This Program Announcement expires on February 28, 2004, unless reissued.

INTERNATIONAL RESEARCH SCIENTIST DEVELOPMENT AWARD

Release Date:  December 1, 2000

PA NUMBER:  PAR-01-025

Application Deadline:  February 13

Fogarty International Center

PURPOSE

The International Research Scientist Development Award (IRSDA) is offered by 
the Fogarty International Center (FIC) for U.S. postdoctoral biomedical 
scientists, in the formative stages of their careers, who seek an opportunity 
to continue research in, or extend their research experience into, developing 
countries.  It provides the successful candidate with a period of mentored 
research as part of a strong, established collaboration between a U.S. sponsor 
and leading developing country scientist at an internationally recognized 
research institution.  It is expected that, following this experience, the 
candidate will be able to pursue an independent and productive international 
research career, involving ongoing collaboration with developing country 
scientists on research relevant to stemming a major global health problem.
  
BACKGROUND

In this award the Fellow will have the opportunity to work in a direct 
collaboration with an established foreign scientist and maintain a scientific 
base with a U.S. investigator who is involved in collaborative research at the 
developing country institution where the applicant will work.  It is expected 
that these awards will serve to forge working relationships between 
outstanding U.S. scientists, early in their careers, who are potential future 
heads of basic, clinical and behavioral/social health research programs in the 
U.S., and established, developing country researchers, to study global health 
problems of mutual interest.

The IRSDA is part of a long-term FIC strategy to support centers of research 
excellence in developing countries that address global health research 
priorities.  This support is envisioned to:

o  Attract new research talent to and enhance the multi-disciplinary synergy 
among the research collaborators at the U.S. and foreign sites;

o  Leverage existing research and training support for developing country 
scientists and U.S. scientists committed to international research;

o  Support the coalescence of the critical, sustainable components necessary 
to move developing country institutions with significant potential to new 
levels of research excellence; and

o  Stimulate a more effective translation of the results of research on global 
health problems into practical public health actions.

Overall, this strategy seeks to reduce health disparities between developed 
and developing countries and between population groups within countries.

HEALTHY PEOPLE 2010

The Public Health Service (PHS) is committed to achieving the health promotion 
and disease prevention objectives of "Healthy People 2010," a PHS-led national 
activity for setting priority areas.  This Program Announcement (PA), IRSDA, 
is related to one or more of the priority areas.  Potential applicants may 
obtain a copy of "Healthy People 2010" at 
http://www.health.gov/healthypeople/.

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic, for-profit and non-profit 
organizations, public and private, such as universities, colleges, hospitals, 
laboratories, units of State and local governments, and eligible agencies of 
the Federal government.  Racial/ethnic minority individuals, women, and 
persons with disabilities are encouraged to apply as principal investigators.

To be eligible for the award the applicant must:

1.  Be a U.S. citizen or non-citizen national or lawfully admitted for 
permanent residence and in possession of an Alien Registration Receipt Card 
(I-151 or I- 551) or some other verification of legal admissions as a 
permanent resident.  Non-citizen nationals are usually born in areas that are 
not states but are under U.S. sovereignty, jurisdiction or administration.  
Individuals on temporary or student visas are not eligible;

2.  Hold a doctoral, dental or medical degree or the equivalent in a health 
science field;

3.  Have earned the relevant degree within seven years of the application 
receipt date (time spent in clinical training does not count toward seven year 
limit);

4.  Have demonstrated a commitment and competence in health research as well 
as the potential to engage in independent and productive basic biomedical, 
behavioral or epidemiological/clinical research in the period following the 
award;

5.  Have mentors in the United States and in the eligible developing country 
who have ongoing, funded, international collaborative research in the foreign 
mentor’s country or region.  Funding may include, but is not limited to, 
sources such as a National Institutes of Health (NIH) R01 grant with a foreign 
component, Fogarty International Research Collaboration Award, World Health 
Organization grant, Burroughs-Wellcome Foundation grant or other international 
agency funding. 

o  The developing country mentor should be in an internationally recognized 
developing country research institution addressing one or more of that 
country's major health problems.  Eligible countries include those in the 
following regions (subject to U.S. State Department travel restrictions):  
Africa, Asia (except Japan, Singapore, South Korea and Taiwan), Russia and 
countries of the Former Soviet Union, Central and Eastern Europe, Latin 
America and the Caribbean, the Middle East (except Israel) and the Pacific 
Ocean Islands (except Australia and New Zealand).  Applications to work in 
institutions in sub-Saharan Africa are especially encouraged.

o  The U.S. mentor should be at a U.S. institution of higher learning or 
nonprofit research institution.

6.  Submit a research proposal related to but not overlapping with the 
collaborative research project of the U.S. and foreign site mentors;

7.  Candidates must justify the need for 36 months of mentored research 
training, including research experience at the foreign site.  The applicant 
must be able to show that the proposed period of support will substantially 
enhance his/her career and/or will allow the pursuit of a novel or promising 
approach to a particular developing country health research problem.

8.  Applications must be submitted on behalf of the candidate by the U.S. 
mentor's institution, which must be a U.S. non- federal, public or private, 
institution of higher education (or academic medical centers affiliated with 
such institutions).  The applicant need not already be at the U.S. mentor's 
institution at the time of application, but it is expected that the U.S. 
component of the project will be carried out by the Fellow at the U.S. 
mentor's institution. 

9.  Candidates who are more than seven years beyond the eligible degree, but 
who have interrupted their careers because of illness or family commitments, 
may also apply.  They must clearly demonstrate the potential for productive 
independent research and the need for an additional period of mentored 
research experience in order to accomplish an effective scientific re-entry.

10.  Candidates who have been involved in clinical training that puts them 
more than seven years beyond their degree may also be eligible to apply.

MECHANISM OF SUPPORT

This PA will use the NIH career development (K01) award mechanism.  
Responsibility for the planning, direction, and execution of the proposed 
project will be the responsibility of the candidate, her/his mentor at the 
foreign site and her/his U.S. mentor on behalf of the applicant institution. 

The IRSDA offers a total of 36 funded months, which can be spread out over a 
maximum of five years.  The award is for an intensive, mentored research 
experience in a clinical, field or lab setting associated with a strong 
research collaboration at a well-recognized research institution in a 
developing country.  A total of at least 24 months should be at the foreign 
site under the joint supervision of the U.S. and foreign mentors.  A period of 
work in the foreign country should be at least three months in length.  A 
total of up to 12 months will be funded for work at the U.S. institution under 
the U.S. mentor's supervision in order to support the transitions between 
foreign and U.S. institutions.  Grantees who obtain a tenure-track faculty 
position at any U.S. institution may submit a competitive renewal application 
during the final 12 months of the award for an additional two years of funding 
for continuing collaborative international research studies.

RESEARCH OBJECTIVES

The IRSDA provides international research opportunities (in eligible 
developing countries) for U.S. postdoctoral biomedical, 
epidemiological/clinical and behavioral scientists, with cutting-edge 
technical training, and who are committed to careers in international health 
research.  The award supports direct collaboration between the U.S. scientist 
and established developing country sponsor on a research project of mutual 
interest in the context of an ongoing relationship between the U.S. and 
foreign sponsors.  The award is specifically designed to facilitate the 
candidate's transition between the U.S. and foreign institutions and to 
enhance subsequent pursuit of an independent research career.  In the long 
term, it is expected that these awards will serve to forge relationships 
between a new generation of U.S. scientists and established scientists in 
developing countries.  It is expected that such ongoing collaborations will 
work to address global health problems and to reduce global health 
disparities.

The specific research training may be new to the candidate or an extension of 
the candidate's prior research, but should focus on international research 
areas pertinent to health in developing countries.  Applications are 
encouraged to address one of the global health research priorities defined by 
the World Health Organization (http://www.who.ch) which include, but are not 
limited to, infectious diseases, chronic/degenerative conditions and mental 
health disorders.  Basic, behavioral/social and clinical biomedical research 
will be supported in clinical, field or laboratory settings. 

The FIC recognizes that there will be significant differences in the U.S. and 
foreign institutional environments, applicants, U.S. sponsor and foreign 
mentor backgrounds and approaches to international research collaboration 
among applications.  Therefore, applicants should define their specific 
research and training goals, methods to achieve these goals, and specific 
measurable objectives to enable assessment of their proposed project with 
reference to the overall goals described above.

SPECIAL REQUIREMENTS

Evaluation

Recipients may be contacted periodically after the completion of the award for 
updates on the progress of their careers including their employment history, 
publications, receipt of research grants or contracts, honors and awards, 
professional activities and achievements and other information required for an 
evaluation of the impact of the program.

Protection of Research Subjects

Applicable provisions for the protection of research subjects and laboratory 
animals must be met in both domestic and foreign institutions, including 
obtaining any necessary single project assurances.  Applicants should see 
Title 45 CFR, Part 46 for information concerning the Department of Health and 
Human Services regulations for the Protection of Human Subjects and the PHS 
Policy on Humane Care and Use of Laboratory Animals.  These are available 
from: 

The Office for Human Research Protections,
Department of Health and Human Services 
6100 Executive Boulevard, Suite 3B01, MSC 7507
Rockville, MD 20892-7507
http://www.hhs.gov/ohrp.
ohrp@osophs.dhhs.gov 

Office of Laboratory Animal Welfare
National Institutes of Health
RKL1, Suite 1050, MSC 7982
6705 Rockledge Drive
Bethesda, MD 20892-7982
http://grants.nih.gov/grants/olaw/olaw.htm

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and 
their sub-populations must be included in all NIH-supported biomedical and 
behavioral research projects involving human subjects, unless a clear and 
compelling rationale and justification are provided indicating that inclusion 
is inappropriate with respect to the health of the subjects or the purpose of 
the research. This policy results from the NIH Revitalization Act of 1993 
(Section 492B of Public Law 103-43).

All investigators proposing research involving human subjects should read the 
UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in 
Clinical Research," published in the NIH Guide for Grants and Contracts on 
August 2, 2000 (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html); 
a complete copy of the updated Guidelines are available at 
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm: The 
revisions relate to NIH defined Phase III clinical trials and require: a) all 
applications or proposals and/or protocols to provide a 
description of plans to conduct analyses, as appropriate, to address 
differences by sex/gender and/or racial/ethnic groups, including subgroups if 
applicable; and b) all investigators to report accrual, and to conduct and 
report analyses, as appropriate, by sex/gender and/or racial/ethnic group 
differences.
 
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by the 
NIH, unless there are scientific and ethical reasons not to include them.  
This policy applies to all initial (Type 1) applications submitted for receipt 
dates after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines on the Inclusion of Children as Participants in 
Research Involving Human Subjects" that was published in the NIH Guide for 
Grants and Contracts, March 6, 1998, and is available at the following URL 
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html.

Investigators also may obtain copies of these policies from the program staff 
listed under INQUIRIES.  Program staff may also provide additional relevant 
information concerning the policy.

URLS IN NIH GRANT APPLICATIONS OR APPENDICES

All applications and proposals for NIH funding must be self-contained within 
specified page limitations.  Unless otherwise specified in an NIH 
solicitation, internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no obligation 
to view the Internet sites.  Reviewers are cautioned that their anonymity may 
be compromised when they directly access an Internet site.

APPLICATION PROCEDURES

Applications are to be submitted on the grant application form PHS 398 (rev. 
4/98).  Applicants should use the additional instructions for preparing in 
Individual Research Career Award Application “K”series on pages IV1-IV7 in 
Form 398 when preparing their applications. Application kits are available at 
most institutional offices of sponsored research and may be obtained from the 
Division of Extramural Outreach and Information Resources, National Institutes 
of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 
301/435-0714, email:  GrantsInfo@nih.gov, website:  
http://grants.nih.gov/grants/forms.htm.

The title and number of the program announcement must be typed on line 2 of 
the face page of the application form and the YES box must be marked.

The application must address the following issues:

Candidate

o  Establish the candidate's commitment to a career in international 
biomedical, clinical or behavioral research addressing a major global health 
problem;

o  Establish the candidate's potential to develop into a successful 
independent investigator;

o  Summarize the candidate's immediate and long-term career objectives, 
explaining how the award will contribute to their attainment.

o  Letters of recommendation.  Three sealed letters of recommendation from 
senior research scientists, addressing the candidate's potential for an 
international research career, must be included as part of the application.  
One of the three letters should be from the applicant's thesis advisor, 
research supervisor, chief of staff or department head.  Letters of 
recommendation should not be submitted from either the U.S. or foreign 
sponsor.

Career Development Plan

o  Describe the candidate's career development plan.  The plan should 
incorporate a detailed description of Ph.D. and other previous research 
experiences as well as an explanation of long-term career goals of the 
applicant and role of this award in achieving them including future foreign 
collaboration.  It should delineate a systematic approach to obtain the 
necessary basic biomedical or behavioral science background and research 
experience to launch an independent international research career addressing a 
major global health problem.

Training in Responsible Conduct of Research

o  Candidates must describe evidence of previous training or plans to receive 
instruction in the responsible conduct of research in an international 
context.  The topics of, format, frequency and duration of instruction as well 
as the amount and nature of faculty participation should be detailed.  No 
award will be made if an application lacks this component.

Research Plan

o  Describe the research plan as outlined in form PHS 398 and the use of a 
basic science or clinical approach to a biomedical or behavioral problem 
including the Specific Aims, Background and Significance, Progress 
Report/Preliminary Studies, Research Design and Methods sections.  It should 
include an annual schedule of planned activities at the U.S and foreign sites 
during the award period.  The research plan should serve as a justification 
for conducting research abroad and provide a clear description of the 
relationship between the proposed research and current research efforts at 
U.S. and foreign labs.

U.S. and Foreign Mentor Statements

o  The application must include information from the U.S. and foreign mentors 
including their research qualifications and previous experience and record in 
supervising research training (number of Ph.D. and post-docs mentored and 
their current career status).  Both U.S. and foreign mentors should submit 
Biographical Sketches, Other Support and Resources Forms.  The application 
must also include a detailed plan for the supervision of the Fellow, by both 
mentors, at each institution, during the proposed award period.

U.S. and Foreign Institutional Commitments

o  The extent and quality of the research environment, relevant to the 
candidate's research focus, should be described for the U.S. and foreign 
institutions.  The research environment includes faculty and staff capable of 
productive collaboration with the candidate, seminars and opportunities for 
interactions with other research groups and scientists and available research 
facilities and equipment.

o  A detailed description of overall research funding at the foreign 
institution (government, non-governmental and international sources), specific 
for the proposed research area, should be included to support its status as an 
existing or potential center of research excellence.

BUDGET

Budget requests must be provided according to instructions in form PHS 398 as 
modified by the Just-In-Time Procedures instituted in 1996 (NIH Guide for 
Grants and Contracts, Vol. 25, No. 10, March 29, 1996 and as modified in Vol. 
25, Number 16, May 17, 1996), including information on the mentor's pending 
and current research support, as stipulated.

No detailed budget is required.  However, total direct costs for all years 
must be provided in addition to the name, role on project and percent effort.  
In addition, Other Support information for the applicant is not required as 
part of the initial application.  However, Other Support information is 
required for the mentor and co-mentor.  If there is a possibility for an 
award, necessary budget and Other Support information for the applicant will 
be requested by FIC staff following the initial review. 

Total direct costs over 36 months may not exceed $300,000 prorated at a rate 
of $8333 direct costs per month ($6250 per month direct costs for salary and 
fringe benefits; $2083 per month for all other allowable direct costs). 

Allowable direct costs within the cap include:

1.  Salary and fringe benefits for up to $75,000 per 12 months, prorated at 
$6250 per month, equivalent to a full time, 12-month staff appointment based 
on the level of experience of the candidate (i.e. comparable to other staff 
members of equivalent qualifications, rank and responsibilities in the U.S. 
sponsor's department).  The institution may supplement the NIH contribution to 
the candidate's salary up to a level that is consistent with the institution's 
salary scale.  Institutional supplementation of salary must not require extra 
duties or responsibilities that would interfere with the purpose of the award.  
The FIC will consider a request for an administrative supplement, up to 
$20,000, during the third year of the award, for candidates who obtain a 
tenure-track faculty position upon return to the U.S., in order to bring the 
salary to a level more consistent to the institution's scale for that status; 
2.  Travel Costs:  Round trip economy class airfare (on a U.S. carrier) and 
necessary ground transportation for the candidate to the foreign site up to 
five times over the duration of the project; Roundtrip economy airfare for 
each dependent accompanying the awardee for six months or more abroad; Excess 
baggage allowance;
3.  Health insurance and Living Allowance:  May cover health insurance costs 
of up to $50 per month, for the candidate and each dependent, during the time 
abroad, and allow a supplemental living allowance of $150 per month for each 
dependent accompanying the awardee for six months or more abroad; 
4.  Research Development Support: These funds may be used for the following 
expenses:  (a) tuition, fees, and books related to career development; (b) 
research  expenses, such as supplies, equipment and technical personnel; (c) 
in-country travel required for research, 
research meetings or training; (d) statistical and computational services 
(including personnel and computer time (e) Language training.  All expenses 
must be directly related to the proposed research career development program.  

Facilities and Administrative costs of eight percent are applied to allowable 
direct costs.

Submit a signed, typewritten original of the application, including the 
Checklist, and three signed photocopies in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

Send two (2) copies and appendices to Dr. Madelon Halula(listed in INQUIRIES 
below).

Applications must be received by the application receipt date listed in the 
heading of this PA.  If an application is received after that date, it will be 
returned to the applicant without review.

The Center for Scientific Review (CSR) will not accept any application in 
response to this PA that is essentially the same as one currently pending 
initial review, unless the applicant withdraws the pending application.  This 
does not preclude the submission of substantial revisions of an application 
already reviewed, but such applications must include an introduction 
addressing the previous critique.

REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by CSR.  Incomplete 
applications will be returned to the applicant without further consideration.

Applications that are complete and responsive to the PA will be evaluated for 
scientific and technical merit.  Peer review will be conducted by an 
appropriate scientific review group convened by the National Institute of 
Allergy and Infectious Diseases (NIAID) in accordance with the standard NIH 
peer review procedures.  As part of the initial merit review, all applications 
will receive a written critique and undergo a process in which only those 
applications deemed to have the highest scientific merit, generally the top 
half of applications under review, will be discussed, assigned a priority 
score, and receive a second level review by the FIC Advisory Board.

Review Criteria

The goals of NIH supported research are to advance our understanding of 
biological systems, improve the control of disease and enhance health.

The following specific review criteria will be applied:

Candidate

o  Commitment to an independent international research career including 
potential to contribute to knowledge that will address a major global health 
problem;

o  Potential to develop (or evidence of the capacity to develop) as an 
independent investigator pursuing international research;

o  Quality and relevance of prior scientific training and experience including 
detailed description of previous research, record of previous research support 
and publications;

Career Development Plan

o  Likelihood that the plan will contribute substantially to the scientific 
development of the candidate, the achievement of scientific independence and 
ongoing involvement in collaborative international research;

o  Appropriateness of the research plan to the career goals of the candidate;

o  Appropriateness of the plan to increase conceptual and theoretical 
knowledge in the research area proposed;

o  Consistency of the career development plan with the candidate's prior 
research and academic experience and the stated career goals;

o  Clarity of the goals and scope of the plan and the need for the proposed 
research experience at the foreign site;

o  Adequacy of the proposed training for responsible conduct of research in an 
international context.

Research Plan

o  Usefulness of the research plan as a vehicle for enhancing existing 
research skills as described in the career development plan;

o  Scientific and technical merit of the research question, design and 
methodology judged in the context of the candidate's previous training and 
experience;

o  Relevance of the proposed research to a major global health problem;

o  Relevance of the proposed research to the candidate's career objectives;

U.S. and Foreign Mentors

o  Appropriateness of U.S. and foreign mentors’ research and training 
qualifications for the proposed project;

o  The extent of the commitment of each mentor to supervising and guiding the 
candidate throughout the award period;

o  Adequacy of each mentor's previous experience in fostering the development 
of independent researchers highlighting persons involved in international 
research;

o  Adequacy of each mentor's research productivity and grant support related 
to the proposed project.

U.S. and Foreign Institutional Environment

o  Adequacy of the research facilities at the U.S. and foreign institutions;

o  Adequacy of the training opportunities and quality of the environment for 
scientific and professional development at the U.S. and foreign institutions.  

Budget

Justify the budget requests in relation to career development goals and 
research aims and plans.

AWARD CRITERIA

The criteria that will be used to make the award decisions include the 
scientific, technical and educational merit of the application as determined 
by peer review, the likelihood that the proposal will contribute to the 
achievement of the FIC's objectives and the availability of funds.

INQUIRIES

Inquiries concerning this PA are encouraged.  The opportunity to clarify any 
issues or questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Kathleen Michels, Ph.D.
Division of International Training and Research
Fogarty International Center
Building 31, Room B2C39
31 Center Drive MSC2220
Bethesda, MD  20892-2220
Telephone:  (301) 496-1653
FAX:  (301) 402-0779
Email:  IRSDA@nih.gov

Direct inquiries regarding review issues to:  
(if appropriate)

Madelon Halula, Ph.D.
Scientific Review Program
NIAID DEA 
6700-B Rockledge Blvd, Room 2217
Bethesda, MD 20817 (Fed Ex) or
Bethesda, MD 20992-7616 (US mail)
Telephone:  (301) 402-2636
FAX:  (301) 402-2638 (fax)
Email:  mh30x@nih.gov

Direct inquiries regarding fiscal matters to:

Ms. Lee Ann Gschwind
Division of International Training and Research
Fogarty International Center
Building 31 Room B2C39
31 Center Drive MSC2220
Bethesda, MD 20892-2220
Telephone:  (301) 402-7335
FAX:  (301) 402-0779
Email:  gschwind@nih.gov

AUTHORITY AND REGULATIONS 

This program is described in the Catalog of Federal Domestic Assistance No. 
93.121.  Awards are made under authorization of sections 301 and 405 of the 
Public Health Service Act as amended (42 USC 241 and 284) and administered 
under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 
74 and 92.  This program is not subject to the intergovernmental review 
requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a 
smoke-free workplace and promote the non-use of all tobacco products.  In 
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking 
in certain facilities (or in some cases, and portion of a facility) in which 
regular or routine education, library, day care, health care or early 
childhood development services are provided to children.  This is consistent 
with the PHS mission to protect and advance the physical and mental health of 
the American people.


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