ANIMAL MODELS OF HUMAN PAPILLOMAVIRUS INFECTIONS FOR EVALUATION OFEXPERIMENTAL THERAPIES NIH GUIDE, Volume 21, Number 28, August 7, 1992 RFP: NIH-NIAID-DMID-93-05 P.T. 34 Keywords: Viral Studies (Virology) Disease Model Pathogenesis National Institute of Allergy and Infectious Diseases The Antiviral Research Branch of the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, is seeking investigators to employ appropriate animal model systems of human papillomaviral infections to evaluate the efficacy of experimental therapies and provide basic information on the natural history and pathogenesis of papillomavirus infections. Current treatment for papillomavirus infection is limited to topical therapies which destroy tissue, are limited to visible lesions, and are associated with unacceptably high recurrence rates. Consequently, there is a clear need to identify effective systemic chemotherapeutic agents. The availability of animal model systems mimicking human papillomavirus infection makes it feasible to continue a program to identify therapeutic agents for these infections. The primary objective of the Animal Models Program of the Antiviral Research Branch is to evaluate experimental therapies for potential clinical efficacy and toxicity in animal models of clinically important human viral infections. In addition, the animal models are used to study disease pathogenesis and host response to infection. In the future, when appropriate, these models will also be used for a limited amount of vaccine evaluation and pharmacokinetic studies. Animal models that are predictive of human response to a therapeutic intervention are invaluable for the identification of experimental therapies with the best clinical potential. They are also important for evaluation of dosing regimens, combination drug therapies and delivery strategies. The animal models program has made many significant contributions to the development of new therapies. This recompetition is planned to assure the continuation of this vital resource for the development of antiviral therapies. This program currently includes models of the following infections: influenza, parainfluenza, respiratory syncytial virus, measles, neonatal herpes, herpes encephalitis, genital herpes, varicella zoster virus, cytomegalovirus, and papillomaviruses. The emphasis for this solicitation will be to support animal models that: (a) share significant features of pathology and natural history with human papillomavirus infections, (b) utilize either a human virus or an animal virus with considerable homology to the human virus, and (c) have been, or can be expected to be, predictive for human efficacy. As in the past, basic studies on model development, disease pathogenesis, and natural history will be encouraged as an adjunct to the primary focus on therapeutic evaluation. Occasionally, when appropriate, these models will also be utilized for vaccine evaluation and for pharmacokinetic analysis of a compound. Any contract awarded will be subject to the Department of Health and Human Services regulations regarding the animal subjects in research. This announcement is a new solicitation. The issuance of the RFP will be on or about August 4, 1992 and proposals will be due at close of business on September 21, 1992. It is expected that two contracts with a five-year period of performance will be awarded as a result of this solicitation. The request for the RFP should be addressed to: Mr. Carl Henn Contracting Officer Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 Please provide this office with two self-addressed mailing labels. This advertisement does not commit the Government to award a contract. .
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