DEVELOPMENT OF NONMAMMALIAN MODELS AND RELATED BIOLOGICAL MATERIALS FOR RESEARCH Release Date: June 17, 1999 PA NUMBER: PAR-99-115 (Reissued as PA-06-498) National Center for Research Resources SOME APPLICATIONS UNDER THIS PA USE THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. THE PA INCLUDES DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS PA. This PA replaces PA-93-109, which was published in the NIH Guide, Vol. 22, No. 33, September 17, 1993. PURPOSE The Comparative Medicine area, National Center for Research Resources (NCRR) is issuing this program announcement to encourage the submission of applications for the development of nonmammalian models and associated biological materials for biomedical research. Models to be considered must be applicable to the research interests of two or more categorical disease institutes of the NIH. The overall goal of these studies is to develop new nonmammalian research models of broad interest and expand on the usefulness of existing nonmammalian model systems. Accordingly, the mechanisms for Research Projects (R01), Exploratory/Developmental (R21) and Resource-Related Research Projects (R24) grants apply. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, Development of Nonmammalian Models and Related Biological Materials for Research, is related to several priority areas, including cancer, heart disease and stroke, diabetes and chronic disability conditions, maternal and infant health, and others. Potential applicants may obtain a copy of "Healthy People 2000 (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Applications may be submitted by foreign and domestic, for-profit and non- profit organizations, public and private, such as universities, college, hospitals, laboratories, units of State or local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as principal investigators. MECHANISM OF SUPPORT The support mechanisms for this program will be the individual investigator- initiated Research Project (R01), Exploratory/Developmental (R21) or Resource- Related Research Projects (R24) grants, as applicable. Under these mechanisms, the applicant will plan, direct, and carry out the research program. The proposed project period during which the research will be conducted should adequately reflect the time required to accomplish the stated goals and be consistent with the policy for grant support. Because the nature and scope of the research proposed in response to the PA may vary, it is anticipated that the size of an award will vary, as well. However, because the purpose of R21 grants is to help applicants acquire preliminary data for use in preparing R01 or R24 applications, support for the R21 grants is limited to two years with a maximum of $100,000 direct costs requested per year. In addition, for R01 and R24 applications, in accordance with NIH policy, applicants planning to submit an investigator-initiated new (type 1), competing continuation (type 2), competing supplement, or any amended/revised version requesting $500,000 or more in direct costs for any year are advised that they must contact Comparative Medicine, NCRR, program staff before submitting the application, i.e., as plans for the study are being developed. Furthermore, the applicant must obtain agreement from staff that the NCRR will accept the application for consideration for award. Finally, the applicant must identify, in a cover letter sent with the application, the staff member at the NCRR who agreed to accept assignment of the application. This policy requires an applicant to obtain agreement for acceptance of both any such application and any such subsequent amendment. Refer to the NIH Guide for Grants and Contracts, March 20, 1998 at https://grants.nih.gov/grants/guide/notice-files/not98-030.html Applications requesting $250,000 or less in direct costs should conform to modular grant application procedures as outlined below under the section APPLICATION PROCEDURES. For applications requesting $250,000 or less in direct costs, specific application instructions have been modified to reflect "MODULAR GRANT" and "JUST-IN-TIME" streamlining efforts being examined by the NIH. Complete and detailed instructions and information on Modular Grants can be found at https://grants.nih.gov/grants/funding/modular/modular.htm. RESEARCH OBJECTIVES Strength in biomedical research relates to the development of new model systems and continued development of tools related to existing model systems which make those models more useful or more widely applicable. Some biological characteristics may be revealed more readily in less complex, more tractable species because of structural simplicity, especially at the genetic or cellular levels. The objective of this announcement is to stimulate research on the development of nonmammalian models and related research materials for biomedical research. Examples of types of models which will be considered include nonmammalian species such as fishes, amphibians, reptiles, invertebrates, and microorganisms, and in vitro systems, such as cell lines (including embryonic stem cells). Preferred models are those which can be extensively studied from a number of perspectives and which have the potential to provide well-understood principles that can be described in detail in terms of genetics, biochemistry, physiology, or other aspects. For purposes of this PA, models must be of interest to at least two categorical/disease Institutes of the National Institutes of Health. Research materials which are closely related to nonmammalian models and which, when made available, will broaden the utility of the models for research of interest to at least two categorical/disease Institutes of the National Institutes of Health may be considered. Examples of such models and related materials of interest include, but are not limited to: o viable, preserved germ cells o cell lines and cell culture models for nonmammalian animals where culture systems are not well developed but would be widely used o collections of stocks of animals with transposable element insertions o collections of stocks of transgenic animals with Green Fluorescent Protein fusions in the genome o efficient methods of gene knockout or targeted gene replacement in animals o research tools for proteome analysis For R24 applications, the applicant must demonstrate a need for the resource in the biomedical community. This information should be included in the Significance section of the application and, where appropriate, may include letters of support from potential beneficiaries of the resource to be developed. It is recommended that potential applicants contact Comparative Medicine program staff, as indicated below before submitting the application. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 4/98) and will be accepted at the standard application deadlines as indicated in the application kit. Application kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD, 20892-7910, telephone 301-710-0267, email: [email protected]. Forms are on-line at https://grants.nih.gov/grants/funding/phs398/phs398.html. The program announcement title and number must be typed on line 2 of the face page of the application form and the YES box must be marked. Applications requesting $250,000 or less in direct costs per year should conform to modular grant application procedures as announced in the NIH Guide, December 15, 1998. The modular grant concept establishes specific modules in which direct costs may be requested as well as a maximum level for requested budgets. Only limited budgetary information is required under this approach. The just-in-time concept allows applicants to submit certain information only when there is a possibility for an award. It is anticipated that these changes will reduce the administrative burden for the applicants, reviewers and Institute staff. Instructions for the PHS 398 form should be followed except, for applications under modular grant procedures, the following special instructions apply: o FACE PAGE: Items 7a and 7b should be completed, indicating Direct Costs (in $25,000 increments up to a maximum of $250,000) and Total Costs [Modular Total Direct plus Facilities and Administrative (F&A) costs] for the initial budget period. Items 8a and 8b should be completed indicating the Direct and Total Costs for the entire proposed period of support. o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form Page 4 of the PHS 398. It is not required and will not be accepted with the application. o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete the categorical budget table on Form Page 5 of the PHS 398. It is not required and will not be accepted with the application. o NARRATIVE BUDGET JUSTIFICATION - Use a Modular Grant Budget Narrative page. (See https://grants.nih.gov/grants/funding/modular/modular.htm for sample pages.) At the top of the page, enter the total direct costs requested for each year. o Under Personnel, List key project personnel, including their names, percent of effort, and roles on the project. No individual salary information should be provided. o For Consortium/Contractual costs, provide an estimate of total costs (direct plus facilities and administrative) for each year, each rounded to the nearest $1,000. List the individuals/organizations with whom consortium or contractual arrangements have been made, the percent effort of key personnel, and the role on the project. Indicate whether the collaborating institution is foreign or domestic. The total cost for a consortium/ contractual arrangement is included in the overall requested modular direct cost amount. o Provide an additional narrative budget justification for any variation in the number of modules requested. o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information used by reviewers in the assessment of each individual"s qualifications for a specific role in the proposed project, as well as to evaluate the overall qualifications of the research team. A biographical sketch is required for all key personnel, following the instructions below. No more than three pages may be used for each person. A sample biographical sketch may be viewed at: https://grants.nih.gov/grants/funding/modular/modular.htm -Complete the educational block at the top of the form page, -List position(s) and any honors -Provide information, including overall goals and responsibilities, on research projects ongoing or completed during the last three years. -List selected peer-reviewed publications, with full citations, o CHECKLIST - This page should be completed and submitted with the application. If the F&A rate agreement has been established, indicate the type of agreement and the date. It is important to identify all exclusions that were used in the calculation of the F&A costs for the initial budget period and all future budget years. o The applicant should provide the name and phone number of the individual to contact concerning fiscal and administrative issues if additional information is needed following the initial review. Submit the signed, original, single-sided application, along with five exact, single-sided copies and five collated sets of appendix materials to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040-MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) REVIEW CONSIDERATIONS Applications will be reviewed for completeness by the Center for Scientific Review and for responsiveness to this program announcement by the NCRR staff. Incomplete and/or non-responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NCRR in accordance with NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and may undergo a process in which only those applications deemed to have the highest scientific merit, generally the top one half of applications under review, will be discussed, assigned a priority score, and receive a second level review by the National Advisory Research Resources Council, NCRR. Review Criteria for R01 and R24 Applications The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. In the written comments, reviewers will be asked to discuss the following aspects of the application in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. o Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? o Approach: Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? o Innovation: Does the project employ novel concepts, approaches or methods? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? o Investigator: Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? o Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? Review Criteria for R21 Applications The review of R21 application will include the same criteria as applied to R01 and R24 applications. However, this grant mechanism is designed to emphasize exploratory/developmental research and to provide the opportunity to collect sufficient preliminary data to demonstrate study feasibility in order to apply for further support through other mechanisms. Therefore, review of R21 applications will emphasize 1) the potential to provide a significant advance in biomedical research and 2) the originality of the project. All Applications: In addition to the above criteria, in accordance with NIH policy, all applications will be reviewed with respect to the following: o Appropriateness of the proposed budget and duration in relation to the proposed research. o The adequacy of the proposed protection for humans, animals or the environment, to the extent they may be adversely affected by the project proposed in the application. AWARD CRITERIA Applications will compete for available funds with all other recommended applications assigned to the NCRR. The following will be considered when making funding decisions: o Quality of the proposed project as determined by peer review o Availability of funds o Program balance among research areas of the announcement INQUIRIES Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Michael C. Chang, Ph.D. Division of Comparative Medicine National Center for Research Resources 6705 Rockledge Drive, Room 6172 Bethesda, MD 20892 Telephone: (301) 435-0744 FAX: (301) 480-3819 E-mail: [email protected] Direct inquiries regarding fiscal matters to: Ms. Irene Grissom Office of Grants Management National Center for Research Resources 6705 Rockledge Drive, Room 6212 Bethesda, MD 20892 Telephone: (301) 435-0844 E-mail: [email protected] AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.849. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74 and 92. This program is not subject to the intergovernmental review requirement of Executive Order 12372 or Health Systems Agency Review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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