and Human Services (HHS)
EXPIRED
Participating Organization(s) |
National Institutes of Health (NIH) |
National Institute of General Medical Sciences (NIGMS) |
|
Funding Opportunity Title |
Dynamics of Host-Associated Microbial Communities (R01) |
Activity Code |
R01 Research Project Grant |
Announcement Type |
Reissue of RFA-GM-12-001 |
Related Notices |
|
Funding Opportunity Announcement (FOA) Number |
RFA-GM-13-001 |
Companion FOA |
None |
Catalog of Federal Domestic Assistance (CFDA) Number(s) |
93.859 |
FOA Purpose |
This Funding Opportunity Announcement (FOA) issued by the National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH), solicits applications that propose genetic, physiological, and ecological studies designed to reveal the basic principles and mechanisms that govern the symbiotic systems dynamics of host-associated microbial communities. |
Posted Date |
September 28, 2011 |
Open Date (Earliest Submission Date) |
December 13, 2011 |
Letter of Intent Due Date |
December 13, 2011 |
Application Due Date(s) |
January 13, 2012, by 5:00 PM local time of applicant organization. |
AIDS Application Due Date(s) |
Not applicable |
Scientific Merit Review |
June-July, 2012 |
Advisory Council Review |
October, 2012 |
Earliest Start Date(s) |
December 1, 2012 |
Expiration Date |
January 14, 2012 |
Due Dates for E.O. 12372 |
Not Applicable |
Required Application Instructions
It is critical that applicants follow the instructions in the SF 424 (R&R) Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.
Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission
Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information
This Funding Opportunity Announcement (FOA) issued by the National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH), solicits applications that propose genetic, physiological, and ecological studies designed to reveal the basic principles and mechanisms that govern the symbiotic systems dynamics of host-associated microbial communities.
Background
Microbes comprise over 90% of the cells of the human body, forming distinctive communities in different parts of the body. These complex and dynamic communities of microbes (the human microbiota) have a major impact on human health by promoting proper development of host organs, stimulating development of the immune system, providing nutrients to the human host, and excluding potential pathogens. Alteration of indigenous microbial communities can cause pathological conditions, including periodontal disease, ulcers, and secondary pneumonia. Recent studies indicate that microbial communities may influence many other aspects of human health, from obesity to chronic diseases like atherosclerosis. Microbial communities also affect our environment, including the health of animals and plants on which we depend, and the health of the environment as it relates to issues such as water quality, bioremediation, the global cycling of CO2 and other gases, and effects upon climate. Rather than the traditional concept of one microbe, one disease, it has become clear that some diseases are polymicrobial caused by altered communities of microbes. The microbial communities of the gut, in particular, have important implications for health by affecting metabolism of food and drugs. The gut inhabitants transform chemicals we consume into beneficial, harmless, and harmful compounds, thereby influencing the level of human exposure to pharmaceutically active compounds.
Given the key role of indigenous microbial communities in influencing human health and disease, personalized medicine will likely require an understanding of the microbial communities associated with the individual, in addition to an individual’s genome sequence. However, such approaches to personalized medicine are currently beyond our capacity because, although it is often possible to identify the representative microbes in a particular environment, the interactions and processes within their communities, and between these communities and the host, are complex and poorly understood. To partially address this shortcoming, the NIH Roadmap Human Microbiome Project (HMP) (http://nihroadmap.nih.gov/hmp/) will generate massive amounts of sequencing data reflecting microbial community composition from a number of human niches and reflecting a handful of normal and disease states. However, there is still a need to provide insight into the basic physiological and ecological principles that govern the formation and persistence of host-associated microbial communities. Studies of model systems may provide useful tools to answer questions in this regard, such as: what factors distinguish microbes that comprise the core of the community from those that are transient; what are the key characteristics of niche environments that favor particular assemblages of microbes; by what means do the microbes in the community interact with each other and with the host, and how do the communities evolve i.e., what is their natural history?
To this end, NIGMS sponsored a conference in November 2008 to explore opportunities in the study of host-microbe communities. The recommendations of this conference form the basis of this FOA and can be found at: http://www.nigms.nih.gov/News/Reports/Host_Associated_Microbial_Communities_Conference_2009.htm.
Research Objectives
To advance the nascent science of host-associated microbial community ecology, this FOA solicits research grant applications for innovative genetic, physiological, and ecological studies that are designed to reveal the basic principles and mechanisms that govern host-associated microbial community structure and function. Applications are solicited in the following areas, but are not limited to:
Model systems
Model systems could have significant advantages for the discovery of common principles of host-associated microbial community structure and function, in as much as both host and microbes can be subject to high resolution morphological, genetic, physiological, and biophysical analysis. Model systems also can be platforms for developing novel, effective tools for these studies. The further development of existing model systems and the development of new systems that are particularly well suited to address fundamental questions of host-community structure and function are encouraged. Synthetic systems may also be appropriate.
Community physiology
Nutrient flow in microbial communities is complex, and it will be essential to develop ways to measure it in order to understand community dynamics. It is likely that the overall physiology of the host-microbe community system cannot be understood by focusing solely on the individual members of the system. The exchange of metabolites, signaling molecules, and energy sources between microbes and the host comprises a complex network. Understanding how microorganisms contribute to or draw from the available nutrient pool, how they cooperate to synthesize metabolites, and how community members compete for nutrients is of critical importance within the scope of this announcement. Equally important is understanding how the host’s physiology responds to, and in turn influences, the microbial component. The complex reciprocity of the problem requires innovative approaches, which may include new analytical techniques, genetic methods, and use of network analysis and mathematical modeling/simulation.
Community genetic interactions
In addition to the ability of microbes to exchange signals that affect gene expression, share metabolites, and create nutrient and other chemical gradients, microbes also exchange genetic material. Recent metagenomic studies on bacterial viruses indicate that there is a surprising amount of exchange of genetic information between microbes in natural environments. Innovative methods to study the dynamics and consequences of this gene flow in host-microbe communities are encouraged.
Community dynamics
The principles that explain how communities develop population structures that both resist and recover from perturbation (robustness) are not well understood. Among the possible approaches to analyzing these properties could be innovative genetic techniques, including metagenomics and directed mutation, in conjunction with computational modeling. Direct experimental tests of predictions about how the flow of metabolites, signaling molecules, or genetic information between host and members of the microbial community contribute to community stability are encouraged. Perturbations of community structure could also provide key evidence for the existence of stabilizing networks that account for robustness to change. New approaches to adapt mutational approaches to poorly characterized microbial communities are also encouraged.
Development of new technologies
Many of the questions regarding the physical and functional architecture of microbial communities may not be addressable with existing methods, demanding new technological advances. For example, single cell tracking and functional analysis in complex assemblages such as biofilms may require advances in microscopy and gene tagging. Improvements also are likely to be required in the use of isotopically labeled substrates to map metabolite flows in complex mixtures of organisms, and their hosts. The architecture of microbial communities in unique micro-niches within the host may have to be explored at fine resolution to provide the basis for elucidating the rules of community assembly and evolution.
In summary, this FOA will support research on fundamental principles and mechanisms that govern the symbiotic systems dynamics of host-associated microbial communities. NIGMS recognizes that most of these questions are complex in nature, and the applicants are encouraged to utilize interdisciplinary approaches, including bioinformatic/computational/modeling, and/or experimental manipulations to the study of host-associated microbial community ecology. Although the focus of this FOA is on mixed microbe communities (where community is defined as two or more phenotypically distinct populations of microbes), their internal dynamics and how that relates to those of the host, we also recognize that there may be experimental models that, regardless of the number of microbial species involved, have the potential to make breakthrough contributions to understanding the fundamental ecological principles underlying community dynamics in the host.
This FOA will not support narrowly focused mechanistic studies, descriptive studies that are designed solely to carry out metagenomic sequencing or surveys of microbial diversity or studies that have a focus on a particular disease (as opposed to basic principles of the dynamics of host-microbe community), or are likely to yield only incremental information.
See Section VIII, Other Information - Required Federal Citations, for policies related to this announcement.
Funding Instrument |
Grant |
Application Types Allowed. |
New The OER Glossary and the SF 424 (R&R) Application Guide provide details on these application types. |
Funds Available and Anticipated Number of Awards |
NIGMS intends to commit $2.5 million in FY 2013. Approximately 5-7 awards are anticipated. |
Award Budget |
Although the size of award will vary with the scope of the research proposed, budget requests should not exceed $250,000 (direct cost) per year except that in first year additional funds not to exceed $100K (direct cost) may be requested for exceptional equipment needed for highly specialized purposes (e.g., single molecule imaging microscope, germ-free mice incubator, etc.). |
Award Project Period |
Scope of the proposed project should determine the project period. The maximum award period is 5 years although most awards will be for 4 years. |
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Governments
Other
Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Applicant organizations must complete the following registrations
as described in the SF 424 (R&R) Application Guide to be eligible to apply
for or receive an award. Applicants must have a valid Dun and Bradstreet
Universal Numbering System (DUNS) number in order to begin each of the following
registrations.
All Program Director(s)/Principal Investigator(s) (PD(s)/PI(s))
must also work with their institutional officials to register with the eRA
Commons or ensure their existing eRA Commons account is affiliated with the eRA
Commons account of the applicant organization.
All registrations must be completed by the application due date. Applicant
organizations are strongly encouraged to start the registration process at
least four (4) weeks prior to the application due date.
Any individual(s) with the skills, knowledge, and resources
necessary to carry out the proposed research as the Program Director(s)/Principal
Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to
develop an application for support. Individuals from underrepresented racial
and ethnic groups as well as individuals with disabilities are always
encouraged to apply for NIH support.
For institutions/organizations proposing multiple PD(s)/PI(s), visit the Multiple
Program Director/Principal Investigator Policy and submission details in the Senior/Key
Person Profile (Expanded) Component of the SF 424 (R&R) Application Guide.
This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application. NIH will not accept any application that is essentially the same as one already reviewed. Resubmission applications (from RFA-GM-12-001 ONLY) may be submitted, according to the NIH Policy on Resubmission Applications from the SF 424 (R&R) Application Guide.
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications.
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information:
The letter of intent should be sent to:
Shiva P. Singh, Ph.D.
Division of Genetics and Developmental Biology
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2As.37C, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-3900
FAX: (301) 480-2753
Email: [email protected]
The forms package associated with this FOA includes all applicable components, mandatory and optional. Please note that some components marked optional in the application package are required for submission of applications for this FOA. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate optional components.
All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.
U.S. applicants submitting an application with direct costs in each year of $250,000 or less (excluding consortium Facilities and Administrative [F&A] costs) must use the PHS398 Modular Budget component.
U.S. applicants requesting more than $250,000 in annual direct costs and all foreign applicants must complete and submit budget requests using the Research & Related Budget component
Budget Justification: Follow all instructions in the SF 424 (R&R) Application Guide.
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:
Resource Sharing Plan
Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies; GWAS) as provided in the SF424 (R&R) Application Guide, with the following modifications:
Appendix
Do not use the appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.
Foreign (non-US) institutions must follow policies described in the NIH Grants Policy Statement, and procedures for foreign institutions described throughout the SF424 (R&R) Application Guide.
Part I. Overview Information contains information about Key Dates. Applicants are encouraged to submit in advance of the deadline to ensure they have time to make any application corrections that might be necessary for successful submission.
Organizations must submit applications via Grants.gov, the online portal to find and apply for grants across all Federal agencies. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH’s electronic system for grants administration.
Applicants are responsible for viewing their application in the eRA Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Pre-award costs are allowable only as described in the NIH Grants Policy Statement.
Applications must be submitted electronically following the instructions described in the SF 424 (R&R) Application Guide. Paper applications will not be accepted.
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically.
Important
reminders:
All PD(s)/PI(s) must include their eRA Commons ID in the
Credential field of the Senior/Key Person Profile Component of the SF
424(R&R) Application Package. Failure to register in the Commons and
to include a valid PD(s)/PI(s) Commons ID in the credential field will prevent
the successful submission of an electronic application to NIH.
The applicant organization must ensure that the DUNS number it provides on the
application is the same number used in the organization’s profile in the eRA
Commons and for the Central Contractor Registration (CCR). Additional
information may be found in the SF424 (R&R) Application Guide.
See more
tips for avoiding common errors.
Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review and responsiveness by the National Institute of General medical Sciences, NIH. Applications that are incomplete and/or nonresponsive will not be reviewed.
Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115.
Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review system.
Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).
Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Significance
Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Investigator(s)
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD(s)/PI(s), do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
Innovation
Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
Approach
Are the overall strategy, methodology, and analyses
well-reasoned and appropriate to accomplish the specific aims of the project?
Are potential problems, alternative strategies, and benchmarks for success
presented? If the project is in the early stages of development, will the
strategy establish feasibility and will particularly risky aspects be managed?
If the project involves clinical research, are the plans for 1) protection of
human subjects from research risks, and 2) inclusion of minorities and members
of both sexes/genders, as well as the inclusion of children, justified in terms
of the scientific goals and research strategy proposed?
Environment
Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact/priority score, but will not give separate scores for these items.
Protections for Human Subjects
For research that involves human subjects but does
not involve one of the six categories of research that are exempt under 45 CFR
Part 46, the committee will evaluate the justification for involvement of human
subjects and the proposed protections from research risk relating to their
participation according to the following five review criteria: 1) risk to
subjects, 2) adequacy of protection against risks, 3) potential benefits to the
subjects and others, 4) importance of the knowledge to be gained, and 5) data
and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or
more of the six categories of research that are exempt under 45 CFR Part 46,
the committee will evaluate: 1) the justification for the exemption, 2) human
subjects involvement and characteristics, and 3) sources of materials. For
additional information on review of the Human Subjects section, please refer to
the Human
Subjects Protection and Inclusion Guidelines.
Inclusion of Women, Minorities, and Children
When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. For additional information on review of the Inclusion section, please refer to the Human Subjects Protection and Inclusion Guidelines.
Vertebrate Animals
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.
Biohazards
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
Resubmissions
For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.
Renewals
Not Applicable.
Revisions
Not Applicable.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact/priority score.
Applications from Foreign Organizations
Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.
Select Agent Research
Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Resource Sharing Plans
Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan; 2) Sharing Model Organisms; and 3) Genome Wide Association Studies (GWAS) (Not Applicable).
Budget and Period of Support
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Applications will be evaluated for scientific and technical
merit by (an) appropriate Scientific Review Group(s) convened by NIGMS, in accordance with NIH peer
review policy and procedures, using the stated review
criteria. Review assignments will be shown in the eRA Commons.
As part of the scientific peer review, all applications:
Applications will compete for available funds with all other recommended applications submitted in response to this FOA. Following initial peer review, recommended applications will receive a second level of review by the National General Medical Sciences Advisory Council . The following will be considered in making funding decisions:
After the peer review of the application is completed, the PD(s)/PI(s) will be able to access his or her Summary Statement (written critique) via the eRA Commons.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement.
If the application is under consideration for funding, NIH
will request "just-in-time" information from the applicant as
described in the NIH
Grants Policy Statement.
A formal notification in the form of a Notice of Award (NoA) will be provided
to the applicant organization for successful applications. The NoA signed by
the grants management officer is the authorizing document and will be sent via
email to the grantee’s business official.
Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection
of an application for award is not an authorization to begin performance. Any
costs incurred before receipt of the NoA are at the recipient's risk. These
costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this FOA will be subject to the DUNS,
CCR Registration, and Transparency Act requirements as noted on the Award
Conditions and Information for NIH Grants website.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.
Cooperative Agreement Terms and Conditions of Award
Not Applicable.
When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants Policy Statement.
A final progress report, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.
We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
Grants.gov
Customer Support (Questions regarding Grants.gov registration and
submission, downloading or navigating forms)
Contact Center Phone: 800-518-4726
Email: [email protected]
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process, finding NIH grant resources)
Telephone 301-710-0267
TTY 301-451-5936
Email: [email protected]
eRA Commons Help Desk(Questions regarding eRA Commons
registration, tracking application status, post submission issues)
Phone: 301-402-7469 or 866-504-9552 (Toll Free)
TTY: 301-451-5939
Email: [email protected]
Shiva P. Singh, Ph.D.
Division of Genetics and Developmental Biology
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2As.37C, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-3900
FAX: (301) 480-2753
Email: [email protected]
Helen R. Sunshine, Ph.D.
Chief, Office of Scientific Review
National Institute of General Medical Sciences, NIH
Building 45, Room 3AN.12
45 Center Drive, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-2881
Fax: (301) 480-8506
Email: [email protected]
Nicole Fleisher
Division of Extramural Activities
National Institute of General Medical Sciences, NIH
Building 45, Room 2AN.50E
45 Center Drive, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-3923
Fax: (301) 480-2554
Email: [email protected]
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92.
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