INTERNATIONAL COLLABORATIVE ORAL HEALTH RESEARCH PLANNING GRANT 

Release Date:  November 23, 1999

PA NUMBER:  PAR-00-012

National Institute of Dental and Craniofacial Research

THIS PA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. IT INCLUDES 
DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED 
WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS PA.

PURPOSE

The National Institute of Dental and Craniofacial Research (NIDCR) will 
provide grant support for planning and protocol development of biomedical, 
epidemiological and behavioral studies in priority international research 
areas as identified in the Institute's Strategic Plan and facilitated by the 
Office of International Health (OIH), in consultation with the international 
research community.  The purpose of this initiative is to bring together 
international researchers through collaborative partnerships that conduct 
research according to common protocols.

The planning grant is intended to provide support for the development of a 
refined study design, organizational plan, detailed protocol criteria, and 
budget, for implementation of cross-national studies whose rationale and 
basic design are considered scientifically meritorious, and which cannot be 
accomplished solely within the U.S.  (For the purposes of this PA, “cross-
national” means that at least three countries are involved.)  After these are 
completed, planning grant awardees may submit applications to conduct the 
full-scale study, in collaboration with international funding partners.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2000," a PHS-
led national activity for setting priority areas.  This PA, NIDCR 
International Collaborative Oral Health Research Planning Grant, addresses 
the priority areas of dental, oral and craniofacial health.  Potential 
applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 
017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the 
Superintendent of Documents, Government Printing Office, Washington, DC 
20402-9325 (telephone 202-512-1800).

ELIGIBILITY REQUIREMENTS

Applications may be submitted by foreign and domestic, for-profit and non-
profit organizations, public and private, such as universities, colleges, 
hospitals, laboratories, units of State and local governments, and eligible 
agencies of the Federal government. Racial/ethnic minority individuals, 
women, and persons with disabilities are encouraged to apply as principal 
investigators.  All multi-center applications must include a coordinating 
center.

Applicants must demonstrate linkages for international collaborative efforts 
with institutions in other industrialized and/or developing nations as may be 
appropriate to address the scientific question.

Applicant institutions that have a General Clinical Research Center (GCRC) 
funded by the NIH National Center for Research Resources may wish to identify 
the GCRC as a resource for conducting the proposed research.  If so, a letter 
of agreement from either the GCRC Program Director or Principal Investigator 
should be included with the application.

MECHANISM OF SUPPORT

The mechanism of support for the NIDCR International Collaborative Oral 
Health Research Planning Grant is the exploratory/developmental research 
grant (R21). Applicants may request up to $75,000 in direct costs per year 
for each of two years. Responsibility for the planning, direction, and 
execution of the proposed project will be solely that of the applicant.

Specific application instructions have been modified to reflect "MODULAR 
GRANT" and "JUST-IN-TIME" streamlining efforts being examined by the NIH. 
Complete and detailed instructions and information on Modular Grant 
applications can be found at 
http://grants.nih.gov/grants/funding/modular/modular.htm

For this PA, funds must be requested in $25,000 direct cost modules.  A 
maximum of three modules can be requested for each of 2 years.  A feature of 
the modular grant is that no escalation is provided for future years, and all 
anticipated expenses for all years of the project must be included within the 
number of modules being requested. Only limited budget information is 
required and any budget adjustments made by the Initial Review Group will be 
in modules of $25,000.

RESEARCH OBJECTIVES

Dental, oral  and craniofacial diseases and disorders are among the most 
common health problems affecting the people of the United States and around 
the world. The burden imposed by a variety of dental, oral and craniofacial 
diseases and disorders range from birth defects such as cleft lip and palate, 
which occurs in every 1 in 525 to 714 live births, to injuries to the head 
and face, resulting in nearly 20 million emergency room visits per year, to 
devastating head and neck cancers, accounting for 8000 deaths and over 30,000 
new cases per year in the U.S. alone.  In the U.S., the treatment of over 1.2 
million cancer patients each year can lead to painful mouth ulcers, 
mucositis, rampant dental caries, fungal infections, impaired taste and loss 
of function of the salivary glands.  Oral infections still remain common in 
our populations.  Dental caries is experienced by 45% of school children and 
94% of adults have experienced this infection at some point in life.  
Periodontal infections occur in 90% of individuals older than 13 years and 
may be associated with other systemic diseases or conditions such as 
diabetes, cardiovascular disease, respiratory infections, and pre-term/low 
birth weight babies. Orofacial pain is likely to have been experienced by 
over 20% of adults in the past six months, is a major component of 
temporomandibular joint diseases (TMD) for at least 6% of adults, and is a 
major component of Bell's palsy, trigeminal neuralgia and fibromyalgia.  
Salivary gland dysfunction in the form of Sjogren's syndrome affects between 
1 and 4 million Americans while over 30,000 individuals who have cystic 
fibrosis are also at higher risk for concomitant salivary gland dysfunction. 
Further, over 500 prescription drugs have xerostomic (dry mouth) side 
effects, increasing the risk for both bacterial and fungal oral infections as 
well as other oral conditions.  Oral candidiasis is commonly found in HIV-
infected patients.

These health issues, though prevalent in the U.S., know no geographic 
boundaries.  Oral conditions affect populations around the globe.  Some of 
these conditions are more prevalent in certain countries or regions, while 
others are found in virtually all countries, but to varying degrees.  There 
are many research topics that require international collaboration for 
questions to be appropriately addressed.  For example, there are many areas 
of research that, because of limited access to patient populations within any 
single country, can only be conducted by international teams of scientists 
with access to large groups of people with the disease/condition to be 
studied.  Similarly, there are areas of research where progress would be 
enhanced with the addition of unique scientific expertise only found 
internationally.  The purpose of this initiative is to bring together 
international researchers through collaborative partnerships that investigate 
these special research issues according to common protocols.

In pursuing new scientific opportunities, the NIDCR outlined its Strategic 
Plan, which focuses on and reorganizes its work into the following areas of 
research:

o  Inherited Diseases and Disorders

The objective of this scientific program is to promote research that will 
advance our understanding of the underlying causes of craniofacial 
dysmorphologies such as ectodermal dysplasia, enamel dysplasia, cleft lip and 
palate, and osteogenesis imperfecta.  These genetic malformations are 
estimated to occur in about five percent of the entire U.S. population, but 
prevalence is even higher within some groups in the U.S. and internationally.  
International collaboration in relevant areas such as genetic research, 
epidemiology, genetic registries, and treatment modalities can help speed 
progress toward the goal of improved prevention, diagnosis and treatment by 
combining scientific talents from different countries to focus on selected 
populations at high risk.  An international approach that includes all 
disciplines relevant to specific craniofacial anomalies might dramatically 
enhance the possibility of resolving the many complex issues surrounding 
these malformations.

o  Infectious Diseases and Immunity

This program encourages and supports basic, applied and developmental 
research in four broadly based scientific areas that will provide the basis 
for rapid development of knowledge of the etiology, pathogenesis, 
epidemiology, prevention, diagnosis, and treatment of oral infectious 
diseases such as periodontitis, dental caries, and oral candidiasis, and 
other infectious diseases which affect the oral and craniofacial complex such 
as HIV/AIDS, noma, and leishmaniasis. Although some of these emerging or re-
emerging infectious diseases are rare in many of the industrialized parts of 
the world, they are quite prevalent in some developing countries, and are 
increasing rapidly in areas of poverty, malnutrition, and poor sanitary 
conditions.  International collaboration can help to bring together 
researchers and resources to study these infectious diseases, and help to 
shed light on the epidemiology, the disease process and the role of the 
environment.  Important areas of research might include factors contributing 
to microbial virulence, colonization and transmission; sequence analysis of 
the genome of oral microorganisms; molecular and cellular pathogenesis; and, 
host response and inflammation and the use of novel immunizing strategies, as 
well as other prevention interventions targeted on behavioral, social and 
environmentally-based determinants of infection and immunity.

o  Neoplastic Diseases

This scientific program encompasses basic and applied research related to the 
prevention, etiology, early detection, progression, metastasis and treatment 
of oral cancer. The continuing poor prognosis for patients with oral cancers 
and the extreme disfigurement caused both by these malignancies and the 
treatments currently utilized to combat them emphasize the importance of 
multifaceted and innovative approaches to research in this area.  A 
significant cause of mortality and poor quality of life, oral cancer is 
especially prevalent in Asian countries, parts of Europe, and the United 
States.  Fortunately, the international community has numerous centers of 
expertise from which to draw for important collaborative studies.  
International collaboration can provide new perspectives in all aspects of 
the disease, from the clarification of risk factors to the control of these 
risk factors, early detection, pain management, the provision of effective 
treatment, and ultimately the prevention of disease.

o  Chronic and Disabling Diseases

This multifaceted scientific program addresses research involving the chronic 
disabling diseases associated with the oral/craniofacial complex such as 
osteoporosis and related bone disorders, temporomandibular joint disorders, 
neuropathies and neurodegenerative diseases including those involving oral 
sensory and motor function, and autoimmune diseases such as Sjogren's 
syndrome and rheumatoid arthritis.  Other research areas include studies 
aimed at elucidating the relationship between diseases of the 
oral/craniofacial complex and other systemic diseases (e.g., periodontitis in 
relation to diabetes, oral pathogens and cardiovascular disease, and oral 
pathogens and low birthweight infants).

o  Biomaterials, Biomimetics and Tissue Engineering

This scientific program supports and encourages basic, clinical and applied 
research in the areas of biomimetics, tissue engineering and biomaterials in 
order to enhance the development of natural and synthetic materials used for 
the repair, regeneration, restoration and reconstruction of oral and 
craniofacial tissues and organs. The biomimetics aspect of the portfolio 
focuses on interdisciplinary materials science research that combines 
information from the study of biological structures and their function with 
physics, mathematics, chemistry and engineering, with the goal to develop 
novel materials (e.g., adhesives, new filling materials, temporomandibular 
joints).  International coordination and networking is required for 
developing promising materials in the laboratory, conducting biologic 
assessment, and implementing clinical trials.

o  Behavior, Health Promotion and Environment

This scientific program encourages and supports research aimed at assessing 
the interactive role of socio-environmental, behavioral, genetic and 
biomedical factors in oral/craniofacial diseases and conditions.  Oral health 
promotion and disease prevention are keys to meeting public health objectives 
and enhancing clinical and biomedical interventions related to oral health.  
Removing inequalities in oral health is a prominent component of the U.S. 
Healthy People 2000 goals.  International collaborative research is vital to 
understanding differences in health status among subgroups in a population 
resident in various settings, as well as the impact of various national 
systems of oral health care and education on oral health outcomes.  Other 
topics for international research include traditional health beliefs and 
practices, systems of health care financing, and targeted community-based 
health promotion/disease prevention programs which would serve o reduce 
health disparities within a society.

Applications under this PA must contain research planning proposals which fit 
within these strategic areas.  Further information about these research 
topics may be obtained from NIDCR's Extramural Research website at 
http://www.nidcr.nih.gov/research/extramural/sciprog.htm.

In each of these priority areas, a broad-based coalition of scientific talent 
is envisioned to encompass research needs in areas from molecular biology to 
the translational patient-oriented, epidemiological, behavioral, social and 
related health promotion sciences as may be appropriate for the research 
questions involved.  The product of these research planning grants would be 
the enhanced or new infrastructure needed to enable submission of full-scale 
studies in the given subject area.  These applications could then be 
submitted as investigator-initiated projects to the US government and/or any 
other potential collaborating funding agency, institution or foundation.  
Those applications coming subsequently to the NIH also will be peer-reviewed 
according to standard NIH procedures.  Applicants should note that NIDCR 
funding of a planning grant does not imply a commitment by NIDCR to fund the 
proposed full-scale study.

Applicants for research planning grants may include funds for activities such 
as but not limited to:

o  Travel expenses of individuals from multiple sites to planning meetings 
for the project.

o  Preliminary studies to guide selection of and/or refine research agenda, 
questions, and hypotheses

o  Analyses of existing data needed for refinement of study design and 
protocols

o  Preparation of detailed protocols. These protocols must be included in the 
Final Report for this award.

The planning grant proposal should describe:

o  Importance and relevance of the scientific question.  Describe the 
research project(s) under consideration and the potential for advancing the 
science and improving health.

o  The principal hypotheses to be tested, and the rationale for doing so.	

o  Justification of the need for a global approach.   Is the problem global 
in nature?  Why is a multicountry project necessary to answer the question?  
Why can't the question be answered with a single-site study?

o  The organizational approach and timetable to be followed in building an 
international coalition, defining the research agenda and developing a 
specific international collaborative research protocol.

o  The participants in the planning process, their roles in the development 
of the plan, and their experience in related studies.

o  Ability of the Principal Investigator to bring together the necessary 
international network.  While the actual building of the network is to be 
done after the planning grant is awarded, there must be clear evidence of 
commitment from researchers and institutions in other countries.  Letters of 
commitment, including biosketches, by collaborating partners should be 
included.  Describe the mechanism for identification and selection of 
additional collaborators.  A proposal involving several (three or more) 
countries is expected.

o  Identifiable outcome of the grant.  What products/documents are expected 
from the grant?  How will this be used in developing the next stages of 
research?

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and 
their subpopulations must be included in all NIH supported biomedical and 
behavioral research projects involving human subjects, unless a clear and 
compelling rationale and justification is provided that inclusion is 
inappropriate with respect to the health of the subjects or the purpose of 
the research.  This policy results from the NIH Revitalization Act of 1993 
(Section 492B of Public Law 103-43).

All investigators proposing research involving human subjects should read the 
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical 
Research," which have been published in the Federal Register of March 20, 
1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 
23, No. 11, March 28, 1994, available on the web at: 
http://grants.nih.gov/grants/guide/notice-files/not94-100.html. 

INCLUSION OF CHILDREN IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subject research, conducted or supported by the 
NIH, unless there are scientific and ethical reasons not to include them.  
This policy applies to all initial (Type 1) applications submitted for 
receipt dates after October 1, 1998.

All investigators proposing research involving children as subjects should 
read the "NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS 
PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS," which were published in 
the NIH Guide for Grants and Contracts, Volume 27, No. 8, March 6, 1998, and 
is available at the following URL address: 
http://grants.nih.gov/grants/guide/notice-files/not98-024.html.

APPLICATION PROCEDURES

Applications are to be submitted on the grant application form PHS 398 (rev. 
4/98) and will be accepted at the standard application deadlines as indicated 
in the application kit.  Applications kits are available at most 
institutional offices of sponsored research and maybe obtained from the 
Division of Extramural Outreach and Information Resources, National 
Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-
7910, telephone 301/435-0714, email: grantsinfo@nih.gov. The title and number 
of the program announcement must be typed in Section 2 on the face page of 
the application.  As with most applications to NIH, the research plan is 
limited to 25 pages.  All information for review of the NIDCR International 
Collaborative Oral Health Research Planning Grant application must be 
included in the body of the application; appendices will not be considered 
during the review for this mechanism.

BUDGET INSTRUCTIONS

Modular Grant applications will request direct costs in $25,000 modules, up 
to a total direct cost request of $250,000 per year. (Applications that 
request more than $250,000 direct costs in any year must follow the 
traditional PHS398 application instructions.)The total direct costs must be 
requested in accordance with the program guidelines and the modifications 
made to the standard PHS 398 application instructions described below:

PHS 398

o FACE PAGE: Items 7a and 7b should be completed, indicating Direct Costs (in 
$25,000 increments up to a maximum of $250,000) and Total Costs [Modular 
Total Direct plus Facilities and Administrative (F&A) costs] for the initial 
budget period Items 8a and 8b should be completed indicating the Direct and 
Total Costs for the entire proposed period of support.

 o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form Page 
4 of the PHS 398. It is not required and will not be accepted with the 
application.

o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete the 
categorical budget table on Form Page 5 of the PHS 398. It is not required 
and will not be accepted with the application.

o NARRATIVE BUDGET JUSTIFICATION - Prepare a Modular Grant Budget Narrative 
page. (See http://grants.nih.gov/grants/funding/modular/modular.htm for 
sample pages.) At the top of the page, enter the total direct costs requested 
for each year. This is not a Form page.

o Under Personnel, List key project personnel, including their names, percent 
of effort, and roles on the project. No individual salary information should 
be provided. However, the applicant should use the NIH appropriation language 
salary cap and the NIH policy for graduate student compensation in developing 
the budget request.

For Consortium/Contractual costs, provide an estimate of total costs (direct 
plus facilities and administrative) for each year, each rounded to the 
nearest $1,000. List the individuals/organizations with whom consortium or 
contractual arrangements have been made, the percent effort of key personnel, 
and the role on the project. Indicate whether the collaborating institution 
is foreign or domestic. The total cost for a consortium/contractual 
arrangement is included in the overall requested modular direct cost amount.  
Include the Letter of Intent to establish a consortium.

Provide an additional narrative budget justification for any variation in the 
number of modules requested.

o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information used by 
reviewers in the assessment of each individual's qualifications for a 
specific role in the proposed project, as well as to evaluate the overall 
qualifications of the research team. A biographical sketch is required for 
all key personnel, following the instructions below. No more than three pages 
may be used for each person. A sample biographical sketch may be viewed at: 
http://grants.nih.gov/grants/funding/modular/modular.htm

- Complete the educational block at the top of the form page;
- List position(s) and any honors;
- Provide information, including overall goals and responsibilities, on 
research projects ongoing or
completed during the last three years.
- List selected peer-reviewed publications, with full citations;

o CHECKLIST - This page should be completed and submitted with the 
application. If the F&A rate agreement has been established, indicate the 
type of agreement and the date. All appropriate exclusions must be applied in 
the calculation of the F&A costs for the initial budget period and all future 
budget years.

o The applicant should provide the name and phone number of the individual to 
contact concerning fiscal and administrative issues if additional information 
is necessary following the initial review.

The completed original application and three legible copies must be sent or 
delivered to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD 20892
BETHESDA, MD 20817 (for express/courier service)

In order to facilitate the review of applications assigned to the NIDCR, the 
applicant must, at the same time, mail or deliver two copies of the 
application to:

Dr. H. George Hausch
Division of Extramural Research
National Institute of Dental and Craniofacial Research
45 Center Drive, Room 4AN-38D þ MSC 6402
Bethesda, MD  20892-6402

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed for completeness by the CSR and 
responsiveness by NIDCR.  Applications that are complete and responsive will 
be reviewed and evaluated for scientific and technical merit by an 
appropriate peer review group convened by the NIDCR in accordance with the 
review criteria stated below.  As part of the initial merit review all 
applications will receive a written critique and undergo a process in which 
only those applications deemed to have the highest scientific merit, 
generally the top half of applications under review, will be discussed, 
assigned a priority score, and receive a second level review by the National 
Advisory Dental and Craniofacial Research Council.

Review Criteria

The goals of NIH-supported research are to advance our understanding of 
biological systems, improve the control of disease, and enhance health.  In 
the written comments, reviewers will be asked to discuss the following 
aspects of the application in order to judge the likelihood that the proposed 
research will have a substantial impact on the pursuit of these goals.  Each 
of these criteria will be addressed and considered in assigning the overall 
score, weighting them as appropriate for each application.  Note that the 
application does not need to be strong in all categories to be judged likely 
to have major scientific impact and thus deserve a high priority score.  For 
example, an investigator may propose to carry out important work that by its 
nature is not innovative but is essential to move a field forward.

Significance.  Does this proposal address an important U.S or international 
problem?  If the aims of the application are achieved, how will scientific 
knowledge be advanced?  What will be the effect of these studies on the 
concepts or methods that drive this field?  To what degree does the proposed 
collaboration present opportunities for furthering research through the use 
of unusual talents, resources, populations, or environmental conditions in 
other countries?

Approach.  Are the conceptual framework, design and methods adequately 
developed, well integrated, and appropriate to the aims of the project?  Does 
the applicant acknowledge potential problem areas and consider alternative 
tactics?  Does the applicant propose concepts and strategies sensitive and 
appropriate to the potential research partners internationally?

Innovation.  Does the project employ novel concepts, approaches or method?  
Are the aims original and innovative? Does the project challenge existing 
paradigms or develop new methodologies or technologies?

Investigators.  Are the investigators appropriately trained and well suited 
to carry out this work?  Is the work proposed appropriate to the experience 
level of the principal investigator and other researchers partners?

Environment.  Does the scientific environment in which the work will be done 
contribute to the probability of success?  Do the proposed collaborative 
arrangements take advantage of unique features of the scientific environment?  
Is there evidence of collaborative institutional support?

The initial review group will also examine: the appropriateness of proposed 
project budget and duration; the adequacy of plans to include both genders, 
minorities and their subgroups, and children as appropriate for the 
scientific goals of the research and plans for the recruitment and retention 
of subjects; the provisions for the protection of human and animal subjects; 
and the safety of the research environment.

AWARD CRITERIA

Applications will compete for available funds with all other recommended 
applications.  Quality of the proposed project as determined by peer review, 
availability of funds, and program priority will be considered in making 
funding decisions.  Applicants should be aware that, in addition to 
scientific merit, program priorities and program balance, the total cost of 
the proposed project and the availability of funds will be considered by the 
NIDCR staff and the National Advisory Dental and Craniofacial Research 
Council in making funding recommendations. In addition, the NIDCR values 
complementary funding from other public and private sources including 
foundations and industrial concerns.  In circumstances in which applications 
have similar scientific merit, but vary in cost-competitiveness, the NIDCR is 
likely to select the more cost-competitive application for funding.

INQUIRIES

Written, email and telephone inquiries are encouraged early in the 
development of the application.  The opportunity to clarify any issues or 
questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Dr. Judy Small
Craniofacial Anomalies and Injuries Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24
Bethesda, MD  20892-6402
Telephone:  (301) 594-2425
FAX:  (301) 480-8318
Email:  Judy.Small@nih.gov

Dr. Dennis Mangan
Infectious Diseases Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24
Bethesda, MD  20892-6402
Telephone:  (301) 594-2421
FAX:  (301) 480-8318
Email:  Dennis.Mangan@nih.gov

Dr. Ann Sandberg
Neoplastic Diseases Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24
Bethesda, MD  20892-6402
Telephone:  (301) 594-2419
FAX:  (301) 480-8318
Email:  Ann.Sandberg@nih.gov

Dr. Eleni Kousvelari
Biomaterials and Biomimetics and Tissue Engineering Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24
Bethesda, MD  20892-6402
Telephone:  (301) 594-2427
FAX:  (301) 480-8318
Email:  Eleni.Kousvelari@nih.gov

Dr. Ken Gruber
Chronic Diseases Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24
Bethesda, MD  20892-6402
Telephone:  (301) 594-4836
FAX:  (301) 480-8318
Email:  Ken.Gruber@nih.gov

Dr. Norman Braveman
Clinical, Behavioral and Health Promotion
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24
Bethesda, MD  20892-6402
Telephone:  (301) 594-2089
FAX:  (301) 480-8318
Email:  Norman.Braveman@nih.gov

Direct inquiries regarding fiscal matters to:

Mr. Martin Rubinstein
Office of Grants Management
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-44A
Bethesda, MD  20892-6402
Telephone:  (301) 594-4800
FAX:  (301) 480-8301
Email:  Martin.Rubinstein@nih.gov


AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance No. 
93.121.  Awards are made under authorization of the Public Health Service 
Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 
USC 241 and 285) and administered under PHS grants policies and Federal 
Regulations 42 CFR 52 and 45 CFR Part 74.  This program is not subject to the 
intergovernmental review requirements of Executive Order 12372 or Health 
Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a 
smoke-free workplace and promote the non-use of all tobacco products.  In 
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking 
in certain facilities (or in some cases, any portion of a facility) in which 
regular or routine education, library, day care, health care or early 
childhood development services are provided to children.  This is consistent 
with the PHS mission to protect and advance the physical and mental health of 
the American people. 


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