NIH Guide: EQUIPMENT SUPPLEMENTS TO NIGMS MBRS SCORE GRANTS

EQUIPMENT SUPPLEMENTS TO NIGMS MBRS SCORE GRANTS

RELEASE DATE: December 19, 2003

RFA Number: RFA-GM-05-003 (see correction NOT-OD-04-029)

Department of Health and Human Services (DHHS)

PARTICIPATING ORGANIZATION:
National Institutes of Health (NIH)
(http://www.nih.gov)

COMPONENT OF PARTICIPATING ORGANIZATION:
National Institute of General Medical Sciences (NIGMS)
(http://www.nigms.nih.gov)

CATALOG OF FEDERAL DOMESTIC ASSISTANCE NUMBER: 93.859

LETTER OF INTENT RECEIPT DATE: January 23, 2004
APPLICATION RECEIPT DATE: February 23, 2004

THIS RFA CONTAINS THE FOLLOWING INFORMATION

o Purpose of this RFA
o Research (Program) Objectives
o Mechanism of Support
o Funds Available
o Eligible Institutions
o Individuals Eligible to Become Principal Investigators
o Special Requirements
o Where to Send Inquiries
o Letter of Intent
o Submitting an Application
o Peer Review Process
o Review Criteria
o Receipt and Review Schedule
o Award Criteria
o Required Federal Citations

PURPOSE

Minority Opportunity for Research (MORE) Division, Minority Biomedical
Research Support (MBRS) Branch of the National Institute of General
Medical Sciences (NIGMS) announces a limited competition for supplements
to Support for Continuous Research Excellence (SCORE) grants to acquire
laboratory equipment. Although equipment is an allowable cost in SCORE
grants, these supplements should provide SCORE individual PIs or groups of
PIS with equipment that is either not readily available or lacking but
that is essential for meeting the specific aims of SCORE funded projects
or those of the parent grant.

PROGRAM OBJECTIVES

Supplemental funds may be used to purchase new equipment for meeting the
specific aims of SCORE parent grants, including those of funded core
facilities, the specific aims of individual SCORE projects, or to upgrade
equipment currently being used in SCORE programs including equipment used
in a core facility.

Types of Equipment Requests

Individual Equipment Items: Applicants may request costs for individual
pieces of equipment necessary to facilitate progress in a particular
SCORE-funded research subproject. Justification for the equipment should
be based on its utility to drive the research forward and its present
unavailability at that institution.

Multi-user research core facilities: Costs for multi-user research core
facilities are allowable. The core may include substantial equipment and
services that will be shared by one or more SCORE-funded regular research
or pilot subprojects. A plan for access to the facility, its maintenance,
management and use must be included. The core may also include a
technical assistant to maintain and service the equipment and instruct
others in its use. To aid in the review, it is suggested that a tabular
summary show the estimated or actual proportional use of this core
component by each SCORE-funded project and other investigators (including
non-SCORE funded investigators). Justify this core component by
discussing ways in which these centralized services improve quality, bring
about an economy of effort, and/or save overall costs as compared to their
inclusion as part of one or more SCORE-funded research projects. Plans to
maintain the core facility beyond the grant period should be discussed.
Support for large pieces of equipment, however, may be limited by the NIH
MBRS budget.

MECHANISM OF SUPPORT

This RFA for competing supplements (Type 3) will use an existing NIH S06
award mechanism. As an applicant you will be solely responsible for
planning, directing, and executing the proposed project. This RFA is a
one-time solicitation and awards are not renewable. The anticipated award
date is January 2005.

This RFA uses just-in-time concepts. It uses the non-modular budgeting
formats (see https://grants.nih.gov/grants/funding/modular/modular.htm).
This program does not require cost sharing as defined in the current NIH
Grants Policy Statement at
https://grants.nih.gov/archive/grants/policy/nihgps_2001/part_i_1.htm.

FUNDS AVAILABLE

NIGMS intends to commit approximately $3-7 million in FY 2005 to fund 10-
30 equipment supplements to SCORE grants in response to this RFA. Because
the nature and cost of the equipment may vary, it is anticipated that the
size of each award will also vary. Awards pursuant to this RFA are
contingent upon the availability of funds and the receipt of a sufficient
number of meritorious applications.

ELIGIBLE INSTITUTIONS

You may submit an application (Type 3) if your institution has an active
MBRS SCORE grant and will have at least one year of support remaining at
the time of award. The supplemental award may not extend beyond the parent
grant. MBRS SCORE grantee institutions that responded to earlier
announcements of this RFA or that have previously received funds under
this RFA are eligible to reapply.

INDIVIDUALS ELIGIBLE TO BECOME PRINCIPAL INVESTIGATORS

The PI for this supplement must be the current Program Director of the
MBRS SCORE parent grant.

SPECIAL REQUIREMENTS

Equipment requested under this RFA must be used to accomplish the funded
specific aims of the SCORE parent grant or SCORE-funded regular research
or SCORE-funded pilot projects and may not expand the scope of the parent
grant or of funded SCORE research projects. Institutions that received an
equipment supplement grant in response to a previous RFA (FY 2002 or 2003)
must give details of the equipment purchased under previous awards,
including how it is being used and how it relates to the equipment
requested under this RFA. Additionally, when equipment is being requested
to support a specific SCORE-funded regular or pilot research project,
provide a description of the equipment currently available to or being
used by the PI to accomplish the funded research goals and specific
objectives.

Supplement may not extend beyond parent grant.

A report on the value added by the acquired research equipment will be
required as a part of a subsequent non-competing grant progress report
(Type 5), competing renewal (Type 2) application, or of the close-out
package if a competing renewal application is not awarded.

Allowable Costs

Under this RFA, only grant applications with a minimum aggregate cost of
$50,000 and a maximum of $1,000,000 will be considered. Individual
equipment (not including the cost of ancillary equipment) costing a
minimum of $20,000 and a maximum of $750,000 is allowable under this
program. Applications requesting equipment outside these ranges will be
returned without review.

In addition, when fully justified, support up to $40,000 per year for a
technical assistant to maintain and teach others in the use of the
equipment is allowed and may be requested for the term of the parent SCORE
grant. Continued support, up to $40,000 per year for a technical
assistant position awarded under this RFA, may be requested during
competing renewal of MBRS SCORE grants.

Unallowable Costs

Unallowable costs include:
o Computers for individual use
o Computers and audiovisual equipment for general classroom use
o Individual equipment costing less than $20,000 or more than $750,000

WHERE TO SEND INQUIRIES

We encourage inquiries concerning this RFA and welcome the opportunity to
answer questions from potential applicants. Inquiries may fall into three
areas: programmatic, peer review, and financial or grants management
issues:

o Direct your questions about programmatic issues to:

Derrick C. Tabor, Ph.D.
Program Director, MORE Division
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2AS.37, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301)594-3900
FAX: (301)480-2753
E-mail: tabord@nigms.nih.gov

o Direct your questions about peer review issues to:

Richard I. Martinez, Ph.D.
Office of Scientific Review
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 3AN.12, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301)594-2489
FAX: (301)480-8506
E-mail: rm63f@nih.gov

o Direct your questions about financial or grant management matters to:

Antoinette Holland
Grants Management Officer
Grants Management Branch
Division of Extramural Activities
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2AN.50, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301)594-5132
FAX: (301)480-2554
E-mail: hollanda@nigms.nih.gov

LETTER OF INTENT

Prospective applicants are asked to submit a letter of intent that
includes the following information:

o Descriptive title of the proposed research
o Name, address, and telephone number of the Principal Investigator
o Name of the applicant institution
o Names of other key personnel
o Number and title of this RFA.

Although a letter of intent is not required, is not binding, and does not
enter in to the review of a subsequent application, the information that
it contains allows NIGMS staff to estimate the potential review workload
and plan the review.

The letter of intent is to be sent by the date listed at the beginning of
this document. The letter of intent should be sent to:

Derrick C. Tabor, Ph.D.
Program Director, MORE Division
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2AS.37, MSC 6200
Bethesda, MD 20892-3900
Telephone: (301) 594-3900
Fax: (301) 480-2753
E-mail: tabord@nigms.nih.gov

SUBMITTING AN APPLICATION

Applications must be prepared using the PHS 398 research grant application
instructions and forms (rev. 5/2001). Applications must have a DUN and
Bradstreet (D&B) Data Universal Numbering System (DUNS) number as the
Universal Identifier when applying for Federal grants or cooperative
agreements. The DUNS number can be obtained by calling (866) 705-5711 or
through the web site at http://www.dunandbradstreet.com/. The DUNS number
should be entered on line 11 of the face page of the PHS 398 form. The PHS
398 document is available at
https://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive
format. For further assistance contact GrantsInfo, Telephone (301) 710-0267, Email: GrantsInfo@nih.gov.

SUPPLEMENTARY INSTRUCTIONS: In addition to following the PHS 398
instructions for supplements, for example, all supplements are required to
have a one page introduction; the instructions given below should also be
followed.

RESEARCH PLAN (Not to exceed 25 pages)

Under the Research Plan, the PI should provide the information requested
below. This section may not exceed 25 pages. Equipment quotations,
letters from collaborators and consultants, and the checklist are excluded
from the 25 page limit.

Section 1: Describe how the requested equipment has (1) relevance to the
institution's goals and specific objectives, (2) immediate utility to
specific research project(s), and (3) how the investigator(s) will take
advantage of unique features of the equipment to enhance progress of the
research project(s). Describe how the requested equipment will provide an
innovative approach to the research being conducted. Describe how the
equipment will significantly enhance the scientific environment in which
the research is being conducted and how it will contribute to the
probability of meeting the goals and objectives of the SCORE program.

Section 2: Describe the plan for maintenance of the requested equipment
and how the institution will assist in support of the equipment requested.

Section 3: Describe your plans to share data generated from the requested
equipment (if applicable).

Section 4: Complete Section 3 ("Facilities and Administrative Costs") of
the PHS 398 Form Checklist.

USING THE RFA LABEL: The RFA label is available in the PHS 398 (rev.
5/2001) application. Type the RFA number on the label. Failure to use
this label could result in delayed processing of the application such that
it may not reach the review committee in time for review. In addition,
the RFA title and number must be typed on line 2 of the face page of the
application form and the YES box must be marked. The RFA label is also
available at: https://grants.nih.gov/grants/funding/phs398/label-bk.pdf.

SENDING AN APPLICATION TO THE NIH: Submit a signed, type written original
of the application, including the Checklist, and three signed photocopies
of the application in one package by February 23, 2004 to:

Richard I. Martinez, Ph.D.
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710
Bethesda, MD20817 (for express/courier service)

At the time of the submission to CSR, two additional copies of the
application and five copies of the appendix materials must be sent to:

Office of Scientific Review
National Institute of General Medical Sciences
45 Center Drive, Room 3AN.12, MSC 6200
Bethesda, MD 20892-6200

APPLICATION PROCESSING: Applications must be received on or before the
application receipt date listed in the heading of this RFA. If an
application is received after that date, it will be returned to the
applicant without review.

Although there is no immediate acknowledgement of the receipt of an
application, applicants are generally notified of the review and funding
assignment within 8 weeks.

The Center for Scientific Review (CSR) will not accept any application in
response to this RFA that is essentially the same as one currently pending
initial review, unless the applicant withdraws the pending application.
However, when a previously unfunded application, originally submitted as
an investigator-initiated application, is to be submitted in response to
an RFA, it is to be prepared as a NEW application. That is, the
application for RFA must not include an Introduction describing the
changes and improvements made, and the text must not be marked to indicate
the changes from the previous unfunded version of the application.

PEER REVIEW PROCESS

Upon receipt, applications will be reviewed for completeness by the CSR
and responsiveness by the NIGMS. Incomplete applications will not be
reviewed.

Applications that are complete and responsive to the RFA will be evaluated
for scientific and technical merit by an appropriate peer review group
convened by the NIGMS in accordance with the review criteria stated below.
As part of the initial merit review, all applications will:

o Undergo a process in which only those applications deemed to have the
highest scientific merit, generally the top half of applications under
review, will be discussed and assigned a priority score
o Receive a written critique
o Receive a second level review by the National Advisory General Medical
Sciences Council.

REVIEW CRITERIA

The goals of NIH-supported research are to advance our understanding of
biological systems, improve the control of disease, and enhance health.
In the written comments, reviewers will be asked to discuss the following
aspects of your application in order to judge the likelihood that the
proposed research will have a substantial impact on the pursuit of these
goals. The scientific review group will address and consider each of the
following criteria in assigning your application's overall score,
weighting them as appropriate for each application

o Significance
o Approach
o Innovation
o Investigator
o Environment

The application does not need to be strong in all categories to be judged
likely to have major scientific impact and thus deserve a high priority
score. For example, an investigator may propose to carry out important
work that by its nature is not innovative but is essential to move a field
forward.

Applications submitted in response to this RFA are supplemental to an
existing award. Since these were previously reviewed using the NIH
standard review criteria, the following review criteria will be used to
determine the merit of the supplemental application for equipment:

(1) SIGNIFICANCE: For research subproject equipment: Does the requested
equipment have relevance and immediate utility and will the investigator
take advantage of unique features of the equipment to enhance progress of
his/her research project? For equipment core: Does the proposed equipment
core satisfy the needs of specific research and pilot projects and is
there a plan for coordinating equipment core use by several faculty
members?

(2) APPROACH: For subproject equipment: Is there a plan for its
maintenance? For equipment core: If technical assistance for core is
requested, does the technician have the appropriate background and skills
to maintain the equipment and instruct others in its use? If a technical
assistant is not requested, is the plan for its maintenance and service
adequate?

(3) INNOVATION: For all equipment: Has the investigator shown that the
equipment will provide an innovative approach to accomplishing the
original aims of the research project(s)?

(4) INVESTIGATOR: For subproject equipment: Has the investigator been
productive in documenting his/her research findings in refereed journals?
Will this equipment enhance his/her productivity?

(5) ENVIRONMENT: For all equipment: Will the equipment significantly
enhance the scientific environment in which the research is being
conducted and contribute to the probability of meeting the goals and
objectives of the SCORE program? For all equipment: Is there evidence of
institutional support?

ADDITIONAL REVIEW CRITERIA: In addition to the above criteria, your
application will also be reviewed with respect to the following:

Sharing Research Data

Applicants requesting more than $500,000 in direct costs in any year of
the proposed research are expected to include a data sharing plan in their
application. The reasonableness of the data sharing plan or the rationale
for not sharing research data will be assessed by the reviewers. However,
reviewers will not factor the proposed data sharing plan into the
determination of scientific merit or priority score.

BUDGET: The reasonableness of the proposed budget and the requested
period of support in relation to the proposed research.

RECEIPT AND REVIEW SCHEDULE

Letter of Intent Receipt Date: January 23, 2004
Application Receipt Date: February 23, 2004
Peer Review Date: June-July 2004
Council Review: September 2004
Earliest Anticipated Award Date: January 2005

AWARD CRITERIA

Award criteria that will be used to make award decisions include:

o The likelihood that the applicant institution will fulfill the proposed
objectives and further the goals of the MBRS program
o The effective use of previously awarded equipment supplements
o Scientific merit (as determined by peer review)
o Availability of funds
o Programmatic priorities

REQUIRED FEDERAL CITATIONS

SHARING RESEARCH DATA: Starting with the October 1, 2003 receipt date,
investigators submitting an NIH application seeking $500,000 or more in
direct costs in any single year are expected to include a plan for data
sharing or state why this is not possible.
https://grants.nih.gov/grants/policy/data_sharing. Investigators should
seek guidance from their institutions, on issues related to institutional
policies, local IRB rules, as well as local, state and Federal laws and
regulations, including the Privacy Rule. Reviewers will consider the data
sharing plan but will not factor the plan into the determination of the
scientific merit or the priority score.

PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT: The
Office of Management and Budget (OMB) Circular A-110 has been revised to
provide public access to research data through the Freedom of Information
Act (FOIA) under some circumstances. Data that are (1) first produced in
a project that is supported in whole or in part with Federal funds and (2)
cited publicly and officially by a Federal agency in support of an action
that has the force and effect of law (i.e., a regulation) may be accessed
through FOIA. It is important for applicants to understand the basic
scope of this amendment. NIH has provided guidance at
https://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm.

Applicants may wish to place data collected under this PA in a public
archive, which can provide protections for the data and manage the
distribution for an indefinite period of time. If so, the application
should include a description of the archiving plan in the study design and
include information about this in the budget justification section of the
application. In addition, applicants should think about how to structure
informed consent statements and other human subjects procedures given the
potential for wider use of data collected under this award.

URLs IN NIH GRANT APPLICATIONS OR APPENDICES: All applications and
proposals for NIH funding must be self-contained within specified page
limitations. Unless otherwise specified in an NIH solicitation, Internet
addresses (URLs) should not be used to provide information necessary to
the review because reviewers are under no obligation to view the Internet
sites. Furthermore, we caution reviewers that their anonymity may be
compromised when they directly access an Internet site.

HEALTHY PEOPLE 2010: The Public Health Service (PHS) is committed to
achieving the health promotion and disease prevention objectives of
"Healthy People 2010," a PHS-led national activity for setting priority
areas. This RFA is related to one or more of the priority areas. Potential
applicants may obtain a copy of "Healthy People 2010" at
http://www.healthypeople.gov/.

AUTHORITY AND REGULATIONS: This program is described in the Catalog of
Federal Domestic Assistance at http://www.cfda.gov/ and is not subject to
the intergovernmental review requirements of Executive Order 12372 or
Health Systems Agency review. Awards are made under the authorization of
Sections 301 and 405 of the Public Health Service Act as amended (42 USC
241 and 284) and under Federal Regulations 42 CFR 52 and 45 CFR Parts 74
and 92. All awards are subject to the terms and conditions, cost
principles, and other considerations described in the NIH Grants Policy
Statement. The NIH Grants Policy Statement can be found at
https://grants.nih.gov/grants/policy/policy.htm

The PHS strongly encourages all grant recipients to provide a smoke-free
workplace and discourage the use of all tobacco products. In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in
certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care, or early
childhood development services are provided to children. This is
consistent with the PHS mission to protect and advance the physical and
mental health of the American people.

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