TRANSITION TO INDEPENDENT POSITIONS (TIP)
Release Date: April 3, 2000
RFA: ES-00-001
National Institute of Environmental Health Sciences
Letter of Intent Receipt Date: June 8, 2000
Application Receipt Date: July 12, 2000
PURPOSE
Human health and human disease result from three interactive
elements: (1) environmental exposures, (2) individual
susceptibility, and (3) time. The mission of the National
Institute of Environmental Health Sciences (NIEHS) is to
reduce the burden of human illness and dysfunction from
environmental exposures by understanding each of these
elements and how they interrelate. The NIEHS achieves its
mission through multi-disciplinary biomedical research
programs, prevention and intervention efforts, and
communication strategies that encompass training, education,
technology transfer, and community outreach.
An important element of the NIEHS mission is to develop the
next generation of exceptionally talented young scientists who
are committed to understanding the impact of environmental
exposures on human health. The NIEHS TIP Program is a
Research Scholar Development Award (K22) program targeted to
talented postdoctoral scientists. It provides a unique
mechanism for attracting and supporting exceptionally talented
new investigators who can impact our understanding of the
problems and mechanisms associated with exposure to
environmental agents in order to better protect the public
health.
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the
health promotion and disease prevention objectives of "Healthy
People 2010," a PHS-led national activity for setting priority
areas. This Request for Applications (RFA), Transition to
Independent Positions (TIP), is related to the priority area
of Environmental Health. Potential applicants may obtain a
copy of "Healthy People 2010" at
http://www.health.gov/healthypeople/ .
ELIGIBILITY REQUIREMENTS
There are specific eligibility criteria that must be met in
order to apply for this program. If an applicant is uncertain
of his/her eligibility, he/she is strongly encouraged to
contact the program administrator listed at the end of
this announcement.
MECHANISM OF SUPPORT
The NIEHS TIP Program will use the NIH Research Scholar
Development Award (K22). Responsibility for the planning,
direction, and execution of the proposed project will be
solely that of the applicant. The requested costs and project
period will be $100,000 (direct cost) per year for a maximum
of three years (a maximum of $300,000 direct costs). Scholar
Development grants (K22s) are not renewable but may be
extended at no additional costs at the discretion of the
sponsoring institution where the TIP award has been made.
The anticipated award date is September, 2001.
FUNDS AVAILABLE
The total estimated funds available for this Request for
Applications is approximately $500,000 which will support 4 to
5 awards. This level of support is dependent on the receipt
of a sufficient number of applications of high scientific
merit.
RESEARCH OBJECTIVES
Background
The Congress of the United States enacted the National
Research Service Act Program in 1974 to help ensure that
highly trained scientists would be available in adequate
numbers and in appropriate research areas to carry out the
Nation"s biomedical and behavioral research agenda. Under this
congressional authority, the National Institute of
Environmental Health Sciences (NIEHS) awards the NRSA
individual postdoctoral fellowship (F32) and Intramural
Research Training Award (IRTA) to the most promising
applicants to support full-time research training related to
the mission of the NIEHS. The goal of these and other
postdoctoral training programs is to develop the next
generation of exceptionally talented young scientists who are
committed to understanding the impact of environmental
exposures on human health. The NIEHS has determined that
there is a need for a mechanism to assist exceptionally
talented investigators in making the career transition from
postdoctoral training to independent academic research
positions. To meet this need, the NIEHS has initiated the TIP
Program to facilitate the transition of the most talented
postdoctoral investigators into career positions relevant to
the research priorities of the NIEHS.
Goals and Scope
The NIEHS TIP Program is designed for exceptionally talented
new environmental health scientists in basic, clinical or
population-based (epidemiology) research who have demonstrated
outstanding scientific abilities during their training. The
objective of the program is to provide a commitment of support
for the most promising new investigators early in their career
while they establish their independent research program in a
research intensive environment relevant to environmental
health sciences. The TIP investigators are expected to design
and pursue their research projects independently in their
areas of interest. It is anticipated the successful applicant
will use the award to establish an independent research
program and obtain preliminary data that will be the basis for
a future research application. Specifically, the TIP
investigator is expected to use the preliminary data as a
basis for an investigator initiated research grant (R01) or
equivalent to the NIH in an area of a science relevant to the
mission of the NIEHS within the first 24 months after
initiation of the award.
The NIEHS has identified priority areas of research that can
significantly contribute to our understanding of the impact of
environmental exposure on human health. Research proposals
which address one of these areas will receive a priority for
funding. The current areas of special emphasis are:
o Molecular Epidemiology (this is an emerging area of science
of particular importance to NIEHS)
o Basic Molecular Mechanisms of Environmental Insult
o Development of Alternative Models for Environmental Health
Research and Toxicology Testing
o Genetic Susceptibility
o Human Health Effects of Complex Mixtures
o Human Health Effects of Endocrine Disrupting Chemicals
o Role of the Environment in Neurodegenerative Diseases,
including Parkinson’s Disease
o Prevention Research-Molecular and Community-Based
Approaches
o Impact of Environmental Exposures on Special Populations
(Women, Children and Minorities)
Additional information about these research topics is
available on the NIEHS website at:
http://www.niehs.nih.gov/dert/programs/special/special.htm.
This site is updated each year.
GENERAL REQUIREMENTS
Individuals with a research or health professional doctoral
level degree or equivalent with no more than six years of
postdoctoral research training at the time of application, and
with demonstrated outstanding abilities in basic, clinical or
population-based (e.g., epidemiologic) research, are eligible
to apply. This includes individuals with postdoctoral
research experience in any environment (e.g., academic,
industry, government). Individuals who have had more than six
years of postdoctoral research experience are NOT eligible to
apply. However, years of clinical training will not count
against the six years of relevant research experience.
Individuals who have held research or other professorship or
equivalent positions in academe or elsewhere or have been
principal investigators on either PHS research grants (e.g.,
R29, R01, P01, or its subprojects) or non-PHS peer-reviewed
research grants are NOT eligible to apply for this award.
Minorities and women are encouraged to apply. Candidates must
be U.S. citizens or non-citizen nationals, or must have been
lawfully admitted for permanent residence and possess an Alien
Registration Card (I-151 or I-152) or some other verification
of legal admission as a permanent U.S. resident, at the time
of submission. Non-citizen nationals, although not U.S.
citizens, owe permanent allegiance to the U.S. They are
usually born in lands that are not states, but are under U.S.
sovereignty, jurisdictions, or administration. Individuals on
temporary or student visas are NOT eligible to apply. The TIP
K22 is a domestic U.S. award and may not be awarded to non-
U.S. grantee institutions.
SPECIFIC REQUIREMENTS
To be eligible to apply for a TIP Award the following
additional criteria will apply:
1. The applicant must be either:
A. A current or former NIEHS Individual National Research
Service Fellow (NRSA, F32), or
B. A current or former NIH Individual NRSA Fellow who is
training in an area specific to the mission of the NIEHS, but
whose support is from another
Institute, Center or Division (IC) of the NIH, or
C. A current NIEHS Intramural Research Training Awardee
(IRTA), staff fellow, or clinical fellow who has competed
successfully in the NIEHS Intramural eligibility process.
NIEHS clinical fellows with the M.D., M.D.-Ph.D., D.O.,
D.D.S., Pharm.D-MS, Pharm. D-Ph.D., RN-Ph.D or comparable
clinical or combined clinical/research degrees are eligible to
apply. In most cases, clinical fellow applicants will have
finished their clinical training and may have had some
research experience in either a laboratory or clinical setting
prior to an appointment in the NIEHS Intramural Program.
Clinical candidates should possess aptitudes for independent
research in clinically relevant, patient-oriented or
population- based research (e.g., epidemiology, behavior, or
disease prevention) areas. The Intramural contact person for
this program is Dr. Steven Akiyama, 919-541-3467 or
akiyama@niehs.nih.gov.
The NIEHS will return applications not considered relevant
either to the mission or to the research priorities of the
NIEHS as part of the initial review described in the section,
REVIEW CONSIDERATIONS of this Request for Applications. This
decision is final. Fellows are STRONGLY ENCOURAGED to contact
the program administrator listed at the end of this Request
for Applications to determine the priority and relevance of
his/her research topic to the NIEHS prior to submitting an
application. Applicants should identify an NIEHS area of
special emphasis that is relevant to his/her research
interests. This information is available on the NIEHS web
site at
http://www.niehs.nih.gov/dert/programs/special/special.htm.
2. The applicant must have COMPLETED at least 18 months of
postdoctoral training at the time of submission of an
application (Receipt Date Announced in the RFA).
3. The applicant must submit the application on a PHS
Research Grant Application form (PHS 398, rev. 4/98).
4. The applicant must include three letters of recommendation
which address the applicant’s potential to become an important
contributor to basic or clinical biomedical or behavioral
research or population-based (e.g., epidemiological) research
relevant to the mission of NIEHS. One of the letters of
recommendation must be from the current postdoctoral mentor
and one must be from the applicant’s predoctoral program,
preferably the mentor. Applications without letters of
recommendation will be considered incomplete and will not be
accepted. Late receipt of letters of recommendation (e.g.
letters not submitted with the application) will not be
allowed. Letters should be mailed directly to Dr. Linda Bass
at the address given in the Supplemental Instructions section
of this RFA.
Note: The letter from the current postdoctoral mentor should
address the following points.
1. The applicant’s role and intellectual contribution to the
laboratory research activities.
2. The current postdoctoral mentor’s role in the development
of the proposed project.
3. The applicant’s potential for independent research.
All applicants are encouraged to contact the NIEHS regarding
their eligibility for this award (see INQUIRIES section).
ALLOWABLE COSTS
The final budget for the TIP award will be $100,000 direct
cost per year for three years. The total direct costs for
this award are $300,000 over a period of three years.
Indirect costs will be reimbursed at eight percent of modified
total direct costs or at the actual indirect cost rate,
whichever is less.
The awardee and sponsoring institution will have considerable
latitude in deciding how these funds will be expended, with
the exception of salary (described below). This is to allow
sufficient flexibility and benefit the awardee’s research and
academic career.
1. Salary: The awardee may request up to $50,000 per year
(plus fringe benefits) from this award for salary. The award
does not require that salary support be derived from the
award, use of the entire direct costs for research related
expenses is allowed.
The total salary requested must be based on a full-time, 12
month staff appointment. It must be consistent both with the
established salary structure at the institution and with
salaries actually provided by the institution to other staff
members of equivalent qualifications, rank, and
responsibilities in the department.
2. Research-Related Expenses: The entire direct costs of this
award, or the balance remaining after subtracting the amount
devoted to salary, may be used for supplies, equipment,
technical personnel, travel and other research-related
expenses.
3. Ancillary Personnel Support: Salary for secretarial or
administrative assistance is not allowed.
AWARD PROCESS AND INITIATION
At the time a decision is made to make an award, the applicant
will be provided a Letter to Commitment Funds that states an
intent to commit funds which will be signed by the NIEHS
Grants Management Officer. This letter states the conditional
intent of the NIEHS to make a grant award and may be used by
the candidate when entering into negotiations for a position
with a suitable institution to document potential grant
support for the candidate’s research project. Please note
that this is different from the usual NIH process since this
commitment is not made initially to a specific institution.
After a TIP investigator has identified a permanent position,
preferably tenure-track or equivalent, at a research intensive
institution (sponsoring grantee institution), the sponsoring
institution will request that an award be issued by submitting
the appropriately prepared form PHS 398 (competing grant
application) that includes a detailed budget. The application
must also include letters from the institutional official
signing the application describing the position and confirming
that the TIP investigator has been offered and has accepted a
permanent, preferably tenure-track or equivalent, position.
In addition, a statement from the Department Chair or
equivalent official must be included which describes the
resources that will be available for the TIP investigator.
Finally, if the research involves animals/human subjects,
the certification that the protocols were approved by the
appropriate institutional committee of the designated grantee
institution must be provided. These and other relevant
materials are to be submitted to the NIEHS Grants Management
Office at the address listed on the Letter of Commitment.
These materials will be used by NIEHS staff to carefully
assess the appropriateness and soundness of the proposed
arrangement. The institution will be examined for its ability
to make a significant commitment of resources, time and other
factors conducive to the research project and career
establishment of the TIP investigator. In addition, the TIP
investigator must be appointed to a permanent position in a
research intensive environment relevant to environmental
health sciences. It is the intent of the NIEHS that the
applicant relocate to another, different research intensive
institution, and not remain at the current postdoctoral
institution. Arrangements in which a candidate moves from a
postdoctoral position to that of an assistant professor at the
same institution are specifically discouraged, and if proposed
by the TIP investigator, must document an especially strong,
compelling case for such a position’s eligibility for
consideration.
Please note that an award can ONLY be made after the TIP
investigator has accepted a position at a sponsoring
institution, and this has been confirmed by the institutional
official. Finally, it is important to note that no funds can
be obligated or used until the award has been made to a
grantee sponsoring institution.
NIEHS recognizes that each TIP investigator will have unique
circumstances that will affect the timing for the initiation
of the award. Thus, the NIEHS will allow the TIP investigator
up to eighteen months between the date of the Letter to Commit
Funds notice for funding an application and the start of a
permanent position at a research intensive institution.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN
SUBJECTS
It is the policy of the NIH that women and members of minority
groups and their subpopulations must be included in all NIH
supported biomedical and behavioral research projects
involving human subjects, unless a clear and compelling
rationale and justification is provided that inclusion is
inappropriate with respect to the health of the subjects or
the purpose of the research. This policy results from the NIH
Revitalization Act of 1993 (Section 492B of Public Law 103-
43).
All investigators proposing research involving human subjects
should read the
"NIH Guidelines For Inclusion of Women and Minorities as
Subjects in Clinical Research," which have been published in
the Federal Register of March 28, 1994 (FR 59 14508-14513) and
in the NIH Guide for Grants and Contracts, Vol. 23, No. 11,
March 18, 1994 available on the web at the following URL
address:
http://grants.nih.gov/grants/guide/notice-files/not94-100.html
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING
HUMAN SUBJECTS
It is the policy of NIH that children (i.e., individuals under
the age of 21) must be included in all human subjects
research, conducted or supported by the NIH, unless there are
scientific and ethical reasons not to include them. This
policy applies to all initial (Type 1) applications submitted
for receipt dates after October 1, 1998.
All investigators proposing research involving human subjects
should read the "NIH Policy and Guidelines on the Inclusion of
Children as Participants in Research Involving Human Subjects"
that was published in the NIH Guide for Grants and Contracts,
March 6, 1998, and is available at the following URL address:
http://grants.nih.gov/grants/guide/notice-files/not98-024.html
Investigators also may obtain copies of these policies from
the program staff listed under INQUIRIES. Program staff may
also provide additional relevant information concerning the
policy.
LETTER OF INTENT
Prospective applicants are asked to submit, by June 8, 2000, a
letter of intent that includes a descriptive title of the
proposed project, the name, address, and telephone number of
the Principal Investigator, the identities of other key
personnel and participating institutions if planned
collaborations are known, and the number and title of this
RFA. Although a letter of intent is not required, is not
binding, and does not enter into the review of subsequent
applications, the information that it contains is helpful in
planning for the review of applications. It allows NIEHS
staff to estimate the potential review workload and to avoid
conflict of interest in the review.
The letter of intent is to be sent to:
Linda Bass, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, EC-24
111 T.W. Alexander Drive, EC-24 (for express/courier service)
Research Triangle Park, NC 27709
Telephone: (919) 541-1307
FAX: (919) 541-2503
Email: bass@niehs.nih.gov
APPLICATION PROCEDURES
The research grant application form PHS 398 (rev. 4/98) is to
be used in applying for these grants. Application kits are
available at most institutional offices of sponsored research
and may be obtained from the Division of Extramural Outreach
and Information Resources, National Institutes of Health, 6701
Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone
301/710-0267, email: Grantsinfo@nih.gov.
SUPPLEMENTAL INSTRUCTIONS
The following supplemental instructions, which are provided as
specific additional information for this RFA announcement,
should be carefully noted:
Only one grant application may be submitted by a principal
investigator for a receipt date.
The Request for Applications title and number must be typed on
Line 2 of the face page of the application form and the YES
box must be marked.
The sample RFA label available at:
http://grants.nih.gov/grants/funding/phs398/label-bk.pdf has
been modified to allow for this change. Please note this is
in pdf format.
The applicant institution information requested on the face
page should be that for the institution from which the
application is being submitted. The abstract page (BB) should
appear as page two. The Detailed Budget for the Initial Budget
Period (Form Page 4-DD) and Budget for Entire Proposed Period
of Support (Form Page 5-EE) are NOT required for the initial
application and should be omitted. A detailed budget is
subsequently required only for the activation of the award at
the academic institution of employment. At that time,
applicants must budget travel costs associated with a
professional meeting (one per year) in their applications. The
project period for these awards is a maximum of three years.
The maximum amount awarded to each grantee on this Request for
Applications will be $300,000 direct costs for a three-year
project period. The amount awarded for any given year (budget
period) will not exceed $100,000 direct costs. Equipment will
be limited to $100,000 direct costs for the three-year project
period. The maximum salary allowed from this award is $50,000
per year.
A two section narrative presentation (two-page maximum) should
be inserted in the application just prior to the research plan
titled "Future Goals and Objectives" and "Biography",
respectively. In the Future Goals and Objectives section
(one-half page maximum), the applicant should briefly describe
his/her career track vision and describe the types of
positions to be pursued. In the Biography section (one and
one-half page maximum), the applicant should describe their
scientific development from graduate school through
postdoctoral experience(s). For each training experience, the
applicant should describe his/her role in the
laboratory/project and cite relevant publications that
resulted from the experience. The applicant should also
include in this section a short narrative on how the proposed
research project will lead to a successful R01 application.
The Research Plan itself (Specific Aims, Background and
Significance, Preliminary Studies, Research Design and Methods
sections) is not to exceed 15 pages. Tables and figures but
not the reference bibliography are included in the 15 page
limitation. Applications that exceed the page limitations
stated in this RFA announcement or the PHS 398 requirements
for font size (height or letters), type density (characters
per inch), and margins (see PHS 398 directions) will be
returned to the investigator.
The Research Plan is expected to follow the typical NIH grant
application organization and structure, and should include,
but is not limited to the following:
o a one page description (or less) of the long term research
goals and how his/her research program would impact on an
environmental health problem, and
o a specific testable hypothesis, and
o a set of specific aims to address the hypothesis, and
o methods to obtain data to satisfy the specific aims.
If the application is a revision of a previously considered
application, there should be a clear indication of changes
marked as indicated in the instructions for the PHS 398
application.
It is expected that a TIP award would provide an investigator
the opportunity to obtain the scientific data needed for a
subsequent investigator-initiated research grant (R01) or
equivalent to the NIH in an area of a science relevant to the
mission of the NIEHS.
Color/glossy photos may be submitted as an appendix, however,
the appendix may not be used to circumvent the page
limitation. Letters of recommendation are not considered
appendices, and do not count towards the 15-page limit.
The applicant must provide 1-3 publications from his/her Ph.D.
work and one publication from his/her postdoctoral work.
A PHS 398 form biographical sketch of the postdoctoral mentor
should be included in the application.
Submit a signed, typewritten original of the application,
including the checklist, and three signed, clear, and single-
sided photocopies in one package to:
CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)
At the time of submission, applicants are encouraged to send
two additional copies of the application to:
Linda Bass, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P. O. Box 12233, EC-24
111 T.W. Alexander Drive, EC-24 (for express/courier service)
Research Triangle Park, NC 27709
Applications must be received by July 12, 2000. If an
application is received
after that date, it will be returned to the applicant without
review.
REVIEW CONSIDERATIONS
Upon receipt, applications will be reviewed for completeness
by the Center for Scientific Review (CSR) and responsiveness
to the RFA by senior scientific staff of the Division of
Extramural Research and Training, NIEHS. Only those
applications considered to be responsive to the RFA will be
forwarded for peer review. Applications that are incomplete
and/or considered non-responsive to the Request for
Applications will be inactivated and returned to the applicant
without further consideration.
Applications that are complete and responsive to the RFA will
be evaluated for scientific and technical merit by a peer
review group convened by the NIEHS in accordance with the
standard NIH peer review procedures. As part of the initial
review process, those applications deemed to have the highest
scientific merit, generally the top half of applications under
review, will be discussed and assigned a priority score.
Applications judged to be in the lower half of applications
under review may or may not be discussed or assigned a
priority score.
Review Criteria
Candidate
o the applicants potential to become an important contributor
to basic, clinical or population-based (e.g., epidemiological)
research or behavioral science relevant to the mission of
NIEHS,
o the qualifications and research experience of the Principal
Investigator and staff, particularly, but not exclusively, in
the area of the proposed research.
Research Plan
o the originality, innovation and scientific or medical
significance of the project as to new concepts and ideas,
o the appropriateness and adequacy of the experimental
approach and methodology proposed to carry out the research,
the appropriateness of the work proposed to the experience
level of the principal investigator, the acknowledgment of
potential problem areas and consideration of alternative
tactics,
o the adequacy of plans to include both genders, minorities,
and their subgroups as appropriate for the scientific goals of
any clinical research activities. Plans for the recruitment
and retention of subjects will also be evaluated.
o the adequacy of the proposed protection for humans,
animals, or the environment to the extent they may be
adversely affected by the activities proposed in the
application.
Budget
o Although a budget is not required, the appropriateness of
the scope of work for the funds that are available through
this grant will be considered. The applicant should assume
that general laboratory equipment items such as
spectrophotometer, centrifuges, etc., will be available at the
institution. However, highly sophisticated or limited use
equipment required for the studies should be identified and
funds for the use of such equipment should be considered by
the applicant in developing the research plan. For example,
magnetic resonance imaging equipment and fluorescence cell
sorters are available for a fee at many institutions, and the
cost for their use should be considered by the applicant.
AWARD CRITERIA
The anticipated date of notification of a Letter to Commit
Funds is March-April, 2001. The following will be considered
in making funding decisions:
o potential of the applicant to make a significant
contribution to the NIEHS mission,
o quality of the proposed projects scientific merit as
determined by peer review,
o availability of funds, and
o program balance among research areas of the announcement.
INQUIRIES
Written and telephone inquiries concerning this Request for
Applications are encouraged. The opportunity to clarify any
issues or questions from potential applicants is welcome.
Direct inquiries regarding programmatic issues to:
Michael E. McClure, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, EC-23
111 T.W. Alexander Drive, EC-23 (for express/courier service)
Research Triangle Park, NC 27709
Telephone: (919) 541-7825
FAX: (919) 541-5064
Email: mm461n@nih.gov
Direct inquiries regarding fiscal matters to:
Ms. Dorothy Duke
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P. O. Box 12233, EC-22
111 T.W. Alexander Drive, EC-22 (for express/courier service)
Research Triangle Park, NC 27709
Telephone: (919) 541-1373
FAX: (919) 541-5064
Email: Duke3@niehs.nih.gov
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic
Assistance No. 93.113 and 93.115. Awards are made under
authorization of Sections 301 and 405 of the Public Health
Service Act, as amended (42 USC 241 and 284) and
administered under NIH grants policies and Federal Regulations
42 CFR 52 and 45 CFR Part 74 and 92. This program is not
subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.
The Public Health Service (PHS) strongly encourages all grant
and contract recipients to provide a smoke-free workplace and
promote the non-use of all tobacco products. In addition,
Public Law 103-227, the Pro Children Act of 1994, prohibits
smoking in certain facilities (or in some cases, any portion
of a facility) in which regular or routine education, library,
day care, health care or early childhood development services
are provided to children. This is consistent with the PHS
mission to protect and advance the physical and mental health
of the American people.
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