Full Text PA-96-017 NCRR SHARED INSTRUMENTATION GRANT NIH GUIDE, Volume 25, Number 1, January 26, 1996 PA NUMBER: PA-96-017 P.T. 18 Keywords: INSTRUMENTS/INSTRUMENTATION/DEVICE National Center for Research Resources Application Receipt Date: March 27, 1996 PURPOSE The National Center for Research Resources (NCRR) is continuing its competitive Shared Instrumentation Grant (SIG) Program initiated in Fiscal Year 1982. The (1992) National Report on Academic Research Equipment and Equipment Needs for Biological Sciences, cosponsored by the National Institutes of Health (NIH) and the National Science Foundation, identified research equipment of the type provided through this program as top-priority. The objective of the program is to make available to institutions with a high concentration of NIH-supported biomedical investigators expensive research instruments which can only be justified on a shared-use basis and for which meritorious research projects are described. Awards under this Program Announcement (PA) will use the Shared Instrumentation Grant mechanism (S10). ELIGIBILITY REQUIREMENTS Under the general research support authority of Section 301 (a)(3) of the Public Health Service Act, Shared Instrumentation Grant awards are made to public and non-profit institutions only. For purposes of these guidelines, an "institution" is defined as the organizational component identified on page 1, item 11 of the PHS 398 (rev. 5/95), for which descriptive information is provided on page 9-10 in the PHS 398 kit. These institutions include health professional schools, other academic institutions, hospitals, health departments, and research organizations. Federal institutions, foreign institutions, and for-profit institutions are not eligible to apply. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. An eligible institution may submit more than one application for different instrumentation for the March 27, 1996, deadline. However, if several applications are submitted for similar instrumentation from one or more eligible institutions on the same campus of a university, documentation from a high administrative official must be provided stating that this is not an unintended duplication but part of a campus- wide institutional plan. MECHANISM OF SUPPORT Shared Instrumentation Grants (S10) provide support for expensive state-of-the-art instruments utilized in both basic and clinical research. Applications are limited to instruments that cost at least $100,000 per instrument or system. The maximum award is $400,000. Because the nature and scope of the instruments that may be requested will vary, it is anticipated that the size of an award will vary also. RESEARCH OBJECTIVES This program is designed to meet the special problems of acquisition and updating of expensive shared-use instruments which are not generally available through other NIH mechanisms, such as the regular research project, program project, or center grant programs. Proposals for research on advancing the design or for the development of new instrumentation will not be considered. Types of instrumentation supported include, but are not limited to, nuclear magnetic resonance systems, electron microscopes, mass spectrometers, protein sequencer/amino acid analyzers and cell sorters. Support will not be provided for general purpose equipment or purely instructional equipment, personal computers, personal work stations, printers, and ethernet interfaces. Proposals for "stand alone" computer systems will only be considered if the instrument is solely dedicated to the research needs of a broad community of NIH-supported investigators. Awards will be made for the direct costs of the acquisition of new, or the updating of existing, research instruments. The institution must meet those costs (not covered in the normal purchase price) required to place the instrumentation in operational order as well as the maintenance, support personnel, and service costs associated with maximum utilization of the instrument. There is no upper limit on the cost of the instrument, but the maximum award is $400,000. Grants will be awarded for a period of one year and are not renewable. Supplemental applications will not be accepted. The program does not provide indirect costs or support for construction or alterations and renovations. Cost sharing is not required. If the amount of funds requested does not cover the total cost of the instrument, the application should describe the proposed sources(s) of funding for the balance of the cost of the instrument. Documentation of the availability of the remainder of the funding, signed by an appropriate institutional official, must be presented to NCRR prior to the issuance of an award. Requests for a multiple instrument purchase totalling over $400,000 must specify and justify which instrument(s) should be supported within the $400,000 ceiling. Applicants proposing the direct purchase of an instrument that the institution has secured or is planning to secure via a leasing agreement are strongly encouraged to consult with their institutional sponsored projects office regarding applicable PHS policy prior to executing the leasing agreement. If the leasing agreement was executed more than one year prior to submission of the SIG application, the applicant must provide strong justification for the requested Federal funds. Further, the instrument must be considered state-of-the-art at the time of submission of the SIG application. Since the intent of the program is to promote sharing, a major user group of three or more investigators must be identified. A minimum of three major users must be Principal Investigators on NIH peer reviewed research grants at the time of the application and award. For purposes of this program research grants are defined as those grants awarded with the following activity codes: P01, R01, U01, R29, R35, and R37. The application must show a clear need for the instrumentation by projects supported by multiple NIH research awards and demonstrate that these projects will require at least 75 percent of the total usage of the instrument. Major users can be individual researchers, or a group of investigators within the same department or from several departments at the applicant institution. NIH extramural awardees from other nearby institutions may also be included. If the major user group does not require total usage of the instrument, access to the instrument should be made available to other users upon the advice of the internal advisory committee. These users need not be NIH awardees, but priority should be given to NIH-supported scientists engaged in biomedical/behavioral research. To encourage optimal sharing among individual investigators, research groups, and departments, and to foster a collaborative multidisciplinary environment, instruments should be integrated into central core facilities, whenever possible. Each applicant institution must propose a Principal Investigator who can assume administrative/scientific oversight responsibility for the instrumentation requested. An internal advisory committee to assist in this responsibility should also be utilized. The Principal Investigator and the advisory group are responsible for the development of guidelines for shared use of the instrument, for preparation of all reports required by the NIH, for relocation of the instrument within the grantee institution if the major user group is significantly altered, and for continued support for the maximum utilization and maintenance of the instrument in the post-award period. A plan should be proposed for the day-to-day management of the instrument including designation of a qualified individual to supervise the operation of the instrument and to provide technical expertise to the users. Specific plans for sharing arrangements and for monitoring the use of the instrument should be described. If a grant award is made, a final progress report will be required that describes the use of the instrument, listing all users and indicating the value of the instrumentation to the research of the major users and to the institution as a whole. This report is due within 90 days following the end of the project period. APPLICATION PROCEDURES The research grant application form 398 (rev. 5/95) is to be used in applying for these grants. These forms are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Information, Division of Research Grants, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone (301) 710-0267, email: girg@drgpo.drg.nih.gov. 1. Form page 1 (Face page of the application) - Item 1. Name the type of instrument requested. (Note in bold type at the bottom of the face page if a duplicate application has been sent to NSF or to another organization or agency.) Item 2. Check the box marked "YES" and enter the title and number of this program announcement. Item 4. If human subjects are involved in the research, follow the instructions for completing Item 4 on the Face Page of Form PHS 398, certifying that an Institutional Review Board (IRB) approved by PHS has reviewed and approved the protocols involving human subjects. If the protocols are ongoing and have already received prior IRB review and approval within one year of the submission date of this application, then additional IRB review is not necessary. However, this fact must be noted in Item 4 on the Face Page, and, if space is insufficient, the date(s) of prior IRB review and approval of each protocol involving human subjects should be listed in the "Research Plans." Item 5. If live vertebrate animals are involved in the research, follow the instructions for completing Item 5 on the Face Page of Form PHS 398, verifying that an Institutional Animal Care and Use Committee (IACUC) approved by PHS (OPRR) has reviewed and approved the protocols involving animals. If the protocols are ongoing and have already received prior IACUC review and approval within three years of the submission date of this application, then additional IACUC review is not necessary. However, this fact must be noted in Item 5 on the Face Page and, if space is insufficient, the date(s) of prior IACUC review and approval of each protocol involving animals should be listed in the "Research Plan." Item 6. Write in 04/01/97 through 03/31/98. Item 8A. Use this block to give the total amount requested from NCRR for this instrument or system. Item 11. Insert the appropriate code identification. 2. Form page 2. Complete the abstract as directed. Under "Key Personnel," give data on the Principal Investigator and the major user group as required. 3. Form page 4. Describe the instrument requested including manufacturer and model number. The model chosen should be justified by comparing its performance with other available instruments. Provide a detailed budget breakdown of the main equipment and accessories requested including tax and import duties, if applicable. An itemized quote from a vendor should be included. If a project involves a potential biohazard, funds for accessory containment equipment for the instrument or instrument system may be included in the requested budget. 4. Form page 5. Budget Estimates for All Years. Not applicable; do not complete. 5. Form page 6 - Biographical Sketch. In addition to the personnel listed on page 2, include a biographical sketch of the person(s) who will be in charge of maintenance and operation of the instrument and a brief statement of the qualifications of the individual(s). Biographical sketches should not exceed 2 pages for each individual. 6. Form page 7 - Other Support. Provide the requested information for each major user and for each application for the same instrumentation sent to NSF or another organization or agency. 7. Research Plan section of the application. (If this is a revised application, note the special instructions on page 15 in the PHS 398 kit regarding completion of this section of the application.) Provide information relative to the points identified under criteria for review including: a. Inventory similar instruments existing at the institution or otherwise accessible; describe (with supporting documentation) why they are unavailable or inappropriate for the proposed research and provide a clear justification why new or updated equipment is needed, including accessories. b. The major users should describe their research projects and indicate how the requested instrumentation and/or accessories would enhance the progress of their research projects. While most projects are included in currently funded applications, some represent new directions. In the case of funded projects, the description should not exceed four pages per user but should point out the benefit of the proposed instrument to the research objectives of each major user. New directions and their requirements for the proposed instrumentation should be described in sufficient detail to allow adequate review (including preliminary data or supplemental materials). Use a table to list the names of the users, brief titles of the projects, the NIH grant numbers and the estimated percentage of use. List the page number of this table under "Table of Contents" (Form page 3) after "Resources and Environment." Make a separate table to indicate the major users' needs for requested accessories. If possible, each user should highlight those publications that demonstrate the user's expertise in using the requested instrumentation. c. Describe the organizational plan including the internal advisory committee for administration of the grant. d. Submit a specific plan for long-term operation and maintenance of the instrument. Provide documentation (e.g., separate letters signed by appropriate institutional officials) describing the required institutional commitment in support of the proposed plan. Applications must be received by March 27, 1996. Applications received after this date will not be accepted for review in this competition and will be returned to the applicant. The completed, signed original and four exact photocopies of the signed application and any appendix material* must be sent to: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) *Since the appendix will not be duplicated, if glossy photographs or color images are included, a separate set of originals must accompany each application. One copy of the application and appendix material must be addressed to: Shared Instrumentation Program Biomedical Technology National Center for Research Resources 6705 Rockledge Drive, Room 6154 - MSC 7965 Bethesda, MD 20892-7965 REVIEW CONSIDERATIONS Applications that are complete and responsive to the program announcement will be evaluated for scientific and technical merit by an appropriate peer review group convened in accordance with NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and may undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed, assigned a priority score, and receive a second level review by the National Advisory Research Resources Council, NCRR. Applications are reviewed by specially convened initial review groups of the Division of Research Grants (DRG) for scientific and technical merit and for program considerations by the National Advisory Research Resources Council (NARRC) of the NCRR. Approximately half of the applications will be reviewed at the September 1996 NARRC meeting and the remainder at the NARRC meeting in February 1997. Funding decisions on all applications received for the March 27, 1996, deadline will not be made until the program receives an appropriation for FY 1997. The Council date will not affect funding decisions. Applications that request a single instrument with a total purchase cost of more than $500,000, and that would normally be eligible for submission to both NIH and NSF, may be submitted to NIH for joint funding with NSF by including necessary NSF documentation. The Agencies will review such proposals in a special review group that will be convened by NIH as a special NIH study section with NSF participation. Under this arrangement, the agencies may offer joint funding in excess of the current award limit of $400,000. Contact the NSF Division of Biological Instrumentation and Resources for additional information on the NSF documentation (cover sheet and cost sharing agreement). Review Criteria o The Scientific Need The extent to which an award for the specific instrument would meet the scientific needs and enhance the planned research endeavors of the major users by providing an instrument that is unavailable or to which availability is highly limited. o Technical Expertise The availability and commitment of the appropriate technical expertise within the major user group or the institution for use of the instrumentation. o Management Plan The adequacy of the organizational plan for use of the instrument and the internal advisory committee for oversight of the instrument including sharing arrangements. o Institutional Commitment The institution's commitment for continued support of the utilization and maintenance of the instrument. o Overall Benefit The benefit of the proposed instrument to the overall research community it will serve. AWARD CRITERIA In making funding decisions, the NCRR will give consideration to ensure program balance among various types of instruments supported and/or geographic distribution of awards. INQUIRIES Inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic or scientific issues to: Marjorie A. Tingle, Ph. D. Director, Shared Instrumentation Grant Program National Center for Research Resources One Rockledge Centre, Room 6154 6705 Rockledge Drive, MSC 7965 Bethesda, MD 20892- 7965 Telephone: (301) 435-0772 Fax: (301) 480-3775 Email: SIG@EP.NCRR.NIH.GOV Direct inquiries regarding fiscal matters to: Ms. Carmen Herbert Office of Grants and Contracts Management National Center for Research Resources One Rockledge Centre, Room 6205 6705 Rockledge Drive, MSC 7965 Bethesda, MD 20892-7965 Telephone: (301) 435-0837 Email: CarmenH@ep.ncrr.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance number 93.337, Biomedical Research Support. Awards will be made under authorization of the Public Health Service Act, Titles III and IV, (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 287) and administered under PHS grants policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. .
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