BIOCHEMICAL SCREENS FOR AGENTS EFFECTIVE AGAINST AIDS-RELATEDOPPORTUNISTIC INFECTION NIH GUIDE, Volume 21, Number 41, November 13, 1992 RFP: NIAID-DAIDS-93-19 P.T. 34 Keywords: Bioassay AIDS Screening of Drugs/Agents Enzymes National Institute of Allergy and Infectious Diseases The Developmental Therapeutics Branch, Basic Research and Development Program, Division of AIDS, National Institute of Allergy and Infectious Disease (NIAID), NIH has a requirement to apply established biochemically-based enzymatic or non-enzymatic assays to screen agents for inhibition of one or more steps in the metabolism of AIDS-associated opportunistic pathogens. These biochemical prescreens are considered particularly useful for rapid testing of compounds. Examples of such assays may include, but not be limited to: protein synthesis, dihydrofolate reductase, and dihydropteroate synthase. The major effort of this contract will involve the screening of a large number of compounds. A secondary focus of this contract will be development/modification of automated biochemical assays and their application to drug testing against opportunistic infections in AIDS. It is anticipated that some assays will require isolation of enzymes from relevant microorganisms or cloning to obtain the protein. However, most of the enzymes and recombinant proteins required for the development of assays in this project will be provided by the AIDS Reference and Reagent Repository. Other non-enzymatic assays may be developed /used to evaluate drug activities in vitro. At the present time, NIAID has one contract that is scheduled to end in 1993 to screen agents in enzymatic assays. This NIAID sponsored project will take approximately three years to complete. A level-of-effort, cost reimbursement contract is anticipated. It is expected that one award will be made. This is an announcement for an anticipated Request for Proposal (RFP). RFP NIH-NIAID-DAIDS-93-19 will be issued on or about November 12, 1992, with a closing date tentatively set for January 15, 1993. INQUIRIES Requests for the RFP may be directed in writing to: Cyndie Cotter Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 To receive a copy of the RFP, please supply this office with three self-addressed mailing labels. Telephone inquiries will not be honored and all inquiries must be in writing. A short- form version of the RFP will be provided first, which includes only the Statement of Work and the Evaluation Criteria to be used for selection of the awardee. After examining this, a full-text version of the RFP must be requested, in writing, for those offerors interested in responding. FAX requests are acceptable for the full-text version only (FAX: 301-402-0972). All proposals from responsible sources will be considered by the NIAID. This advertisement does not commit the Government to award a contract. .
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