NIDDK SHORT-TERM TRAINING FOR MEDICAL STUDENTS (T35)

RELEASE DATE:  April 7, 2004

PA NUMBER:  PAR-04-090

EXPIRATION DATE: February 1, 2007, unless reissued. 

Department of Health and Human Services (DHHS)

PARTICIPATING ORGANIZATION: 
National Institutes of Health (NIH) 
 (http://www.nih.gov)

COMPONENT OF PARTICIPATING ORGANIZATION:  
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 
 (http://www.niddk.nih.gov/)

CATALOG OF FEDERAL DOMESTIC ASSISTANCE NUMBER(S):  93.847, 93.848, 93.849

THIS PA CONTAINS THE FOLLOWING INFORMATION

o Purpose of the PA
o Research Objectives
o Mechanism of Support 
o Eligible Institutions
o Individuals Eligible to Become Principal Investigators
o Special Requirements 
o Where to Send Inquiries
o Submitting an Application
o Supplementary Instructions
o Peer Review Process
o Review Criteria
o Award Criteria
o Required Federal Citations

PURPOSE OF THIS PA 
 
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 
invites new and competing continuation applications for its ongoing Short-
Term Training for Medical Students program.  This trans-NIDDK program 
provides short-term research support for medical students, or students in 
health professional schools, to expose them to career opportunities in 
research related to diabetes, obesity, endocrine disorders, metabolic 
diseases, nutritional disorders, digestive diseases, liver disease, kidney 
diseases, urologic diseases, and hematologic disorders.  These Institutional 
National Research Service Award (NRSA) grants (T35) provide support for 
training experiences of eight to twelve consecutive weeks under the 
supervision of experienced researchers. This exposure to an active research 
environment may encourage students to pursue a biomedical or behavioral 
research career.  In addition to the research experience, institutions are 
encouraged to provide seminars, research forums, guest lecturers, student 
presentations, special courses, or travel to a scientific meeting of interest 
to the student.

RESEARCH OBJECTIVES

The NIDDK Short-Term Research Training program is intended to

o expose medical, or other health professional, students, early in their 
training, to the excitement and challenges of a research career;

o encourage students to seriously consider pursuing either a basic, 
behavioral, or clinical research career in the areas of research that are 
important to the NIDDK;

o provide valuable experience and references for students who hope to obtain 
further research training and funding in the future; and 

o increase the pool of physician scientists engaged in biomedical or 
behavioral research in those areas necessary to continue the mission of the 
NIDDK.

MECHANISM OF SUPPORT 

This PA will use the National Institutes of Health (NIH) National Research 
Service Award (NRSA) Short-Term Training grant (T35) award mechanism.  As an 
applicant, you will be solely responsible for planning, directing, and 
executing the proposed training program.

The total project period for an application submitted in response to this PA 
may not exceed five years.  

ELIGIBLE INSTITUTIONS 

Only domestic, non-profit, private or public institutions may apply for 
grants to support research training programs.  The applicant institution must 
have a strong research program in the area(s) proposed for research training 
and must have the requisite staff and facilities to carry out the proposed 
program.

INDIVIDUALS ELIGIBLE TO BECOME PRINCIPAL INVESTIGATORS

Any individual with the skills, knowledge, and resources necessary to 
organize and implement a high quality research training program is invited to 
work with their institution to develop an application for support.  
Individuals from underrepresented racial and ethnic groups, disadvantaged 
backgrounds, or individuals with disabilities are always encouraged to apply 
for NIH programs.  The research training program director at the institution 
will be responsible for the selection and appointment of students to the 
training grant and for the overall direction, management, and administration 
of the program.

SPECIAL REQUIREMENTS 

The applicant institution must have the available research facilities, 
personnel, and support for the program in the areas of diabetes, 
endocrinology, metabolic disorders, digestive diseases, nutrition, obesity, 
kidney, urology, or hematologic diseases.  These grants will support short-
term research training experiences of consecutive two to three months 
duration, generally between the first and second years of medical school. 

Trainees must have successfully completed at least one semester at a school 
of medicine, optometry, osteopathy, dentistry, veterinary medicine, pharmacy, 
or public health prior to participating in the program.  Institutions must 
adhere strictly to these requirements when selecting trainees.  These grants 
are intended to introduce students to research that would not otherwise be 
available through their regular course of studies.  The research period must 
not be a requirement for the degree being earned, nor may the research period 
be used for credit towards the degree being earned.

Trainees must be citizens or non-citizen nationals of the United States or 
must have been lawfully admitted for permanent residence (i.e., in possession 
of a currently valid Alien Registration Receipt Card I-551, or some other 
legal verification of such status).  Non-citizen nationals are generally 
persons born in outlying possessions of the United States (e.g., American 
Samoa and Swains Island).  Individuals on temporary or student visas and 
individuals holding Ph.D., M.D., D.V.M., or equivalent doctoral degrees in 
the health sciences are not eligible. 

Trainees appointed to the program need not be from the applicant institution, 
but may be students from other institutions as long as they fulfill the 
eligibility requirements listed above.

WHERE TO SEND INQUIRIES

We encourage your inquiries concerning this PA and welcome the opportunity to 
answer questions from potential applicants.  Inquiries may fall into three 
areas:  scientific/research, peer review, and financial or grants management 
issues:

o Direct your questions about scientific/research issues to:

Judith Podskalny, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases 
6707 Democracy Boulevard, Rm. 667
Bethesda, MD 20892-5450
Telephone:  (301) 594-8876
FAX:  (301) 480-8300
E-mail:  jp53s@nih.gov 

o Direct your questions about peer review issues to: 

Francisco Calvo, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases 
6707 Democracy Boulevard, Rm. 752
Bethesda, MD 20892-5452
Telephone:  (301) 594-8897
FAX:  (301) 480-8300
E-mail:  fc15y@nih.gov 

o Direct your questions about financial or grants management matters to:

Denise Payne
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Boulevard, Rm. 733
Bethesda, MD 20892-5456
Telephone:  (301) 594-8845
FAX:  (301) 480-3504
E-mail:  dp43b@nih.gov 

SUBMITTING AN APPLICATION

Applications must be prepared using the PHS 398 research grant application 
instructions and forms (rev. 5/2001). Applications must have a Dun and 
Bradstreet (D&B) Data Universal Numbering System (DUNS) number as the 
Universal Identifier when applying for Federal grants or cooperative 
agreements. The DUNS number can be obtained by calling (866) 705-5711 or 
through the web site at http://www.dunandbradstreet.com/. The DUNS number 
should be entered on line 11 of the face page of the PHS 398 form. The PHS 
398 is available at http://grants.nih.gov/grants/funding/phs398/phs398.html 
in an interactive format.  For further assistance contact GrantsInfo, 
Telephone (301) 435-0714, Email: GrantsInfo@nih.gov.

The title and number of this program announcement must be typed on line 2 of 
the face page of the application form and the YES box must be marked.

SUPPLEMENTARY INSTRUCTIONS 

Institutions may request support for at least 6, but not more than 35 
trainees per budget period, based on a full-time, three month appointment.  A 
trainee must be appointed for a minimum of two months and a maximum of three 
months during a budget period.  Institutions are encouraged to appoint a 
trainee for more than one budget period, if scheduling allows, i.e. for two 
or more consecutive summers.  A student may be appointed, in special 
circumstances, to more than one 3-month period during a budget period, 
provided prior approval is obtained from the staff of the NIDDK.  All 
research training must be full-time during the specified training period.  It 
is expected that most programs will provide a summer research training 
program, but other innovative program designs and time schedules will be 
considered.  The requested number of short-term trainees must be justified in 
the application based on the number of students enrolled in the medical or 
health professional school; the magnitude and focus of the research supported 
at the applicant institution, particularly its relevance to the areas of 
research supported by the NIDDK; the interest of the investigators to serve 
as training faculty, and role models; and the level of interest of the 
students.  Students should be able to pursue basic, behavioral, and/or 
clinical research projects in the broad areas of diabetes, obesity, 
endocrinology, metabolic diseases, digestive and hepatobiliary diseases, 
nutrition, and kidney, urologic, and hematologic disorders.

Funds may be requested for:

o Stipends – The FY04 stipend level for trainees is $1731 per month.  The 
stipend level actually awarded will be that in effect for predoctoral 
trainees at the time the award is issued. Stipends may be supplemented from 
non-Federal funds, however, under no circumstances may the conditions of the 
supplementation interfere with, detract from or prolong the participant’s 
NRSA supported training program. 

o Training-related Expenses – up to $183 per month per trainee may be 
requested yearly.  This may be used for faculty, laboratory, and secretarial 
assistance; supplies and equipment; consultant costs; and tuition and fees.

o Travel Expenses – The institution may request up to $1,000 per year per 
trainee to cover the cost of travel to a relevant scientific meeting.  The 
meeting should typically be one held in the same budget period as that in 
which the training occurs.

A Statement of Appointment form (PHS 2271, rev. 4/98) must be submitted at 
the start of each trainee appointment and reappointment.  This form is 
available at the following URL address: 
http://grants.nih.gov/training/phs2271.pdf . Trainees supported under this 
program are not required to sign an NRSA Payback Agreement; however, they 
must submit an NRSA termination Notice.

Every NRSA trainee supported by an institutional training grant must receive 
instruction in the Responsible Conduct of Research.  (For more information on 
this provision, see the current announcement for NRSA Intuitional Research 
training grants [T32] published in the NIH Guide for Grants and Contracts[PA-
02-109; Release Date: Nay 16, 2002] or at the following URL address: 
http://grants.nih.gov/grants/guide/pa-files/PA-02-109.html
 
APPLICATION RECEIPT DATES: Applications submitted in response to this program 
announcement will be accepted at the standard application deadlines for 
Institutional National Research Service Awards – January 10, May 10, and 
September 10. Application deadlines are also indicated in the PHS 398 
application kit.

SENDING AN APPLICATION TO THE NIH: Submit a signed, typewritten original of 
the application, including the Checklist, and three signed, photocopies, in 
one package to:
 
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040
Bethesda, MD  20892-7710
Bethesda, MD  20817 (for express/courier service)
 
At the time of submission, two additional copies of the application and all 
copies of the appendix material must be sent to:

Chief, Review Branch 
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Boulevard, Rm. 752
Bethesda, MD  20892-5452
(for express/courier service: Bethesda, MD  20817)

APPLICATION PROCESSING: Applications must be mailed on or before the receipt 
dates described at 
http://grants.nih.gov/grants/funding/submissionschedule.htm.  The CSR will 
not accept any application in response to this PA that is essentially the 
same as one currently pending initial review unless the applicant withdraws 
the pending application.  The CSR will not accept any application that is 
essentially the same as one already reviewed.  This does not preclude the 
submission of a substantial revision of an unfunded version of an application 
already reviewed, but such application must include an Introduction 
addressing the previous critique.  

Although there is no immediate acknowledgement of the receipt of an 
application, applicants are generally notified of the review and funding 
assignment within 8 weeks.

PEER REVIEW PROCESS

Applications submitted for this PA will be assigned on the basis of 
established PHS referral guidelines. Appropriate scientific review groups 
convened in accordance with the standard NIH peer review procedures 
(http://www.csr.nih.gov/refrev.htm) will evaluate applications for scientific 
and technical merit.  

As part of the initial merit review, all applications will:

o Undergo a selection process in which all submitted applications will be 
discussed and assigned a priority score
o Receive a written critique
o Receive a second level review by the National Diabetes and Digestive and 
Kidney Diseases Advisory Council.

REVIEW CRITERIA

The following criteria will be considered when evaluating the applications:

o the objectives and design of the research training program;

o the qualifications of the program director and the participating preceptors 
as basic and clinical researchers, including publications and successful 
competition for research support;

o past training record of both the program director and the designated 
preceptors;

o the institutional training environment, including the institutional 
commitment to training students in basic and clinical research, quality of 
the facilities, availability of appropriate courses and seminars, and the 
availability of research support;

o the proposed plans for advertisement, selection, and assignment of trainees 
to preceptors;

o the availability of high quality trainees; and

o the institution’s plan for measuring the effectiveness of the training 
program, including the productivity of the trainees (e.g. publications, 
abstracts, presentations); the impact of the program on the institution; and 
the impact of the program on the career choices, opportunities, and further 
research activities of the trainees.

The review group will also comment on each application’s plan for attracting 
individuals from underrepresented minority groups into the research training 
program and for training in the responsible conduct of research.

PROTECTION OF HUMAN SUBJECTS FROM RESEARCH RISK: The involvement of human 
subjects and protections from research risk relating to their participation 
in the proposed research will be assessed. (See criteria included in the 
section on Federal Citations, below).
http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm 

INCLUSION OF WOMEN, MINORITIES AND CHILDREN IN RESEARCH: The adequacy of 
plans to include subjects from both genders, all racial and ethnic groups 
(and subgroups), and children as appropriate for the scientific goals of the 
research will be assessed.  Plans for the recruitment and retention of 
subjects will also be evaluated. (See Inclusion Criteria in the sections on 
Federal Citations, below).

CARE AND USE OF VERTEBRATE ANIMALS IN RESEARCH: If vertebrate animals are to 
be used in the project, the five items described under Section f of the PHS 
398 research grant application instructions (rev. 5/2001) will be assessed.  

BUDGET: The reasonableness of the proposed budget and the requested period of 
support in relation to the proposed research training.

AWARD CRITERIA

Applications will compete for available funds with all other approved 
applications assigned to the National Institute of Diabetes and Digestive and 
Kidney Diseases.  The following will be considered in making funding 
decisions:

o Quality of the proposed training program as determined by peer review;
o Availability of funds;
o Program priority, i.e. how focused on NIDDK research areas is the proposed 
training; and
o Geographic distribution.

REQUIRED FEDERAL CITATIONS 

HUMAN SUBJECTS PROTECTION:  Federal regulations (45CFR46) require that 
applications and proposals involving human subjects must be evaluated with 
reference to the risks to the subjects, the adequacy of protection against 
these risks, the potential benefits of the research to the subjects and 
others, and the importance of the knowledge gained or to be gained. 
http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm

DATA AND SAFETY MONITORING PLAN:  (NIH Policy for Data and Safety Monitoring, 
NIH Guide for Grants and Contracts, June 12, 1998: 
http://grants.nih.gov/grants/guide/notice-files/not98-084.html). 

SHARING RESEARCH DATA:  Starting with the October 1, 2003 receipt date, 
investigators submitting an NIH application seeking $500,000 or more in 
direct costs in any single year are expected to include a plan for data 
sharing or state why this is not possible. 
http://grants.nih.gov/grants/policy/data_sharing Investigators should seek 
guidance from their institutions, on issues related to institutional 
policies, local IRB rules, as well as local, state and Federal laws and 
regulations, including the Privacy Rule. Reviewers will consider the data 
sharing plan but will not factor the plan into the determination of the 
scientific merit or the priority score.

INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH: It is the policy of 
the NIH that women and members of minority groups and their sub-populations 
must be included in all NIH-supported clinical research projects unless a 
clear and compelling justification is provided indicating that inclusion is 
inappropriate with respect to the health of the subjects or the purpose of the 
research. This policy results from the NIH Revitalization Act of 1993 (Section 
492B of Public Law 103-43).

All investigators proposing clinical research should read the "NIH Guidelines 
for Inclusion of Women and Minorities as Subjects in Clinical Research - 
Amended, October, 2001," published in the NIH Guide for Grants and Contracts 
on October 9, 2001 
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html); 
a complete copy of the updated Guidelines are available at 
http://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm   
The amended policy incorporates: the use of an NIH definition of clinical 
research; updated racial and ethnic categories in compliance with the new OMB 
standards; clarification of language governing NIH-defined Phase III clinical 
trials consistent with the new PHS Form 398; and updated roles and 
responsibilities of NIH staff and the extramural community.  The policy 
continues to require for all NIH-defined Phase III clinical trials that: a) 
all applications or proposals and/or protocols must provide a description of 
plans to conduct analyses, as appropriate, to address differences by 
sex/gender and/or racial/ethnic groups, including subgroups if applicable; 
and b) investigators must report annual accrual and progress in conducting 
analyses, as appropriate, by sex/gender and/or racial/ethnic group 
differences.

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS: 
The NIH maintains a policy that children (i.e., individuals under the age of 
21) must be included in all human subjects research, conducted or supported 
by the NIH, unless there are scientific and ethical reasons not to include 
them. This policy applies to all initial (Type 1) applications submitted for 
receipt dates after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines" on the inclusion of children as participants in 
research involving human subjects that is available at 
http://grants.nih.gov/grants/funding/children/children.htm. 

REQUIRED EDUCATION ON THE PROTECTION OF HUMAN SUBJECT PARTICIPANTS: NIH 
policy requires education on the protection of human subject participants for 
all investigators submitting NIH proposals for research involving human 
subjects.  You will find this policy announcement in the NIH Guide for Grants 
and Contracts Announcement, dated June 5, 2000, at 
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.

HUMAN EMBRYONIC STEM CELLS (hESC): Criteria for federal funding of research on 
hESCs can be found at http://stemcells.nih.gov/index.asp and at  
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-005.html.  Only 
research using hESC lines that are registered in the NIH Human Embryonic Stem 
Cell Registry will be eligible for Federal funding (see http://escr.nih.gov).   
It is the responsibility of the applicant to provide, in the project 
description and elsewhere in the application as appropriate, the official NIH 
identifier(s)for the hESC line(s)to be used in the proposed research.  
Applications that do not provide this information will be returned without 
review. 

PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT: The 
Office of Management and Budget (OMB) Circular A-110 has been revised to 
provide public access to research data through the Freedom of Information Act 
(FOIA) under some circumstances.  Data that are (1) first produced in a 
project that is supported in whole or in part with Federal funds and (2) 
cited publicly and officially by a Federal agency in support of an action 
that has the force and effect of law (i.e., a regulation) may be accessed 
through FOIA.  It is important for applicants to understand the basic scope 
of this amendment.  NIH has provided guidance at 
http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm.

Applicants may wish to place data collected under this PA in a public 
archive, which can provide protections for the data and manage the 
distribution for an indefinite period of time.  If so, the application should 
include a description of the archiving plan in the study design and include 
information about this in the budget justification section of the 
application. In addition, applicants should think about how to structure 
informed consent statements and other human subjects procedures given the 
potential for wider use of data collected under this award.

STANDARDS FOR PRIVACY OF INDIVIDUALLY IDENTIFIABLE HEALTH INFORMATION:  The 
Department of Health and Human Services (DHHS) issued final modification to 
the “Standards for Privacy of Individually Identifiable Health Information”, 
the “Privacy Rule,” on August 14, 2002.  The Privacy Rule is a federal 
regulation under the Health Insurance Portability and Accountability Act 
(HIPAA) of 1996 that governs the protection of individually identifiable 
health information, and is administered and enforced by the DHHS Office for 
Civil Rights (OCR). Those who must comply with the Privacy Rule (classified 
under the Rule as “covered entities”) must do so by April 14, 2003 (with the 
exception of small health plans which have an extra year to comply).  

Decisions about applicability and implementation of the Privacy Rule reside 
with the researcher and his/her institution. The OCR website 
(http://www.hhs.gov/ocr/) provides information on the Privacy Rule, including 
a complete Regulation Text and a set of decision tools on “Am I a covered 
entity?”  Information on the impact of the HIPAA Privacy Rule on NIH 
processes involving the review, funding, and progress monitoring of grants, 
cooperative agreements, and research contracts can be found at 
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-025.html.

URLs IN NIH GRANT APPLICATIONS OR APPENDICES: All applications and proposals 
for NIH funding must be self-contained within specified page limitations. 
Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) 
should not be used to provide information necessary to the review because 
reviewers are under no obligation to view the Internet sites.   Furthermore, 
we caution reviewers that their anonymity may be compromised when they 
directly access an Internet site.

HEALTHY PEOPLE 2010: The Public Health Service (PHS) is committed to 
achieving the health promotion and disease prevention objectives of "Healthy 
People 2010," a PHS-led national activity for setting priority areas. This PA 
is related to one or more of the priority areas. Potential applicants may 
obtain a copy of "Healthy People 2010" at http://www.healthypeople.gov/.

AUTHORITY AND REGULATIONS: This program is described in the Catalog of 
Federal Domestic Assistance at http://www.cfda.gov/ and is not subject to the 
intergovernmental review requirements of Executive Order 12372 or Health 
Systems Agency review.  Awards are made under the authorization of Sections 
301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) 
93.847, 93.848, and 93.849 and under Federal Regulations 42 CFR 52 and 45 CFR 
Parts 74 and 92. All awards are subject to the terms and conditions, cost 
principles, and other considerations described in the NIH Grants Policy 
Statement.  The NIH Grants Policy Statement can be found at 
http://grants.nih.gov/grants/policy/policy.htm 

The PHS strongly encourages all grant recipients to provide a smoke-free 
workplace and discourage the use of all tobacco products.  In addition, 
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in 
certain facilities (or in some cases, any portion of a facility) in which 
regular or routine education, library, day care, health care, or early 
childhood development services are provided to children.  This is consistent 
with the PHS mission to protect and advance the physical and mental health of 
the American people.


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices


Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS)
  USA.gov - Government Made Easy


Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.