ALCOHOL RESEARCH RESOURCE AWARDS (R24) Release Date: September 2, 1999 PA NUMBER: PAR-99-161 Update: The following update relating to this announcement has been issued: March 12, 2009 - This PAR has been reissued as (PAR-09-128). National Institute on Alcohol Abuse and Alcoholism PURPOSE In the pursuit of alcohol-related research, resources are occasionally developed that are used by and benefit the broader alcohol research community and are shared with scientists at both the resource developer"s home institution and at external institutions. While support for maintenance of these resources is often provided through a Regular Research Project Grant (R01) award or the core of an Alcohol Research Center (P50), situations may arise in which continued support of the resource through any or all of these instruments is not feasible. For example, demand for the resource by individuals from outside the home institution may exceed the capacity of support available through an investigator"s R01 or an institution"s P50. As well, the developers of the resource may have a reduced need for the resource, while other investigators continue to benefit from the resource. The objective of this Program Announcement (PA) is to provide general support of already established research resources that serve the alcohol research community. Under special circumstances, the mechanism may be used to support development of a new resource. It is anticipated that the request for resource support through the research resource grant (R24) mechanism will occur on an infrequent basis and only in circumstances where other mechanisms of support from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) are not appropriate. Applicants must demonstrate an interest in the resource by investigators from at least three different institutions, one of which may be their home institution. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA is related to the priority area of alcohol abuse and alcoholism. Potential applicants may obtain a copy of "Healthy People 2000" at http://odphp.osophs.dhhs.gov/pubs/hp2000. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign, for-profit and non- profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. All applicants must document that alcohol researchers from at least three different domestic institutions have need for the proposed resource. In addition to the core user group at three or more institutions, the resource should be made available to additional users at the applicant institution and should be opened to investigators at other institutions. Prior consultation with NIAAA and written approval is required before the submission of an application. MECHANISM OF SUPPORT This PA will use the National Institutes of Health (NIH) research resource grant (R24) mechanism. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. The total project period for an application submitted in response to this PA may not exceed 5 years. Competing renewal applications may be submitted for additional years beyond the initial project period. FUNDS AVAILABLE It is anticipated that up to $750,000 in total costs will be available annually for approximately three R24 awards, including both new and continuation awards. Because the nature and scope of the research resource proposed in response to this PA, it is anticipated that the size of an award will vary. RESEARCH OBJECTIVES The following list is intended to provide examples of potential alcohol research resources but is not intended to limit the range of potential resources: - Tissue and Data Resources -- Centralized facilities to provide human or animal tissue, to improve access to otherwise unavailable specimens and/or provide increased economy over existing resources. - Maintenance and Distribution of Animal Models of High Relevance to Alcohol Research -- Animal resources may include selected animal lines as well as transgenics, knockouts, and related resources. - Unique Database Resources Supporting Research Activities -- Costs may include those for collection, storage, analysis, and quality control of clinical and research data. Applicants should clearly describe the issues which the data resource will address and the importance of the resource to the user community. - Agent Development -- Resources to provide specific reagents, ligands or drugs useful in alcohol-related research. - Assay Support -- Operation of a laboratory providing non-commercially available assays of interest in alcohol research. APPLICATION PROCEDURES Prior written approval from NIAAA staff is required before an application will be accepted. A copy of this approval must be included as an appendix to the application. Applications are to be submitted on the grant application form PHS 398 (rev. 4/98) and will be accepted at the standard application deadlines as indicated in the application kit. Applications kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, email: firstname.lastname@example.org. For those applicants with internet access, the 398 kit may be found at https://grants.nih.gov/grants/forms.htm. The PA title and number must be typed on line 2 of the face page of the application form and the YES box must be marked. Page limits and limits on size of type are strictly enforced. Non-conforming applications will be returned without being reviewed. Submit a signed, typewritten original of the application, including the Checklist, and five signed photocopies in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the Center for Scientific Review. Incomplete applications will be returned to the applicant without further consideration. Applications will be evaluated for scientific and technical merit by an appropriate peer review group convened by the National Institute on Alcohol Abuse and Alcoholism in accordance with the review criteria stated below. As part of the initial merit review, a process will be used by the initial review group in which applications receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed, assigned a priority score, and receive a second level review by the National Advisory Council on Alcohol Abuse and Alcoholism. Review Criteria The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. The reviewers will comment on the following aspects of the application in their written critiques in order to judge the likelihood that the proposed research resource will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered by the reviewers in assigning the overall score weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have a major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. 1. Significance: Does the proposed resource address an important scientific need? Is that need adequately justified? Could the need have been easily satisfied in other ways? Will the resource support progress in the field? 2. Innovation: Does this application propose a resource not otherwise available to the broader research community? 3. Approach: (Plans to oversee operation of the resource and organizational plans for implementing them.) Are the plans for the operation and maintenance of the resource adequately developed? Are appropriate plans in place for assurance of quality control? Are appropriate procedures in place for handling requests for the resource, and for the adequate distribution of the resource? 4. Investigators: Are the qualifications of the resource leader(s) and key personnel well suited to organize and maintain the resource, maintain quality control and equitable access, and manage record keeping? 5. Environment: Are the facilities and equipment for the resource adequate? As appropriate, is outside scientific expertise available to advise on governance, management, and function of the resource? The initial review group will also examine: the appropriateness of the proposed project budget and duration, the provisions for the protection of human and animal subjects, and the safety of the research resource environment. AWARD CRITERIA Applications will compete for available funds with all other recommended applications assigned to NIAAA. The following will be considered in making funding decisions: quality of the proposed resource as determined by peer review, availability of funds, and program priority. INQUIRIES Inquiries are strongly encouraged to determine the responsiveness of proposed applications to the PA. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Kenneth R. Warren, Ph.D. Office of Scientific Affairs National Institute on Alcohol Abuse and Alcoholism 6000 Executive Boulevard, Room 409, MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-4375 FAX: (301) 443-6077 Email: Kwarren@willco.niaaa.nih.gov Direct inquiries regarding fiscal matters to: Judy Simons Grants Management Office National Institute on Alcohol Abuse and Alcoholism 6000 Executive Boulevard, Room 504, MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-2434 FAX: (301) 443-3891 Email: Jsimons@willco.niaaa.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance, No. 93.273. Awards are made under the authorization of the Public Health Service Act, Sections 301 and 464H, and administered under the NIH grants policies and Federal Regulations at Title 42 CFR Part 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency Review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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