Full Text PA-95-062

FELLOWSHIPS AND CAREER DEVELOPMENT IN INFLAMMATORY BOWEL DISEASE RESEARCH

NIH GUIDE, Volume 24, Number 17, May 19, 1995

PA NUMBER:  PA-95-062

P.T. 44

Keywords: 
  Digestive Diseases & Disorders 
  Inflammation 


National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Allergy and Infectious Diseases

PURPOSE

The Division of Digestive Diseases and Nutrition of the National
Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and
the Division of Allergy, Immunology, and Transplantation of the
National Institute of Allergy and Infectious Diseases (NIAID) invite
applications for individual National Research Service Award
fellowships (F32s) or Mentored Clinical Scientist Development Awards
(K08s) from physicians and basic scientists interested in pursuing
research related to inflammatory bowel disease (IBD).  The intent of
this Program Announcement (PA) is to encourage research and career
development for individuals with a strong commitment to a research
career in the area of the inflammatory bowel diseases, either in one
of the basic sciences relevant to IBD or, more specifically, in work
aimed at either Crohn's disease or ulcerative colitis.  Research
related to the role of the immune system in the pathogenesis and/or
treatment of these diseases is of particular interest.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Fellowships and Career Development in Inflammatory Bowel Disease
(IBD) Research, is related to the priority area of chronic disabling
conditions.  Potential applicants may obtain a copy of "Healthy
People 2000 (Full Report:  Stock No. 017-001-00474-0 or Summary
Report:  Stock No. 017-001-00473-1) through the Superintendent of
Documents, Government Printing Office, Washington, DC 20402-9325
(telephone 202-783-3238).

ELIGIBILITY REQUIREMENTS

Applications for F32 awards may be submitted by domestic and foreign
for-profit and non-profit organizations, public and private, such as
universities, colleges, hospitals, laboratories, units of State and
local governments, and eligible agencies of the Federal government.
Applications for K08 awards may only be submitted by domestic
organizations.  Racial/ethnic minority individuals, women, and
persons with disabilities are encouraged to apply as principal
investigators.

Applicants for both NRSA fellowships and Mentored Clinical Scientist
Development Awards (K08) must be U.S. citizens or permanent residents
of the United States.  Grant funds are for research and career
development only and may not be used for the support of clinical
training or clinical services.  K08 applicants must have received a
clinical degree, or its equivalent, have completed residency
requirements, and must not have previously been principal
investigator on a research project grant (R01), or its equivalent.
F32 applicants must have received the Ph.D., M.D., or equivalent
degree prior to the beginning date of their appointment.  NRSA
postdoctoral support is limited to three years.

MECHANISM OF SUPPORT

Support of this program will be through the Individual National
Research Service Award (F32) and the Mentored Clinical Scientist
Development Award (K08).  Details on each of these mechanisms are
available from the Division of Research Grants, Office of Grants
Information, 6701 Rockledge Drive, Room 3032, MSC 7762, Bethesda, MD
20892-7762, telephone (301) 435-0714.

RESEARCH OBJECTIVES

The objective of this program announcement is to encourage
individuals to pursue research careers in the area of inflammatory
bowel disease in order to increase the number of trained physicians
and basic scientists interested in pursuing research related to the
elucidation of the pathogenesis, progression, and treatment of
inflammatory bowel disease.  It has become clear recently that
inflammatory bowel diseases may be caused by dysregulation of the
immune system.  Training either in the basic science areas of
immunology, cell biology, or genetics as they relate to IBD or in the
clinical areas of the diagnosis and treatment for Crohn's or
ulcerative colitis are encouraged.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN
SUBJECTS

It is the policy of the NIH that women and members of minority groups
and their subpopulations must be included in all NIH supported
biomedical and behavioral research projects involving human subjects,
unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the
subjects or the purpose of the research.  This new policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public Law
103-43) and supersedes and strengthens the previous policies
(Concerning the Inclusion of Women in Study Populations, and
Concerning the Inclusion of Minorities in Study Populations), which
have been in effect since 1990.  The new policy contains some
provisions that are substantially different from the 1990 policies.

All investigators proposing research involving human subjects should
read the "NIH Guidelines For Inclusion of Women and Minorities as
Subjects in Clinical Research," which have been published in the
Federal Register of March 28, 1994 (FR 59 14508-14513) and reprinted
in the NIH Guide for Grants and Contracts, Volume 23, Number 11,
March 18, 1994.

Investigators also may obtain copies of the policy from the program
staff listed under INQUIRIES.  Program staff may also provide
additional relevant information concerning the policy.

APPLICATION PROCEDURES

Applications for K08 awards are to be submitted on the grant
application form PHS 398 (rev. 9/91) and will be accepted at the
standard application deadlines as indicated in the application kit.
Applications for NRSAs are to be submitted on the grant application
form PHS 416-1 (rev. 10/91) and will be accepted at the standard
application deadlines as indicated in the application kit.

Both application kits are available at most institutional offices of
sponsored research and may be obtained from the Office of Grants
Information, Division of Research Grants, National Institutes of
Health, 6701 Rockledge Drive, Room 3032, MSC 7762, Bethesda, MD
20892-7762, telephone (301) 435-0714.  The title and number of the
program announcement must be typed in Section 2a on the face page of
the application.

Applications must include three selaed letters of recommendations
address ing the candidate's potential for a research career.
Applications without the required number of letters of
recommendations will be considered incomplete and and will be
returned without review.

For K08 applications, the completed original application and five
legible copies must be sent or delivered to:

DIVISION OF RESEARCH GRANTS
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

For F32 applications, the completed original application and two
legible copies must be sent or delivered to the same address.

REVIEW CONSIDERATIONS

Applications will be assigned on the basis of established PHS
referral guidelines.  K08 applications will be reviewed for
scientific and technical merit by review groups of the Institute to
which they are assigned in accordance with standard NIH peer review
procedures.  NRSA fellowship applications will be reviewed for
scientific and technical merit by review groups within the Division
of Research Grants.

Following scientific-technical review, K08 applications will receive
a second-level review by the appropriate National Advisory Councils;
the F32 applications will receive a second-level review by staff of
the Institutes.

The general review criteria for applications received in response to
this PA are the same as those for unsolicited NRSA fellowship and K08
applications.  Specifically these are:

o  the applicant's potential for and commitment to a research career
in the areas specified by this PA;

o  training potential of the proposed research;

o  scientific merit of the proposed research; and

o  qualifications, research expertise, and training experience of the
sponsor along with adequate institutional commitment to ensure
completion of the proposed training.

The initial review group, either in the Institute for K08
applications, or in the DRG for NRSA fellowship applications, will
also examine the provisions for the protection of human and animal
subjects and the safety of the research environment.

AWARD CRITERIA

Applications will compete for available funds with all other approved
applications assigned to that IC. The following will be considered in
making funding decisions: quality of the proposed project as
determined by peer review, the availability of funds, and program
priority.

INQUIRIES

Inquiries are encouraged.  The opportunity to clarify any issues or
questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Judith M. Podskalny, Ph.D.
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 6AN-12E
45 Center Drive MSC 6600
Bethesda, MD  20892-6600
Telephone:  (301) 594-8876
FAX:  (301) 480-8300
Email:  jp53s@nih.gov

Lawrence Prograis, M.D.
Division of Allergy, Immunology, and Transplantation
National Institute of Allergy and Infectious Diseases
Solar Building, Room 4A24
6003 Executive Boulevard MSC 7640
Bethesda, MD  20892-7640
Telephone:  (301) 496-1886
FAX:  (301) 402-2571
Email:  lp13r@nih.gov

Direct inquiries regarding fiscal and administrative matters to:

Mrs. Nancy Dixon
Division of Extramural Activities
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 6AN-44C
45 Center Drive MSC 6600
Bethesda, MD  20982-6600
Telephone:  (301) 594-8854
Email:  nd11m@nih.gov

Ms. Jacqueline Johnson
Grants Management Branch
National Institute of Allergy and Infectious Diseases
Solar Building, Room 4B26
6003 Executive Boulevard MSC 7610
Bethesda, MD  20892-7610
Email:  jj19e@nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic
Assistance No. 93.848 and 93.855.  Awards are made under
authorization of the Public Health Service Act, Title IV, Part A
(Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and
285) and administered under PHS grants policies and Federal
Regulations 42 CFR 52 and 45 CFR Part 74.  This program is not
subject to the intergovernmental review requirements of Executive
Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to
provide a smoke-free workplace and promote the non-use of all tobacco
products.  In addition, Public Law 103-227, the Pro-Children Act of
1994, prohibits smoking in certain facilities (or in some cases, any
portion of a facility) in which regular or routing education,
library, day care, health care or early childhood development
services are provided to children.  This is consistent with the phs
mission to protect and advance the physical and mental health of the
american people.

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