Full Text AG-94-006 NATHAN SHOCK CENTERS OF EXCELLENCE IN BASIC BIOLOGY OF AGING NIH GUIDE, Volume 23, Number 32, August 26, 1994 RFA: AG-94-006 P.T. 04 Keywords: Trauma Aging/Gerontology National Institute on Aging Letter of Intent Receipt Date: October 15, 1994 Application Receipt Date: November 29, 1994 PURPOSE The National Institute on Aging (NIA) invites applications for support of centers of excellence in research on basic biological mechanisms of aging, to be known as Nathan Shock Centers of Excellence in Basic Biology of Aging. These Centers will provide support for a research development core; a core to support resources such as animal resources, biometric services, molecular/cell biology services, and shared equipment; and a program enrichment core in support of basic biological research on aging. The purpose of this core center grant is to provide funding for core facilities and associated staff that serve the various ongoing research on aging projects on a shared basis so as to enhance the quality of research in the basic biology of aging, facilitate the planning and coordination of research on aging activities, and provide a suitable environment for fellows and junior faculty to acquire research skills and experience at institutions that have demonstrated commitment to, and expertise in, research on basic biology of aging. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Nathan Shock Centers of Excellence in Basic Biology of Aging, is related to the priority area of chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic non-profit organizations and institutions, State and local governments and their agencies, and authorized Federal institutions. To be eligible for award as a Nathan Shock Center of Excellence, the applicant institution must currently support a minimum of fifteen peer-reviewed, externally funded research projects. In the case of currently funded program projects (P01s), or similar grants, each research component will be deemed to be a separate project. Supportive core components do not qualify. Minority individuals and women from qualifying institutions are encouraged to apply. MECHANISM OF SUPPORT The Nathan Shock Centers will be supported through the NIH Core Center Grants (P30) mechanism. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. The total project period for applications submitted in response to this RFA may not exceed five years. The anticipated award date is July 1995. FUNDS AVAILABLE Support may be requested for a period of five years. The direct costs requested for the first year may not exceed $325,000, exclusive of indirect consortium costs. Applications with budget requests exceeding this amount will not be accepted by the NIA and will be returned to the applicant. Budget increments for subsequent years will be limited to no more than four percent. Plans are to make two or three awards in fiscal year 1995 and further awards in fiscal years 1996 and 1997 depending upon availability of funds. RESEARCH OBJECTIVES Background Human life expectancy has increased some 25 years in less than a century, a figure that is nearly equal to the gain that had been achieved in the preceding 5,000 years. This has resulted in an unprecedented increase in the number and proportion of older persons in the population. It is therefore important for social, cultural, and economic reasons that research efforts to understand the underlying mechanisms of aging be expanded. One of the mandates of the NIA is to develop research approaches to extend the vigorous and productive years of life. It is clear that aging is not only complex, but also highly variable. Why is individual aging so varied? How do we explain a longer life expectancy for women than men in view of the fact the women report more illness and health care utilization than men at every age comparison? How can physiological age be determined and related to chronological age? How can the various theories of aging be integrated to provide a more unified description of biological aging and thus, an indicator for fruitful directions for future research on aging? The goal of the Core Center program is to enhance the ability of institutions with well-developed research programs in basic research on aging to provide the strongest environment for the conduct of research on aging by providing state-of-the-art research resources to find answers to the many complex questions of aging. Thus, institutions without a substantial ongoing program of basic research on aging are not encouraged to apply for a Nathan Shock Center of Excellence in Basic Biology of Aging award. Objective and Scope A Core Center grant for aging research is awarded to enhance the quality of research in the basic biology of aging, facilitate the planning and coordination of aging research activities, and provide support and a suitable environment for fellows and junior faculty to acquire research skills and experience at institutions that have demonstrated commitment to, and expertise in, basic biology of aging research. The purpose of the core grant is to provide funding for core facilities and associated staff that serve the various aging research projects on a shared basis. The Core Center is a mechanism designed to enhance and extend the effectiveness of a group of related projects and investigators that are already funded through other mechanisms such as research projects grants (R01), program projects (P01), FIRST awards (R29), MERIT awards (R37), or other Federal or non-Federal peer-reviewed extramurally- funded grants. In this respect, the Core Center mechanism builds upon an established base of research excellence that emphasizes common themes or foci. Each Core Center Grant must include (a) a core resources component and (b) a limited program enrichment component in support of administrative functions and advisory committee expenses. Activities such as animal facilities, biometric support, molecular/cell biology and/or equipment, which must be utilized by three or more projects on aging research that are already funded, would be supported in the Resources core. A research development core and an expanded program enrichment core to support conferences, symposia, travel to scientific meetings and special consultants are optional. The research development core would provide support for pilot/feasibility projects or temporary salary support to investigators just entering the research on aging arena to a point where they can compete for independent support. Such salary support usually would not exceed two years. An appropriately qualified scientist must be named as a director of each core proposed as well as a Center Director for overall direction. Resources Core (Required) This core will provide support for personnel, equipment, supplies and renovation costs needed to develop new, or improve existing resources that foster shared use and collaborative research. Renovation costs may not exceed $150,000 for the entire award period. Since a supply of appropriate animal models that are free of disease is essential for research on biological aging, support will be provided for the development and maintenance of animal resources to meet this need. Support may be requested for necessary personnel, facility improvement costs, animal model development costs, and equipment, supplies and animal purchase costs for the operation of a quality animal core resource facility in support of three or more basic research projects. Simply having appropriate animals available for the conduct of research is not enough; it is necessary that they be used in an effective manner (experimental design) to achieve reliable data for hypothesis testing. Proper experimental design and subsequent data analysis is a necessity for meaningful results, not only of animal studies, but of all research. Therefore, personnel and equipment costs for biometrics support of all center research may be requested. To gain insight into the mechanisms of aging through understanding the underlying intrinsic biology of aging requires a molecular/cellular biology capability. Therefore, this core may also provide molecular/cellular research resources for on-going funded research projects at the institution. Examples of such core resources include, but are not limited to: o Cell culture facility o DNA sequencing o Computing and statistical analysis o Cell sorting/flow cytometry o Monoclonal antibody production o Preparation of cloning vectors o Ultracentrifugation equipment o Analytical services, e.g., mass spectrometry, HPLC, GLC Support may be requested both to purchase equipment and for personnel to operate and maintain the equipment. Any equipment or facility supported in this core should involve sharing by at least three independently supported research projects and must be justified in terms of need to meet the goals of these projects. Since this component may consist of several cores, each may use a maximum of 10 pages. Research Development Core (Optional) The Research Development Core is to provide support for personnel, equipment, and other resources that will enhance the quality of currently supported research, support pilot study projects, and serve as a resource for pursuing an exciting new finding beyond the limits that current support allows. Activities that focus resources from a variety of disciplines on understanding biological processes of aging are encouraged. The focus of proposed core activities should conform with needs of funded research projects at the institution. Applicants should describe concisely the currently supported projects that will use the core facilities. The description of the projects proposed should include a rationale to show how the core will support the research effort in a cost effective manner, and how they will enhance the quality of research and/or provide a suitable environment for training and career development of research fellows and junior faculty in basic biology of aging. This core may also provide temporary salary support, not to exceed 24 months, for one newly named principal investigator in specified areas of research complementary to ongoing activities of the group. No more than three junior faculty may receive salary support through this core at any one time and no individual may receive salary support for more than three years. It must be clearly described how any requested salary support in this core will enhance the existing program. The budget for each pilot project may not exceed $50,000 per year (direct cost) and the total budget for pilot projects under this core may not exceed $100,000 per year (direct cost). Request for Research Development Core support must contain (1) a plan for the selection of junior faculty to be supported, (2) a general plan for the career development of individuals who will be selected for these positions, (3) a plan for review and selection of pilot projects to be pursued, and (4) a list of senior faculty who will participate in research career development, along with their curriculum vitae and current research support. The institution must be able to demonstrate adequate resources for the support of the research efforts of proposed junior investigators and a plan for monitoring their progress and development toward independence. The research development core may also serve to encourage the career development of other junior faculty (in addition to those receiving salary support from this core) by coordinating the use of research core resources by those whose salary support will be provided from other sources. Funds may also be requested for salary support for a director of the research development core, who will be responsible for coordination of all activities within said core. Narrative description of this core is limited to 10 pages and description of individual pilot projects to one page. Program Enrichment Core (Required) This core is required in so far as it provides support for the administrative management of the overall Center as well as support for the required outside advisory panel. The remaining elements of this core, i.e., conferences, symposia, meeting travel, are optional. The Center Director should be a scientist who can provide effective administrative and scientific leadership. The Administrator (if one is used) will assist the Director in managing the Center, addressing issues of fiscal management and compliance with institutional, PHS, NIH and NIA policies. In addition, each Center must have an advisory panel of experts from outside the institution that will meet at least once a year to review Center activities. This panel should not be named until after the review process is completed, but must be approved by NIA prior to funding of awards. This panel will provide a written evaluation report on the progress of the Center which must be included with each Center's annual progress report to NIA. Funds may be requested to permit travel by junior staff (whose travel is not otherwise covered) to scientific meetings or by the Director and one other senior staff to Bethesda for meetings with NIA staff and/or staff of other Centers. Narrative description of this core is limited to 10 pages. STUDY POPULATIONS INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This new policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43) and supersedes and strengthens the previous policies (Concerning the Inclusion of Women in Study Populations, and Concerning the Inclusion of Minorities in Study Populations), which have been in effect since 1990. The new policy contains some provisions that are substantially different from the 1990 policies. All investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and reprinted in the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18, 1994. Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. LETTER OF INTENT Potential applicants are asked to submit, by October 15, 1994, a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains allows NIA staff to estimate the potential review workload and to avoid conflict of interest in the review. The letter of intent is to be sent to Dr. Richard L Sprott at the address listed under INQUIRIES. APPLICATION PROCEDURES The applicant is to submit the application using PHS 398 (rev. 9/91). Application kits containing this form and the necessary instructions are available in most institutional offices of sponsored research and may be obtained from the Office of Grants Information, Division of Research Grants, National Institutes of Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone 301/710-0267. Applicants are urged to obtain from the NIA Scientific Review Office, guidelines for preparing multicomponent applications, which contain information not found in the standard PHS 398 kit. NIA program staff are available to provide guidance, in relation to both scientific and administrative issues, in the development of the application. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number must be typed in line 2a of the face page of the application form and the YES box must be marked. Send or deliver the original, signed application and three legible complete photocopies to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Send two additional copies of the application to: Michael Oxman, Ph.D. Scientific Review Office National Institute on Aging Gateway Building, Room 2C212 7201 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-9666 FAX: (301) 402-0066 It is important to send these two copies at the same time as the original and three copies are sent to the Division of Research Grants. Any application received after the receipt date will be returned to the applicant without review. REVIEW CONSIDERATIONS Applications must be received by November 29, 1994. Upon receipt, applications will be reviewed for completeness and responsiveness by NIA staff. To be complete, an application must be approved, as appropriate, by an applicant institution's IRB and IACUC. Incomplete applications will be returned to the applicant without further consideration. If NIA staff find that the application is not responsive to the RFA, or if the first year budget request exceeds $325,000 in direct costs, exclusive of indirect costs requested for consortiums, it will be returned without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NIA in accordance with the review criteria stated below. As part of the initial merit review, a process (triage) may be used by the initial review group in which applications will be determined to be competitive or non-competitive based on their scientific merit relative to other applications received in response to the RFA. Applications judged to be competitive will be discussed and, if found to have significant and substantial merit, will be assigned a priority score. Applications determined to be non-competitive will be withdrawn from further consideration and the principal investigator/program director and the official signing for the applicant organization will be promptly notified. Because a site visit is not currently anticipated, each application must be thorough and complete enough to stand on its own merits. The second-level review will be made by the National Advisory Council on Aging at its May 1995 meeting, for funding beginning in July 1995. The primary criterion for review by the NIA review committee in evaluating each grant application will be the potential of the proposed center to enhance research programs on basic mechanisms of aging. Not all additional criteria are applicable to every application, depending on number and extent of proposed cores. Specific review criteria are: 1. Contribution of cores to enhancement of ongoing research at the proposed Center to better understand basic mechanisms of aging. 2. Extent to which cores would provide opportunities for research experience for fellows and junior faculty. 3. Leadership ability and scientific stature of the program director and his/her ability to meet the program's demands of time and effort. 4. Qualifications, experience, and commitment of the investigators responsible for core units and their ability to devote the required time and effort to the program. 5. Presence of an administrative and organizational structure conducive to attaining the objectives of the proposed program. 6. Arrangements for internal quality control of ongoing research, the allocation of funds, day-to-day management, contractual agreements, and the internal communication and cooperation among investigators in the program. 7. Resource-related expenses on existing research project grants which can be transferred to the budget for this center to achieve greater efficiency and promote collaboration. 8. Quality of proposed external review process. 9. Appropriateness of the total budget and budgetary requests for the cores and new program development projects. 10. Academic and physical environment as it bears on space and equipment and on the potential for interaction among scientists within the center and with scientists from other departments, and/or institutions. 11. Institutional commitment to the requirements of the program. 12. The adequacy of the means for protecting against risks to human subjects, vertebrate animals and/or the environment. AWARD CRITERIA The anticipated date of the first year award will be July 1995. Funding criteria will be scientific merit (based on the review criteria listed above), availability of funds, and programmatic priorities. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues and address the letter of intent to: Richard L. Sprott, Ph.D. Biology of Aging Program National Institute on Aging Gateway Building, Room 2C231 7201 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-4996 FAX: (301) 402-0010 Direct inquiries regarding fiscal issues to: Robert Pike Grants and Contracts Management Office National Institute on Aging Gateway Building, Room 2N212 7201 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-1472 FAX: (301) 402-3672 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.866. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The Public Health Service (PHS) strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. .
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