GENETIC SEQUENCE VARIABILITY OF HIV-1 AND RELATED LENTIVIRUSES

NIH GUIDE, Volume 21, Number 41, November 13, 1992



RFP:  NIH-NIAID-DAIDS-93-22



P.T. 34



Keywords:

  Human Genome 

  Data Management/Analysis+ 



National Institute of Allergy and Infectious Diseases



The National Institute of Allergy and Infectious Diseases (NIAID), NIH,

has a requirement for a contractor to receive samples infected with

HIV-1 or related lentiviruses, to amplify virus-specific genetic

sequences from these samples, and to clone and sequence these amplified

fragments.  The Contractor will be required to design gene

amplification primers for distinct regions of the virus genome and for

diverse viral isolates.  The Contractor will be required to amplify and

clone sizable genomic fragments (>1500 base pairs), and carry out

large-scale genetic sequencing (approximately 200,000 bases/year).



Specifically, the selected contractor shall be responsible for:  (1)

amplifying, cloning and sequencing HIV-1 and related

lentivirus-specific gene fragments from samples derived from

HIV-infected individuals provided through the Project Officer; (2)

compiling and analyzing genetic sequence data, and transferring data to

the HIV Genetic Sequence Database and Analysis Unit at the Los Alamos

National Laboratory; (3) receiving, cataloging, processing, storing

samples, and distributing samples to other investigators; and (4)

providing an Inventory and Database Management System.



This is an announcement for an anticipated Request for Proposals (RFP).

RFP NIH-NIAID-DAIDS-93-22 will be issued on or about November 9, 1992,

with a closing date tentatively set for January 5, 1993.  One contract

will be awarded as a result of this solicitation.  It is expected that

the contract will have a five-year period of performance.  A

level-of-effort cost-reimbursement contract is anticipated.



INQUIRIES



Requests for the RFP are to be directed in writing to:



Kristiane E. Hofacker, Contract Specialist

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

Bethesda, MD  20892



Please provide this office with three self-addressed mailing labels.

Telephone inquiries will not be honored and all inquiries must be in

writing.  A short-form version of the RFP will be provided first, this

includes only the Statement of Work and the Evaluation Criteria to be

used for selection of the awardee.  After examining this, a full-text

version of the RFP must be requested, in writing, for those offerors

interested in responding.  FAX requests are acceptable for full-text

versions of the RFP only (FAX: 301/402-0972).  All proposals from

responsible sources will be considered by the NIAID.  This

advertisement does not commit the Government to award a contract.



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