Department of Health and Human Services

Part 1. Overview Information
Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

Fogarty International Center (FIC)
National Institute of Mental Health (NIMH)

Funding Opportunity Title

Training Programs for Critical HIV Research Infrastructure for Low- and Middle-Income Country Institutions (G11)

Activity Code
G11- Extramural Associate Research Development Award 
Announcement Type

New

Related Notices

NOT-TW-10-006; NOT-TW-11-010; NOT-TW-11-016; NOT-TW-11-015; NOT-TW-11-014

  • April 25, 2013 - This PAR has been expired and reissued as PAR-13-215.
  • January 25, 2012 - See Notice NOT-TW-12-007. This Notice is to inform potential applicants that the Fogarty International Center is clarifying and correcting information relating to application instructions and Additional review criteria.
Funding Opportunity Announcement (FOA) Number

PAR-12-069

Companion FOA

PAR-12-070 (D71), PAR-12-068 (D43)

Number of Applications

See Section III. 3. Additional Information on Eligibility.

Catalog of Federal Domestic Assistance (CFDA) Number(s)

93.989, 93.242

FOA Purpose

The purpose of this FOA is to encourage U.S. institutions with research collaborations at low-and middle-income country (LMIC) institutions to submit applications for training programs to strengthen the leadership and expertise in selected critical research infrastructure areas at their collaborating LMIC institutions.  This FOA can support training related to technical expertise, administration and financial management in support of:

  • dedicated research offices
  • offices of research integrity
  • ethics committees for protection of human subjects
  • committees for animal care and use in research
  • health sciences  libraries (library and information science)
  • information and communications technology systems (ICT) - (expertise  to keep systems up and running) 
Key Dates
Posted Date

December 22, 2011

Open Date (Earliest Submission Date)

June 24, 2012

Letter of Intent Due Date

June 24, 2012, June 24, 2013, June 24, 2014

Application Due Date(s)

July 24, 2012, July 24, 2013, July 24, 2014, by 5:00 PM local time of applicant organization.

AIDS Application Due Date(s)

Not Applicable

Scientific Merit Review

October/November 2012, October/November 2013, October /November 2014

Advisory Council Review

January 2013, January 2014, January 2015

Earliest Start Date(s)

April 2013, April 2014, April 2015

Expiration Date

(Now Expired April 26, 2013 per issuance of PAR-13-215), Originally July 25, 2014

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the SF 424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

The overall goal of the Fogarty HIV Research Training Program is to strengthen the human capacity to contribute to the ability of institutions in low- and middle-income countries (LMIC) to conduct HIV-related research on the evolving HIV-related epidemics in their country and to compete independently for research funding.  See http://data.worldbank.org/about/country-classifications/country-and-lending-groups for the countries defined as low-and middle-income.

The Fogarty HIV Research Training Program encourages applications under three different Funding Opportunities Announcements (FOAs).  The Fogarty International Center (FIC) and the National Institute of Mental Health (NIMH), through this FOA (G11), are encouraging applications from U.S. institutions to support training to develop and strengthen leadership and expertise in specific research infrastructure areas at an LMIC institution with which the U.S. applicant institution has on-going HIV research collaborations. This training is expected to strengthen the HIV research capacity of the specified LMIC institution.  Applicants interested in scientific research training should consult the D71 and D43 FOAs (PAR-12-070, PAR-12-068). 

The Fogarty International Center (FIC), with co-funding from other NIH Institutes, Centers and Offices, has provided 25 years of support to HIV research through two HIV research training programs, the AIDS International Training and Research Program (AITRP) and the International Clinical, Operations and Health Services Research Training Award for AIDS TB program (ICOHRTA AIDS TB (ICOHRTA AIDS TB).  Awards under these two programs have supported research training of LMIC individuals who have participated in important HIV research, conducted at LMIC institutions and in partnership with U.S. and other international scientists and scientific institutions.  Over the years, some of the most important recent scientific advances in HIV/AIDS, including interventions to reduce mother-to-child HIV transmission, to address HIV/TB co-infection, and to prevent HIV infection through behavior change, microbicides, and antiretroviral drugs, have been facilitated through partnerships with LMIC scientists and supported by the FIC research training programs.

Efforts to implement research findings within the context of increased provision of HIV prevention, care and treatment services in LMIC over the past ten years have led to the emergence of new research issues, such as combination HIV prevention interventions, better linking of newly diagnosed individuals into care programs, and integration of HIV programs with other health services. As LMICs implement HIV prevention, care and treatment programs for their populations, these and other, yet undefined, research issues will need evidenced based solutions.  Because the social context of an LMIC will influence the research designed to answer these evolving research questions, LMIC institutions and their researchers, who intimately understand the social context of their country and with the research capacity to design and conduct the research, are best positioned to conduct the most relevant research, disseminate the results in-country, and influence policymakers, program managers and medical/public health practice.  Continued investment in training to strengthen research and research capacity at LMIC institutions is needed to address the on-going HIV epidemic in LMICs.

FIC decided to consolidate the two FIC HIV research training programs in FY2013 into a new program, Fogarty HIV Research Training Program.  This new program is designed to focus each individual award on specific research capacity at an identified LMIC institution. The new program will move beyond simple output indicators (number and type of people trained) to outcome indicators (increased research capacity at an institutional level) for more meaningful monitoring and evaluating both of individual awards and of the program as a whole. This FOA complements the other two FOAs, which are focused on scientific research training, by supporting training that addresses several research infrastructure areas considered critical to successful high quality research.  It provides opportunities for U.S. institutions and their LMIC institutional research partner to collaborate to identify gaps in capacity and to design training to bring the partner LMIC institution to the next level of capacity in a critical research infrastructure area.  Research infrastructure training programs will maximize previous FIC and other NIH research and research training investments in LMIC institutions, will further strengthen the LMIC institution's research and research training capabilities, and will provide additional and more accessible research infrastructure training opportunities to others in their own country and in other LMICs.

This FOA under the Fogarty HIV Research Training Program can support training related to technical expertise, administration and financial management in support of:

Each individual application will need to:

The proposed training is expected to raise the LMIC institution to the next level of capacity in the research infrastructure area.  In some cases, it is anticipated that the proposed program will complement other ongoing research infrastructure training programs occurring at the LMIC institution. The applicant should describe any other research infrastructure programs at the LMIC institution, regardless of the source of funding, and explain what distinguishes the proposed training program from the other training programs, how their program will synergize with the others, if applicable, and make it clear that the pool of training staff, potential trainees, and resources are robust enough to support additional programs.

Awards made for applications in response to this FOA can  support a mix of short-(three months or less), medium-(over three months and up to six months) and long-(six months and longer) term training to support increased capacity in the specified research infrastructure area at the LMIC institution identified in the application.  Only individuals who are or are expected to be associated with that LMIC institution are eligible for training under this FOA. 

Emphasis should be on training that provides the theoretical and applied depth needed by an individual or by a group of individuals in the LMIC institution to support capacity in the specific research infrastructure area that will be maintained at a level of high quality after the training.   Over time, it is anticipated that some of the LMIC institutions could reach a level of capacity that they could serve as training sites in their defined research infrastructure area for other LMIC institutions, and existing staff at LMIC institutions are eligible for further training to achieve that goal.

Training should be appropriate to the context of the LMIC institution, and training sites may include institutions other than the applicant or LMIC institution named in the application. Innovative approaches and topics for training, such as a practicum, collaborative exchanges, leadership training, organizational planning, career development planning, mediation/negotiation training, are encouraged.  Distance learning with sufficient mentoring and support at the LMIC institution can be an option.  Training-related projects must be conducted or involve data from the LMIC or the LMIC institution identified in the application.

Proposed training staff and mentors should have expertise and experience relevant to the proposed training program. Mentors must be committed to continue their involvement throughout the total period of the mentee’s participation in this award.

Applicants are encouraged to review the FIC Strategic Plan at http://www.fic.nih.gov/About/Pages/Strategic-Plan.aspx and the NIH Plan for HIV-Related Research for the year they are applying, available at http://www.oar.nih.gov/strategicplan/.  Applicants are also encouraged to explore research training in topics of interest to PEPFAR (http://www.pepfar.gov/) and the U.S. Global Health Initiative (http://www.ghi.gov/).

Section II. Award Information
Funding Instrument

Grant

Application Types Allowed

New
Resubmission
The OER Glossary and the SF 424 (R&R) Application Guide provide details on these application types.

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious applications.

Award Budget

Application budgets are limited to $92,000 direct costs. Facilities and Administrative (F&A) costs requested by consortium participants are not included in the direct cost limitation, see NOT-OD-05-004.  Facilities and administrative costs are limited to 8% for all awards and sub-awards.

Award Project Period

Three years  

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Higher Education Institutions

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

Nonprofits Other Than Institutions of Higher Education

Eligible U.S. institutions must demonstrate active and strong HIV-related collaborations with the LMIC institution named in their application.  The applicant institution must have a strong and high quality research infrastructure program in the area proposed under this FOA and must have the requisite training staff and facilities to conduct the proposed training program.

The applicant institution must assure support for the proposed program. Both the applicant institution and LMIC institution named in an application must demonstrate institutional commitment to the proposed training by identifying a tangible means of support. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program.

Foreign Institutions

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Required Registrations

Applicant organizations must complete the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following registrations.

All Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization.

All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least 4-6 weeks prior to the application due date.

Eligible Individuals (Program Director(s)/Principal Investigator(s))

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research infrastructure training as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Women and individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PD(s)/PI(s), visit the Multiple Program Director(s)/Principal Investigator(s) Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) Application Guide.

The PD(s)/PI(s) should be an established expert in the research infrastructure area in which the application is targeted and capable of providing both administrative and professional leadership to the development and implementation of the proposed training. The PD(s)/PI(s) will be expected to monitor and assess the program and submit all documents and reports as required.

The PD(s)/PI(s) must include relevant staff and training staff expected to facilitate the proposed training program and contribute to its ability to bring the LMIC institution to the next level of capacity in the specific research infrastructure area.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility

Number of Applications

Applicant organizations may submit more than one application, provided that each application is programmatically distinct.

NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application. NIH will not accept any application that is essentially the same as one already reviewed. Resubmission applications may be submitted, according to the NIH Policy on Resubmission Applications from the SF 424 (R&R) Application Guide.

 Current AITRP and Phase II ICOHRTA AIDS TB award institutions are not eligible to submit applications under this FOA until the last year of their current AITRP or Phase II ICOHRTA AIDS TB project period.

Section IV. Application and Submission Information

1. Requesting an Application Package

Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.

2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

For information on Application Submission and Receipt, visit Frequently Asked Questions – Application Guide, Electronic Submission of Grant Applications.

Letter of Intent

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information:

The letter of intent should be sent to:

Jeanne McDermott
Program Officer
Division of International Training and Research
Fogarty International Center, NIH
Bldg 31 Rm B2 C39
31 Center Dr. MSC 2220
Bethesda MD 20892-2220 U.S.A.
Telephone: 301-496-1492
Email: jeanne.mcdermott@nih.gov

Required and Optional Components

The forms package associated with this FOA includes all applicable components, mandatory and optional.  Please note that some components marked optional in the application package are required for submission of applications for this FOA. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate “optional” components.

Page Limitations

All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

SF424(R&R) Cover Component, SF424(R&R) Project/Performance Site Locations Component

Item 12.  Proposed Project Start and Ending Dates - Use the “Earliest Anticipated Start Dates” given in this FOA as the Proposed Project Start Date.

Include the applicant institution, the identified LMIC institution in the application and any other participating institutions, both U.S. and foreign as performance sites.

SF424(R&R) Other Project Information Component

Follow all instructions provided in the SF424 (R&R) Application with the following modifications:

Item 6. Foreign Award or With Foreign Component- Check YES and list the foreign countries in 6a for all of the performance sites that you listed in SF 424 (R&R) Project/Performance Site Locations Component.

Project Summary /Abstract. Provide an abstract for the entire application, including the long-term goals and objectives of the program, key elements of the training plan, and a brief description of planned training program. Include the country and name of the LMIC institution and the specified research infrastructure area for which training is being proposed.  Include the rationale and design of the training program, the expected increased research capacity and the measures the applicant will use to demonstrate that increased capacity.

Project Narrative-  Include the name of the LMIC and the LMIC institution, the specified research infrastructure area for which training is being proposed, and describe the public health relevance of the increased research capacity to the LMIC.

SF424(R&R) Senior/Key Person Profile Expanded Component

Follow the directions in SF424 for whom to include as Senior or key personnel. In addition,

Include the name of one person at the LMIC institution who will serve as the main collaborator, select “Other,” and list their role as “Key Collaborator.”

Include at least ONE person at all of the other U.S. and foreign participating institutions as senior/Key Personnel and identify their role.

R&R Budget Component

This FOA will not use the modular budget.  Refer to the Other Award Budget Information Section in this FOA, and follow all instructions provided in the SF424 (R&R) Application Guide with the following modifications:

PHS 398 Research Plan Component

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:

Specific Aims:

Include the research infrastructure area for which training is being proposed and identify the LMIC institution for which the training is being proposed.

Describe the proposed training program, including the goals, objectives, and how the program will meet the objectives outlined in this FOA, “to bring the LMIC institution to the next level of capacity” in the specified research infrastructure area.

Research Strategy (Capacity Building Strategy)

Use the directions below for Research Strategy (Capacity building Strategy) in place of the instructions in the 424 Application Guide:

a) Significance

Describe why the specific research infrastructure area was selected for the particular LMIC institution identified in the application. Identify areas of mutual interest with the priorities of the LMIC, the LMIC institution and co-sponsoring NIH Institutes, Centers or Offices identified on this FOA.

Describe the existing resources that already exist at the applicant and participating institutions that will contribute to the success of the proposed training program. Identify research infrastructure gaps in important resources necessary for HIV research and describe how these gaps could be filled by the proposed training. Letters of support that describe how these other programs will collaborate with the proposed training program should be included under item 14: Letters of Support.

b) Investigators

Describe how the LMIC institutional leadership and relevant professional staff from the LMIC institution were involved in the planning, decision-making and development of the application.

Describe the prior and current HIV research collaborations among the applicant institution, LMIC institution and other participating institution(s), and how they demonstrate strong partnerships that will support the proposed training. Letters of support that describe how the on-going collaboration will support the training and vice versa should be included under item 14: Letters of Support.

Describe the qualifications of the PD(s)/PI(s) to provide leadership for the proposed training program, including relevant scientific or professional background and relevant training experience.

Indicate the level of effort and activities for which the PD(s)/PI(s) will be responsible.

Provide a short description of the expertise for each of the professional staff from all participating institutions that is relevant to their role in the proposed training plan. Applications should include descriptions of the roles and bio-sketches for relevant faculty, mentors and other teaching staff expected to participate in the proposed training

If multiple PD(s)/PI(s) are involved in the training program, applicants must describe how the training program and trainees will benefit from the arrangement and include the required Leadership Plan. See Section III.1.B and Section IV.2 in this FOA for NIH multiple PD(s)/PI(s) instructions: Multiple Principal Investigators, and information in Section 8.7.10 of the Research Training Program Plan Component Instructions. 

c) Innovation

Describe innovative strategies that will be used to engage trainees in training-related research infrastructure activities that relate to on-going HIV research at the LMIC institution.

Describe how the training approach and /or the resulting expected increased capacity in the critical research infrastructure area will expand the expectations of the LMIC institution in its research capacity.

d) Approach

Indicate how the proposed program relates to prior and current training activities, relevant to the specified research infrastructure area, by others at the LMIC institution, regardless of funding source. Describe how the proposed training will leverage and support, but not duplicate, the current training activities.  Letters of support that describe how these other programs will collaborate with the proposed training program should be included under item 14: Letters of Support

Provide a three-year training implementation plan that describes and provides the rationale for the type of training, topics of the training and the expected candidates for each type of training included.

Describe courses and research infrastructure project opportunities that will be available to trainees.

Describe a plan for providing mentoring that will support trainees while in and following courses and while conducting training-related projects relevant to the specified research infrastructure area.

Describe the plans for the integration of the proposed training with other relevant capacity building activities at the LMIC institution.

Describe the criteria, recruitment and selection procedures for trainees defined in the three-year training implementation plan. Describe the role of the LMIC institution professional staff in the process.  Criteria should include a list of standards that will be used to ensure that trainees have appropriate prior training and experience, are likely to complete the training, and are likely to contribute to the increased capacity of the LMIC institution in the specified research infrastructure area. Identify potential trainees from existing LMIC institution staff and why they would be recruited.

Describe a plan for retaining students in the program until completion.

Define measures that can be used to demonstrate increased capacity at the end of the three-year funding period in the specific research infrastructure area for which the training program is proposed.

Describe how the data for those measures will be collected and how they will be monitored over the three-year period.

Describe the mechanism to be used to annually review the capacity measures, the progress of the trainees and other indications of the effectiveness of your training program.  Describe the roles of the professional staff at the LMIC institution and all other participating institutions, of current and former trainees in the review process.

e) Environment

Include short descriptions of all of the on-going HIV research at the LMIC, regardless of funding source, and describe how the training in the specified research infrastructure area will support this research.

Describe the institutional support and commitment to the goals of the training program by the applicant and LMIC institutions.  The application should include a description of support (financial and otherwise) to be provided to the proposed program. This could include, for example, space, shared laboratory facilities and equipment, funds for curriculum development, release time for the PD(s)/PI(s) and/or participating training and professional staff, support for additional trainees in the program, or any other creative ways to improve the climate for the establishment and growth of the training program.  Letters of support from officials at LMIC government or LMIC institution that describe how they will support and collaborate with the future training program should be included under item 14: Letters of Support.

Describe the administrative structure of the training program and the distribution of responsibilities within, including a description of how the PD(s)/PI(s) will obtain continuing advice with respect to the operation of the program from the LMIC collaborator and other participating partners.

Items 4-11 under Research Plan Attachments are not applicable for this FOA

Resource Sharing Plan

Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the SF424 (R&R) Application Guide, with the following modification:

Appendix

Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.

3. Submission Dates and Times

Part I. Overview Information contains information about Key Dates. Applicants are encouraged to submit in advance of the deadline to ensure they have time to make any application corrections that might be necessary for successful submission.

Organizations must submit applications via Grants.gov, the online portal to find and apply for grants across all Federal agencies. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH’s electronic system for grants administration.

Applicants are responsible for viewing their application in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

4. Intergovernmental Review (E.O. 12372)

This initiative is not subject to intergovernmental review.

5. Funding Restrictions

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement.

6. Other Submission Requirements and Information

Applications must be submitted electronically following the instructions described in the SF 424 (R&R) Application Guide.  Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically.

Important reminders:
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF 424(R&R) Application Package. Failure to register in the Commons and to include a valid PD(s)/PI(s) Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization’s profile in the eRA Commons and for the Central Contractor Registration (CCR). Additional information may be found in the SF424 (R&R) Application Guide.

See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review, NIH. Applications that are incomplete will not be reviewed.

Post Submission Materials

Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115.

Section V. Application Review Information

1. Criteria

Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review system.

For this particular announcement, note the following:

The research infrastructure training program proposed should be evaluated for its expected ability to bring the LMIC institution to the next level of capacity in the critical research infrastructure area proposed in the application.  The applicant should provide a clear rationale for the selection of the research infrastructure area as critical to the research capacity of the LMIC institution.  The applicant should describe how the proposed training will build or strengthen the LMIC institutional capacity in the proposed research infrastructure area.  While the applicant can and should collaborate and leverage other efforts at the designated LMIC institution, regardless of funding source, the application will need to demonstrate that the proposed training is “distinct” and not duplicative of other efforts at the LMIC institution in that research infrastructure area.

Overall Impact

Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research capacity in research infrastructure areas at LMIC institutions, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Scored Review Criteria

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Significance

Does the project address an important problem or a critical barrier to progress in the field at the LMIC institution? If the aims of the project are achieved, how will the research capacity at the LMIC institution be improved? Does the proposed program provide training that will support research capacity that will be maintained at a higher level of quality after the project period?

Investigator(s)    

Does the history of collaborations among the training staff/mentors at the participating institutions provide a strong platform for the proposed training? Does the PD(s)/PI(s) have the technical background, expertise, and experience to provide strong leadership, direction, management, and administration to the proposed research infrastructure training program?  Does the PD(s)/PI(s) plan to commit sufficient time to the program to ensure its success?  Are sufficient numbers of experienced professional staff and mentors with appropriate expertise and funding available to support the proposed training program? Do the professional staff/mentors have strong records as professionals in areas directly related to the proposed training program? Do the training staff and mentors have strong records of training individuals from LMICs?  

Innovation

Has the applicant described innovative strategies for trainees to be engaged in the specified research infrastructure area in relation to HIV-related research at LMIC institution? Will the training approach and /or the resulting expected increased capacity in the critical research infrastructure area expand the expectations of the LMIC institution in its research capacity? 

Approach

Does the design of the proposed training (the objectives, design, direction and mix of short-, medium- and long- term training) provide an effective training program in the specified research infrastructure area?  Does the proposed training program take advantage of the LMIC institution’s research infrastructure and of previous and current investments and support from FIC, NIH, and other organizations? Does the proposed training appear to be distinct and not duplicative of training or efforts in the specified research administration area being provided by others at the LMIC institution?  Is a recruitment plan proposed with strategies to attract appropriate and high quality trainees? Are there well-defined and justified selection criteria and retention strategies?

How well has the applicant defined measures that can be used to demonstrate increased capacity in the particular research infrastructure area at the end of the three-year funding period? Does the program have a rigorous evaluation plan to assess the quality and effectiveness of the training over the three-year period? How adequate is the proposed method to monitor the long-term impact of the training experience on the subsequent research capacity at the LMIC institution? Are effective mechanisms in place for obtaining feedback from current and former trainees?    

Environment

Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available from both the applicant and LMIC institutions to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?  Is sufficient administrative and training support provided for the program? Does the application and PD/PI demonstrate true partnership with the LMIC institution and key collaborator in the planning, implementation and evaluation of the proposed training? 

Additional Review Criteria

As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact/priority score, but will not give separate scores for these items.

Protections for Human Subjects

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Inclusion of Women, Minorities, and Children 

When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. For additional information on review of the Inclusion section, please refer to the Human Subjects Protection and Inclusion Guidelines.

Vertebrate Animals

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer

Biohazards

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer

Resubmissions

For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.

Renewals

Not Applicable

Revisions

Not Applicable

Additional Review Considerations

As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact/priority score.

Applications from Foreign Organizations

Not applicable.

Select Agent Research

Not Applicable.

Resource Sharing Plans

Not Applicable.

Budget and Period of Support

Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

2. Review and Selection Process

Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) of Center for Scientific Review, in accordance with NIH peer review policy and procedures, using the stated review criteria. Review assignments will be shown in the eRA Commons.

As part of the scientific peer review, all applications:

Applications will be assigned  to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the FIC Advisory Board. The following will be considered in making funding decisions:

3. Anticipated Announcement and Award Dates

After the peer review of the application is completed, the PD(s)/PI(s) will be able to access his or her Summary Statement (written critique) via the eRA Commons

Information regarding the disposition of applications is available in the NIH Grants Policy Statement.

Section VI. Award Administration Information

1. Award Notices

If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement.

A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee’s business official.

Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.      

Any application awarded in response to this FOA will be subject to the DUNS, CCR Registration, and Transparency Act requirements as noted on the Award Conditions and Information for NIH Grants website.

2. Administrative and National Policy Requirements

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General  and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.

Cooperative Agreement Terms and Conditions of Award

Not Applicable.

3. Reporting

When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants Policy Statement.  Awards providing funds for mentored research projects by medium- or long-term trainees must report on the trainees and mentors selected for funding, the status of the research projects, and any resulting publications.  Grantees will be requested to enter information annually concerning long- term trainees into FIC’s CareerTrac, a database to track the training history and accomplishments of trainees over time.  The database will be made available to grantees after the award is made.

A final progress report, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement.

The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later.  All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000.  See the NIH Grants Policy Statement for additional information on this reporting requirement. 

Section VII. Agency Contacts

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

Application Submission Contacts

Grants.gov Customer Support (Questions regarding Grants.gov registration and submission, downloading or navigating forms)
Contact Center Phone: 800-518-4726
Email: support@grants.gov

GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources)
Telephone 301-435-0714
TTY 301-451-5936
Email: GrantsInfo@nih.gov

eRA Commons Help Desk (Questions regarding eRA Commons registration, tracking application status, post submission issues)
Phone: 301-402-7469 or 866-504-9552 (Toll Free)
TTY: 301-451-5939
Email: commons@od.nih.gov

Scientific/Research Contact(s)

Jeanne McDermott
Fogarty International Center (FIC)
Telephone: 301-496-1492
Email: jeanne.mcdermott@nih.gov

Dr. Willo Pequegnat
National Institute of Mental Health
Telephone:  301-443-1187
Email: wpequegn@mail.nih.gov

Peer Review Contact(s)

Hilary D. Sigmon, Ph.D., R.N.
Center for Scientific Review (CSR)
Telephone:  301-357-9236
Email:  hilary.sigmon@nih.gov

Financial/Grants Management Contact(s)

Bruce Butrum
Fogarty International Center (FIC)
Telephone: 301-496-1670
Email: Bruce.Butrum@nih.gov

Rita Sisco
National Institute of Mental Health (NIMH)
Telephone: (301) 443-2805
Email: siscor@mail.nih.gov

Section VIII. Other Information

Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Authority and Regulations

Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 287b) and under Federal Regulations 42 CFR Part 63a.


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