactic phase that may include training in areas such as biostatistics, scientific writing and oral presentation, biotechnology, and epidemiology. The program must include appropriate training in the responsible conduct of research. CHRCDA Scholars, as well as the Principal Investigator and Program Director, are expected to attend an annual CHRCDA centers meeting. One purpose of this meeting is to allow Scholars to present their career development award- supported research to their peers. Principal Investigators and Program Directors are expected to attend these meetings to demonstrate their support of the program and the junior investigators. In addition, they will have an opportunity at these meetings to exchange ideas about common problems and make suggestions to NICHD staff about possible modifications in the program. (g) CHRCDA Scholars The scholar position is a junior faculty position offered to a pediatrician who is no more than three years beyond subspecialty training and who has not previously been the Principal Investigator of an NIH research grant or contract. Scholars must have an M.D. degree and have completed a pediatric residency and subspecialty training. The scholar position is not a fellowship or an extension of a fellowship position. Similarly, these positions are not to be offered to more senior faculty members who are in need of funding. This junior faculty appointment should be extended to candidates who are willing to spend a minimum of 75 percent of full-time professional effort in research and research career development activities. During the award period, the scholars are encouraged and expected to seek independent grant support. The K12 grant application should indicate the number of CHRCDA Scholar appointments proposed for each year and provide evidence that this number of worthwhile projects is likely to be forthcoming. The number of new projects to be supported must be commensurate with the institution’s capacity to develop and recruit appropriate candidates. CHRCDA projects may be clinical or non-clinical, as long as they relate to the goals of the CHRCDA program. Support of scholars is renewable at the discretion of the Principal Investigator, contingent upon presentation of evidence of satisfactory progress to the Advisory Committee and to the NICHD in the required annual progress report. The pool of potential scholars and criteria for selecting CHRCDA Scholars should be described in the grant application. Institutions are encouraged to develop novel mechanisms for recruiting qualified pediatricians to become grant-supported investigators. Such mechanisms could include, for example, part-time appointments for individuals with families and special efforts to recruit members of minority groups. Annual progress reports must include a Biographical Sketch and other pertinent information on the new scholar recruits for the year reported. SPECIAL REQUIREMENTS The CHRCDA grant may provide funds for three purposes: (1) Administration of the CHRCDA Career Development Program o Salaries and support for a Program Director (maximum 10 percent time and effort), a part-time secretary, and a recruiting officer (maximum 20 percent time and effort). o Administrative support services, including supplies, duplicating equipment, telephone, or maintenance contracts for equipment if not covered by institutional overhead charges. o Travel of Principal Investigator and Program Director to an annual CHRCDA scientific meeting. (2) Shared Core Laboratory o Salaries and support for shared core laboratory staff, including a Core Director. o Supplies and animals. o Scientific equipment (purchase and maintenance). o Computer costs. (3) New Project Development Support Up to $100,000 annually may be used per CHRCDA Scholar for projects that are pursued in their own laboratories, in the shared core laboratory, and/or in the laboratories of the established investigators. Individual Scholars are eligible for up to $75,000 per year in salary. For each person supported in this category, the maximum expenditure for equipment is $10,000 annually and for travel, $3,500 annually. Awards to CHRCDA Scholars need not all be equal in size. These funds may be used for salary and to defray the costs of materials, supplies, technical assistance, and miscellaneous expenses generated by these projects in the laboratories of the established investigators who serve as mentors of the awardees, for supplies needed for work in the core laboratory that are beyond the capacity of that laboratory"s budget, for small items of equipment, for travel, and for a portion of the salaries and fringe benefits of the junior investigators. Items that may not be supported with CHRCDA grant funds include: o Direct support of the laboratories, salaries, fringe benefits, travel, and research projects of the established investigators, except for reimbursement of costs from new project development support within the CHRCDA center. o Salary and support for central institutional administrative personnel usually paid from institutional F & A costs, such as budget officers, grant assistants, and building maintenance personnel. o Salary and support for administrative activities such as public relations or health and educational services. o Travel of the Principal Investigator, the Program Director, the Core Laboratory Director, or other established investigators to scientific meetings except as previously noted. o Patient care costs such as inpatient bed days or outpatient visits, except for clinical laboratory analyses essential for the research. o Alterations and renovations. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH-supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," published in the NIH Guide for Grants and Contracts on August 2, 2000 (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html), a complete copy of the updated Guidelines is available at http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm. The revisions relate to NIH-defined Phase III clinical trials and require: a) all applications or proposals and/or protocols to provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable, and b) all investigators to report accrual, and to conduct and report analyses, as appropriate, by sex/gender and/or racial/ethnic group differences. INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects," published in the NIH Guide for Grants and Contracts, March 6, 1998, and available at: http://grants.nih.gov/grants/guide/notice-files/not98-024.html. Investigators also may obtain copies of these policies from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policies. URLS IN NIH GRANT APPLICATIONS OR APPENDICES Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site. REQUIRED EDUCATION ON THE PROTECTION OF HUMAN SUBJECT PARTICIPANTS NIH policy requires education on the protection of human subject participants for all investigators submitting NIH proposals for research involving human subjects. This policy announcement is found in the NIH Guide for Grants and Contracts Announcement dated June 5, 2000, at the following website: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html. PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT The Office of Management and Budget (OMB) Circular A-110 has been revised to provide public access to research data through the Freedom of Information Act (FOIA) under some circumstances. Data that are (1) first produced in a project that is supported in whole or in part with Federal funds and (2) cited publicly and officially by a Federal agency in support of an action that has the force and effect of law (i.e., a regulation) may be accessed through FOIA. It is important for applicants to understand the basic scope of this amendment. NIH has provided guidance at: http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm. Applicants may wish to place data collected under this RFA in a public archive, which can provide protections for the data and manage the distribution for an indefinite period of time. If so, the application should include a description of the archiving plan in the study design and include information about this in the budget justification section of the application. In addition, applicants should think about how to structure informed consent statements and other human subjects procedures given the potential for wider use of data collected under this award. LETTER OF INTENT Prospective applicants are asked to submit a letter of intent that includes a descriptive title of the proposed application, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel (established investigators excepted) and participating institutions, and the number and title of this RFA. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains allows NICHD staff to estimate the potential review workload and plan the review. The letter of intent is to be sent to Dr. Karen Winer, at the address listed under INQUIRIES, below, by January 25, 2002. APPLICATION PROCEDURES The PHS 398 research grant application instructions and forms (rev. 5/2001) at http://grants.nih.gov/grants/funding/phs398/phs398.html are to be used in applying for these grants. This version of the PHS 398 is available in an interactive, searchable PDF format. For further assistance contact GrantsInfo, Telephone 301-710-0267, E-mail: GrantsInfo@nih.gov. Application Instructions Refer to the Research Career Award section in the PHS 398 for guidance in preparing applications, noting modifications below. Page limitations on research project grant applications, as stated in the guidelines and instructions for PHS Form 398, do not apply to these K12 applications, although applicants are encouraged to be concise. The application must include a TABLE OF CONTENTS and should include all information requested under Section I: Basic Administrative Data. Section II: Specialized Information should be modified as follows: This section should begin with an overview of the proposed CHRCDA program. o The Candidate: Describe, in general, the pool of potential candidates including information about the types of prior research training. Describe criteria used for candidate selection and evaluation. o Competing renewal applications must name all scholars who have received funding from this award, their current academic status, gender and minority information, and all funding awarded to the candidate since CHRC funding was initiated. This information should be provided in a table. Additionally, a list of peer reviewed articles published since the initiation of CHRCDA support with the scholar’s name in bold is also required. Describe the previous success of the CHRCDA and what might be changed in the future. o Statement by Sponsor: Summarize the long-term objectives of the program. Describe the career development plans for prospective candidates. The application should contain a description of how the career development plan will be tailored to the needs of the prospective candidates. o Environment and Institutional Commitment: Provide information and documentation establishing the commitment of the applicant institution. Describe the institution’s research environment and the pool of mentors. o Research Plan: For each potential mentor, include a paragraph on his or her research relevant to the goals expressed in this RFA that may be the foundation of the CHRCDA scholar’s research experience. Biographical Sketch Biographical Sketches for the Principal Investigator, Program Director, Core Laboratory Director, and potential mentors should be provided, using the appropriate Format Page. Budget Instructions Each application submitted in response to this RFA should include the following information, using PHS 398 (rev. 5/2001) Form Pages 4 and 5, including appropriate budget justification, as indicated: Using Form Page 4, DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD, provide the following individual budgets, using separate pages for each: o A budget for the administrative core, including Personnel, Supplies, Travel Expenses for the Principal Investigator and Program Director to the annual CHRCDA scientific meeting, and Other Expenses, for the first year. o A budget for the shared core laboratory including Personnel, Equipment, Supplies, and Other Expenses, for the first year. o A budget for new project development funds for the first year, providing under Other Expenses the total dollars and minimum number of positions requested. The new project development funds budget need not be allocated into categories in the initial application, since these will vary with the projects supported. It should be specified to what extent these funds will be used for salaries. Using Form Page 5, BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT, provide the following: o A composite budget, reflecting the sum of the individual budgets, in categories, for the first year and for the entire proposed period of support. New project development funds should be listed under Other Expenses. Provide budget justification in narrative form. Submission Instructions The RFA label available in the PHS 398 (rev. 5/2001) must be stapled to the bottom of the face page of the application and must display the RFA number HD-01-019. A sample RFA label is available at http://grants.nih.gov/grants/funding/phs398/label-bk.pdf. Please note this is in the pdf format. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title (CHILD HEALTH RESEARCH CAREER DEVELOPMENT AWARD) and number (HD-01-019) must be typed on line 2 of the face page of the application and the YES box must be marked. Submit a signed, typewritten original of the application, including the Checklist and three signed photocopies, in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application should be sent to: Robert Stretch, Ph.D. Acting Director Division of Scientific Review National Institute of Child Health and Human Development 6100 Executive Boulevard, Room 5E03, MSC 7510 Bethesda, MD 20892-7510 Rockville, MD 20852 (for express/courier service) Applications prepared in response to this RFA must be received by February 26, 2001. If an application is received after that date, it will be returned to the applicant without review. The Center for Scientific Review (CSR) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the CSR and for responsiveness by the NICHD. Incomplete and/or non-responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NICHD in accordance with the review criteria stated below. As part of the initial merit review, all applications will receive a written critique and may undergo a process in which only those applications deemed to have the highest scientific merit will be discussed, assigned a priority score, and receive a second level review by the National Advisory Child Health and Human Development Council. Review Criteria o Applicant institution’s commitment to appropriate broadly based research, resting on the interests of established investigators who can act as mentors or senior collaborators for scholars. The research at the institution must be relevant to the current areas of interest of the research and programmatic needs of the NICHD. Research should not be narrowly defined by a specific disease category or organ system. o Institutional commitment to the requirements of the program, such as recruitment efforts, salaries, equipment, core laboratory support, or other forms of cost sharing. o Evidence of the availability of a pool of prospective investigators, trained locally or recruited from elsewhere, who could benefit from receiving career development support from the CHRCDA. o Appropriateness of the number of planned awards for the size of the institution, the number and skills of the established investigators who will serve as mentors, and the magnitude of the request for administration and core laboratory resources. o Availability of research-oriented faculty positions at the grantee institution for new investigators previously trained by the CHRCDA. o Evidence of previous success of the institution in developing new pediatric investigators. o The likelihood that the career development plan will contribute significantly to the scientific development of the candidates. Appropriateness of the development plan for achieving scientific independence for the prospective candidates. o Evidence of cost-effectiveness and procedures for quality control in allocation of resources. o For renewal (competing continuation) applications, or subsequent new applications from an institution with a previously funded center, success of the center-funded junior investigators in producing research publications and in obtaining independent, competitively funded support for pediatric research. o Efforts to develop novel mechanisms for recruiting candidates for new project development awards from women and minority groups under-represented in pediatric research. o Evidence of a scientifically sound and equitable system for evaluating candidates for new project development funds and providing internal quality control of ongoing research. o Quality of the proposed training in the responsible conduct of research. o Appropriateness of the requested budget. o Probable impact of the CHRCDA on enhancing the capacity of the grantee institution to develop well-qualified new pediatric investigators, thereby advancing pediatric research at the grantee institution, in the local medical environment, and in the nation, especially with regard to the application of basic research developments to clinical problems in pediatrics. Schedule Letter of Intent Receipt Date: January 25, 2002 Application Receipt Date: February 26, 2002 Peer Review Date: June 2002 Council Review: September 2002 Earliest Anticipated Award Date: December 1, 2003 AWARD CRITERIA Criteria that will be used in making funding decisions include scientific and technical merit, as determined by peer review, availability of funds, and programmatic priorities. INQUIRIES Inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcomed. Prospective applicants are urged to discuss their plans with Institute staff. Direct inquiries regarding programmatic issues and address the letter of intent to: Karen K. Winer, M.D. Center for Research for Mothers and Children National Institute of Child Health and Human Development 6100 Executive Boulevard, Room 4B11, MSC 7510 Bethesda, MD 20892-7510 Telephone: (301) 435-6877 FAX: (301) 480-9791 E-mail: winerk@exchange.nih.gov Direct inquiries regarding fiscal matters to: Ms. Mary Daley Grants Management Branch National Institute of Child Health and Human Development 6100 Executive Boulevard, Room 8A17, MSC 7510 Bethesda, MD 20892-7510 Telephone: (301) 496-1305 FAX: (301) 402-0915 E-mail: daleym@exchange.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.865, Research for Mothers and Children. Awards are made under authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices



NIH Office of Extramural Research Logo
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS)
  USA.gov - Government Made Easy
NIH... Turning Discovery Into Health®



Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.