NURSING RESEARCH EXPLORATORY CENTER GRANTS

Release Date:  May 22, 2000

RFA:  NR-01-001

National Institute of Nursing Research (http://www.ninr.nih.gov)

Letter of Intent Receipt Date:  October 9, 2000
Application Receipt Date:       November 14, 2000

PURPOSE

The National Institute of Nursing Research (NINR) invites applications for 
exploratory center grants in key clinical and basic areas of nursing research 
that establish a scientific basis for the care of individuals across the life 
span. NINR seeks to increase the numbers of research-intensive schools of 
nursing through the Nursing Research Exploratory Center grants (P20s).  The 
Exploratory Center Grant, targeted to schools of nursing that are developing 
research programs, will augment the research resources in schools of nursing 
by facilitating the growth of infrastructure to centralize resources and 
facilities in a specific area of inquiry that has a beginning base of research 
funding. By developing infrastructure components, funded investigators will 
have the opportunity to enhance their research productivity. 

HEALTHY PEOPLE 2010

The Public Health Service (PHS) is committed to achieving the health promotion 
and disease prevention objectives of "Healthy People 2010," a PHS-led national 
activity for setting priority areas.  This Request for Applications (RFA), 
Nursing Research Exploratory Center Grants, is related to one or more of the 
priority areas.  Potential applicants may obtain a copy of "Healthy People 
2010" at http://www.health.gov/healthypeople/.

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic, for-profit and non-profit 
organizations, public and private, such as universities, colleges, hospitals, 
laboratories, units of State and local governments, and eligible agencies of 
the Federal government. Foreign institutions are not eligible for the center 
program grants.  Racial/ethnic minority individuals, women, and persons with 
disabilities are encouraged to apply as Principal Investigators.

Institutions eligible for the Nursing Research Exploratory Center Grants are 
those that are developing research programs and have not been major recipients 
of NIH support.  The institution must have at least two (2) projects funded by 
Department of Health and Human Services (DHHS) research support grants from 
selected mechanisms (specifically, R01, R15, R18, R29) or comparable peer 
reviewed research projects (including those funded by State governments and 
private foundations) related to the scientific area of nursing inquiry. Each 
of these projects in the research base must have at least one (1) year of 
committed support remaining at the time of the application receipt date. Both 
of the projects must be in the college, school, or department of nursing. A 
larger number of NIH awards in the scientific area of inquiry would strengthen 
an application. Institutions may not apply if they are: (1) current recipients 
of a NINR Core Center Grant (P30), and/or (2) ineligible for NIH Academic 
Research Enhancement Award (AREA) grants.  

An applicant organization may submit only one (1) P20 application.  Joint 
applications will not be accepted from investigators at neighboring, 
independent institutions, but subcontracts are allowed if their usage enhances 
the development of the scientific area of inquiry and stays within the dollar 
limits of the RFA.  Linkage with minority-serving institutions is encouraged.  

MECHANISM OF SUPPORT

This RFA will use the National Institutes of Health (NIH) Exploratory Center 
Grant mechanism (P20). The purpose of this mechanism is to support planning 
for new programs, expansion or modification of existing resources, and 
feasibility studies to explore various approaches to developing  
interdisciplinary research programs that address areas consistent with the 
missions of NINR.  Responsibility for the planning, direction, and execution 
of the proposed Center project will be solely that of the applicant.  The 
total project period for an application submitted in response to this RFA may 
not exceed three (3) years, and is not renewable.  This RFA is a one-time 
solicitation.  The anticipated award date is August 2001.

FUNDS AVAILABLE

The NINR intends to commit approximately $2,000,000 in FY 2001 to fund seven 
(7) to nine (9) new grants in response to this RFA.

An applicant may request a project period of three (3) years and a budget for 
direct costs of up to $150,000 for the first year.  Cost-of-living or 
inflationary increases in subsequent budget years for recurring costs such as 
personnel and supplies may not exceed three percent (3%) escalation per year. 

Although the financial plans of the NINR provide support for this program, 
awards pursuant to this RFA are contingent upon the availability of funds and 
the receipt of a sufficient number of applications of outstanding scientific 
and technical merit. 

RESEARCH OBJECTIVES

The National Institute of Nursing Research (NINR) has historically supported 
the development of research infrastructure in schools of nursing by funding 
centers.  NINR’s current centers program consists of research center core 
grants (P30s), focused on key clinical and basic areas of nursing research 
that establish a scientific basis for the care of individuals across the life 
span. The Nursing Research Center Core grants provide the infrastructure to 
centralize resources and facilities to support an active center of excellence 
in a specific area of inquiry that has a strong base of research funding.   

However, many institutions are in the earlier stages of establishing nursing 
research programs. The Nursing Research Exploratory Centers RFA is designed to 
assist these institutions with developing research programs and a research 
infrastructure by augmenting the research resources in schools, colleges, or 
departments of nursing.  Funds will support planning for new research programs 
to facilitate growth and development, expansion or modification of existing 
research resources, pilot or feasibility studies, and interdisciplinary 
collaboration. 

Applicants should select a scientific area of inquiry based on a conceptually 
sound integration of currently funded projects in the research base. The link 
to nursing practice issues within the center should be explicit. Applications 
should contain innovative ideas consistent with NINR’s mission, and use sound 
methodologies.  Applicants are encouraged to consider the following areas of 
inquiry that have been identified as specific areas of scientific opportunity: 

o  Chronic illness experiences, such as managing symptoms, avoiding 
complications of disease and disability, supporting family caregivers, 
promoting adherence and self-management activities, and promoting healthy 
behaviors within the context of the chronic condition.  

o  Cultural and ethnic considerations in health and illness, including 
culturally sensitive interventions to decrease health disparities among groups 
by focusing upon health promotion activities and chronic illness management 
strategies.

o  End of life/palliative care research, focusing on clinical management of 
physical and psychological symptom management, communication, ethics and 
clinical decision-making, caregiver support, and care delivery issues. 

o  Health promotion and disease prevention research, particularly as it 
relates to lifestyle changes and healthy behavior maintenance across the 
lifespan.  

o  Implications of genetic advances, including reducing factors that increase 
risk of disease, issues related to genetic screening, and subsequent gene 
therapy techniques.

o  Quality of life and quality of care, to include cost savings for the 
patient, health care system, and society.

o  Symptom management of illness and treatment, such as pain, cognitive 
impairment, fatigue, nausea and vomiting, and sleep problems.

o  Telehealth interventions and monitoring or other emerging technologies to 
promote patient education for competent self-management and to optimize the 
effectiveness of treatment.

In addition to the above areas, applications should note the following NINR 
research program categories that describe the broad areas of interest; 
however, proposed scientific areas for this RFA are not limited to the 
following concepts.

o  Research in cardiopulmonary health and critical care, including prevention 
and care of individuals with cardiac or respiratory conditions. This area also 
includes research in critical care, trauma, wound healing, and organ 
transplantation.

o  Research in chronic illness and long-term care, including care of 
individuals with arthritis, diabetes, and urinary incontinence; and long-term 
care and caregiving.

o  Research in health promotion and risk behaviors, including studies of 
women's health; developmental transitions, such as adolescence and menopause; 
environmental health; and health and behavior research, such as studies of 
exercise, nutrition, and smoking cessation.

o  Research in immune responses and oncology, including care of individuals 
experiencing symptoms primarily associated with cancer and AIDS, such as 
fatigue, nausea and vomiting, and cachexia. Prevention research on specific 
risk factors is also included. 

o  Research in neurofunction and sensory conditions, including pain 
management, sleep disorders, and symptom management for persons with cognitive 
impairment or chronic neurological conditions. This area also includes 
research on patient care in acute care settings. 

o  Research in reproductive and infant health, including prevention of 
premature labor, reduction of health-risk factors during pregnancy,  normal 
physiologic processes of labor and delivery, delivery of prenatal care, care 
of neonates, infant growth and development, and fertility issues.

Applicants from institutions that have a General Clinical Research Center 
(GCRC) funded by the NIH National Center for Research Resources may wish to 
identify the GCRC as a resource.  Details of the interactions of the 
exploratory center staff with the GCRC staff and research personnel may be 
provided in a statement describing the collaborative linkages being developed.  
A letter of agreement from the GCRC Program Director must be included with the 
application.

SPECIAL REQUIREMENTS

The Center must be an identifiable organizational unit either within a college 
or school of nursing or within a department of nursing in a university-
affiliated medical center or hospital or other similar entity. 

A Nursing Research Exploratory Center Grant benefits from an interdisciplinary 
approach. When multiple organizations within an institution are represented in 
the application, clear lines of authority and sanction by the appropriate 
institutional officials must be specified.

Each applicant institution must name a Center Director who will be the key 
figure in the administration and management of the Center grant. The Director 
will be responsible for the organization and operation of the Center.  The 
Director should be experienced in conducting research and have demonstrated 
ability to coordinate, integrate, and provide guidance in the establishment of 
new programs in the scientific area of inquiry.  The Director must make an 
appropriate time commitment.  

Funding is intended to support shared resources and facilities (core units) 
that will enhance and extend the effectiveness of research at the applicant 
institution.

CORES

A core is a shared central facility or other resource, designed to enhance 
productivity or in other ways benefit a group of investigators to accomplish 
their stated goals.  The Exploratory Center grant must consist of (1) an 
administrative and planning core providing administrative, coordinating, 
planning, logistical, and/or methodological (e.g., research design, data 
analysis) support, and (2) a pilot/feasibility studies core.  Each core should 
be directed by an investigator with substantial expertise related to the core.  
An important consideration is the degree to which core facilities will be 
utilized by and benefit individual ongoing and/or proposed projects and Center 
investigators, and will assist in the development of the scientific area of 
inquiry. 

It is not sufficient for the applicant merely to identify such shared 
resources.  Rather, the applicant must demonstrate exactly how each core would 
augment or enhance the present capabilities of the investigators and make 
possible new activities.  In addition, after an award is made, the NINR will 
require documentation in annual progress reports and in renewal applications 
that sharing of resources has been achieved.

ADMINISTRATIVE CORE

An Administrative Core is mandatory for all Centers, and should manage the 
overall activities of the Center.  Its description should including the 
following: 

1.  A specified Director;
2.  A description of the administrative structure;
3.  A general description of overall facilities and institutional commitment.
	
It is expected that the Center administrative structure will accomplish the 
following:
1.  manage, coordinate, and integrate the components and activities of the 
Center;
2.  review utilization of funds, including funds for pilot and feasibility 
studies;
3.  manage the shared resources of the Center, such as data sets, community or 
clinical research facilities, or provide research design and data 
analysis/statistical service;
4.  advise the Center Director on the activities of the Center.

While the final administrative structure of the Center will, for the most 
part, be left to the discretion of the applicant institution, NIH's experience 
has demonstrated that the effective development of Center programs requires 
interaction among the Director, the core leaders, the Principal Investigators 
of research projects, appropriate institutional administrative personnel and 
the staff of the awarding agency. To facilitate communication between the 
Center staffs and the NINR, the NINR expects that each Center application will 
include funds for the Center Director to travel to an annual meeting in 
Bethesda, Maryland.

An Executive Committee, consisting of the heads of both cores and the business 
official, should be established to assist the Director in making the 
scientific and administrative decisions relating to the Center.  In addition 
to coordination of the Center, the Director, with his or her Executive 
Committee, will be responsible for allocation of Center funds, the 
identification and selection of key personnel, and the planning and evaluation 
of the Center activities.

The complex nature of administrative requirements of the Center will 
necessitate the assistance of a person with business management expertise.  It 
is important that such an official be identified and directly involved with 
the fiscal aspects of the Center application and grant. An appropriate amount 
of this individual's time and effort should be committed for this purpose.  
The institutional business official should be a member of the Executive 
Committee.  While budget formulation and planning will undoubtedly begin with 
the Director in collaboration with the scientific staff, the business official 
should be involved in the process and provide consultation in matters of 
fiscal administration and evaluate such issues as equipment on hand versus 
that requested for the core facilities. 

An external Advisory Committee should be established and composed of 
scientists and administrators with expertise and experience relevant to the 
scientific program of the center.  The Advisory Committee will comprise 
individuals from within the institution and at least two (2) scientists from 
outside the institution.  This committee may also be used in evaluating the 
overall research programs of the Center, the effectiveness of communications 
within the Center, and any other activities in which problems arise for which 
expertise is required or desirable.  The Advisory Committee should meet at 
least once annually.  However, the nature of its responsibilities may require 
ad hoc meetings at more frequent intervals.  A member of the NINR extramural 
program staff is to be invited to attend each meeting as an observer.

PILOT/FEASIBILITY STUDIES CORE

Pilot and/or feasibility studies are a mandatory component of the Center 
application.  These are intended to enable eligible investigators to explore 
the feasibility of a concept within the scientific area of inquiry and to 
amass sufficient data to pursue it through other funding mechanisms. The 
monies provide modest research support for a limited time (one year or two 
years maximum with clear justification for the time length). Eligible 
investigators include:

1.  An established investigator in the scientific area of inquiry with a 
proposal for testing the feasibility of a new or innovative idea that is 
conceptually related but represents a clear and distinct departure from 
his/her ongoing research interest;

2.  An established, supported investigator with no previous work in the 
scientific area of inquiry who will test the applicability of his/her 
expertise on a conceptually related problem;

3.  A new investigator who has not been a Principal Investigator in the past, 
or who is not currently funded with an DHHS research project grant (e.g., R01, 
R15, P01, R29).

Applications must propose a minimum of three (3) and a maximum of five (5) 
pilot and/or feasibility studies to be carried out during the first year.  A 
minimum of three pilot/feasibility studies must be determined acceptable by 
the reviewers.   Standard guidelines for IRB/IACUC approval apply. The 
theoretical basis for the pilot and/or feasibility studies must be clearly 
explicated.  An interdisciplinary approach should be utilized to promote the 
collaboration of nurse scientists with scientists of other disciplines as 
appropriate.  Each pilot and/or feasibility study is limited to fifteen pages 
of description for the Research Plan, Sections a through d, and should 
delineate the question being asked, detail the procedures to be followed, and 
discuss how the data will be analyzed. The application must indicate how the 
proposed pilot/feasibility study fits within the scientific area of nursing 
inquiry selected for the Center, and how the investigator satisfies the 
eligibility criteria listed above.  The application should indicate how the 
proposed pilot/feasibilities were selected.

Subsequent pilot/feasibility studies (a minimum of two (2) ongoing each year) 
will be developed during the course of the award. A description of how the 
pilot and/or feasibility studies will be reviewed and selected in the future 
must be provided.  Results of each pilot and/or feasibility study must be in 
the Center's annual progress reports to the NINR along with the plan used to 
solicit the new pilot and/or feasibility studies.

For pilot and/or feasibility studies involving clinical research, NIH requires 
applicants to give special attention to the inclusion of women, minorities and 
children in study populations.  Study populations must be described in the 
research design and methods section for each pilot and/or feasibility study.  
If women, minorities or children are not included in the study populations for 
the clinical studies, a specific justification for each of these exclusions 
must be provided.  Applications without such documentation will not be 
accepted for review.  Further information about this policy may be requested 
from NINR staff. 

The application must describe the process that will be used to review pilot 
and/or feasibility studies for future years of the proposed center.  The 
review process may be carried out by the Advisory Committee, by an ad hoc 
Review Committee, by a mail review, or by a combination of these methods.  It 
is recommended that the Center Director utilize at least two (2) scientists 
with expertise relevant to the scientific area of inquiry of the Center from 
outside the institution during the review process.

EVALUATION PLAN  

A plan for evaluating progress toward aims and/or goals of both cores and the 
overall Center is required. This plan should include the specific criteria and 
methods that will be used for the evaluation. The plan should specify the 
types of evaluation information that will be submitted in the Center’s annual 
progress reports. Annual progress reports of the funded Exploratory Centers 
will be reviewed by NINR staff. 

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and 
their subpopulations must be included in all NIH supported biomedical and 
behavioral research projects involving human subjects, unless a clear and 
compelling rationale and justification are provided that inclusion is 
inappropriate with respect to the health of the subjects or the purpose of the 
research.  This policy results from the NIH Revitalization Act of 1993 
(Section 492B of Public Law 103-43

All investigators proposing research involving human subjects should read the 
"NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical 
Research," which was published in the Federal Register of March 28, 1994 (FR 
59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No. 
11, March 18, 1994, and is available on the web at: 
http://grants.nih.gov/grants/guide/notice-files/not94-100.html. 

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by the 
NIH, unless there are scientific and ethical reasons not to include them.  
This policy applies to all initial (Type 1) applications submitted for receipt 
dates after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines" on the Inclusion of Children as Participants in 
Research Involving Human Subjects that was published in the NIH Guide for 
Grants and Contracts, March 6, 1998, and is available at the following URL 
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html

Investigators also may obtain copies of these policies from the program staff 
listed under INQUIRIES.  Program staff may also provide additional relevant 
information concerning the policy.

URLS IN NIH GRANT APPLICATIONS OR APPENDICES

All applications and proposals for NIH funding must be self-contained within 
specified page limitations.  Unless otherwise specified in an NIH 
solicitation, internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no obligation 
to view the Internet sites.  Reviewers are cautioned that their anonymity may 
be compromised when they directly access an Internet site.

LETTER OF INTENT

Prospective applicants are asked to submit a letter of intent that includes a 
descriptive title of the proposed research, the name, address, and telephone 
number of the Principal Investigator, the identities of other key personnel 
and participating institutions, and the number and title of the RFA in 
response to which the application may be submitted.  Although a letter of 
intent is not required, is not binding, and does not enter into the review of 
a subsequent application, the information that it contains allows IC staff to 
estimate the potential review workload and plan the review.

The letter of intent is to be sent by the letter of intent receipt date listed 
to:
Dr. Mary Stephens-Frazier
Scientific Review Administrator
National Institute of Nursing Research
Building 45, Room 3AN-12
Bethesda, MD  20892-6300
Telephone:  (301) 594-5971 or 6906  
FAX:  (301) 480-8260
e-mail: frazierm@mail.nih.gov

APPLICATION PROCEDURES

The research grant application form PHS 398 (rev. 4/98) is to be used in 
applying for these grants.  These forms are available at most institutional 
offices of sponsored research and from the Division of Extramural Outreach and 
Information Resources, National Institutes of Health, 6701 Rockledge Drive, 
MSC 7910, Bethesda, MD 20892-7910, telephone 301/435-0714, email: 
GrantsInfo@nih.gov.

Potential applicants are encouraged to obtain a copy of the Nursing Research 
Exploratory Center Grants Application Guidelines, which contain sample tables 
and additional information on the application format and contents.  These 
Application Guidelines are available upon request from 301/594-6906.

Page Limitations: Each core is limited to 25 pages and each pilot study is 
limited to 15 pages for the Research Plan sections a through d. Lesser numbers 
of pages are acceptable.

Budget: A separate budget page, with appropriate justification pages, is 
required for each core and pilot study.

The RFA label available in the PHS 398 (rev. 4/98) application form must be 
affixed to the bottom of the face page of the application.  Type the RFA 
number on the label.  Failure to use this label could result in delayed 
processing of the application such that it may not reach the review committee 
in time for review.  In addition, the RFA title and number must be typed on 
line 2 of the face page of the application form and the YES box must be 
marked.

The sample RFA label available at: 
http://grants.nih.gov/grants/funding/phs398/label-bk.pdf has been modified to 
allow for this change.  Please note this is in pdf format.

Submit a signed, typewritten original of the application, including the 
Checklist, and three signed, photocopies, in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, two additional copies of the application must be 
sent to:
Dr. Mary Stephens-Frazier
Scientific Review Administrator
Division of Extramural Activities
National Institute of Nursing Research
Building 45, Room 3AN-12 MSC 6300
Bethesda, MD  20892-6300
Telephone:  (301) 594-6906

Applications must be received by the application receipt date listed in the 
heading of this RFA.  If an application is received after that date, it will 
be returned to the applicant without review.
 
The Center for Scientific Review (CSR) will not accept any application in 
response to this RFA that is essentially the same as one currently pending 
initial review, unless the applicant withdraws the pending application.  The 
CSR will not accept any application that is essentially the same as one 
already reviewed. This does not preclude the submission of substantial 
revisions of applications already reviewed, but such applications must include 
an introduction addressing the previous critique.

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed for completeness by the CSR and 
responsiveness by NINR.  Incomplete and/or non-responsive applications will be 
returned to the applicant without further consideration.

Applications that are complete and responsive to the RFA will be evaluated for 
scientific and technical merit by an appropriate peer review group convened by 
NINR in accordance with the review criteria stated below.  As part of the 
initial merit review, all applications will receive a written critique and 
undergo a process in which only those applications deemed to have the highest 
scientific merit, generally the top half of the applications under review, 
will be discussed, assigned a priority score, and receive a second level 
review by the National Advisory Council for Nursing Research.

Review Criteria

The goals of NIH-supported research are to advance our understanding of 
biological systems, improve the control of disease, and enhance health.  In 
the written comments, reviewers will be asked to give careful consideration of 
the information in the SPECIAL REQUIREMENTS section of the RFA and the review 
criteria listed below in order to judge the likelihood that the proposed 
Center will have a substantial impact on the pursuit of these goals.  Each of 
these criteria will be addressed and considered in assigning the overall 
score, weighting them as appropriate for each application.  Note that the 
application does not need to be strong in all categories to be judged likely 
to have major scientific impact and thus deserve a high priority score.  For 
example, an investigator may propose to carry out important work that by its 
nature is not innovative but is essential to move a field forward.

RESEARCH BASE

1.  Focus and depth of funded investigations that are currently in progress.
2.  Presence of current and emerging collaborations and interactions among 
investigators  with common research interests within the area of scientific 
inquiry, and among the investigators within the research base.
3.  Impact that funded investigators have made in their respective fields, as 
indicated by publications and other factors.
4.  The qualifications, experience, and commitment of the Center investigators 
responsible for the individual research projects, and their willingness to 
interact with each other.
5.  The appropriateness of the investigators as participants of the Center, 
and whether their activities warrant core support.

ADMINISTRATIVE CORE 

1.  The adequacy of the Administrative core to manage the overall activities 
of the Center.
2.  The appropriateness and relevance of the proposed core and the modes of 
operation, facilities, and potential for contribution to ongoing nursing 
research.
3.  Appropriate justification for the core, including the duplication of 
existing resources or services and anticipated future use of the core.
4.  The qualifications of the Director of the Administrative core. 
5.  The adequacy of the multiple aspects related to the administrative 
structure for the center, including the ability of the center director to 
provide the scientific and administrative leadership for the project; 
strategies to promote scientific planning, interaction, implementation, and 
evaluation; and arrangements for the fiscal management of the grant.
6.  The proposed composition and functions of the Executive Committee to 
support the proposed activities of the Center.  
7.  The proposed composition and function of the external Advisory Committee 
to support the proposed activities of the Center.

PILOT AND/OR FEASIBILITY STUDIES CORE

1.  The scientific merit of the research proposed and the importance of the 
information sought to the mission of the NINR.
2.  The process for selecting the pilot/feasibility studies included in the 
application.
3.  The proposed process for reviewing and selecting future pilot/feasibility 
studies.  
4.  How well the pilot/feasibility study fits into the area of scientific 
inquiry selected for the Center.
5.  The justification for eligibility of the investigator(s) according to 
criteria listed in the RFA.
6.  The feasibility and promise of the proposed methods.
7.  The novelty or originality of the applications.
8.  The training, experience, and research competence of the investigator(s).
9.  The suitability of the facilities for the proposed research, including the 
availability of required special resources.
10.  The appropriateness and justification of the requested budget for the 
proposed work.
11.  Provisions for the protection of human subjects and the humane care of 
animals.
12.  The qualifications of the Director of the Pilot and/or Feasibility 
Studies core.

OVERALL CENTER CORE GRANT APPLICATION

1.  The overall scientific merit and the potential of the research program for 
making a significant contribution to achieving the goals of the NINR.
2.  The scientific gain from linking the research projects in a center grant, 
i.e., the degree of interrelatedness and synergism among the components of the 
center.
3.  Evidence of collaborative and/or interdisciplinary research, and 
interdisciplinary approach of the Center.
4.  The qualifications of the Center Director and other key investigators and 
the commitment of participating investigators to a common goal and to 
collaboration.
5.  The adequacy of the available resources and the quality of the research 
environment.
6.  The institutional commitment to the Center in terms of space, resources, 
administrative authority, and other necessary support, e.g., donated faculty 
time, and the extent to which the Center is recognized as a major element 
within the organizational structure of the institution.
7.  The plans for developmental activities, including recruitment and 
expansion, insofar as these are justified by the proposed research program.
8.  The plans for outreach and collaboration with other groups doing related 
work.
9.  Provisions for the protection of human subjects and the humane care of 
animals.
10. A plan for evaluation of activities of the Center.
11.  Appropriateness of the requested budget for the work proposed.

In addition to the above criteria, in accordance with NIH policy, all 
applications will also be reviewed with respect to the following:

o  The adequacy of plans to include both genders, minorities and their 
subgroups, and children as appropriate for the scientific goals of the 
research.  Plans for the recruitment and retention of subjects will also be 
evaluated.

o  The reasonableness of the proposed budget and duration in relation to the 
proposed research.

o  The adequacy of the proposed protection for humans, animals or the 
environment, to the extent they may be adversely affected by the project 
proposed in the application.

Schedule

Letter of Intent Receipt Date:    October 9, 2000  
Application Receipt Date:         November 14, 2000  
Peer Review Date:                 February 2001
Council Review:                   May 2001
Earliest Anticipated Start Date:  August 2001

AWARD CRITERIA

Award criteria that will be used to make award decisions include:

o  scientific merit (as determined by peer review)
o  availability of funds
o  programmatic priorities.

INQUIRIES

Inquiries concerning this RFA are encouraged.  The opportunity to clarify any 
issues or answer questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Carole Hudgings, PhD, RN, FAAN
Chief, Office of Extramural Programs
National Institute of Nursing Research
Building 45, Room 3AN-12 MSC 6300
Bethesda, MD 20892-6300
Telephone:  (301) 594-5976
FAX:  (301) 480-8260
E-mail:  carole_hudgings@nih.gov

Direct inquiries regarding review issues to:

Dr. Mary Stephens-Frazier
Scientific Review Administrator
Division of Extramural Activities
National Institute of Nursing Research
Building 45, Room 3AN-12 MSC 6300
Bethesda, MD  20892-6300
Telephone:  (301) 594-6906
FAX: (301) 480-8260
E-mail: frazierm@mail.nih.gov

Direct inquiries regarding fiscal matters to:

Jeff Carow
Grants Management Officer
Office of Grants and Contracts Management
National Institute of Nursing Research
Building 45, 3AN-12 MSC 6300
Bethesda, MD 20892
Telephone:  (301) 594-6869
FAX:  (301) 480-8260
Email: jeff_carow@nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance No. 
93.361.  Awards are made under authorization of Sections 301 and 405 of the 
Public Health Service Act as amended (42 USC 241 and 284) and administered 
under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 
74 and 92.  This program is not subject to the intergovernmental review 
requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant recipients to provide a smoke-free 
workplace and promote the non-use of all tobacco products.  In addition, 
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain 
facilities (or in some cases, any portion of a facility) in which regular or 
routine education, library, day care, health care, or early childhood 
development services are provided to children.  This is consistent with the 
PHS mission to protect and advance the physical and mental health of the 
American people.


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