MOLECULAR TARGET DRUG DISCOVERY FOR CANCER: COMPETING SUPPLEMENTS Release Date: February 16, 2000 PA NUMBER: PAR-00-062 National Cancer Institute Letter of Intent Receipt Date: June 6, 2000 Application Receipt Date: July 18, 2000 PURPOSE The National Cancer Institute (NCI) defines new, extraordinary research opportunities through stated goals in a "Bypass Budget". Among the priorities of the 2001 Bypass Budget was to identify and use molecular targets for the discovery and clinical testing of new anticancer agents based on the molecular mechanisms that underlie neoplastic transformations, cancer growth and metastasis. Accordingly, the Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI), and the Chemoprevention Agent Development Research Group, the Division of Cancer Prevention, NCI invite competitive supplement applications for existing NIH grants to exploit molecular targets for drug discovery. New insights into our understanding of cancer cell biology provide a new opportunity for a fundamental re-ordering of approaches to cancer drug discovery. Rather than depending on in vitro and in vivo screens for antiproliferative activity, investigators can now focus on new molecular targets and pathways essential for the development and maintenance of the cancer phenotype. As a result, the NCI is reorganizing its drug development programs from early drug discovery phases to the conduct of clinical trials in order to bring forward new types of agents based on strong rationales. The plan also involves changes in the clinical evaluation of new agents that will include appropriate measurements to verify target modulation. In addition to this announcement, the NCI announces following three related initiatives in molecular target drug discovery for cancer treatment and prevention: Cooperative Agreement (U01) applications (see http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-00-002.html) which are suitable for more mature projects defined by preliminary data, Small Business Innovation Research (SBIR) and Small Business Technology Transfer Programs (STTR) (see http://grants.nih.gov/grants/guide/pa-files/PAR-00-061.html) which are directed to those of the small business community who need research assistance in launching commercial products, Exploratory/Development Grant (R21) awards (http://grants.nih.gov/grants/guide/pa-files/PAR-00-060.html) for pilot projects for which preliminary data are lacking that would make the project competitive for a regular research grant. See the Home Pages of either the Developmental Therapeutics Program (http://dtp.nci.nih.gov) or the Chemoprevention Agent Development Group(http://dcp.nci.nih.gov/cb) for further information or contact individuals listed under INQUIRIES of this PA. Further information on research opportunities regarding molecular targets in drug discovery can be found in the NCI ByPass Budget, The Nation’s Investment in Cancer Research: A Budget Proposal for Fiscal Year 2001 at http://2001.cancer.gov. The purpose of this Program Announcement (PA) is to reorganize the front end or gateway to drug discovery. Investigators are being asked to identify a novel molecular target, to validate the target as a basis for cancer drug discovery, or to develop an assay for the target. Given the fact that some investigators may already have considerable preliminary data on a signaling pathway, they nevertheless may not have focused on the point of greatest vulnerability in the pathway and therefore, perhaps the optimal point of drug attack. This PA would support an investigator to validate a target and/or develop an assay based on the target. Applicants may address targets related to the treatment of established cancers, or the prevention of molecular changes which may cause cancer. Investigators may use their own creativity in defining their approach. For example, some may prefer to 1) use a genetic, structural biology or molecular biology approach to target identification/validation using information from genetic studies or studies of pathways, whereas others may prefer to 2) identify the function of a cellular target after first finding the target as a result of exploring binding patterns of natural products or other ligands to the novel target. The PA requires that the proposed target(s) in each application be novel and not addressed by drugs already approved for clinical use. It is envisioned that supplements to funded NIH projects related to target or pathway elucidation/validation might enable an extension of projects to include goals relevant to drug discovery. For example, a successful competitive supplement could add specific aim(s) such as: expression system development to generate large quantities of target protein, target structure determination by NMR or X-ray diffraction, development of a target into a drug discovery screen, or a chemical library synthesis to explore target validation questions. Applications submitted to the NIH will be reviewed by the NCI according to the criteria established for this PA as described below under REVIEW CONSIDERATIONS. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, Molecular Target Drug Discovery for Cancer, is related to priority areas of human cancer treatment and prevention. Potential applicants may obtain a copy of "Healthy People 2000" at http://odphp.osophs.dhhs.gov/pubs/hp2000. ELIGIBILITY REQUIREMENTS These competing supplements are directed to existing NCI grantees. Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and Local governments, and eligible agencies of the Federal Government. Applications may also be submitted by a foreign institution. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as principal investigators. MECHANISM OF SUPPORT The administrative and funding instrument to be used for these awards is the competing supplement to existing NCI-funded research project grants (R01, R15, R29, R35, R37, P01 and UO1 mechanisms). In the case of Program Projects, one supplement submission for each constituent project would be permitted. The total project period requested for supplement applications submitted in response to this PA may not exceed the number of years remaining in the Principal Investigator"s active grant at the "start date" of the supplement award. A minimum of two years from the date of the supplement request should remain in the parent grant. The earliest anticipated award date is April 1, 2001. Because the nature and scope of the research proposed in response to this PA may vary, it is anticipated that the size of supplements will vary, but in any case are non-renewable, continuation of projects developed under this program must be through other grant mechanisms. Unless otherwise noted, all NIH grants policies apply RESEARCH OBJECTIVES Background The past 20 years have seen an explosion in the understanding of how cancer cells work. Specific molecules have been identified which cause the initiation and progressive growth of tumors. From this work, a fundamental re-ordering of the approach to drug discovery and development for the treatment and prevention of cancer has emerged. There is the opportunity to move away from screening agents by their effects on tumor cell growth, in vivo or in vitro, and targets that have been thoroughly exploited. While it remains true that these methods might continue to be the basis for the development of clinically useful agents, these agents may not be the best lead compounds that effect a particular pathway of biologic importance specific for cancer establishment or progression. Drugs discovered by these early methods have historically demonstrated clear limitations in clinical efficacy. The hope is that drugs targeting new, specific molecular lesions in cancer cells will provide more effective therapy or prevention approaches, alone or in combination with other agents. The focus of attention in this new approach to cancer drug discovery is a compound’s effect against a novel molecular target, or a target operating in a defined biochemical pathway, with the intent of causing a gain or loss in function to reverse, stop, or delay cancer progression. The cancer cell selectivity of lead compounds should be enhanced by screens based on a novel target or a critical pathway that represents a true Achilles heel. The evaluation of drugs in the clinic which have emerged from these types of approaches is beginning. Examples would include the farnesyl transferase inhibitors (FTIs), protein kinase (PK) antagonists of various sorts, matrix metalloprotease inhibitors, and growth factor receptor or other effector antagonists (endothelin, tamoxifen, TRAIL, etc.). It is striking that in this process the pharmaceutical industry has clearly seized a defining role in expeditiously advancing potentially useful compounds to a clinical test. However, in each of the instances cited, the pioneering studies on the targets to which these drugs are directed occurred largely (if not exclusively) in the academic sector. Objectives and Scope The goal of these supplemental awards is to expand NCI-funded projects in order to enhance the prospects of molecular target discovery and validation for cancer prevention or treatment intervention. Identification of a potential target might present varying degrees of difficulty, but validation (an indication of a target’s predictive capacity to aid in the selection of clinical drugs) is apt to be uniformly more problematic. Leads for many existing clinical drugs were not discovered through the use of macro- molecular targets but rather through in vivo or in vitro anti-proliferative assays. Accordingly, the cornerstone of this effort is the validation of targets of demonstrated importance. The competing supplements to existing NCI-funded grants, herein described, should arise from projects that could extend ongoing work toward the identification or validation of molecular targets or their development into a screening tool. Approaches and projects appropriate for this PA should be in three general areas as follows: First, investigative activities establishing a molecule as a potential cancer drug discovery target can have as its focus any aspect of early dysplasia or cancer cell biology that may reveal a vulnerability in the cancer cell. These might include cell cycle checkpoints, DNA repair, cell stress, or cell death pathways, cassettes of altered transcription factor activity, or activation of pathways allowing cell growth in hypoxic or hypo-vascularized conditions. Oncogenic viral targets also would be appropriate. In fact, any difference between a cancer and normal cell could potentially be exploitable as a therapeutic maneuver. Modern science has afforded numerous opportunities to demonstrate the likely value of this approach. These include: (1) engineered animals of various sorts (transgene-expressing, knock-out, etc.), (2) smart assays designed to give information, not only about phenotypic alteration, such as growth arrest or cell death, but also about the effect on particular molecular targets of pathways known or suspected to have biological relevance to cancer, (3) array technology, where the action of a candidate drug lead against its target can be placed rapidly in the context of expected action against other cellular and indeed organ-specific molecules, and (4) cancer gene discovery programs, such as the Cancer Genome Anatomy Project (CGAP) ( http://www.ncbi.nlm.nih.gov/CGAP/ ), which has identified numerous mutational sites in cancer cells, some of which are possibly unique to specific types of cancer. Accordingly, a requirement is to establish that a molecular target likely affects important aspects of cancer cell function. Second, the validation of new molecular targets, with the intent of discovering new agents for the treatment or prevention of cancer, is an important and necessary activity. At present, science appears to offer too many targets. Therefore, projects should focus on determining which of these numerous potential defects are sites of critical vulnerability which could be exploited for intervention. Ideally one would expect to demonstrate that manipulation of the target function would cause a phenotypic change in the cancer cell. Clearly if a prime target is fully validated, such that the target can be used to totally exploit a unique difference between a healthy and a cancerous cell, control of cancer would then only await the discovery of a drug molecule through a systematic screening and/or drug design program, in real laboratory experience, validation occurs in stages or degrees. Demonstration of some phenotypic or functional change that is desirable, such as elimination or reversal of dysplasia, tumor shrinkage or change in a validated surrogate marker, would provide evidence of the importance of a target. Approaches to target validation might involve the use of antisense or engineered animals, such as transgene-expressing or gene knock-outs. Small, bioactive molecules, obtained either from natural products libraries or from chemical libraries, may be used as ligands to select and validate proteins from arrays. If an investigator chooses to utilize crude extracts of natural products, as from the NCI Active Repository, expertise must be available for chemical fractionation of the extracts. Thus, validation can be conceptualized as a series of milestones. A proposal to reach validation milestones could be responsive to this PA. There are many good rationales for selecting targets, but validation requires considerable imagination and skill on the part of the investigator. Therefore, also responsive to this PA would be an insightful and clever validation of a target suggested by others as a possible intervention point. While it is true that the ultimate validation can only come from a successful clinical trial, having information on the importance of the target prior to the trial should provide important feedback in case therapies are ineffective. Third, the target system should be amenable to conversion into a screen for effectors of the target’s function (at minimum on a laboratory scale), or the molecular structure determined through biophysical techniques as a prelude to drug discovery studies . These aspects are critical components which would form the thrust of any molecularly focused drug discovery effort. The practical nature of drug discovery research is of high importance. While the desirability of this approach might seem obvious, the tools for accomplishing this task are only now becoming routinely available. These include sequence information defining the primary structure of relevant target proteins or other macromolecules, expression vectors for their large scale production, biophysical (e.g. X-ray and NMR) and computational techniques to allow the determination of three-dimensional structure, advances in screening technology to allow ever increasing speed and efficiency in assessing large numbers of candidate structures, and combinatorial chemistry to generate large numbers of candidate drug structures. Supplement requests may include but certainly are not limited to the following: o Expression of Target: Successful applicants whose program requires production of quantities of expressed target protein for either structure elucidation and/or assays will be eligible for supplements to achieve this goal. This could be accomplished either through production at their own institution or at a contract research facility using constructs emanating from the applicant’s laboratory. o Structural Analysis of Target: Applicants will be encouraged to describe in the application, when it exists, ongoing relationships with structural biologists who will be responsible for structure determination using relevant physical techniques such as X-ray crystallography or NMR. At a point in the progress of a project when structural analysis might seem appropriate, funds for support of biophysical studies may be requested. Lacking that initial collaboration, grantees could obtain supplemental funding through, for example, a consortium arrangement with a structural biologist. o Chemistry/Screening: Following definition of a candidate assay relevant to a target, efforts to create libraries of compounds and conduct screening activities that are based on the target’s structure may be undertaken. NCI may take the lead in developing specific "made to order" libraries or libraries may emerge from existing collections available to NCI. In the event that an MTDD project supplement produces its own libraries, these would remain the property of the originator, and maintenance of a voucher collection by NCI would not be required. Screening, in the event it cannot be done in the PI’s laboratory, may be conducted by supplementation of the award to include the cost of screening. SPECIAL REQUIREMENTS Patent Coverage. Since the discovery of new targets, assays and improved anticancer treatments is the objective of this effort and since transfer of intellectual property to industrial laboratories for extended developmental purposes is facilitated by the existence of adequate patent coverage, it is essential that applicants provide plans to assure such coverage. Each applicant must therefore provide a detailed description of the approach to be used for obtaining patent coverage and for licensing where appropriate, in particular where the invention may involve investigators from more than one institution. Procedures must be described for resolution of legal problems should they arise. Your attention is drawn to P.L. 96-517 as amended by P.L. 98-620 and 37 CFR Part 401. Instructions were also published in the NIH Guide for Grants and Contracts, Vol. 19, No. 23, June 22, 1990. A formal statement of patent procedures and plan for transfer of materials embodying intellectual property to other parties as well as a detailed description of procedures to be followed for resolution of legal problems which may develop, signed and dated by the organizational official authorized to enter into intellectual property arrangements for each applicant and collaborators, if any, must be developed. The signed agreement must be submitted prior to award to Dr. John Beisler at the address provided at the GCOB web site, http://dtp.nci.nih.gov (On the panel, left side, click on "Funding", then scroll down to "Staff"). Applicants proposing to access the Natural Products Repository of the NCI must obtain and execute the Natural Products Repository Material Transfer Agreement prior to receiving an award. Similarly, applicants proposing to access the synthetic repository of the NCI must obtain and execute the synthetic Material Transfer Agreement prior to receiving an award. These agreement forms are available at http://dtp.nci.nih.gov. (On the panel, left side, click on "Organization", select "Natural Products Branch", select "Natural Products Repository", then scroll down to and select "Material Transfer Agreement"). For information concerning the NCI synthetic or natural product repositories go to the Developmental Therapeutics web site, http://dtp.nci.nih.gov (On the panel, left side, click on "Samples and Services"). For applications involving natural products, the applicant must provide a formal statement signed by an authorized representative of the applicant institution which assures that an equitable portion of royalties or profits arising from drugs discovered, if any, will benefit indigenous peoples, research collaborators, research institutions or governmental entities as appropriate, in the country of origin of the natural product sample from which the drug was derived. Plans for the procurement of proper collection and export permits must be provided. The signed document must be submitted prior to award to Dr. Gordon Cragg at the Developmental Therapeutics Program web site, http://dtp.nci.nih.gov (On the panel, left side, click on "Organization", select "Natural Products Branch" then click on "Organization/ Staff Directory"). If applicable, a plan must be developed for disposition of natural products samples, chemical libraries, etc. The signed document must be submitted prior to award to Dr. John Beisler at the address provided at the GCOB web site, http://dtp.nci.nih.gov (On the panel, left side, click on "Funding", then scroll down to "Staff"). The four documents listed above will not be included with review material, and therefore, will NOT be required at the time of application. However, awards will not be made until they are received and approved by NCI. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43) All investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18, 1994, available on the web at the following URL address: http://grants.nih.gov/grants/guide/notice-files/not94-100.html. Investigators may also obtain copies of the policy from the program staff mentioned in the GCOB web site, http://dtp.nci.nih.gov (On the panel, left side, click on "Funding", then scroll down to "Staff"). INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS. It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are clear and compelling scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html. LETTER OF INTENT Prospective applicants are asked to submit, by June 6, 2000, a letter of intent that includes a descriptive title of the proposed research, name, address, and telephone number of the Principal Investigator, identities of other key personnel and participating institutions, and number and title of the PAR in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information allows NCI staff to estimate the potential review workload and to avoid conflict of interest in the review. The Letter of Intent is to be sent to a program representative listed under INQUIRIES by the letter of intent receipt date listed in the heading of this PA. APPLICATION PROCEDURES Applicants must use the research grant application form PHS 398 (rev. 4/98). Alternatively, NIH intramural project applicants must follow the directions in Section 5, Additional Instructions for NIH Intramural Project Applicants" below. Application kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/435-0714, E-mail: grantsinfo@nih.gov. PHS 398 application kits are also available at: http://grants.nih.gov/grants/funding/phs398/forms_toc.html. All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site (see http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-004.html). SPECIAL INSTRUCTIONS FOR ALL APPLICANTS The PA title, MOLECULAR TARGET DRUG DISCOVERY FOR CANCER: COMPETITIVE SUPPLEMENTS, and the number of this PA must be typed on line 2 of the face page of the application form and the YES box must be marked. The plans below, if appropriate for the proposed work, should be included in the application after the LITERATURE CITED section. Formal agreements signed by an authorized representative of the applicant institution will be required before award. o A plan for patent coverage and licensing, for transfer of material embodying intellectual property to other parties, for resolution of legal problems should they arise. o A plan for assurance to return benefits to the country of origin in the use of natural products. o A plan for the disposition of natural products samples and chemical libraries. Competitive supplement applicants (NIH intramural project applicants must use the address in "Additional Instructions for NIH Intramural Project Applicants" below) should submit a typewritten, signed original of the application, including the checklist, and three signed photocopies, in one package to: Center for Scientific Review National Institutes of Health 6701 Rockledge Drive, Room 1040 - MSC 7710 Bethesda, MD 20892-7710 Bethesda, MD 20817 (for express/courier service) At the time of submission, two additional signed photocopies of the application must also be sent to: Ms. Toby Friedberg Referral Officer Division of Extramural Activities National Cancer Institute 6116 Executive Boulevard, Room 8062, MSC 8239 Bethesda, MD 20892-8239 Rockville, MD 20852 (for express/courier service) Applications must be received by July 18, 2000. If an application is received after that date, it will be returned to the applicant without review. The Center for Scientific Review (CSR) will not accept any application in response to this PA that is essentially the same as a research project application currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of a substantial revision of an application already reviewed, but such an application must follow the guidance in the PHS Form 398 application instructions for the preparation of revised applications, including an introduction addressing the previous critique. REVIEW CONSIDERATIONS: Upon receipt, applications will be reviewed for completeness by CSR and for adherence to the guidelines by NCI. Incomplete applications will be returned to the applicant without further consideration. Applications that are complete will be evaluated for scientific and technical merit by an appropriate peer review group convened by the Division of Extramural Activities of the NCI in accordance with the review criteria stated below. As part of the initial merit review, a process will be used by the initial review group in which applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed, assigned a priority score, and receive a second level review by the National Cancer Advisory Board. Review Criteria The goals of NIH-sponsored research are to advance our understanding of biological systems, improve the control of disease, and enhance health. Within this framework, the specific goals of this PA are the discovery and/or validation of new molecular targets with the potential for developing assays for the discovery of new agents to treat or prevent cancer. For example, these supplemental funds may be requested to identify or characterize (de novo, or from the literature) a target, to implement a validation plan, or to develop a method to render a validated target into a drug assay. Meritorious projects will include imaginative intervention points and insightful validation approaches, which overall will reveal an exploitable site of critical vulnerability. The reviewers will comment on the five criteria listed below in their written critiques of the applications in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered by the reviewers in assigning the overall score weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have a major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? Is the proposed molecular target of importance to development and maintenance of the transformed phenotype? Is the target new and not one which has been the object of other evaluative studies? What is the likelihood that assays using this target will lead to a new class of agents for the prevention or treatment of cancer? Approach: Are the conceptual framework, design, methods, and analyses adequately developed, well integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternate tactics? How well has the applicant addressed the major goals of the PA: identification of a novel target, its validation as an intervention point, and assay development? What is the likelihood that a high-throughput screen can be developed with the target? Has the applicant designed an appropriate set of experiments to demonstrate a critical site of vulnerability in the cancer cell which can exploited for treatment or prevention? If crude natural product extracts are proposed, are strategies for compound isolation and identification adequate? If structural biology studies are proposed, are plans adequate for the production of materials and have appropriate collaborations been arranged? If screening is proposed, are data handling procedures adequate, and is the assay validated and appropriate for large- scale or high throughput use? Innovation: Does the project employ novel concepts, approaches, or methods? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies? Will the approaches advance the use of new, validated molecular targets for new drug discovery? Investigator: Is the investigator appropriately trained and suited to carry out the project? Is the research proposed appropriate to the experience level of the PI and other researchers (if any)? Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ valuable collaborative arrangements? Additional Considerations The initial review group will also examine: the appropriateness of the proposed budget and duration, the adequacy of plans to include both genders and minorities and their subgroups as appropriate for the scientific goals of the research and plans for the recruitment and retention of subjects, the adequacy of plans for including children as appropriate for the scientific goals of the research, or justification for exclusion, the provisions of human and animal subjects, and the safety of the research environment. AWARD CRITERIA Applications recommended by the National Cancer Advisory Board will be considered for award based upon (a) scientific and technical merit, (b) program balance, including in this instance, sufficient compatibility of features to make a successful collaborative program a reasonable likelihood, and (c) availability of funds. INQUIRIES Written and telephone inquiries concerning this PA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues in cancer treatment, to the appropriate individuals given in the GCOB web site: http://dtp.nci.nih.gov/ (On the panel, left side, click on "Funding", then scroll down to "Staff"). Inquiries regarding access to the Natural Products Repository and inquiries regarding access to the Synthetic Compound Repository of NCI refer to the appropriate paragraph in the SPECIAL REQUIREMENTS section. Direct inquiries regarding programmatic issues in cancer prevention to the DCP web site: http://dcp.nci.nih.gov/cb Direct inquiries regarding review issues to: Ms. Toby Friedberg Referral Officer Division of Extramural Activities National Cancer Institute 6116 Executive Boulevard, Room 8062, MSC 8239 Bethesda, MD 20892-8239 Rockville, MD 20852 (for express/courier service) Telephone (301) 496-3428 Fax: (301) 402-0275 Email: tf12w@nih.gov Direct inquiries regarding fiscal matters to: Ms. Kathleen Shino Grants Administration Branch National Cancer Institute Executive Plaza South 243 Bethesda, MD 20892-7150 Telephone: (301) 496-8635 Fax: (301) 496-8601 Email: shinok@gab.nci.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.395, Cancer Treatment Research. Awards are made under authorization of Sections 301 and 405 of the Public Health Service Act, as amended, (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities ( or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices



NIH Office of Extramural Research Logo
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS)
  USA.gov - Government Made Easy
NIH... Turning Discovery Into Health®



Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.