United States Department of Health and Human Services (HHS)
Participating
Organizations
Centers for Disease Control and Prevention (CDC) (http://www.cdc.gov/)
Agency for Toxic Substances and Disease Registry (http://www.atsdr.cdc.gov)
Components of
Participating Organizations
Office of Public Health Research
(OPHR/CDC), http://www.cdc.gov/od/science/PHResearch/)
Coordinating Office for Global
Health (COGH/CDC), http://www.cdc.gov/cogh/
Coordinating Office for Terrorism
Preparedness and Emergency Response (COTPER/CDC), http://www.cdc.gov/maso/pdf/COTPERfs.pdf
National Center for
Injury Prevention and Control (NCIPC/CDC), (http://www.cdc.gov/ncipc/)
National Center for
Environmental Health (NCEH/CDC), http://www.cdc.gov/nceh/default.htm
National Center for
Health Statistics (NCHS/CDC), http://www.cdc.gov/nchs/
National Center for
Health Marketing (NCHM/CDC), http://www.cdc.gov/healthmarketing/
National Center for
Chronic Disease Prevention and Health Promotion (NCCDPHP/CDC), http://www.cdc.gov/nccdphp/
National Center on
Birth Defects and Developmental Disabilities (NCBDDD/CDC), http://www.cdc.gov/ncbddd/
National Office of Public Health
Genomics (NOPHG/CDC), http://www.cdc.gov/genomics/
National Center for
Immunization and Respiratory Diseases (NCIRD/CDC)
National Center for
Zoonotic, Vector-Borne and Enteric Disease (NCZVED/CDC)
National Center for
HIV, Viral Hepatitis, STDs and Tuberculosis Prevention (NCHHSTP/CDC)
National Center for
Preparedness, Detection and Control of Infectious Diseases (NCPDCID/CDC)
National Institute for Occupational
Safety and Health (NIOSH/CDC), http://www.cdc.gov/niosh/homepage.html
Office of Minority Health and Health
Disparities (OMHD/CDC), http://www.cdc.gov/omhd/
Office of the Chief of Public Health
Practice (OCPHP/CDC), http://www.cdc.gov/od/ocphp/
Title: Improving Public Health Practice through Translation Research (R18)
The policies, guidelines, terms, and conditions of the HHS Centers for Disease Control and Prevention (CDC) stated in this announcement may differ from those used by the HHS National Institutes of Health (NIH). If written guidance for completing this application is not available on the CDC website, then applicants will be directed elsewhere for that information.
Authority: Sections 301 and 317(k)(2) of the Public Health Service Act [42 U.S.C. 241 and 247b(k)(2)], and Section 104(i) of the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9604(i)].
Announcement
Type
New
Instructions for Submission of Electronic Research Applications:
NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants.gov (http://www.grants.gov) using the SF424 Research and Related (R&R) forms and the SF424 (R&R) Application Guide.
APPLICATIONS MAY NOT BE SUBMITTED IN PAPER FORMAT
This FOA must be read in conjunction with the application package instructions included with this announcement on Grants.gov/Apply for Grants (hereafter referred to as, Grants.gov/Apply.)
A registration process is necessary before submission, and applicants are highly encouraged to start the process at least four weeks prior to the grant submission date. See Section IV.
Two steps are required for on time submission:
1) The application must be successfully received by Grants.gov no later than 5:00 p.m. Eastern Standard Time on the application submission receipt date (see “Key Dates” below.)
2) Applicants must complete a verification step in the Electronic Research Administration (eRA Commons) within two business days of notification. Note: Since email can be unreliable, it is the responsibility of the applicant to periodically check on their application status in the eRA Commons.
Funding Opportunity Announcement (FOA) Number: RFA-CD-07-005Key
Dates
Release
Date: February 16, 2007
Letter
of Intent Receipt Date: March 12, 2007
Application
Submission Receipt Date(s): April 10, 2007
Peer Review Date(s): June 2007
Council Review Date(s): June/July
2007
Earliest
Anticipated Start Date(s): September 2007
Additional
Information to Be Available Date: Not applicable
Expiration
Date: April 11, 2007
Due Date for E.O. 12372
Executive Order 12372 does not apply to this program.
Additional Overview Content
Executive Summary
A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If you are applying as a bona fide agent of a state or local government, you must provide a letter from the state or local government as documentation of your status. Attach this documentation behind the first page of your application form or for electronic applications, use a PDF file and attach as “Other Documents” and label as appropriate.
Funding Opportunity Announcement Glossary: FOA Glossary Terminology
Table of Contents
Part I Overview Information
Part II Full Text of Announcement
Section I. Funding Opportunity
Description
1. Research Objectives
Section II. Award Information
1. Mechanism(s) of Support
2. Funds Available
Section III. Eligibility
Information
1. Eligible Applicants
A. Eligible Institutions
B. Eligible Investigators
2.Cost Sharing or Matching
3.Other - Special Eligibility Criteria
Section IV. Application and
Submission Information
1. Request Application Information
2. Content and Form of Application
Submission
3. Submission Dates and Times
A. Receipt and Review and
Anticipated Start Dates
1. Letter of
Intent
B. Submitting an
Application to CDC
C. Application Processing
4. Intergovernmental Review
5. Funding Restrictions
6. Other Submission Requirements
Section V. Application Review
Information
1. Criteria
2. Review and Selection Process
A. Additional Review
Criteria
B. Additional Review
Considerations
C. Sharing Research Data
D. Sharing Research
Resources
3. Anticipated Announcement and Award
Dates
Section VI. Award Administration
Information
1. Award Notices
2. Administrative and National Policy
Requirements
A. Cooperative Agreement
1. Recipient Rights and Responsibilities
2. HHS/CDC Responsibilities
3.
Collaborative Responsibilities
3. Reporting
Section VII. Agency Contact(s)
1. Scientific/Research Contact(s)
2. Peer Review Contact(s)
3. Financial/ Grants Management
Contact(s)
4. General Questions Contact(s)
Section VIII. Other Information
- Required Federal Citations
Part II - Full Text of Announcement
Section I. Funding Opportunity Description
1. Research Objectives
The CDC within HHS is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010" and to measuring program performance as stipulated by the Government Performance and Review Act (GPRA). This RFA addresses “Healthy People 2010” priority area(s) of Prevention Research (Chapter 23, Section 17) and is in alignment with CDC’s performance goal(s) to support prevention research to develop sustainable and transferable community-based behavioral interventions. For more information, see www.health.gov/healthypeople and www.whitehouse.gov/omb/mgmt-gpra/.
The purpose of this RFA is the achievement of new scientific knowledge that can accelerate the translation of research findings into public health practice through implementation, dissemination, and diffusion research. The specific objective of the RFA is to conduct translation research using an evidence-based intervention or policy. Proposed research should identify: 1) impediments and/or facilitators to the successful translation of evidence-based public health intervention(s); 2) methodological tools for the successful translation of evidence-based programs, practices, or policies; that retain fidelity, and achieve positive outcomes for target populations; or 3) optimal strategies to enhance the widespread adoption and institutionalization of effective public health intervention programs.
Background
The Center for Disease Control and Prevention (CDC) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010" and the “CDC Health Protection Goals” while measuring program performance as stipulated by the Government Performance and Review Act (GPRA). This RFA addresses “Healthy People 2010” priority area(s) of Educational and Community-Based Programs and is supportive of CDC’s Health Protection four overarching Goals regarding healthy people, healthy places, preparedness, and global health. These Goals create the framework to increase the capacity to accelerate health impact and reduce health disparities. For more information, see www.health.gov/healthypeople, http://www.cdc.gov/about/goals and www.whitehouse.gov/omb/mgmt-gpra/.
CDC’s ultimate goal is to increase the spread and usage of effective public health interventions based on “science that works” so that the greatest health impact for an individual, community or nation can be achieved with the greatest efficiency. While the benefit of public health interventions correlates with its efficacy and effectiveness, the greatest health impact on individuals, the community, racial/ethnic and other populations experiencing health disparities, and the broader population is achieved when an evidence-based intervention is optimally translated into public health practice and policy. This process is complex, dynamic and frequently non-linear. Lessons learned from successful translation should feedback into the discovery science that formulated the intervention. This bi-directional translation of research knowledge (i.e., intervention) to practice and back to science can be defined as the “exchange, synthesis, and application of knowledge between researchers, public health professionals, policy makers, and consumers/users in order to obtain the benefits of research through improved health (Davis 2003).” Amidst increasing demand for services and decreasing budgets, translation into public health practice may be more likely to occur if it is based on high quality evidence. Greater attention to the practice of evidence-based public health has resulted in practice guidelines such as “The Guide to Community Preventive Services (The Community Guide)” and the “Guide to Clinical Preventive Services” (Maibach 2006). These resources synthesize a body of evidence and offer guidance for public health program decision making at the local, state, tribal and national levels. Such guidelines play a role in shaping public health decisions, and also inform decisions outside the public health system, including decisions made by employers, local communities and organizations, and even individual consumers (Maibach 2006). A thriving partnership between evidence-based medicine and public health enhances this process (Briss 2005).
Although most researchers develop evidence-base interventions for public health practice the rate of adoption and implementation is low due to uncharacterized impediments. The Institute of Medicine (IOM) highlighted a parallel problem for clinical medicine in its report “Crossing the Chasm: A New Health System for the 21st Century” in which it summarized the difficulty of effective implementation and diffusion of proven healthcare interventions (Glasgow 2003). The existence of relevant and high quality research findings does not in itself assure good practice. This gap between knowledge generation and use or application is particularly problematic (Johnson 1996) because despite extensive research on the efficacy and effectiveness of health promotion and disease prevention intervention strategies, little is know regarding effective methods for the broader dissemination, adoption, and implementation of these interventions (Oldenburg 1999). In order to improve translation of research findings into public health practice it is important that the following elements are incorporated into translation studies; research incentives and policies, organizational and structural support, appropriate and targeted funding, formal monitoring and evaluation of the activity and its dissemination and impact, ongoing training for both researchers and practitioners, appropriate engagement with the target population, and a clear process for stakeholder selection, interaction and collaboration (Oldenburg, 1996).
Research Objectives
The purpose of this RFA is to accelerate the translation of research findings into public health practice through implementation, dissemination, and diffusion research; these terms are defined below. The specific objective of the RFA is to conduct translation research using an evidence-based intervention or policy. Proposed research should identify: 1) impediments and/or facilitators to the successful translation of evidence-based public health intervention(s); 2) methodological tools for the successful translation of evidence-based programs, practices, or policies that retain fidelity, and achieve positive outcomes for target populations; or 3) optimal strategies to enhance the widespread adoption and institutionalization of effective public health intervention programs.
Translation research broadly studies and examines factors that facilitate efficacious and effective translation of research into everyday public health policies and programs; evaluates the effectiveness of the administrative, management, policy, healthcare and public health practice decisions and/or use of research knowledge; and describes the experience and roles of the stakeholders, practitioners and participants. Practitioners, researchers and public health policy makers must work together to ensure that evidence-based public health interventions are successfully implemented for a significant, sustained and measurable health impact.
Previous efforts to accelerate the translation of research into public health practice and policy often have not satisfactorily characterized the knowledge gap between evidence-based public health interventions and effective delivery; have not sufficiently evaluated the factors necessary for the successful adaptation of interventions or supporting infrastructure; and typically have not described the requirements for stakeholders’ collaboration to facilitate meaningful adoption by the target population or potential for broader public health uptake. Dissemination of an intervention alone (e.g., guideline publication) is often insufficient to change practice habits and result in health benefit.
Definition of Terms
According to CDC, for the purpose of this RFA, the following terminology is defined:
Evidence-based interventions are a key component of translation research. Therefore, for the purposes of this RFA it is important to define and describe the characteristics of an evidence-based intervention:
In the context of an intervention it is extremely important to clarify the concept of “adaptation”, “adoption”, “fidelity”, “outcomes and impacts”, ”scalability” and sustainability which are interrelated and not mutually exclusive terms.
Research Scope
CDC has developed strategic imperatives and Health Protection Goals that create the framework to increase the capacity to accelerate health impact and reduce health disparities. CDC is committed to achieving meaningful improvements in people’s health and has defined specific Health Protection Goals to prioritize and focus its work and investments and measure progress. CDC has developed four overarching Health Protection Goals for healthy people, healthy places, preparedness, and global health. Each overarching Goal is associated with several more specific strategic Goals. (See http://www.cdc.gov/about/goals for additional information about CDC’s Health Protection Goals.) CDC has also developed a critical resource that can be used to identify research priorities and support CDC’s Health Protection Goals. This resource, “Advancing the Nation’s Health: A Guide to Public Health Research Needs, 2006-2015”, contains 138 Research Themes spanning many areas of public health, and was developed with extensive input from its staff and a wide range of partners and stakeholders. (See http://www.cdc.gov/od/science/PHResearch/cdcra/index.htm for an electronic copy of “Advancing the Nation’s Health: A Guide to Public Health Research Needs, 2006-2015”). Applicants are encouraged to use the Guide to Public Health Research Needs to help identify areas of research that support CDC’s Health Protection Goals.
Research Topics
Special importance is given to public health research issues critical to CDC priority populations, including: low-income and minority groups; women, children, the elderly, and individuals with disabilities. Translation research needs to involve multi-disciplinary cooperation and collaboration which uses theories, empirical findings, and methods from a variety of fields not traditionally associated with public health research. Relevant fields include information science; clinical and public health decision-making; organizational and management theory; finance; law; economics; business administration; statistics; communication; individual, group and systems-level behavioral change; anthropology; sociology; learning theory; community psychology; and marketing.
The following are examples of specific topics of interest to CDC. Note that the research topics provided below are examples only and applicants are not limited to addressing only these topics.
The Coordinating Office for Global Health (COGH) provides leadership within CDC and works with partners around the globe to “help CDC help the world." COGH works to ensure that the world knows CDC represents the best values of the United States, illustrated by our compassion, caring, and commitment. We will share our technical strengths and resources to improve global health. COGH works with CDC's global programs and partners to not only achieve today's global health priorities, but to create sound strategies to address tomorrow's challenges.
COGH is interested in research that develops and test models for translation that address its goals, http://www.cdc.gov/cogh/ , especially those that identify synergies between different injury or disease-specific interventions (such as those that address HIV/AIDS and also reproductive health or malaria), or that address critical health systems issues that are critical to public health advances. While research applications addressing these topics may be proposed, special consideration will be given to funding those related to:
• Conduct implementation or diffusion research using an evidence-based intervention in an international setting (i.e., less-developed or middle-income country. Special attention should be paid to the effect of cost-effectiveness on the host country’s stakeholders and target population’s adoption of the intervention).
• Identify innovative ways to increase the translation of proven interventions for Disease Control Priorities in Developing Countries (available at: http://www.dcp2.org/pubs/DCP).
• Characterize best practices to improve translation of proven interventions that map to the appropriate global translation research themes listed in the CDC Research Guide (See: http://www.cdc.gov/od/science/PHResearch/cdcra/index.htm).
The Coordinating Office for Terrorism Preparedness and Emergency Response (COTPER), http://www.cdc.gov/maso/pdf/COTPERfs.pdf , has primary oversight and responsibility for all programs that comprise CDC's terrorism preparedness and emergency response portfolio. Through an all-hazards approach to preparedness that focuses on threats from natural, biological, chemical, nuclear, and radiological events, COTPER helps the nation prepare for and respond to urgent threats to the public's health. COTPER’s mission is to prevent death, disability, disease and injury associated with urgent health threats by improving preparedness of the public health system, the healthcare delivery system and the public through excellence in science and services. Special consideration will be given to funding research that develops and tests models for translation, dissemination, and institutionalization of best practices and evidence-based practices with a focus on these priorities in emergency preparedness and response:
• Characterize the facilitators and impediments, and define strategies for the successful implementation of evidence-based interventions, such as exercises or drills which assist planners in resource allocation for vulnerable communities during a national disaster (example source: Public Health Workbook to Define, Locate and Reach Special, Vulnerable, and At-Risk Populations in an Emergency; http://www.bt.cdc.gov/workbook).
• Characterize the facilitators or impediments, and define strategies for the successful institutionalization of proven interventions, such as exercises or drills used for preparing the public health workforce to accomplish preparedness and response requirements in varied settings and populations (example source: Evidence-Based Early Psychological Intervention for Victims or Survivors of Mass Violence; http://www.dhhs.gov/emergency/index.shtml).
The Coordinating Center for Environmental Health and Injury Prevention (CCEHIP). CCEHIP is comprised of the National Center for Injury Prevention and Control (NCIPC), the National Center for Environmental Health and the Agency for Toxic Substance and Disease Registry.
The mission of the National Center for Injury Prevention and Control (NCIPC) is to save lives and reduce the number and severity of unintentional and violence related injuries. The CDC Injury Research Agenda (http://www.cdc.gov/ncipc/) encompasses: acute injury care, disability and rehabilitation; prevention of home, sports, transportation and community injuries; and prevention of youth violence, intimate partner and sexual violence, child maltreatment and suicidal behavior.
While research addressing all of these topics may be proposed, special consideration will be given to funding the priorities listed below. (Relevant references can be found at http://www.cdc.gov/ncipc/res-opps/translation.htm).
• Older Adult Falls: Conduct implementation or diffusion research on any proven effective interventions such as home visits, exercise programs, home fall-hazard assessment and modification, and multi-faceted approaches adding in medication reviews and vision and hearing checks. Target populations for prevention are high-risk older adults in community dwellings or older adults in assisted living facilities. .
• Adolescent Motor Vehicle Injuries: Identify methods to translate proven transportation safety interventions that reduce crashes and injuries, such as graduated drivers licensing and parental monitoring. Implementation strategies are needed that accelerate adoption of evidence base interventions and their adaptation in diverse settings.
• Child Maltreatment (CM): Identify factors that encourage the adoption and use of evidence-based primary prevention strategies in CM, such as parenting or home visitation programs. To accelerate the widespread use of effective programs, research may address: impediments and facilitators to program adoption and sustained use; levels of skill and training necessary to successfully implement a program; conditions that encourage program use “as prescribed” by developers versus adaptation to local conditions”.
The National Center for Environmental Health (NCEH), http://www.cdc.gov/nceh/default.htm, plans, directs, and coordinates a national program to maintain and improve the health of the American people by promoting healthy environments and by preventing premature death and avoidable illness and disability caused by non-infectious, non-occupational environmental and related factors. The Agency for Toxic Substances and Disease Registry (ATSDR), http://www.atsdr.cdc.gov/, uses the best science, takes responsive public health actions, and provides trusted health information to prevent harmful exposures to toxic substances and exposure-related disease.
While research applications addressing all aspects of environmental health may be proposed, NCEH/ATSDR special consideration will be given to funding the priorities listed below. (Relevant references can be found at http://www.atsdr.cdc.gov/2p-extramural_research_funding.html)
• Healthy Homes and Communities: Identify the facilitators and impediments to implementing more widely evidence-based interventions at the scale of homes (e.g., vector control, lead paint removal, mold control, carbon monoxide detectors, and fall hazard abatement) and/or communities (e.g., mixed land use, activity centers, pedestrian infrastructure, appropriate residential density, greenspace, mass transit).
• Foodborne Illness: Conduct implementation or diffusion research on physical (temperature control, storage practices) and administrative (food inspections, manager food safety certification) interventions that reduce foodborne illness. Focus research on restaurants, the food service industry, governmental agencies, and policy-makers.
• Climate Change: Identify the facilitators and impediments to implementing more widely the proven existing mitigation and adaptation interventions in the public and private sectors. Climate change may affect public health through propagation of infectious diseases, heat waves, severe weather events, and interruptions of the food supply, among other mechanisms.
The Coordinating Center for Health Information and Service (CoCHS) assures that CDC provides high-quality information and programs in the most effective ways to help people, families, and communities protect their health and safety. CoCHS and is comprised of The National Center for Health Statistics (NCHS), National Center for Health Marketing (NCHM), and National Center for Public Health Informatics (NCPHI).
The National Center for Health Statistics (NCHS), http://www.cdc.gov/nchs/, supports statistical and epidemiological activities for the purpose of improving the effectiveness, efficiency, and quality of health services in the United States. This includes collecting statistics on illness and disability of the population and its impact on population well-being, e.g. the U. S. economy; health resources, including health professionals and services; utilization of health care and facilities; health care costs and financing, including trends in prices and cost, sources of payments, and governmental expenditures; family formation, growth, and dissolution.
Areas of focus for this announcement include, but are not limited to: changing patterns of health care usage (e.g., home care and emergency room usage based on changes in insurance coverage; disease screening); prescribing practices of evidence-based health recommendations and/or health policies (e.g., antibiotic or asthma prescribing practices following public health recommendations; changes in Medicare prescription drug benefit); proven interventions which reduce health disparities with emphasis on the reach to and adoption by population subgroups, such as racial and ethnic minorities and low income populations.
NCHS requests research using NCHS data sets, alone or in conjunction with other data sets to:
• Examine the penetration of health recommendations and health policy into the general population, population subgroups and among health care providers. Identify characteristics of those groups that are not reached by the recommendations or those with widespread adoption of the recommendations.
• Examine and improve understanding of the processes by which evidence-based recommendations and policies become institutionalized and also characterize the impediments and facilitators to implementation or diffusion of these policies.
The mission of the National Center for Health Marketing (NCHM), http://www.cdc.gov/healthmarketing/, is to protect and promote health and advance CDC’s goals through innovative health marketing programs, products, and services that are customer-centered, high-impact, and science-based. Health marketing and communication is an emerging field that draws from traditional marketing theories and principles. Health marketing is defined as creating, communicating and delivering health information and interventions using customer-centered and science based strategies to protect and promote the health of diverse populations. NCHM helps define the future of health marketing within CDC, the federal sector and beyond. While research applications addressing all of these topics may be proposed, special consideration will be given to funding translation research related to these three priorities:
• A focus on applying accepted marketing principles and practices to improve the translation of research to practice in the context of enhancing the adoption of proven intervention approaches, such as those recommended by The Guide to Community Preventive Services.
• Research on the utilization of effective partnerships to improve the dissemination of information and proven interventions to targeted high-risk populations.
• A focus on developing innovative methods and models for the dissemination and implementation of interventions and information that largely incorporate electronic (e-health) platforms for use by diverse, high-risk populations.
The Coordinating Center for Health Promotion (CoCHP) works to enhance the potential for full, satisfying and productive living across the lifespan for all people in all communities. CoCHP accomplishes this by promoting the improvement of public health through increased efficiencies, fostering strong collaborations, and integrating synergistic programs and messages. CoCHP is comprised of the National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), the National Center on Birth Defects and Developmental Disabilities (NCBDDD), and the National Office of Public Health Genomics.
The mission of the National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), http://www.cdc.gov/nccdphp/, is to prevent death and disability from chronic diseases; to promote maternal, infant, and adolescent health; to promote healthy personal behaviors; and to accomplish these goals in partnership with health and education agencies, voluntary associations, the private sector, and other federal agencies. NCCDPHP places high priority on chronic diseases and conditions and reproductive health outcomes that have the greatest impact on health, longevity, and quality of life, especially those related to sex, age, race/ethnicity, geography, sexual orientation, socioeconomic status, disability, and special needs.
NCCDPHP is interested in research that develops and test models for translation, dissemination, and institutionalization of effective programs/policies that utilize a community-partnered approach to promote health and prevent disease across all stages of life. Research projects should identify methods that can be implemented at the individual, family, community, and organizational levels that will accelerate the adoption of programs, policies, and behaviors aimed at reducing chronic diseases and conditions and adverse reproductive health outcomes. Projects should focus on the following priorities:
• Implementation: Develop and evaluate strategies to translate and implement evidence-based interventions in populations and in settings where health disparities persist. Sources for interventions having sound experimental design include, but are not limited to, The Guide to Community Preventive Services and the Prevention Research Centers.
• Accessibility: Determine the most efficient/effective ways to implement an evidence-based intervention to those at high-risk. Identify characteristics of effective delivery systems and analyze factors that affect acceptability and adoption of the intervention.
• Sustainability: Increase the translation of evidence-based interventions into sustainable community change using partnerships and collaborations. Analyze factors that contribute to sustainability in diverse, high-risk, and hard-to-reach populations, including facilitators and impediments.
The National Center on Birth Defects and Developmental Disabilities (NCBDDD), http://www.cdc.gov/ncbddd/, promotes the health of babies, children, and adults, and enhances the potential for full, productive living. While research applications addressing all of these topics may be proposed, special consideration will be given to funding translation research related to the following priorities:
• Characterize the facilitators and impediments, and define strategies for the successful implementation of evidence-based interventions recommended by CDC for preconception health and health care, in an applied community or clinical setting, with particular emphasis on those recommendations with evidence-based interventions for improving outcomes (e.g., alcohol, folic acid, smoking, diabetes, and HIV/STD screening prior to pregnancy). For additional information see: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5506a1.htm.
• Characterize the
facilitators and impediments, and define strategies for the successful
implementation of the American Academy of Pediatrics recommendation for
universal developmental screening of infants, children, and adolescents as a
routine part of pediatric practice through training, technical assistance and
practice management. See following URLs for additional information:
http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/1/192
http://www.medicalhomeinfo.org/screening/DPIP.html
http://www.cdc.gov/ncbddd/child/documents/AAP%20Coding%20Fact%20Sheet%20for%20Primary%20Care.pdf
http://www.dbpeds.org/articles/detail.cfm?id=123
The National Office of Public Health Genomics (NOPHG), http://www.cdc.gov/genomics/, works to integrate genomics into public health research, programs, and policy. Special consideration will be given to research proposals addressing the following priorities:
• Family History: Investigate how widespread adoption of validated tools for the collection and analysis of family history can be better used for risk assessment and subsequent preventive measures (e.g., healthcare provider education efforts, public awareness campaigns). Family history is the most consistent known risk factor for common chronic diseases such as cancer and coronary heart disease.
• Genetic Testing: Evaluate the factors (e.g., cost-effectiveness, public health and industry marketing, endorsement by advocacy groups) associated with provider and patient utilization of new genetic tests entering clinical practice, or of genetic tests already in use. Rapid growth in the number of commercially available genetic tests for disease prevention, diagnosis, and treatment poses a challenge for their effective translation into clinical practice.
• Genetics for Early Disease Detection and Intervention: Evaluate the adoption and use of validated interventions providing education about symptom recognition and family history, screening and genetic testing, and referral to appropriate services. Many persons with genetic diseases such as hereditary hemochromatosis or familial hypercholesterolemia are either missed by the healthcare system or not diagnosed early enough for effective and appropriate intervention.
The mission of the Coordinating Center for Infectious Diseases (CoCID) is to protect health and enhance the potential for full, satisfying and productive living across the lifespan of all people in all communities related to infectious diseases. CoCID is comprised of the following proposed National Centers: National Center for Immunization and Respiratory Diseases (NCIRD); the National Center for Zoonotic, Vector-Borne and Enteric Disease (NCZVED); the National Center for HIV, Viral Hepatitis, STDs and Tuberculosis Prevention (NCHHSTP); and the National Center for Preparedness, Detection and Control of Infectious Diseases (NCPDCID).
The mission of the National Center for Immunization and Respiratory Diseases (NCIRD) is to maximize the prevention of disease, disability, and death through immunization and by control of respiratory and related diseases. While research applications addressing all of these topics may be proposed, special consideration will be given to funding translation research related to the following priorities:
• Adolescent immunization: Several vaccines have recently been recommended for routine use in adolescents. Implementation of programs to reach adolescents is challenging because of relatively limited preventive health care encounters in this age group, and a number of other preventive services recommended for this age group. Characterize the facilitators and impediments and identify effective strategies for the achievement of high vaccination coverage in the context of integrated adolescence preventive services to inform future best practices.
• Immunization information systems (IIS): Immunization information systems potentially harness information technology to improve service delivery, quality assurance, and monitor performance in achieving high immunization coverage. Characterize the facilitators and impediments and identify effective strategies for increased provider participation in IIS and the maintenance of comprehensive records in order to expand vaccination coverage across all age groups.
• Characterize the factors that promote successful adoption of global polio eradication initiatives (e.g., cost-effectiveness, training needs, and infrastructure).
The mission of the National Center for Zoonotic, Vector-Borne and Enteric Disease (NCZVED) maximizes public health and safety nationally and internationally through the elimination, prevention, and control of disease, disability, and death caused by suspected and confirmed zoonotic, vector-borne, foodborne, waterborne, mycotic, prion and related infections. While research applications addressing all of these topics may be proposed, special consideration will be given to funding translation research related to these three priorities:
• Characterize the factors necessary to achieve greater implementation of evidence-based interventions to control the neglected tropical diseases such as lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma and intestinal helminthes. The proposal should include how these interventions can be incorporated as part of routine public health prevention activities, leading to sustainable reductions in morbidity and disease transmission.
• Characterize the factors necessary to effectively implement evidence based education and prevention interventions to minimize bacterial illness associated with infant formula use (e.g., health care provider training in powdered and liquid formula use, preparation and patient counseling).
• Characterize variables to increase adoption of hand washing or use of waterless hand gels among young children, their families, and their communities.
The mission of the National Center for HIV, Viral Hepatitis, STDs and Tuberculosis Prevention (NCHHSTP) is to maximize public health and safety nationally and internationally through the elimination, prevention, and control of disease, disability, and death caused by Human Immunodeficiency Virus Infection/Acquired Immunodeficiency Syndrome, Non-HIV Retroviruses, Viral Hepatitis, other Sexually Transmitted Diseases (STD), Tuberculosis, and Non-Tuberculosis Mycobacteria. While research applications addressing all of these topics may be proposed, special consideration will be given to funding translation research related to these three priorities:
• Characterize facilitators or impediments, and define strategies for the successful implementation for a proven intervention to reduce reproductive sequelae of STD for Chlamydia by enhancing screening, treatment, and partner services.
• Characterize the factors necessary for the increased implementation of recommended prevention services of pregnant women infected with Hepatitis B, their exposed newborns, and other family contacts.
• Characterize the factors that can increase providers’ implementation of evidence-based therapies for latent tuberculosis infection for persons infected with tuberculosis and at a high risk of progressing to tuberculosis disease (e.g., contacts of infectious tuberculosis patients, HIV-infected persons).
The mission of the National Center for Preparedness, Detection and Control of Infectious Diseases (NCPDCID) is to maximize prevention, preparedness and response to infectious diseases in order to protect populations domestically and internationally through leadership, partnerships, epidemiologic and laboratory studies, and the use of quality systems, standards, and practices. While research applications addressing all of these topics may be proposed, special consideration will be given to funding translation research related to these three priorities:
• Characterize facilitators and impediments and define strategies for the successful implementation of evidence-based recommendations for reducing transmission and subsequent infection with multi-drug resistant organisms (e.g., methicillin-resistant S. aureus, Clostridium difficile) in both healthcare and other public health settings. Effective prevention measures have been identified through quasi-experimental design studies, prospective trails, and outbreak control, but successful implementation strategies are unclear.
• Characterize facilitators and impediments and define strategies for the successful translation of vaccination recommendations and other evidence-based interventions to prevent infectious diseases among international travelers.
• Identify what travel health practitioners consider the facilitators and impediments, and define strategies for the successful implementation of pre- and post- travel evidence-based recommendations for the reduction of infectious diseases among travelers.
The National Institute for Occupational Safety and Health (NIOSH) is the federal agency responsible for conducting research and making recommendations for the prevention of work-related illnesses, injuries, and fatalities (http://www.cdc.gov/niosh/homepage.html). One of the cornerstones of NIOSH’s efforts is a Research to Practice (r2p) program that focuses on the transfer of research findings, technologies, and risk-reduction methods into effective prevention practices, interventions, and products that will be used in the workplace (http://www.cdc.gov/niosh/r2p/).
For this announcement, NIOSH is interested in research that addresses the dissemination, implementation, and diffusion of proven interventions (e.g., best practices, programs, policies, and behaviors) that reduce or prevent occupational injuries and illnesses. Investigations should include factors that influence managers, workers, contractors, building owners, and others in adopting proven interventions. Results of the investigations should document improvements in workplace health and safety. While research applications may address any aspect of the prevention of work-related illnesses, injuries and fatalities, special consideration will be given to the following areas:
The Office of Minority Health and Health Disparities (OMHD), www.cdc.gov/omhd/, in collaboration with CDC’s National Centers aims to accelerate health impact in the U.S. population and to eliminate health disparities for vulnerable populations as defined by race/ethnicity, socio-economic status, geography, gender, age disability status, risk status related to sex and gender, and among other populations identified to be at-risk for health disparities. Some key OMHD activities include 1) developing CDC-wide health disparities elimination strategies, policies, goals, and programs; 2) supporting partnerships to advance the science, practice, and workforce for eliminating health disparities; and 3) synthesizing, disseminating, and encouraging the use of scientific evidence about effective interventions to achieve health disparities elimination outcomes.
OMHD is interested in translation research that can improve the health of minority or other populations experiencing health disparities and can eliminate health disparities in the United States. Special consideration will be given to the following research priority:
The mission of the Office of the Chief of Public Health Practice (OCPHP), www.cdc.gov/od/ocphp, is to advance achievement of CDC's Health Protection Goals through science-based, practice-oriented standards, policies and law. OCPHP serves as the advocate, guardian, promoter, and conscience of public health practice throughout CDC/ATSDR and in the larger public health community and ensures coordination and synergy of CDC/ATSDR’s scientific and practice activities. Activities in support of the mission are carried out through programs and offices focused on public health law, public health system standards, public health agency accreditation, and surveillance for emerging issues in public health practice. Special consideration will be given the following research priority:
References
1. Briss PA, Brownson RC, Fielding JE, Zaza S. Developing and using the Guide to Community Preventive Services: lessons learned about evidence-based public health. Annu. Rev. Public Health 2004; 25:281-302.
2. Briss PA. Evidence-based: US road and public-health side of the street (letter). Lancet 2005; 365: 828-830.
3. Davis D, Evans M, Jada A, et al. The case for knowledge translation: shortening the journey from evidence to effect. BMJ 2003;327:33-35. Available at URL: http://www.bmj.com/cgi/content/full/327/7405/33.
4. Glasgow R, Lichtenstein E, Marcus AC. Why don’t we see more translation of health promotion research to practice? Rethinking the efficacy-to-effectiveness transition. AM J Public Health 2003;93:1261-1267.
5. GRADE working group. Grading quality of evidence and strength of recommendations BMJ 2004;328:1490.
6. Johnson, J. L., Green, L. W., Frankish, C. J., MacLean, D. R. and Stachenko, S. A dissemination research agenda to strengthen health promotion and disease prevention. Canadian Journal of Public Health, 1996; 87: S5–S10.
7. Implementation Research: A synthesis of the literature. Available at URL: http://nirn.fmhi.usf.edu/resources/publications/Monograph/.
8. Institute of Medicine. Crossing the Quality Chasm: a new health system for the 21st century 2001. Brief report is available from: URL: http://www.iom.edu/CMS/8089/5432/27184.aspx.
9. Lefant C. Shattuck lecture: Clinical research to clinical practice—lost in translation? N Engl J Med 2003; 349: 868-874.
10. Maidbach E, Van Duyn MAS, Bloodgood B. A marketing perspective on disseminating evidence-based approaches to disease prevention and health promotion. Prev Chronic Dis [serial online] 2006 Jul [December 12, 2006]. Available from: URL: http://www.cdc.gov/pcd/issues/2006/jul/05_0154.htm.
11. Mowbray CT, Holter MC, Teague GB, Bybee D. Fidelity criteria: development, measurement, and validation. Am J Eval; 24:315-340. Available from: URL: http://aje.sagepub.com/cgi/content/abstract/24/3/315.
12. Oldenburg BF, Sallis JF,French ML,Owen N. Health promotion research and the diffusion and institutionalization of interventions. Health Education Research. 1999; 14: 121-130.
13. Rohrbach LA, Grana R, Sussman S, Valente TW. Type II Translation: transporting prevention interventions from research to real-world settings. Eval Health Prof 2006; 29: 302-333.
14. Rychetnik L, Frommer M, Hawe P, Shiell A. Criteria for evaluating evidence on public health interventions. J Epidemiol Community Health 2002;56:119-127.
15. Taskforce on Community Preventive Services. Guide to Community Preventive Services 2004. Available at URL: http://www.thecommunityguide.org/ .
16. Sussman S, Valente TW, Rohrbach LA, Skara S, Pentz MA. Translation in the health professions: converting science into action. Eval Health Prof. 2006 Mar;29(1):7-32.
17. US Preventive Taskforce. Available at URL: http://www.ahrq.gov/clinic/uspstfix.htm.
18. Walker AE, Grimshaw J, Johnston M, Pitts N, Steen N, Eccles M. Prime-Process modeling in ImpleMEntation research: selecting a theoretical basis for interventions to change clinical practice. BMC Health Serv Res 2003: 3:22. Available from URL: http://www.biomedcentral.com/1472-6963/3/22.
Helpful Resources
See Section VIII, Other Information - Required Federal
Citations, for policies related to this announcement.
Section II. Award
Information
1. Mechanism(s) of Support
This funding opportunity will use the R18 activity code.
2. Funds Available
The Office of Public Health Research intends to commit approximately $10 million in total cost dollars in FY2007 to fund approximately 28 applications. The average award amount will be approximately $350,000-$450,000 including direct and indirect costs per 12 month budget period (e.g., direct and indirect costs). An applicant may request a project period of up to 3 years. An applicant may request up to $450,000 including direct and indirect costs for each budget year. The approximate range for total project period funded amount is $1,050,000 to $1,350,000 including direct and indirect costs. The anticipated start date for new awards is September 2007.
All estimated funding amounts are subject to availability of funds.
If an applicant requests a funding amount greater than the ceiling of the award range, HHS/CDC will consider the application non-responsive, and it will not enter into the review process. HHS/CDC will notify the applicant that the application did not meet the submission requirements.
Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the CIO (s) provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications.
Section III. Eligibility Information
1.
Eligible Applicants
1.A. Eligible Institutions
Institutions eligible to receive CDC funding: You may submit an application(s) if your organization has any of the following characteristics:
A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If you are applying as a bona fide agent of a state or local government, you must provide a letter from the state or local government as documentation of your status. Attach this documentation behind the first page of your application form or for electronic applications, use a PDF file and attach as “Other Documents” and label as appropriate.
Note: Foreign institutions are not eligible to apply. Applicants wishing to form foreign collaborations may do so as long as the primary domestic grant recipient performs a substantive role in the project and is not acting solely as a conduit to another party.
Institutions eligible to receive ATSDR funding: You may submit an application(s) if your organization has any of the following characteristics, states, or state organizations and political subdivisions thereof, or their bona fide agents such as:
A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If you are applying as a bona fide agent of a state or local government, you must provide a letter from the state or local government as documentation of your status. Attach this documentation behind the first page of your application form or for electronic applications, use a PDF file and attach as “Other Documents” and label as appropriate.
1.B. Eligible Investigators
Any
individual with the skills, knowledge, and resources necessary to carry out the
proposed research as the Project Director/Principal Investigator (PD/PI) is
invited to work with his/her organization to develop an application for
support.
2. Cost Sharing or
Matching
This
program does not require cost sharing or matching.
The most current HHS Grants Policy Statement is available at: http://www.cdc.gov/od/pgo/funding/HHS_GPS_Oct_2006.doc.
3. Other-Special Eligibility Criteria
Note: Title 2 of the United States Code Section 1611 states that an organization described in Section 501(c)(4) of the Internal Revenue Code that engages in lobbying activities is not eligible to receive Federal funds constituting an award, grant, or loan.
Section IV. Application and Submission Information
To download a SF424 (R&R) Application Package and SF424 (R&R) Application Instructions for completing the SF424 (R&R) forms for this FOA, link to http://www.grants.gov/Apply/ and follow the directions provided on that Web site.
A one-time registration is required for institutions/organizations at the following:
PD/PIs should work with their institutions/organizations to make sure they are registered in the eRA Commons.
Several additional actions are required before an applicant institution/organization can submit an electronic application, as follows:
1) Organizational/Institutional Registration in Grants.gov/Get Started
2) Organizational/Institutional Registration in the eRA Commons
3) Project Director/Principal Investigator (PD/PI) Registration in the eRA Commons: Refer to the NIH eRA Commons System (COM) Users Guide.
Note that if a PD/PI is also an HHS peer-reviewer with an Individual DUNS and CCR registration, that particular DUNS number and CCR registration are for the individual reviewer only. These are different than any DUNS number and CCR registration used by an applicant organization. Individual DUNS and CCR registration should be used only for the purposes of personal reimbursement and should not be used on any grant applications submitted to the Federal Government.
Several of the steps of the registration process could take four weeks or more. Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered in both Grants.gov and the eRA Commons. The HHS/CDC strongly encourages applicants to use the Grants.gov electronic applications process and have organizations and PD/PIs complete all necessary registrations.
1.
Request Application Information
Applicants must
download the SF424 (R&R) application forms and SF424 (R&R) Application
Guide for this FOA through Grants.gov/Apply.
Note:
Only the forms package directly attached to a specific FOA can be used. You
will not be able to use any other SF424 (R&R) forms (e.g., sample forms,
forms from another FOA), although some of the "Attachment" files may
be useable for more than one FOA.
For further assistance, contact PGO TIMS: Telephone 770-488-2700,
Email: PGOTIM@cdc.gov.
HHS/CDC Telecommunications for the hearing impaired:
TTY 770-488-2783.
2.
Content and Form of Application Submission
Prepare all
applications using the SF424 (R&R) application forms and in accordance with
the SF424 (R&R) Application Guide (PDF).
The SF424 (R&R) Application Guide is critical to submitting a complete and accurate application to HHS/CDC. There are fields within the SF424 (R&R) application components that, although not marked as mandatory, are required by HHS/CDC (e.g., the “Credential” log-in field of the “Research & Related Senior/Key Person Profile” component must contain the PD/PI’s assigned eRA Commons User ID). Agency-specific instructions for such fields are clearly identified in the Application Guide. For additional information, see “Tips and Tools for Navigating Electronic Submission” on the front page of “Electronic Submission of Grant Applications.”
The SF424 (R&R) application is comprised of data arranged in separate components. Some components are required, others are optional. The forms package associated with this FOA in Grants.gov/APPLY will include all applicable components, mandatory and optional. A completed application in response to this FOA will include the following components:
Required
Components:
SF424
(R&R) (Cover component)
Research & Related Project/Performance Site
Locations
Research & Related Other Project Information
Research & Related Senior/Key Person
Research & Related Budget
PHS398 Cover Page Supplement
PHS398 Research Plan
PHS398 Checklist
Optional
Components:
PHS398 Cover
Letter File
Research & Related Subaward Budget Attachment(s)
Form
3. Submission Dates and Times
See Section IV.3.A for details.
3.A. Submission, Review and Anticipated Start
Dates
Letter of Intent
Receipt Date: March 12, 2007
Application
Submission Receipt Date(s): April 10, 2007
Peer Review Date(s): June 2007
Council Review Date(s): June/July
2007
Earliest
Anticipated Start Date(s): September 2007
3.A.1. Letter of
Intent
Prospective applicants are asked to
submit a letter of intent that includes the following information:
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows CDC Program staff to estimate the potential review workload and plan the review.
The letter of intent is to be sent by the date listed in Section IV.3.A
The letter of intent should be sent to:
Scientific Review Service
Office of Public Health Research
CDC Office of the Chief Science Officer
1600 Clifton Rd., MS D-72
Atlanta, GA 30333
Telephone: (404) 639-4621
Fax: 404-639-4903
Email: ophrinfo@cdc.gov
3.B. Submitting an Application to CDC
To submit an application in response to this FOA, applicants should access this FOA via http://www.grants.gov/applicants/apply_for_grants.jsp and follow steps 1-4. Note: Applications must only be submitted electronically. PAPER APPLICATIONS WILL NOT BE ACCEPTED.
3.C. Application Processing
HHS/CDC must receive applications on or before 5:00 P.M. Eastern Standard Time
on the application submission date(s) described above (Section IV.3.A.). If
HHS/CDC receives an application after that submission date and time, the
application may be delayed in the review process or not reviewed.
Once an application package has been successfully submitted through Grants.gov, any errors have been addressed, and the assembled application has been created in the eRA Commons, the PD/PI and the Authorized Organization Representative/Signing Official (AOR/SO) have two business days to view the application image.