TRANSITION TO INDEPENDENT POSITIONS (TIP)

Release Date:  April 3, 2000

RFA:  ES-00-001

National Institute of Environmental Health Sciences

Letter of Intent Receipt Date:  June 8, 2000
Application Receipt Date:       July 12, 2000

PURPOSE

Human health and human disease result from three interactive 
elements:  (1) environmental exposures, (2) individual 
susceptibility, and (3) time.  The mission of the National 
Institute of Environmental Health Sciences (NIEHS) is to 
reduce the burden of human illness and dysfunction from 
environmental exposures by understanding each of these 
elements and how they interrelate.  The NIEHS achieves its 
mission through multi-disciplinary biomedical research 
programs, prevention and intervention efforts, and 
communication strategies that encompass training, education, 
technology transfer, and community outreach.

An important element of the NIEHS mission is to develop the 
next generation of exceptionally talented young scientists who 
are committed to understanding the impact of environmental 
exposures on human health.  The NIEHS TIP Program is a 
Research Scholar Development Award (K22) program targeted to 
talented postdoctoral scientists.  It provides a unique 
mechanism for attracting and supporting exceptionally talented 
new investigators who can impact our understanding of the 
problems and mechanisms associated with exposure to 
environmental agents in order to better protect the public 
health.

HEALTHY PEOPLE 2010

The Public Health Service (PHS) is committed to achieving the 
health promotion and disease prevention objectives of "Healthy 
People 2010," a PHS-led national activity for setting priority 
areas.  This Request for Applications (RFA), Transition to 
Independent Positions (TIP), is related to the priority area 
of Environmental Health.  Potential applicants may obtain a 
copy of "Healthy People 2010" at 
http://www.health.gov/healthypeople/ .

ELIGIBILITY REQUIREMENTS

There are specific eligibility criteria that must be met in 
order to apply for this program.  If an applicant is uncertain 
of his/her eligibility, he/she is strongly encouraged to 
contact the program administrator listed at the end of
this announcement.

MECHANISM OF SUPPORT

The NIEHS TIP Program will use the NIH Research Scholar 
Development Award (K22).  Responsibility for the planning, 
direction, and execution of the proposed project will be 
solely that of the applicant.  The requested costs and project 
period will be $100,000 (direct cost) per year for a maximum 
of three years (a maximum of $300,000 direct costs).  Scholar 
Development grants (K22s) are not renewable but may be 
extended at no additional costs at the discretion of the 
sponsoring institution where the TIP award has been made.
The anticipated award date is September, 2001.

FUNDS AVAILABLE

The total estimated funds available for this Request for 
Applications is approximately $500,000 which will support 4 to 
5 awards.  This level of support is dependent on the receipt 
of a sufficient number of applications of high scientific 
merit.

RESEARCH OBJECTIVES

Background

The Congress of the United States enacted the National 
Research Service Act Program in 1974 to help ensure that 
highly trained scientists would be available in adequate 
numbers and in appropriate research areas to carry out the 
Nation"s biomedical and behavioral research agenda. Under this 
congressional authority, the National Institute of 
Environmental Health Sciences (NIEHS) awards the NRSA 
individual postdoctoral fellowship (F32) and Intramural 
Research Training Award (IRTA) to the most promising 
applicants to support full-time research training related to 
the mission of the NIEHS.  The goal of these and other 
postdoctoral training programs is to develop the next 
generation of exceptionally talented young scientists who are 
committed to understanding the impact of environmental 
exposures on human health.  The NIEHS has determined that 
there is a need for a mechanism to assist exceptionally 
talented investigators in making the career transition from 
postdoctoral training to independent academic research 
positions.  To meet this need, the NIEHS has initiated the TIP 
Program to facilitate the transition of the most talented 
postdoctoral investigators into career positions relevant to 
the research priorities of the NIEHS.

Goals and Scope

The NIEHS TIP Program is designed for exceptionally talented 
new environmental health scientists in basic, clinical or 
population-based (epidemiology) research who have demonstrated 
outstanding scientific abilities during their training.  The 
objective of the program is to provide a commitment of support 
for the most promising new investigators early in their career 
while they establish their independent research program in a 
research intensive environment relevant to environmental 
health sciences.  The TIP investigators are expected to design 
and pursue their research projects independently in their 
areas of interest.  It is anticipated the successful applicant 
will use the award to establish an independent research 
program and obtain preliminary data that will be the basis for 
a future research application.  Specifically, the TIP 
investigator is expected to use the preliminary data as a 
basis for an investigator initiated research grant (R01) or 
equivalent to the NIH in an area of a science relevant to the 
mission of the NIEHS within the first 24 months after 
initiation of the award.

The NIEHS has identified priority areas of research that can 
significantly contribute to our understanding of the impact of 
environmental exposure on human health.  Research proposals 
which address one of these areas will receive a priority for 
funding.  The current areas of special emphasis are:

o  Molecular Epidemiology (this is an emerging area of science 
of particular importance to NIEHS)

o  Basic Molecular Mechanisms of Environmental Insult

o  Development of Alternative Models for Environmental Health 
Research and Toxicology Testing

o  Genetic Susceptibility

o  Human Health Effects of Complex Mixtures

o  Human Health Effects of Endocrine Disrupting Chemicals

o  Role of the Environment in Neurodegenerative Diseases, 
including Parkinson’s Disease

o  Prevention Research-Molecular and Community-Based 
Approaches

o  Impact of Environmental Exposures on Special Populations 
(Women, Children and Minorities)

Additional information about these research topics is 
available on the NIEHS website at:    
http://www.niehs.nih.gov/dert/programs/special/special.htm.  
This site is updated each year.

GENERAL REQUIREMENTS

Individuals with a research or health professional doctoral 
level degree or equivalent with no more than six years of 
postdoctoral research training at the time of application, and 
with demonstrated outstanding abilities in basic, clinical or 
population-based (e.g., epidemiologic) research, are eligible 
to apply.  This includes individuals with postdoctoral 
research experience in any environment (e.g., academic, 
industry, government).  Individuals who have had more than six 
years of postdoctoral research experience  are NOT eligible to 
apply.  However, years of clinical training will not count 
against the six years of relevant research experience. 
Individuals who have held research or other professorship or 
equivalent positions in academe or elsewhere or have been 
principal investigators on either PHS research grants (e.g., 
R29, R01, P01, or its subprojects) or non-PHS peer-reviewed 
research grants are NOT eligible to apply for this award.

Minorities and women are encouraged to apply.  Candidates must 
be U.S. citizens or non-citizen nationals, or must have been 
lawfully admitted for permanent residence and possess an Alien 
Registration Card (I-151 or I-152) or some other verification 
of legal admission as a permanent U.S. resident, at the time 
of submission.  Non-citizen nationals, although not U.S. 
citizens, owe permanent allegiance to the U.S.  They are 
usually born in lands that are not states, but are under U.S. 
sovereignty, jurisdictions, or administration.  Individuals on 
temporary or student visas are NOT eligible to apply.  The TIP 
K22 is a domestic U.S. award and may not be awarded to non- 
U.S. grantee institutions.  

SPECIFIC REQUIREMENTS

To be eligible to apply for a TIP Award the following 
additional criteria will apply:

1.  The applicant must be either:

A.  A current or former NIEHS Individual National Research 
Service Fellow (NRSA, F32), or

B.  A current or former NIH Individual NRSA Fellow who is 
training in an area specific to the mission of the NIEHS, but 
whose support is from another
Institute, Center or Division (IC) of the NIH, or

C.  A current NIEHS Intramural Research Training Awardee 
(IRTA), staff fellow, or clinical fellow who has competed 
successfully in the NIEHS Intramural eligibility process.  
NIEHS clinical fellows with the M.D., M.D.-Ph.D., D.O., 
D.D.S., Pharm.D-MS, Pharm. D-Ph.D., RN-Ph.D or comparable 
clinical or combined clinical/research degrees are eligible to 
apply.  In most cases, clinical fellow applicants will have 
finished their clinical training and may have had some 
research experience in either a laboratory or clinical setting 
prior to an appointment in the NIEHS Intramural Program. 
Clinical candidates should possess aptitudes for independent 
research in clinically relevant, patient-oriented or 
population- based research (e.g., epidemiology, behavior, or 
disease prevention) areas.  The Intramural contact person for 
this program is Dr. Steven Akiyama, 919-541-3467 or 
akiyama@niehs.nih.gov.
     
The NIEHS will return applications not considered relevant 
either to the mission or to the research priorities of the 
NIEHS as part of the initial review described in the section, 
REVIEW CONSIDERATIONS of this Request for Applications.  This 
decision is final.  Fellows are STRONGLY ENCOURAGED to contact 
the program administrator listed at the end of this Request 
for Applications to determine the priority and relevance of 
his/her research topic to the NIEHS prior to submitting an 
application.  Applicants should identify an NIEHS area of 
special emphasis that is relevant to his/her research 
interests.  This information is available on the NIEHS web 
site at 
http://www.niehs.nih.gov/dert/programs/special/special.htm. 

2.  The applicant must have COMPLETED at least 18 months of 
postdoctoral training at the time of submission of an 
application (Receipt Date Announced in the RFA).

3.  The applicant must submit the application on a PHS 
Research Grant Application form (PHS 398, rev. 4/98).

4.  The applicant must include three letters of recommendation 
which address the applicant’s potential to become an important 
contributor to basic or clinical biomedical or behavioral 
research or population-based (e.g., epidemiological) research 
relevant to the mission of NIEHS.  One of the letters of 
recommendation must be from the current postdoctoral mentor 
and one must be from the applicant’s predoctoral program, 
preferably the mentor.  Applications without letters of 
recommendation will be considered incomplete and will not be 
accepted.  Late receipt of letters of recommendation (e.g. 
letters not submitted with the application) will not be 
allowed.  Letters should be mailed directly to Dr. Linda Bass 
at the address given in the Supplemental Instructions section 
of this RFA. 

Note: The letter from the current postdoctoral mentor should 
address the following points.

1.  The applicant’s role and intellectual contribution to the 
laboratory research activities.

2.  The current postdoctoral mentor’s role in the development 
of the proposed project.

3.  The applicant’s potential for independent research.

All applicants are encouraged to contact the NIEHS regarding 
their eligibility for this award (see INQUIRIES section).

ALLOWABLE COSTS

The final budget for the TIP award will be $100,000 direct 
cost per year for three years.  The total direct costs for 
this award are $300,000 over a period of three years.  
Indirect costs will be reimbursed at eight percent of modified
total direct costs or at the actual indirect cost rate, 
whichever is less.

The awardee and sponsoring institution will have considerable 
latitude in deciding how these funds will be expended, with 
the exception of salary (described below).  This is to allow 
sufficient flexibility and benefit the awardee’s research and 
academic career.

1. Salary:  The awardee may request up to $50,000 per year 
(plus fringe benefits) from this award for salary.  The award 
does not require that salary support be derived from the 
award, use of the entire direct costs for research related 
expenses is allowed.

The total salary requested must be based on a full-time, 12 
month staff appointment.  It must be consistent both with the 
established salary structure at the institution and with 
salaries actually provided by the institution to other staff 
members of equivalent qualifications, rank, and 
responsibilities in the department.

2.  Research-Related Expenses: The entire direct costs of this 
award, or the balance remaining after subtracting the amount 
devoted to salary, may be used for supplies, equipment, 
technical personnel, travel and other research-related
expenses.

3.  Ancillary Personnel Support:  Salary for secretarial or 
administrative assistance is not allowed.

AWARD PROCESS AND INITIATION

At the time a decision is made to make an award, the applicant 
will be provided a Letter to Commitment Funds that states an 
intent to commit funds which will be signed by the NIEHS 
Grants Management Officer. This letter states the conditional 
intent of the NIEHS to make a grant award and may be used by 
the candidate when entering into negotiations for a position 
with a suitable institution to document potential grant 
support for the candidate’s research project.  Please note 
that this is different from the usual NIH process since this 
commitment is not made initially to a specific institution.

After a TIP investigator has identified a permanent position, 
preferably tenure-track or equivalent, at a research intensive 
institution (sponsoring grantee institution), the sponsoring 
institution will request that an award be issued by submitting 
the appropriately prepared form PHS 398 (competing grant 
application) that includes a detailed budget.  The application 
must also include letters from the institutional official 
signing the application describing the position and confirming 
that the TIP investigator has been offered and has accepted a 
permanent, preferably tenure-track or equivalent, position.  
In addition, a statement from the Department Chair or 
equivalent official must be included which describes the 
resources that will be available for the TIP investigator.  
Finally, if the research involves animals/human subjects,
the certification that the protocols were approved by the 
appropriate institutional committee of the designated grantee 
institution must be provided.  These and other relevant 
materials are to be submitted to the NIEHS Grants Management 
Office at the address listed on the Letter of Commitment.

These materials will be used by NIEHS staff to carefully 
assess the appropriateness and soundness of the proposed 
arrangement.  The institution will be examined for its ability 
to make a significant commitment of resources, time and other 
factors conducive to the research project and career 
establishment of the TIP investigator.  In addition, the TIP 
investigator must be appointed to a permanent position in a 
research intensive environment relevant to environmental 
health sciences.  It is the intent of the NIEHS that the 
applicant relocate to another, different research intensive 
institution, and not remain at the current postdoctoral 
institution. Arrangements in which a candidate moves from a 
postdoctoral position to that of an assistant professor at the 
same institution are specifically discouraged, and if proposed 
by the TIP investigator, must document an especially strong, 
compelling case for such a position’s eligibility for 
consideration.

Please note that an award can ONLY be made after the TIP 
investigator has accepted a position at a sponsoring 
institution, and this has been confirmed by the institutional 
official. Finally, it is important to note that no funds can 
be obligated or used until the award has been made to a 
grantee sponsoring institution.

NIEHS recognizes that each TIP investigator will have unique 
circumstances that will affect the timing for the initiation 
of the award.  Thus, the NIEHS will allow the TIP investigator 
up to eighteen months between the date of the Letter to Commit 
Funds notice for funding an application and the start of a 
permanent position at a research intensive institution.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN 
SUBJECTS

It is the policy of the NIH that women and members of minority 
groups and their subpopulations must be included in all NIH 
supported biomedical and behavioral research projects 
involving human subjects, unless a clear and compelling 
rationale and justification is provided that inclusion is 
inappropriate with respect to the health of the subjects or 
the purpose of the research. This policy results from the NIH 
Revitalization Act of 1993 (Section 492B of Public Law 103-
43).

All investigators proposing research involving human subjects 
should read the
"NIH Guidelines For Inclusion of Women and Minorities as 
Subjects in Clinical Research," which have been published in 
the Federal Register of March 28, 1994 (FR 59 14508-14513) and 
in the NIH Guide for Grants and Contracts, Vol. 23, No. 11, 
March 18, 1994 available on the web at the following URL 
address: 

http://grants.nih.gov/grants/guide/notice-files/not94-100.html

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING 
HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under 
the age of 21) must be included in all human subjects 
research, conducted or supported by the NIH, unless there are 
scientific and ethical reasons not to include them. This 
policy applies to all initial (Type 1) applications submitted 
for receipt dates after October 1, 1998.

All investigators proposing research involving human subjects 
should read the "NIH Policy and Guidelines on the Inclusion of 
Children as Participants in Research Involving Human Subjects" 
that was published in the NIH Guide for Grants and Contracts, 
March 6, 1998, and is available at the following URL address: 
http://grants.nih.gov/grants/guide/notice-files/not98-024.html

Investigators also may obtain copies of these policies from 
the program staff listed under INQUIRIES.  Program staff may 
also provide additional relevant information concerning the 
policy.

LETTER OF INTENT

Prospective applicants are asked to submit, by June 8, 2000, a 
letter of intent that includes a descriptive title of the 
proposed project, the name, address, and telephone number of 
the Principal Investigator, the identities of other key
personnel and participating institutions if planned 
collaborations are known, and the number and title of this 
RFA.  Although a letter of intent is not required, is not 
binding, and does not enter into the review of subsequent 
applications, the information that it contains is helpful in 
planning for the review of applications.  It allows NIEHS 
staff to estimate the potential review workload and to avoid 
conflict of interest in the review.

The letter of intent is to be sent to:

Linda Bass, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, EC-24
111 T.W. Alexander Drive, EC-24 (for express/courier service)
Research Triangle Park, NC  27709
Telephone:  (919) 541-1307
FAX:  (919) 541-2503
Email:  bass@niehs.nih.gov

APPLICATION PROCEDURES

The research grant application form PHS 398 (rev. 4/98) is to 
be used in applying for these grants. Application kits are 
available at most institutional offices of sponsored research 
and may be obtained from the Division of Extramural Outreach 
and Information Resources, National Institutes of Health, 6701 
Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 
301/435-0714, email:  Grantsinfo@nih.gov.

SUPPLEMENTAL INSTRUCTIONS

The following supplemental instructions, which are provided as 
specific additional information for this RFA announcement, 
should be carefully noted:

Only one grant application may be submitted by a principal 
investigator for a receipt date.

The Request for Applications title and number must be typed on 
Line 2 of the face page of the application form and the YES 
box must be marked.

The sample RFA label available at: 
http://grants.nih.gov/grants/funding/phs398/label-bk.pdf has 
been modified to allow for this change.  Please note this is 
in pdf format.

The applicant institution information requested on the face 
page should be that for the institution from which the 
application is being submitted. The abstract page (BB) should 
appear as page two. The Detailed Budget for the Initial Budget 
Period (Form Page 4-DD) and Budget for Entire Proposed Period 
of Support (Form Page 5-EE) are NOT required for the initial 
application and should be omitted.  A detailed budget is 
subsequently required only for the activation of the award at 
the academic institution of employment.  At that time, 
applicants must budget travel costs associated with a 
professional meeting (one per year) in their applications. The 
project period for these awards is a maximum of three years.  
The maximum amount awarded to each grantee on this Request for 
Applications will be $300,000 direct costs for a three-year 
project period.  The amount awarded for any given year (budget 
period) will not exceed $100,000 direct costs.  Equipment will 
be limited to $100,000 direct costs for the three-year project 
period.  The maximum salary allowed from this award is $50,000 
per year.

A two section narrative presentation (two-page maximum) should 
be inserted in the application just prior to the research plan 
titled "Future Goals and Objectives" and "Biography", 
respectively.  In the Future Goals and Objectives section 
(one-half page maximum), the applicant should briefly describe 
his/her career track vision and describe the types of 
positions to be pursued.  In the Biography section (one and 
one-half page maximum), the applicant should describe their 
scientific development from graduate school through 
postdoctoral experience(s).  For each training experience, the 
applicant should describe his/her role in the 
laboratory/project and cite relevant publications that 
resulted from the experience.  The applicant should also 
include in this section a short narrative on how the proposed 
research project will lead to a successful R01 application.

The Research Plan itself (Specific Aims, Background and 
Significance, Preliminary Studies, Research Design and Methods 
sections) is not to exceed 15 pages.  Tables and figures but 
not the reference bibliography are included in the 15 page 
limitation.  Applications that exceed the page limitations 
stated in this RFA announcement or the PHS 398 requirements 
for font size (height or letters), type density (characters 
per inch), and margins (see PHS 398 directions) will be 
returned to the investigator.

The Research Plan is expected to follow the typical NIH grant 
application organization and structure, and should include, 
but is not limited to the following:

o  a one page description (or less) of the long term research 
goals and how his/her research program would impact on an 
environmental health problem, and

o  a specific testable hypothesis, and

o  a set of specific aims to address the hypothesis, and

o  methods to obtain data to satisfy the specific aims.

If the application is a revision of a previously considered 
application, there should be a clear indication of changes 
marked as indicated in the instructions for the PHS 398 
application.

It is expected that a TIP award would provide an investigator 
the opportunity to obtain the scientific data needed for a 
subsequent investigator-initiated research grant (R01) or 
equivalent to the NIH in an area of a science relevant to the 
mission of the NIEHS.

Color/glossy photos may be submitted as an appendix, however, 
the appendix may not be used to circumvent the page 
limitation.  Letters of recommendation are not considered 
appendices, and do not count towards the 15-page limit.

The applicant must provide 1-3 publications from his/her Ph.D. 
work and one publication from his/her postdoctoral work.

A PHS 398 form biographical sketch of the postdoctoral mentor 
should be included in the application.

Submit a signed, typewritten original of the application, 
including the checklist, and three signed, clear, and single-
sided photocopies in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)

At the time of submission, applicants are encouraged to send 
two additional copies of the application to:

Linda Bass, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P. O. Box 12233, EC-24
111 T.W. Alexander Drive, EC-24 (for express/courier service)
Research Triangle Park, NC  27709

Applications must be received by July 12, 2000.  If an 
application is received
after that date, it will be returned to the applicant without 
review.

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed for completeness 
by the Center for Scientific Review (CSR) and responsiveness 
to the RFA by senior scientific staff of the Division of 
Extramural Research and Training, NIEHS.  Only those 
applications considered to be responsive to the RFA will be 
forwarded for peer review.  Applications that are incomplete 
and/or considered non-responsive to the Request for 
Applications will be inactivated and returned to the applicant 
without further consideration.

Applications that are complete and responsive to the RFA will 
be evaluated for scientific and technical merit by a peer 
review group convened by the NIEHS in accordance with the 
standard NIH peer review procedures.  As part of the initial 
review process, those applications deemed to have the highest 
scientific merit, generally the top half of applications under 
review, will be discussed and assigned a priority score.  
Applications judged to be in the lower half of applications 
under review may or may not be discussed or assigned a 
priority score.

Review Criteria

Candidate

o  the applicants potential to become an important contributor 
to basic, clinical or population-based (e.g., epidemiological) 
research or behavioral science relevant to the mission of 
NIEHS,

o  the qualifications and research experience of the Principal 
Investigator and staff, particularly, but not exclusively, in 
the area of the proposed research.

Research Plan

o  the originality, innovation and scientific or medical 
significance of the project as to new concepts and ideas,

o  the appropriateness and adequacy of the experimental 
approach and methodology proposed to carry out the research, 
the appropriateness of the work proposed to the experience 
level of the principal investigator, the acknowledgment of 
potential problem areas and consideration of alternative 
tactics,

o  the adequacy of plans to include both genders, minorities, 
and their subgroups as appropriate for the scientific goals of 
any clinical research activities.  Plans for the recruitment 
and retention of subjects will also be evaluated.

o  the adequacy of the proposed protection for humans, 
animals, or the environment to the extent they may be 
adversely affected by the activities proposed in the 
application.

Budget

o  Although a budget is not required, the appropriateness of 
the scope of work for the funds that are available through 
this grant will be considered.  The applicant should assume 
that general laboratory equipment items such as
spectrophotometer, centrifuges, etc., will be available at the 
institution. However, highly sophisticated or limited use 
equipment required for the studies should be identified and 
funds for the use of such equipment should be considered by 
the applicant in developing the research plan.  For example, 
magnetic resonance imaging equipment and fluorescence cell 
sorters are available for a fee at many institutions, and the 
cost for their use should be considered by the applicant.

AWARD CRITERIA

The anticipated date of notification of a Letter to Commit 
Funds is March-April, 2001.  The following will be considered 
in making funding decisions:

o  potential of the applicant to make a significant 
contribution to the NIEHS mission,

o  quality of the proposed projects scientific merit as 
determined by peer review,

o  availability of funds, and

o  program balance among research areas of the announcement.

INQUIRIES

Written and telephone inquiries concerning this Request for 
Applications are encouraged.  The opportunity to clarify any 
issues or questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Michael E. McClure, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, EC-23
111 T.W. Alexander Drive, EC-23 (for express/courier service)
Research Triangle Park, NC  27709
Telephone:  (919) 541-7825
FAX:  (919) 541-5064
Email:  mm461n@nih.gov

Direct inquiries regarding fiscal matters to:

Ms. Dorothy Duke
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P. O. Box 12233, EC-22
111 T.W. Alexander Drive, EC-22 (for express/courier service)
Research Triangle Park, NC  27709
Telephone:  (919) 541-1373
FAX:  (919) 541-5064
Email:  Duke3@niehs.nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic 
Assistance No. 93.113 and 93.115. Awards are made under 
authorization of Sections 301 and 405 of the Public Health 
Service Act, as amended  (42 USC 241 and 284) and  
administered under NIH grants policies and Federal Regulations 
42 CFR 52 and 45 CFR Part 74 and 92.  This program is not 
subject to the intergovernmental review requirements of 
Executive Order 12372 or Health Systems Agency review.

The Public Health Service (PHS) strongly encourages all grant 
and contract recipients to provide a smoke-free workplace and 
promote the non-use of all tobacco products.  In addition, 
Public Law 103-227, the Pro Children Act of 1994, prohibits 
smoking in certain facilities (or in some cases, any portion 
of a facility) in which regular or routine education, library, 
day care, health care or early childhood development services 
are provided to children.  This is consistent with the PHS 
mission to protect and advance the physical and mental health 
of the American people.



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