Full Text PA-97-083 TUBERCULOSIS - BASIC BIOLOGY, IMMUNOLOGY AND PATHOGENESIS NIH GUIDE, Volume 26, Number 24, July 25, 1997 PA NUMBER: PA-97-083 P.T. Keywords: National Institute of Allergy and Infectious Diseases National Heart, Lung, and Blood Institute PURPOSE The National Institute of Allergy and Infectious Diseases (NIAID)and National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), invite applications focused on elucidating the basic biology, immunology and pathogenesis of mycobacteria, and host-mycobacterial interactions relevant to increasing and consolidating our fundamental understanding of tuberculosis. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, "TUBERCULOSIS - BASIC BIOLOGY, IMMUNOLOGY AND PATHOGENESIS", is related to the priority areas of: Immunization and Infectious Disease and HIV Infection and AIDS. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY Applications may be submitted by domestic and foreign, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Foreign institutions are not eligible for FIRST (R29). Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. MECHANISM OF SUPPORT Traditional research project grant (R01) and FIRST award (R29) applications may be submitted in response to this program announcement. Applications for R01 grants may request up to five years of support; applications for R29 grants must request five years of support. Responsibility for the planning, direction, and execution of the proposed research will be solely that of the applicant. RESEARCH OBJECTIVES Background Tuberculosis remains the leading cause of death throughout the world due to a single infectious agent (Mycobacterium tuberculosis or M.tb). In 1989 the U.S. Federal Government declared the goal of eliminating tuberculosis from the United States by the year 2010, with elimination defined as less than 0.1 cases per 100,000 population. It set an interim goal of 3.5 cases per 100,000 by the year 2000. CDC recently reported that in 1995 the US experienced 22.86 cases of tuberculosis per 100,000. Thus we remain far from even our interim goal. It appears evident that tuberculosis will not be eliminated from the US and the world without a more effective vaccine(s). The only currently available vaccine, BCG, has shown marked variability in its effectiveness against adult pulmonary tuberculosis, the major burden of disease. Furthermore, BCG is not recommended for general use in the United States and other countries with relatively low rates of endemic disease, because vaccination with BCG confounds surveillance efforts. Rational design of improved vaccines and other intervention strategies requires a broader and firmer base of fundamental knowledge regarding the biology of mycobacteria and their interactions with the host. Research Objectives and Scope NOTE: Three complementary Program Announcements are being issued: "The Latent State in Tuberculosis Infection"; "Tuberculosis - Basic Biology, Immunology and Pathogenesis"; and "Innovative Approaches to Investigating Human Tuberculosis". Applications which focus on understanding the latent state in tuberculosis infection and/or reactivation of tuberculosis should be submitted in response the PA "The Latent State in Tuberculosis Infection". Applications which focus on the use of model systems and or mycobacterial species other than M.tb to further understanding of any other aspect of tuberculosis should be submitted in response to the PA "Tuberculosis - Basic Biology, Immunology and Pathogenesis"; and applications which primarily focus on use of M.tb and/or human cells, tissues or study populations to study any aspect of human tuberculosis, per se, other than latency/reactivation should be submitted in response to the PA "Innovative Approaches to Investigating Human Tuberculosis". Acquiring the crucial information needed to develop improved intervention and therapeutic strategies for tuberculosis control requires a broad range of studies including, but not limited to: o developing improved tools for genetic manipulation of mycobacteria o determining the molecular basis of relevant pathogen/host cell interactions, including, but not limited to, very early events of infection, mechanisms of phagolysosomal evasion, and identification and isolation of virulence and invasion factors o elucidating the biology and biochemistry of mycobacterial genetic mechanisms and the signals that modulate these processes o characterizing mycobacterial physiology at the molecular and biochemical levels - including, but not limited to, roles of 'housekeeping' genes and their products, unique biochemical pathways, and nutrient transport mechanisms o defining the protective immune response and immunopathogenic mechanisms in mycobacterial infections, including the roles of mucosal immunity and responses directed at nonprotein as well as protein antigens o identifying and elucidating transport mechanisms for bacterial products, including possible translocation of mycobacterial antigens within host cells o developing methods to overcome technical challenges posed by slow-growing mycobacteria; this could include collaborations with bacterial physiologists experienced in molecular and biochemical investigations of other slow-growing organisms (e.g., Archaebacteria, Methanobacteria). These studies, while relevant ultimately to improving our understanding and knowledge of human tuberculosis, may employ model mycobacterial strains and animal systems, as appropriate. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided that inclusion is inappropriate with respect to the health of the subjects of the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research", which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and the NIH Guide for Grants and Contracts, Vol. 23, No. 11, March 18, 1994. Investigators may obtain copies from these sources or from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. APPLICATION PROCEDURES Applications are to be submitted on the grant application for PHS 398 (rev. 5/95) and will be accepted on the standard application deadlines as indicated in the application kit. Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Extramural Outreach and Information, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone (301) 710-0267, email: asknih@odrockm1.nih.gov. For purposes of identification and processing, item 2 on the face page of the application must be marked "YES". The PA number and the PA title must also be typed in section 2. The completed, signed original and five legible, single-sided copies of the application and any appendices must be sent or delivered to: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817-7710 (for express/courier service) R29 applications must include at least three sealed letters of reference attached to the face page of the original application. FIRST applications submitted without the required number of reference letters will be considered incomplete and will be returned without review. Applicants from institutions that have a General Clinical Research Center (GCRC) funded by the NIH National Center for Research Resources may wish to identify the Center as a resource for conducting the proposed research. If so, a letter of agreement from the GCRC Program Director must be included in the application material. REVIEW CONSIDERATIONS Review Procedures Applications will be assigned on the basis of established PHS referral guidelines. Upon receipt, applications will be reviewed for completeness by the NIH Division of Research Grants. Incomplete applications will be returned to the applicant without further consideration. Applications will be reviewed for scientific and technical merit by study sections of the Division of Research Grants, NIH, in accordance with the standard NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed, assigned a priority score, and receive a second level review by the appropriate national advisory council. Review Criteria The five criteria to be used in the evaluation of grant applications are listed below. The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. The reviewers will comment on the following aspects of the application in their written critiques in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered by the reviewers in assigning the overall score weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have a major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. 1. Significance. Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? 2. Approach. Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? 3. Innovation. Does the project employ novel concepts, approaches or method? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? 4. Investigator. Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? 5. Environment. Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? The initial review group will also examine: the appropriateness of proposed project budget and duration; the adequacy of plans to include both genders and minorities and their subgroups as appropriate for the scientific goals of the research and plans for the recruitment and retention of subjects; the provisions for the protection of human and animal subjects; and the safety of the research environment. AWARD CRITERIA Applications will compete for available funds with all other favorably recommended applications. The following will be considered when making funding decisions: quality of the proposed project as determined by peer review, program balance among research areas of the announcement, and availability of funds. INQUIRIES Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Inquiries regarding programmatic issues may be directed to: Ann M. Ginsberg, MD, Ph.D. Division of Microbiology and Infectious Diseases National Institute of Allergy and Infectious Diseases Solar Building, Room 3B06 6003 Executive Blvd. Bethesda, MD 20892-7630 Telephone: (301) 496-5305 Fax: (301) 496-8030 EMAIL: ag73i@nih.gov Hannah H. Peavy, M.D. Division of Lung Diseases National Heart, Lung, and Blood Institute Two Rockledge Centre, Suite 10018, MSC 7952 6701 Rockledge Drive Bethesda, Maryland 20892-7952 Telephone: (301) 435-0222 FAX: (301) 480-3557 E-mail: hannah_peavy@nih.gov Direct inquiries regarding fiscal matters to: Ms. Catherine Walker Division of Extramural Activities National Institute of Allergy and Infectious Diseases Solar Building, Room 4B32 6003 Executive Blvd. Bethesda, MD 20892-7610 Telephone: (301)402-7146 Fax: (301)480-3780 Email: cwalker@mercury.niaid.nih.gov Raymond L. Zimmerman Grants Operations Branch Division of Extramural Affairs National Heart, Lung, and Blood Institute Two Rockledge Centre, Suite 7154, MSC 7926 6701 Rockledge Drive Bethesda, MD 20892-79?? Telephone: (301) 435-0171 FAX: (301) 480-3310 E-mail: raymond_zimmerman@nih.gov AUTHORITY AND REGULATIONS This program is supported under authorization of the Public Health Service Act, Sec. 301(c), Public Law 78-410, as amended. The Catalogue of Federal Domestic Assistance Citations are No. 93.838. and No. 93.856. Awards will be administered under PHS grants policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems review. The Public Health Service strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. This is consistent with the PHS mission to protect and advance the physical and .
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